The emerging role of mTORC1 signaling in placental nutrient-sensing. por Jansson, T, Aye, I, Goberdhan, D

“…Nutrient-sensing signaling pathways regulate cell metabolism and growth in response to altered nutrient levels and growth factor signaling. …”

The emerging role of mTORC1 signaling in placental nutrient-sensing por Jansson, T, Aye, I, Goberdhan, D

“…Nutrient-sensing signaling pathways regulate cell metabolism and growth in response to altered nutrient levels and growth factor signaling. …”

Inflammatory modulation of stem cells by Magnetic Resonance Imaging (MRI)-detectable nanoparticles por Aday, S, Paiva, J, Sousa, S, Gomes, R, Pedreiro, S, So, P, Carr, C, Cochlin, L, Gomes, A, Paiva, A, Ferreira, L

“…In the current work, we labelled human hematopoietic stem cells with polymeric nanoparticles (NPs) that can be tracked by Magnetic Resonance Imaging (MRI) and studied their effect on cell metabolism, proliferation, secretomics, genomics and differentiation. …”

In Vivo HIF-Mediated Reductive Carboxylation Is Regulated by Citrate Levels and Sensitizes VHL-Deficient Cells to Glutamine Deprivation por Gameiro, Paulo A., Yang, Juanjuan, Metelo, Ana M., Baker, Rania, Wang, Zongwei, Arreola, Alexandra, Rathmell, W. Kimryn, Olumi, Aria F., Stephanopoulos, Gregory, Iliopoulos, Othon, Perez-Carro, Rocio, Lopez-Larrubia, Pilar, Gameiro, Paulo A.

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Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes por Bhatt, Shweta, Gupta, Manoj K., Khamaisi, Mogher, Martinez, Rachael, Gritsenko, Marina A., Wagner, Bridget K., Guye, Patrick, Busskamp, Volker, Shirakawa, Jun, Wu, Gongxiong, Liew, Chong Wee, Clauss, Therese R., Valdez, Ivan, El Ouaamari, Abdelfattah, Dirice, Ercument, Takatani, Tomozumi, Keenan, Hillary A., Smith, Richard D., Church, George, Weiss, Ron, Wagers, Amy J., Qian, Wei-Jun, King, George L., Kulkarni, Rohit N.

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Circadian Rhythm Disruption Promotes Lung Tumorigenesis por Papagiannakopoulos, Thales, Bauer, Matthew R., Davidson, Shawn M., Heimann, Megan Kristianne, Subbaraj, Lakshmipriya, Bhutkar, Arjun, Bartlebaugh, Jordan M. E., Vander Heiden, Matthew G., Jacks, Tyler E.

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The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway por Wolfson, Rachel Laura, Sabatini, David

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Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting por Alkan, H. Furkan, Luengo, Alba, Lau, Allison N., Lewis, Caroline A., Vander Heiden, Matthew G.

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Snx3 Regulates Recycling of the Transferrin Receptor and Iron Assimilation por Chen, Caiyong, Garcia-Santos, Daniel, Ishikawa, Yuichi, Seguin, Alexandra, Li, Liangtao, Fegan, Katherine H., Hildick-Smith, Gordon J., Shah, Dhvanit I., Cooney, Jeffrey D., Chen, Wen, King, Matthew J., Yien, Yvette Y., Schultz, Iman J., Anderson, Heidi, Dalton, Arthur J., Freedman, Matthew L., Kingsley, Paul D., Palis, James, Hattangadi, Shilpa M., Ward, Diane M., Kaplan, Jerry, Maeda, Takahiro, Ponka, Prem, Paw, Barry H., Lodish, Harvey F

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Cytosolic Monothiol Glutaredoxins Function in Intracellular Iron Sensing and Trafficking via Their Bound Iron-Sulfur Cluster por Mühlenhoff, Ulrich, Molik, Sabine, Godoy, José R., Uzarska, Marta A., Richter, Nadine, Seubert, Andreas, Zhang, Yan, Stubbe, JoAnne, Pierrel, Fabien, Herrero, Enrique, Lillig, Christopher Horst, Lill, Roland

