Risk stratification and prognosis prediction based on inflammation‐related gene signature in lung squamous carcinoma by Wenyu Zhai, Si Chen, Fangfang Duan, Junye Wang, Zerui Zhao, Yaobin Lin, Bingyu Rao, Yizhi Wang, Lie Zheng, Hao Long

“…Subsequently, a prognostic nomogram including IRG signature, age, and cancer stage was constructed for predicting individualized OS, whose concordance index values were 0.610 (95% CI: 0.568–0.651) in the training set and 0.652 (95% CI: 0.580–0.724) in validation set. …”
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Conditional survival analysis of patients with resected non–small cell lung cancerCentral MessagePerspective by Talib Chaudhry, MD, Vaishnavi Krishnan, MD, Andrew E. Donaldson, MD, Zachary M. Palmisano, BS, Sanjib Basu, PhD, Nicole M. Geissen, DO, Justin M. Karush, MD, Gillian C. Alex, MD, Jeffrey A. Borgia, PhD, Michael J. Liptay, MD, Christopher W. Seder, MD

“…At the time of resection, male sex (hazard ratio [HR], 1.33; 95% confidence interval [CI], 1.03 to 1.72; P = .032), tumor size >3 cm (HR, 1.17; 95% CI, 1.11-1.23; P < .001), node positivity (HR, 3.31; 95% CI, 2.52-4.33; P < .001), and American Joint Committee on Cancer stage (P < .001) were associated with DFS. However, if a patient lived 3 years without recurrence (CS3), these factors were no longer prognostic of DFS. …”
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Treatment and mortality risk of older adults with non‐small cell cancer in Taiwan: A population‐based cohort study by Chun‐Chieh Wang, Shao‐Wen Chiu, Shang‐Jung Wu, Lung‐Kwang Pan, Yung‐Feng Yen, Yun‐Ju Lai, Chu‐Chieh Chen

“…The subgroup analyses stratified by cancer stages also showed consistent findings. Conclusion Elderly patients with NSCLC had significantly decreased mortality risk when receiving curative or palliative treatment compared with those without treatment. …”
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Voltage-Gated Sodium Channel Na_V1.5 Controls NHE−1−Dependent Invasive Properties in Colon Cancer Cells by Osbaldo Lopez-Charcas, Lucile Poisson, Oumnia Benouna, Roxane Lemoine, Stéphanie Chadet, Adrien Pétereau, Widad Lahlou, Serge Guyétant, Mehdi Ouaissi, Piyasuda Pukkanasut, Shilpa Dutta, Sadanandan E. Velu, Pierre Besson, Driffa Moussata, Sébastien Roger

“…In all cases, <i>SCN5A</i> (gene encoding for Na_V1.5) was overexpressed and positively correlated with cancer stage and poor survival prognosis for patients. …”
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Real-world comparison of pembrolizumab and nivolumab in advanced hepatocellular carcinoma by Yen-Hao Chen, Ching-Hua Tsai, Yen-Yang Chen, Chih-Chi Wang, Jing-Houng Wang, Chao-Hung Hung, Yuan-Hung Kuo

“…All patients were staged as Barcelona Clinic Liver Cancer stage C, and 29 patients were classified as Child-Pugh classification B (7). …”
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Prognostic significance of RNA-based TP53 pathway function among estrogen receptor positive and negative breast cancer cases by Amber N. Hurson, Mustapha Abubakar, Alina M. Hamilton, Kathleen Conway, Katherine A. Hoadley, Michael I. Love, Andrew F. Olshan, Charles M. Perou, Montserrat Garcia-Closas, Melissa A. Troester

“…Participants included 3213 women in the Carolina Breast Cancer Study (CBCS) with invasive breast cancer (stages I–III). Tumors were classified for TP53 status (mutant-like/wildtype-like) using an RNA signature. …”
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Tislelizumab in Patients with Previously Treated Advanced Hepatocellular Carcinoma (RATIONALE-208): A Multicenter, Non-Randomized, Open-Label, Phase 2 Trial by Zhenggang Ren, Michel Ducreux, Ghassan K. Abou-Alfa, Philippe Merle, Weijia Fang, Julien Edeline, Zhiwei Li, Lihua Wu, Eric Assenat, Sheng Hu, Lorenza Rimassa, Tao Zhang, Jean-Frédéric Blanc, Hongming Pan, Paul Ross, Chia-Jui Yen, Albert Tran, Guoliang Shao, Mohamed Bouattour, Yajin Chen, Tim Meyer, Jinlin Hou, David Tougeron, Yuxian Bai, Ming-Mo Hou, Zhiqiang Meng, John Wu, Vincent Li, Sandra Chica-Duque, Ann-Lii Cheng

