Molecular recognition by a polymorphic cell surface receptor governs cooperative behaviors in bacteria. by Darshankumar T Pathak, Xueming Wei, Arup Dey, Daniel Wall

“…Cell-cell recognition is a fundamental process that allows cells to coordinate multicellular behaviors. …”
Get full text

A highly conserved amino-acid sequence in thrombospondin, properdin and in proteins from sporozoites and blood stages of a human malaria parasite. by Robson, K, Hall, JR, Jennings, M, Harris, T, Marsh, K, Newbold, C, Tate, V, Weatherall, D

“…As a consequence of gene cloning and DNA sequencing several gene families are emerging in the field of cell-cell recognition. These include immunoglobulins, integrins, certain extracellular glycoproteins and a family of functionally unrelated proteins which include factor B. …”

Determination of the affinity and kinetic constants for the interaction between the human virus echovirus 11 and its cellular receptor, CD55. by Lea, S, Powell, R, McKee, T, Evans, D, Brown, D, Stuart, D, Van Der Merwe, P

“…As reported for interactions between cell-cell recognition molecules, the interaction has a low affinity (KD approximately 3.0 microM) as a result of a very fast dissociation rate constant (kon approximately 10(5) M-1.s-1, koff approximately 0.3 s-1). …”

The human low affinity Fcgamma receptors IIa, IIb, and III bind IgG with fast kinetics and distinct thermodynamic properties. by Maenaka, K, Van Der Merwe, P, Stuart, D, Jones, E, Sondermann, P

“…All three receptors bind Fc or IgG with similarly low affinities (K(D) approximately 0.6-2.5 microm) and fast kinetics, suggesting that FcgammaR-mediated recognition of aggregated IgG and IgG-coated particles or cells is mechanistically similar to cell-cell recognition. Interestingly, the Fc receptors exhibit distinct thermodynamic properties. …”

Differential distribution of major brain gangliosides in the adult mouse central nervous system. by Katarina Vajn, Barbara Viljetić, Ivan Večeslav Degmečić, Ronald L Schnaar, Marija Heffer

“…Gangliosides regulate the activities of proteins in the membranes in which they reside, and also act as cell-cell recognition receptors. Understanding the functions of major brain gangliosides requires knowledge of their tissue distribution, which has been accomplished in the past using biochemical and immunohistochemical methods. …”
Get full text

Ligand binding by the immunoglobulin superfamily recognition molecule CD2 is glycosylation-independent. by Davis, S, Davies, E, Barclay, A, Daenke, S, Bodian, D, Jones, E, Stuart, D, Butters, T, Dwek, R, Van Der Merwe, P

“…In this study a systematic analysis of the effect of glycosylation on the ligand-binding properties of the cell-cell recognition molecule CD2, which consists of two IgSF domains, was undertaken. …”

Comparative analysis of salivary sialic acid levels in patients with chronic obstructive pulmonary disease and chronic periodontitis patients: A biochemical study by Surekha Rathod, Tony Shori, Trupti Satish Sarda, Anubha Raj, Padmaja Jadhav

“…Aim: Sialic acid plays a central role in the functioning of biological systems, in stabilizing the glycoproteins and cellular membranes, assisting in cell–cell recognition and interaction. The aim of this study is to evaluate and compare the periodontal health status and salivary Sialic acid levels in patients suffering from chronic obstructive pulmonary diseases (COPD) and chronic periodontitis patients. …”
Get full text

The adhesion molecule Necl-3/SynCAM-2 localizes to myelinated axons, binds to oligodendrocytes and promotes cell adhesion by Ballivet Marc, Bauer Christoph, Gerber Alan, Pellissier François, Ossipow Vincent

“…<p>Abstract</p> <p>Background</p> <p>Cell adhesion molecules are plasma membrane proteins specialized in cell-cell recognition and adhesion. Two related adhesion molecules, Necl-1 and Necl-2/SynCAM, were recently described and shown to fulfill important functions in the central nervous system. …”
Get full text

Mitochondrial DNA, chloroplast DNA and the origins of development in eukaryotic organisms by Bendich Arnold J

“…This advantage then provided <it>Opportunity</it>, a period of time during which novel processes arose for signaling within and between cells and (in animals) for cell-cell recognition molecules to evolve. <it>Development </it>then led to the enormous diversity of animals and plants.…”
Get full text

Localization of the putative sialic acid-binding site on the immunoglobulin superfamily cell-surface molecule CD22. by Van Der Merwe, P, Crocker, P, Vinson, M, Barclay, A, Schauer, R, Kelm, S

“…Our results provide further evidence that immunoglobulin superfamily cell adhesion molecules use the GFCC'C" beta-sheet of membrane-distal V-set domains to bind structurally diverse ligands, suggesting that this surface is favored for cell-cell recognition.…”

Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates? by H.B. Nader, S.F. Chavante, E.A. dos-Santos, F.W. Oliveira, J.F. de-Paiva, S.M.B. Jerônimo, G.F. Medeiros, L.R.D. de-Abreu, E.L. Leite, J.F. de-Sousa-Filho, R.A.B. Castro, L. Toma, I.L.S. Tersariol, M.A. Porcionatto, C.P. Dietrich

“…These and other studies led to the proposal that heparan sulfate may be involved in the cell-cell recognition phenomena and control of cell growth, whereas heparin may be involved in defense mechanisms against bacteria and other foreign materials. …”
Get full text

