CD2 and the nature of protein interactions mediating cell-cell recognition. by Davis, S, Ikemizu, S, Wild, M, Van Der Merwe, P

“…It seems highly likely that the properties of ligand binding by CD2 are relevant to the general mechanisms of cell-cell recognition. As an example of biological recognition, the defining characteristic of cell-cell contact is that it involves the simultaneous interaction of hundreds, if not thousands, of molecules. …”

A generic cell surface ligand system for studying cell-cell recognition. by Eleanor M Denham, Michael I Barton, Susannah M Black, Marcus J Bridge, Ben de Wet, Rachel L Paterson, P Anton van der Merwe, Jesse Goyette

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A generic cell surface ligand system for studying cell-cell recognition by Denham, E, Barton, M, Black, S, Bridge, M, De Wet, B, Paterson, R, Van Der Merwe, P, Goyette, J

Cell mechanics and cell-cell recognition controls by Toll-like receptors in tissue morphogenesis and homeostasis by Daiki Umetsu

“…In this review, I feature and discuss the non-immune functions of TLRs in the control of epithelial tissue homeostasis, tissue morphogenesis, and cell-cell recognition between cell populations with different cell identities.…”
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NMR analysis of interacting soluble forms of the cell-cell recognition molecules CD2 and CD48. by McAlister, MS, Mott, H, Van Der Merwe, P, Campbell, I, Davis, S, Driscoll, P

The role of charged residues mediating low affinity protein-protein recognition at the cell surface by CD2. by Davis, S, Davies, E, Tucknott, MG, Jones, E, Van Der Merwe, P

“…In contrast, few studies have been done on the very low affinity interactions mediating cell adhesion and cell-cell recognition. As a site of protein-protein recognition, the ligand binding face of the T lymphocyte cell-cell recognition molecule, CD2, which binds its ligands 10(4)- to 10(5)-fold more weakly than do antibodies and proteases, is unusual in being both very flat and highly charged. …”

Crystal structure of the CD2-binding domain of CD58 (lymphocyte function-associated antigen 3) at 1.8-A resolution. by Ikemizu, S, Sparks, L, Van Der Merwe, P, Harlos, K, Stuart, D, Jones, E, Davis, S

“…The specificity of the very weak interactions of proteins mediating cell-cell recognition may often derive largely from electrostatic complementarity, with shape matching at the protein-protein interface being less exact than for interactions that combine specificity with high affinity, such as those involving antibodies.…”

Exploring and exploiting the therapeutic potential of glycoconjugates. by Doores, K, Gamblin, D, Davis, B

“…In particular, carbohydrates are important mediators of cell-cell recognition events and have been implicated in related processes such as cell signaling regulation, cellular differentiation and immune response. …”

The structure and ligand interactions of CD2: implications for T-cell function. by Davis, S, van der Merwe, P

“…Considerable progress has recently been made in understanding the structure and ligand interactions of the T-cell antigen CD2, to the extent that CD2 is now a useful paradigm for considering the structural basis of cell-cell recognition. Here, Simon Davis and Anton van der Merwe review the new data and consider their implications for T-cell function in the context of CD2-knockout experiments.…”

Killer cell immunoglobulin receptors and T cell receptors bind peptide-major histocompatibility complex class I with distinct thermodynamic and kinetic properties. by Maenaka, K, Juji, T, Nakayama, T, Wyer, JR, Gao, G, Maenaka, T, Zaccai, N, Kikuchi, A, Yabe, T, Tokunaga, K, Tadokoro, K, Stuart, D, Jones, E, Van Der Merwe, P

“…These results indicate that KIR/peptide-MHC class I interactions have properties typical of other cell-cell recognition molecules, and they highlight the unusual nature of TCR/peptide-MHC recognition.…”

Molecular recognition by Ig-like receptors, KIRs and Fc gamma Rs by Maenaka, K, Van Der Merwe, P, Stuart, D, Sondermann, P, Jones, E

“…SPR analysis showed that, like other cell-cell recognition molecules interactions, the KIR2DL3 binds peptide-HLA-Cw7 with a low affinity (Kd similar to 10(-5)M), fast kinetics, and favourable entropic changes. …”

Marine Bacterial Sialyltransferases by Takeshi Yamamoto

“…The enzymatic reaction products including sialyl‑glycoproteins, sialyl-glycolipids and sialyl-oligosaccharides are important molecules in various biological and physiological processes, such as cell-cell recognition, cancer metastasis, and virus infection. …”
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Structural basis of cell-cell adhesion by NCAM. by Kasper, C, Rasmussen, H, Kastrup, J, Ikemizu, S, Jones, E, Berezin, V, Bock, E, Larsen, I

“…The neural cell adhesion molecule NCAM, a member of the immunoglobulin superfamily, mediates cell-cell recognition and adhesion via a homophilic interaction. …”

Conserved domains of the class A scavenger receptors: evolution and function. by Bowdish, D, Gordon, S

“…These early receptors may function in cell-cell recognition, aggregation, or lipid recognition, and their involvement in pattern recognition, phagocytosis, and homeostasis may have been adaptations of such conserved patterns. …”

Challenges in the Analysis of Gangliosides by LC-MS by Thomas Muggli, Claudia Bühr, Stefan Schürch

“…Gangliosides are of high abundance in neuronal tissues and are involved in numerous biological processes, such as cell-cell recognition, adhesion, and signal transduction. …”
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Labile disulfide bonds are common at the leucocyte cell surface by Clive Metcalfe, Peter Cresswell, Laura Ciaccia, Benjamin Thomas, A. Neil Barclay

“…The proteins identified include integrins, receptors, transporters and cell–cell recognition proteins. In many cases, at least one cysteine residue was identified by mass spectrometry as being modified by the reduction process. …”
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Glycosylation and lipids working in concert direct CD2 ectodomain orientation and presentation. by Polley, A, Orłowski, A, Danne, R, Gurtovenko, A, Bernardino de la Serna, J, Eggeling, C, Davis, S, Róg, T, Vattulainen, I

“…Proteins embedded in the plasma membrane mediate interactions with the cell environment and play decisive roles in many signaling events. For cell-cell recognition molecules it is highly likely that their structures and behavior have been optimized in ways that overcome the limitations of membrane tethering. …”

Development of Cortical GABAergic Innervation by Alex M Thomson, Jasmina N Jovanovic

“…Finally, as each interneurone class begins to form synapses with only certain postsynaptic targets, cell-cell recognition, most probably via protein-protein interactions across the synaptic cleft, facilitate the formation of appropriate synapses.…”
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Molecular recognition of gangliosides and their potential for cancer immunotherapies by Ute eKrengel, Paula A Bousquet

“…Gangliosides perform important functions through carbohydrate-specific interactions with proteins, for example as receptors in cell-cell recognition, which can be exploited by viruses and other pathogens, and also by regulating signaling proteins through lateral interaction in the membrane. …”
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Labile disulfide bonds are common at the leucocyte cell surface. by Metcalfe, C, Cresswell, P, Ciaccia, L, Thomas, B, Barclay, A

“…The proteins identified include integrins, receptors, transporters and cell-cell recognition proteins. In many cases, at least one cysteine residue was identified by mass spectrometry as being modified by the reduction process. …”