Chemo-Radio-Immunotherapy for NSCLC III: ESR/ATS Thresholds for DL_CO Correlate with Radiation Dosimetry and Pneumonitis Rate by Markus Stana, Brane Grambozov, Josef Karner, Isabella Gollner, Christoph Gaisberger, Elvis Ruznic, Barbara Zellinger, Raphaela Moosbrugger, Michael Studnicka, Gerd Fastner, Felix Sedlmayer, Franz Zehentmayr

“…Introduction: Durvalumab following chemoradiotherapy (CRT) for non-small cell lung cancer stage III has become the standard of care (SoC) in the past few years. …”
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Development and validation of a copper-related gene prognostic signature in hepatocellular carcinoma by Haoting Shi, Jingxuan Huang, Xue Wang, Runchuan Li, Yiqing Shen, Bowen Jiang, Jinjun Ran, Rong Cai, Fang Guo, Yufei Wang, Gang Ren

“…Additionally, the Copper-PSHC was combined with age, sex, and cancer stage to construct a Copper-clinical-related Prognostic Signature (Copper-CPSHC), by multivariate Cox regression. …”
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Lenvatinib Plus Immune Checkpoint Inhibitors Improve Survival in Advanced Hepatocellular Carcinoma: A Retrospective Study by Xiaozhun Huang, Lin Xu, Teng Ma, Xin Yin, Zhangkan Huang, Yihong Ran, Yong Ni, Xinyu Bi, Xu Che, Xu Che

“…The clinical parameters, as well as the outcomes, were assessed.ResultsAll the patients had Barcelona Clinical Liver Cancer Stage C. LEN with ICIs was used as systemic second-, third-, and fourth-line treatments in seven (24.1%), 14 (48.3%), and eight (27.6%) patients, respectively. …”
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Spontaneous Non-Sustained Ventricular Tachycardia and Premature Ventricular Contractions and Their Prognostic Relevance in Patients with Cancer in Routine Care by Annemarie Albrecht, Jan Porthun, Jan Eucker, Andrew J.S. Coats, Stephan von Haehling, Antonio Pezzutto, Mahir Karakas, Hanno Riess, Ulrich Keller, Ulf Landmesser, Wilhelm Haverkamp, Stefan D. Anker, Markus S. Anker

“…Both non-sustained ventricular tachycardia of ≥4 beats and ≥20 PVCs/24 h independently predicted mortality in univariate and multivariate survival analyses, adjusted for all other univariate predictors of mortality as well as relevant clinical factors, including cancer stage and type, performance status (ECOG), prior potentially cardiotoxic anti-cancer drug therapy, coronary artery disease, potassium concentration, and haemoglobin (multivariate adjusted hazard ratios: NSVT ≥4 beats [HR 1.76, <i>p</i> = 0.022], ≥20 PVCs/24 h [HR 1.63, <i>p</i> < 0.0064]). …”
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Systemic therapy with or without transcatheter intra-arterial therapies for unresectable hepatocellular carcinoma: a real-world, multi-center study by Yangxun Pan, Yangxun Pan, Xiaodong Zhu, Jianwei Liu, Jianhong Zhong, Wei Zhang, Shunli Shen, Renan Jin, Hongzhi Liu, Feng Ye, Kuan Hu, Da Xu, Yu Zhang, Zhong Chen, Baocai Xing, Ledu Zhou, Yongjun Chen, Yongyi Zeng, Xiao Liang, Ming Kuang, Tianqiang Song, Bangde Xiang, Kui Wang, Huichuan Sun, Li Xu, Li Xu, China Liver Cancer Study Group Young Investigators (CLEAP)

“…Eligible patients had uHCC of China liver cancer stages IIb to IIIb (Barcelona clinic liver cancer B or C stage), and received first-line systemic therapy with or without concurrent TRIT. …”
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The Impact of the COVID Pandemic on the Incidence of Presentations with Cancer-Related Symptoms in Primary Care by Matthew P. Grant, Charles W. Helsper, Rebecca Stellato, Nicole van Erp, Kristel M. van Asselt, Pauline Slottje, Jean Muris, Daan Brandenbarg, Niek J. de Wit, Carla H. van Gils