Structure-based neural network protein–carbohydrate interaction predictions at the residue level by Samuel W. Canner, Sudhanshu Shanker, Jeffrey J. Gray, Jeffrey J. Gray

“…Carbohydrates dynamically and transiently interact with proteins for cell–cell recognition, cellular differentiation, immune response, and many other cellular processes. …”
Get full text

Recent Advances in Hybrid Biomimetic Polymer-Based Films: from Assembly to Applications by Agata Krywko-Cendrowska, Stefano di Leone, Maryame Bina, Saziye Yorulmaz-Avsar, Cornelia G. Palivan, Wolfgang Meier

“…Biological membranes, in addition to being a cell boundary, can host a variety of proteins that are involved in different biological functions, including selective nutrient transport, signal transduction, inter- and intra-cellular communication, and cell-cell recognition. Due to their extreme complexity, there has been an increasing interest in developing model membrane systems of controlled properties based on combinations of polymers and different biomacromolecules, i.e., polymer-based hybrid films. …”
Get full text

Multicellular Human Gastric Cancer Spheroids Mimic the Glycosylation Phenotype of Gastric Carcinomas by Meritxell Balmaña, Stefan Mereiter, Francisca Diniz, Tália Feijão, Cristina C. Barrias, Celso A. Reis

“…Cellular glycosylation plays a pivotal role in several molecular mechanisms controlling cell–cell recognition, communication, and adhesion. Thus, aberrant glycosylation has a major impact on the acquisition of malignant features in the tumor progression of patients. …”
Get full text

Analysis of Lrrn1 expression and its relationship to neuromeric boundaries during chick neural development by Lumsden Andrew, Peukert Daniela, Andreae Laura C, Gilthorpe Jonathan D

“…This expression is consistent with the emergence of secondary organizer properties at boundaries and its endosomal localisation suggests that Lrrn1 may regulate the subcellular localisation of specific components of signalling or cell-cell recognition pathways in neuroepithelial cells.</p>…”
Get full text

Expression of classic cadherins and δ-protocadherins in the developing ferret retina by Krishna-K K, Etzrodt Johannes, Redies Christoph

“…<p>Abstract</p> <p>Background</p> <p>Cadherins are a superfamily of calcium-dependent adhesion molecules that play multiple roles in morphogenesis, including proliferation, migration, differentiation and cell-cell recognition. The subgroups of classic cadherins and δ-protocadherins are involved in processes of neural development, such as neurite outgrowth, pathfinding, target recognition, synaptogenesis as well as synaptic plasticity. …”
Get full text

Alpha-(1,6)-fucosyltransferase (FUT8) affects the survival strategy of osteosarcoma by remodeling TNF/NF-κB2 signaling by Shanyi Lin, Lenian Zhou, Yang Dong, Qingcheng Yang, Quanjun Yang, Hanqiang Jin, Ting Yuan, Shumin Zhou

“…Abstract Glycosylation is an important modification of membrane proteins that results in functional changes in many cellular activities, from cell-cell recognition to regulatory signaling. Fucosyltransferase 8 (FUT8) is the sole enzyme responsible for core fucosylation, and aberrant fucosylation by dysregulated expression of fucosyltransferases is responsible for the growth of various types of carcinomas. …”
Get full text

Entropically driven MHC class I recognition by human inhibitory receptor leukocyte Ig-like receptor B1 (LILRB1/ILT2/CD85j). by Shiroishi, M, Kuroki, K, Tsumoto, K, Yokota, A, Sasaki, T, Amano, K, Shimojima, T, Shirakihara, Y, Rasubala, L, Van Der Merwe, P, Kumagai, I, Kohda, D, Maenaka, K

“…Kinetic studies demonstrated that LILRB1 binds to MHCIs with fast association and dissociation rates, typical of cell-cell recognition receptors. Thermodynamic analyses showed that LILRB1-MHCI interactions are entropically driven (-TdeltaS = -9.4 approximately -6.6 kcal mol(-1)) with low heat capacity changes (deltaC(p) = -0.22 approximately -0.10 kcal mol(-1) K(-1)). …”

Single-cell RNA-seq analysis reveals ploidy-dependent and cell-specific transcriptome changes in Arabidopsis female gametophytes by Qingxin Song, Atsumi Ando, Ning Jiang, Yoko Ikeda, Z. Jeffrey Chen

“…Remarkably, we uncover new sets of female gametophytic cell-specific transcripts with predicted biological roles; the most abundant transcripts encode families of cysteine-rich peptides, implying roles in cell-cell recognition during double fertilization. Conclusions Transcriptome in single cells doubles in tetraploid plants compared to diploid, while the degree of change and relationship to the cell size depends on cell types. …”
Get full text

The STRIPAK signaling complex regulates dephosphorylation of GUL1, an RNA-binding protein that shuttles on endosomes. by Valentina Stein, Bernhard Blank-Landeshammer, Kira Müntjes, Ramona Märker, Ines Teichert, Michael Feldbrügge, Albert Sickmann, Ulrich Kück

“…In fungi, STRIPAK controls multicellular development, morphogenesis, pathogenicity, and cell-cell recognition, while in humans, certain diseases are related to this signaling complex. …”
Get full text