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De Novo Reconstruction of Adipose Tissue Transcriptomes Reveals Long Non-coding RNA Regulators of Brown Adipocyte Development por Bai, Zhiqiang, Xu, Dan, Yuan, Bingbing, Lo, Kinyui Alice, Yoon, Myeong Jin, Lim, Yen Ching, Knoll, Marko, Chen, Shuai, Chen, Peng, Sun, Lei, Alvarez, Juan Rene, Slavov, Nikolai G, Lodish, Harvey F

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IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress por Lerner, Alana G., Upton, John-Paul, Praveen, P.V.K., Ghosh, Rajarshi, Nakagawa, Yoshimi, Igbaria, Aeid, Shen, Sarah, Nguyen, Vinh, Backes, Bradley J., Heintz, Nathaniel, Greengard, Paul, Hui, Simon, Tang, Qizhi, Trusina, Ala, Oakes, Scott A., Papa, Feroz R., Heiman, Myriam

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Increased Serine Synthesis Provides an Advantage for Tumors Arising in Tissues Where Serine Levels Are Limiting por Sullivan, Mark Robert, Mattaini, Katherine Ruth, Dennstedt, Emily A, Nguyen, Anna, Sivanand, Sharanya, Reilly, Montana F., Meeth, Katrina, Muir, Alexander, Darnell, Alicia, Bosenberg, Marcus W., Lewis, Caroline A., Vander Heiden, Matthew G.

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Postprandial Hepatic Lipid Metabolism Requires Signaling through Akt2 Independent of the Transcription Factors FoxA2, FoxO1, and SREBP1c por Wan, Min, Leavens, Karla F., Saleh, Danish, Easton, Rachael M., Guertin, David A., Peterson, Timothy R., Kaestner, Klaus H., Sabatini, David M., Birnbaum, Morris J., Sabatini, David, Peterson, Timothy Richard

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Mutations in MTFMT Underlie a Human Disorder of Formylation Causing Impaired Mitochondrial Translation por Tucker, Elena J., Hershman, Steven G., Belcher-Timme, Casey A., Patel, Jinal, Goldberger, Olga A., Christodoulou, John, Silberstein, Jonathon M., McKenzie, Matthew, Ryan, Michael T., Compton, Alison G., Jaffe, Jacob D., Carr, Steven A., Calvo, Sarah E., RajBhandary, Uttam L., Thorburn, David R., Mootha, Vamsi K., Koehrer, Caroline

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mTOR: dissecting regulation and mechanism of action to understand human disease. por Goberdhan, D, Boyd, C

“…mTOR (mammalian target of rapamycin) is a highly conserved serine/threonine protein kinase that has roles in cell metabolism, cell growth and cell survival. Although it has been known for some years that mTOR acts as a hub for inputs from growth factors (in particular insulin and insulin-like growth factors), nutrients and cellular stresses, some of the mechanisms involved are still poorly understood. …”

Modelling of blood glucose metabolism using neural networks with online learning por Siti Nadiah Zainal.

“…An overdose of insulin may lead to fatal consequences, as the patients may find a complete lack of blood glucose for their basic cell metabolism. This project attempts to develop a neural model of the glucose cycle for analysis and prediction of effects of disturbance in the form of food intake as well as energy consuming through exercise. …”
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Diurnal fluid expression and activity of intervertebral disc cells. por Sivan, S, Neidlinger-Wilke, C, Würtz, K, Maroudas, A, Urban, J

“…Here, present information on the effect of osmotic changes in disc cell metabolism is reviewed; results indicate that prevailing osmolarity is a powerful regulator of disc cell activity.…”

A temperature-regulated replicon-based DNA expression system. por Boorsma, M, Nieba, L, Koller, D, Bachmann, M, Bailey, J, Renner, W

“…These data suggest that the present expression system could simplify bioprocess engineering strategies, especially in situations where the cloned protein has detrimental effects on host cell metabolism.…”

Vascular K ATP channels: dephosphorylation and deactivation. por Tammaro, P

“…Vascular ATP-sensitive potassium (K(ATP)) channels (Kir6.1/SUR2B) are regulated by both cell metabolism and chemical transmitters. They are the target for a number of vasodilators and vasoconstrictors whose mechanisms of action involve activation of protein kinase A (PKA) and protein kinase C (PKC), respectively. …”