“…For those patients who had underlying cancer, this may have had impacted the cancer stage at diagnosis, treatment, and mortality.…”
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The Marsden Morbidity Index: the derivation and validation of a simple risk index scoring system using cardiopulmonary exercise testing variables to predict morbidity in high-risk... by Z. Nawoor-Quinn, A. Oliver, R. Raobaikady, K. Mohammad, S. Cone, R. Kasivisvanathan

“…These include age, WHO category, body mass index (BMI), prior transient ischaemic attack (TIA) or stroke, chronic renal impairment, diabetes mellitus, chronic obstructive pulmonary disease (COPD), and cancer stage. Both sets of variables were then combined to produce a validated morbidity risk prediction scoring tool called the Marsden Morbidity Index. …”
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Effectiveness Evaluation of Low-dose Spiral Computed Tomography 
for Lung Cancer Screening in Minhang District of Shanghai by Jiaoyue TENG, Weiyuan YAO, Weixi LI, Yingling CHENG, Jun LI, Huilin XU, Wanghong XU

“…Proportions of early-stage cancer (stage 0-I), pathological types, and 5-year observed survival rates of lung cancer cases were estimated and compared between the cases derived from the screened and non-screened populations. …”
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Secondary prevention of reproductive system tumors in women living in the urban and rural environments by I.P. Aminodova, M.D. Vasiliev, E.V. Makarova, V.I. Makarova

“…</p> <p> <b>Conclusion: </b>the establishing of regional "Women's Health Centers" based on multi-disciplinary comprehensive approach will help to improve the detection of tumors of the female reproductive system at the pre-cancer stage, facilitate the timely identification and mitigation of the risk factors of tumor development, and to ensure the prevention of recurrences and progression of hyperplastic processes of the reproductive system in women. …”
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Systematic pan-cancer analysis of the potential tumor diagnosis and prognosis biomarker P4HA3 by Yinteng Wu, Bo Zhang, Juan Nong, Raquel Alarcòn Rodrìguez, Wenliang Guo, Ying Liu, Shijian Zhao, Ruqiong Wei

“…P4HA3 is strongly associated with clinical cancer stage, immune subtypes, molecular subtypes, immune regulatory genes, immune checkpoint genes, RNA modifier genes, immune cell infiltration, cancer-related functional status, tumor stemness index, MMR Gene, DNA Methyltransferase, DNA methylation, CNV, mutational status, TMB, and MSI are closely related. …”
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4180 CD4 count is a prognostic marker in persons living with HIV and non-small cell lung cancer in the Bronx by Madelyn Klugman, Melissa Fazzari, Mindy Ginsberg, Thomas Rohan, David Hanna, Jonathan Shuter, H. Dean Hosgood

“…In PLWH only, we assessed the relationships of CD4 count, CD4/CD8 ratio, and VL at diagnosis with survival adjusting for age, sex, and cancer stage. CD4 count and CD4/CD8 ratio were also examined as time-varying variables using a counting process approach. …”
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Survival Analysis of Infiltrating Ductal Breast Cancer Patients with Cure Rate Regression Model- A Retrospective Cohort Study from a Tertiary Care Hospital in Central Kerala by Rejani Parassery Parameswaran, Shehna Abdul Khader, Paduthol Godan Sankaran, Rajagopalan Pillai Mahadevan, Krishnan Nair Lalithamma Jayakumar

“…The impact of the covariates, age at diagnosis of disease, grade of cancer, stage of disease, tumour stage, status of regional lymph node, distant metastasis, and triple-negative status on survival of patients were studied. …”
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Tracking Cancer: Exploring Heart Rate Variability Patterns by Cancer Location and Progression by Kfir Ben-David, Harrison L. Wittels, Michael J. Wishon, Stephen J. Lee, Samantha M. McDonald, S. Howard Wittels

“…Analysis of variance models were performed comparing the HRV patterns between different cancers, cancer stages (I–IV), and demographic strata. A total of 85% of the cancer patients had breast, gastrointestinal, genitourinary, or respiratory cancer. …”
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تقييم نتائج المعالجة الشعاعية ثلاثية الأبعاد لسرطان الحنجرة T1/T2، خبرة شعبة المعالجة الشعاعية في مستشفى تشرين الجامعي في اللاذقية... by هيثم قطوف, حمزة شبيب, بشرى منصور