“…Methods: The multi-regional phase 2 study, RATIONALE-208, examined single-agent tislelizumab (200 mg intravenously every three weeks) in patients with advanced HCC with Child-Pugh A, Barcelona Clinic Liver Cancer stage B or C, and who had received one or more prior lines of systemic therapy. …”
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Protein disulfide isomerase A3 as novel biomarker for endometrial cancer by Fanrong Yu, Xin Liu, Min Li, Xiufen Liu, Xintai Wang, Xintai Wang, Meixiang Guo

“…Furthermore, PDIA3 expression showed significant correlations with cancer stage and tumor grade. Multivariate Cox regression analysis suggested that the PDIA3 gene holds promise as a prognostic factor for EC patients (HR = 0.47, 95% CI [0.27, 0.82], P = 0.008). …”
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Impact of the COVID-19 Pandemic on Staging Oncologic PET/CT Imaging and Patient Outcome in a Public Healthcare Context: Overview and Follow Up of the First Two Years of the Pandemi... by Andres Kohan, Sumesh Menon, Vanessa Murad, Seyed Ali Mirshahvalad, Roshini Kulanthaivelu, Adam Farag, Claudia Ortega, Ur Metser, Patrick Veit-Haibach

“…Furthermore, OS was not significantly modified by the year patients were staged, even when controlled for non-COVID-19 significant variables (age, type of cancer, stage and gender).…”
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The radiological characteristics, tertiary lymphoid structures, and survival status associated with EGFR mutation in patients with subsolid nodules like stage I-II LUAD. by Mei Xie, Jie Gao, Xidong Ma, Jialin Song, Chongchong Wu, Yangyu Zhou, Tianjiao Jiang, Yiran Liang, Chen Yang, Xinyu Bao, Xin Zhang, Jie Yao, Ying Jing, Jianlin Wu, Jianxin Wang, Xinying Xue

“…Abstract Background Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) recommended for the patients with subsolid nodule in early lung cancer stage is not routinely. The clinical value and impact in patients with EGFR mutation on survival outcomes is further needed to be elucidated to decide whether the application of EGFR-TKIs was appropriate in early lung adenocarcinoma (LUAD) stage appearing as subsolid nodules. …”
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Increased Prevalence of EBV Infection in Nasopharyngeal Carcinoma Patients: A Six-Year Cross-Sectional Study by Abdullah E. Al-Anazi, Bader S. Alanazi, Huda M. Alshanbari, Emad Masuadi, Maaweya E. Hamed, Iman Dandachi, Abdulrahman Alkathiri, Atif Hanif, Islam Nour, Hanadi Fatani, Hadel Alsaran, Fahad AlKhareeb, Ali Al Zahrani, Abdullah A. Alsharm, Saleh Eifan, Bandar Alosaimi

“…Histopathological examination showed that most of the NPC patients were in the advanced stages of cancer: stage III (38.4%) or stage IV-B (37.7%). Only keratinized squamous cell carcinoma was significantly higher in EBV negative NPC patients compared with those who were EBV positive (OR = 0.01, 95%CI = (0.004–0.32; <i>p</i> = 0.009)), whereas the majority of patients (91.8%) had undifferentiated, non-keratinizing squamous cell carcinoma, followed by differentiated, non-keratinizing squamous cell carcinoma (7.5%). …”
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COVID-19 and liver cancer: lost patients and larger tumours by Helen L Reeves, Tim Hoare, Steven Masson, Paul Turner, Lucy Walker, Quentin M Anstee, Stuart McPherson, Mhairi Donnelly, Preya Patel, Beate Haugk, Antony Darne, John Scott, Robyn Watson, Jessica Dyson, Steven White, Gourab Sen, Sanjay Pandanaboyana, John Hammond, Stuart Robinson, Jeremy J French, Mark Hudson, Kirsty Anderson, Derek M Manas, Peter Littler, Daniel Geh, Misti McCain, Alastair Burt, Louise MacDougal, Michael McNeil, Nick Wadd, Syed Asghar, Lavanya Mariappan, Jane Margetts, Yvonne Bury, Shreya Raman, Daniel Parkinson, Benjamin Stenberg

“…Patients received treatment appropriate for their cancer stage, with waiting times shorter for patients with HCC and unchanged for patients with ICC. …”
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Impact of pre‐ and post‐diagnosis physical activity on the mortality of patients with cancer: Results from the Health Examinees‐G study in Korea by Jaesung Choi, Joo‐Yong Park, Ji‐Eun Kim, Miyoung Lee, Kyuwan Lee, Jong‐Koo Lee, Daehee Kang, Aesun Shin, Ji‐Yeob Choi

