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  1. 34121

    The Degradation Product of Ramipril Is Potentially Carcinogenic, Genotoxic and Mutagenic by Katarzyna Regulska, Agnieszka Matera-Witkiewicz, Aleksandra Mikołajczyk, Beata J. Stanisz

    Published 2023-02-01
    “…We intended to check whether its formation and presence in final dosage forms could pose a cancer risk to humans who are treated with RAM due to cardiological indications. The carcinogenicity of this compound was evaluated with respect to two mechanisms: a potential direct DNA-damage and indirect toxicity, secondary to forming mutagenic N-nitroso metabolites. (2) Methods: Firstly, a forced ageing test under dry air was conducted for pure RAM in order to induce its degradation. …”
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  2. 34122

    A PERSONALIZED APPROACH TO ASSESSING THE RISK OF REPEAT CARDIOVASCULAR EVENT AND CHRONIC KIDNEY DISEASE IN PATIENTS WITH MYOCARDIAL INFARCTION AND ACUTE KIDNEY INJURY by Olga Vladimirovna Demchuk, Irina Alexandrovna Sukmanova

    Published 2023-09-01
    “…Develop a calculator - a risk meter for repeated CCC.Materials and methods: the study was performed in the Altai Regional Cardiological Dispensary. 193 patients with MI and PCI (percutaneous coronary intervention) were included, divided into 2 groups: the first - 123 patients aged 62.8±1.1 years with MI and AKI, the second - 70 patients without AKI, age 61.3± 1.6 years. …”
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