“…Materials and methods: The study was performed of 44 patients of scc larengeal cancer stage T1/T2, that underwent RT (2015 – 2017), 84% with glottic cancer, the median age was 63 years, all patients were treated 3D conformal RT, Total dose between (60-66) Gy, 2Gy/fraction (5 fractions in week).Our analysis was to evaluate the acute and late toxicity dure and after radiotherapy, and also the rate of recurrence and survival. …”
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تقييم نتائج المعالجة الشعاعية ثلاثية الأبعاد لسرطان الحنجرة T1/T2، خبرة شعبة المعالجة الشعاعية في مستشفى تشرين الجامعي في اللاذقية... by هيثم قطوف, حمزة شبيب, بشرى منصور

“…Materials and methods: The study was performed of 44 patients of scc larengeal cancer stage T1/T2, that underwent RT (2015 – 2017), 84% with glottic cancer, the median age was 63 years, all patients were treated 3D conformal RT, Total dose between (60-66) Gy, 2Gy/fraction (5 fractions in week).Our analysis was to evaluate the acute and late toxicity dure and after radiotherapy, and also the rate of recurrence and survival. …”
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Disparity in Lung Cancer Screening Among Smokers and Nonsmokers in China: Prospective Cohort Study by Le Wang, Youqing Wang, Fei Wang, Yumeng Gao, Zhimei Fang, Weiwei Gong, Huizhang Li, Chen Zhu, Yaoyao Chen, Lei Shi, Lingbin Du, Ni Li

“…The uptake rate of LDCT screening for evaluated high-risk participants and the detection rate of early-stage lung cancer (stage 0-I) were calculated. The lung cancer incidence, lung cancer mortality, and all-cause mortality were compared between the screened and nonscreened groups. …”
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Use of a Smartphone Self-assessment App for a Tobacco-Induced Disease (COPD, Cardiovascular Diseases, Cancer) Screening Strategy and to Encourage Smoking Cessation: Observational S... by Edouard Stavaux, François Goupil, Guillaume Barreau, Anne Lise Septans, Bertrand Dautzenberg, Armelle Foulet-Rogé, Norbert Padilla, Thierry Urban, Fabrice Denis

“…ObjectiveThe purpose of this study was to assess the incidence of chief symptoms associated with the main tobacco-induced pathologies in both current and ex-smokers through a self-assessment smartphone app and to evaluate the app’s capacity to encourage users to quit smoking or reduce consumption, as well as its impact on early lung cancer stages at the time of diagnosis. MethodsCurrent and ex-smokers were recruited through an advertising campaign in Sarthe county (France) proposing the free download of a smartphone app. …”
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TP53 mutations in Romanian patients with colorectal cancer by Felix Manirakiza, Hidetaka Yamada, Yuji Iwashita, Keiko Ishino, Rei Ishikawa, Zsolt Kovacs, Eva Osvath, Augustin Nzitakera, Simona Gurzu, Haruhiko Sugimura

“…More than 45% (18/40) had an advanced cancer stage (≥ stage III). Mutations were found in 21/40 cases (52.5%), with one case having two mutations, giving a total of twenty-two mutations in the TP53 coding DNA. …”
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New Insights on Old Biomarkers Involved in Tumor Microenvironment Changes and Their Diagnostic Relevance in Non-Small Cell Lung Carcinoma by Katarzyna Wadowska, Piotr Błasiak, Adam Rzechonek, Iwona Bil-Lula, Mariola Śliwińska-Mossoń

“…Conclusion: There is a link between biomarkers of tumor microenvironment changes and tumor markers, and combinations of these markers may be clinically useful in the differential diagnosis of adenocarcinoma and squamous cell carcinoma, as well as lung cancer stages IIB and IIA, and IIIA and IIB.…”
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Abstract Number ‐ 20: Predictors of Outcomes for Patients with Malignancy and Acute Ischemic Stroke Undergoing Endovascular Therapy by Giana Dawod, Harsh Desai, Ning Lin, Srikanth Boddu, Jared Knopman, Babak B Navi, Alexander Ramos

“…Multivariable analyses yielded no significant predictors for successful reperfusion, while higher NIHSS (1.03, 95% CI, 1.01‐1.06, p = 0.011) and higher cancer stage (1.19, 95% CI, 1.04‐1.34, p = 0.014) were found to be predictors for poor clinical outcome. …”
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