“…The Cox proportional hazard model was used to characterize the association between PA and cancer‐specific mortality, adjusting for demographics, behaviors, comorbidities, and cancer stage based on the Surveillance, Epidemiology, and End Results program. …”
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Detecting miRNAs expression as the early prognostic factor for patients with colorectal cancer in Dr. Sardjito Hospital Yogyakarta : A preliminary study by Adeodatus Yuda Handaya, Didik Setyo Heriyanto, Hendra Susanto, Yudi Susanto, Kamal Agung Yudayana, Ida Ayu Setyawati Sri Krisna Dewi, Aditya Rifqi Fauzi, Joshua Andrew, Kevin Radinal, Azriel Farrel Kresna Aditya

“…MiR-195 was also significantly associated to cancer stage (r=-0.570, p=0.001) with significant odds ratio (OR=0.892, 95% CI=0.804–0.990, p=0.031). …”
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Comprehensive Analysis of Prognostic Value and Immune Infiltration of Src Family Kinases in Hepatocellular Carcinoma by Dingjin Yao, Yiran Deng, Si Zhang, Limiao Liang, Li Zhang, Shuqiang Weng, She Chen

“…The mRNA levels of BLK, BRK, FRK, FYN, LCK, LYN, SRC, SRM and YES were correlated with clinical cancer stage. Elevated FYN mRNA levels in HCC were positively correlated with overall survival (OS), whereas SRC was negatively correlated with OS. …”
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Recent trends in the incidence and survival of stage I liver cancer: a surveillance, epidemiology, and end results analysis by Xue-Chen Yu, Ji-Bin Liu, Qing-Hai Tang, Xun Diao, Qi-Yu Fan, Zhong-Yan Huang, Xiao-Mei Tang, Sha Li, Yong-Feng Cao, Yu-Shui Ma, Da Fu

“…These trends emphasized the importance of early detection of liver cancer and regular screening and better treatment for high-risk populations.RESEARCH HIGHLIGHTSImprovements in screening and imaging technologies and treatment of liver disease have influenced the trend in diagnosis for liver cancer.Stage I cases of liver cancer increased most tremendously over the study period, with a greater increase from 2004 to 2012 following a smaller increase from 2012 to 2015.These trends emphasized the importance of early detection of liver cancer and regular screening and better treatment for high-risk populations.…”
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Effect of IL-10-producing B cells in peripheral blood and tumor tissue on gastric cancer by Yoon Ju Jung, Jin Seok Woo, Sun-Hee Hwang, SeungCheon Yang, So Jung Kim, JooYeon Jhun, Seung Yoon Lee, Kun Hee Lee, Mi-La Cho, Kyo Young Song

“…The population of B10 cells in cancerous mucosa increased with cancer stage. When AGS cells were cultured under cell-death conditions, cellular necrosis was significantly decreased, and proliferation was increased, for 1 day after IL-10 stimulation. …”
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Circulating Omentin-1 as a Biomarker at the Intersection of Postmenopausal Breast Cancer Occurrence and Cardiometabolic Risk: An Observational Cross-Sectional Study by Gerasimos Socrates Christodoulatos, Georgios Antonakos, Irene Karampela, Sotiria Psallida, Theodora Stratigou, Natalia Vallianou, Antigoni Lekka, Ioanna Marinou, Evaggelos Vogiatzakis, Styliani Kokoris, Athanasios G. Papavassiliou, Maria Dalamaga

“…In the patients, omentin-1 was inversely associated with tumor, metabolic and inflammatory biomarkers, cancer stage, and the number of infiltrated lymph nodes (<i>p</i> < 0.05). …”
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Bladder cancer-derived exosomal KRT6B promotes invasion and metastasis by inducing EMT and regulating the immune microenvironment by Qiang Song, Hao Yu, Yidong Cheng, Jie Han, Kai Li, Juntao Zhuang, Qiang Lv, Xiao Yang, Haiwei Yang

“…Additionally, clinical correlation analysis showed that the elevated level of KRT6B was highly associated with bladder cancer stage, grade, and metastasis status. GSEA revealed that KRT6B was involved not only in epithelial–mesenchymal transition-related pathways but also in the immune response in bladder cancer. …”
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Telehealth multicomponent exercise and health education in breast cancer patients undergoing primary treatment: rationale and methodological protocol for a randomized clinical tria... by João S. Henkin, Cíntia E. Botton, Mariana S. Simon, Guilherme G. Rocha, Caroline B. Silveira, Ricardo S. Gehrke, Gabriella B. Freitas, Gabriel S. Trajano, Ronei S. Pinto, Stephanie S. Pinto

“…Women undergoing primary treatment (during or after chemotherapy) for breast cancer (stages I–III) will be randomly assigned to MTHE (twice a week) or HE (once a week). …”
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