The tyrosine phosphatase SHP-1 promotes T cell adhesion by activating the adaptor protein CrkII in the immunological synapse by Azoulay-Alfaguter, I, Strazza, M, Peled, M, Novak, H, Muller, J, Dustin, M, Mor, A

“…The adaptor protein CrkII is a key regulator of T cell adhesion through the recruitment of the Rap1-guanine exchange factor, C3G. …”

Carcinoembryonic antigen (CEA) inhibits NK killing via interaction with CEA-related cell adhesion molecule 1. by Stern, N, Markel, G, Arnon, T, Gruda, R, Wong, H, Gray-Owen, S, Mandelboim, O

“…We have previously demonstrated the existence of a novel inhibitory mechanism of NK cell cytotoxicity mediated by the homophilic carcinoembryonic Ag (CEA)-related cell adhesion molecule 1 (CEACAM1) interactions. In this study, we demonstrate that CEACAM1 also interacts heterophilically with the CEA protein. …”

Crystal structure of the extracellular region of the human cell adhesion molecule CD2 at 2.5 A resolution. by Bodian, D, Jones, E, Harlos, K, Stuart, D, Davis, S

Crystal structure at 2.8 A resolution of a soluble form of the cell adhesion molecule CD2. by Jones, E, Davis, S, Williams, A, Harlos, K, Stuart, D

“…The crystal structure of a soluble form of the T lymphocyte antigen CD2 provides the first complete view of the extracellular region of a cell adhesion molecule. The topology of the molecule, which comprises two immunoglobulin-like domains, is the same as that of the first two domains of CD4 but the relative domain orientation is altered by a fairly flexible linker region. …”

Overexpression of GRB2 enhances epithelial to mesenchymal transition of A549 cells by upregulating SNAIL expression by Mitra, Payal, Kalailingam, Pazhanichamy, Thanabalu, Thirumaran, Tan, Hui Bing

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MnSOD mediates shear stress-promoted tumor cell migration and adhesion by Ma, Shijun, Fu, Afu, Lim, Sierin, Chiew, Geraldine Giap Ying, Luo, Kathy Qian

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Transcriptomics indicate nuclear division and cell adhesion not recapitulated in MCF7 and MCF10A compared to luminal a breast tumours by Goh, Jeremy Joon Ho, Goh, Corinna Jie Hui, Lim, Qian Wei, Zhang, Songjing, Koh, Cheng-Gee, Chiam, Keng-Hwee

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Enhanced CLIP Uncovers IMP Protein-RNA Targets in Human Pluripotent Stem Cells Important for Cell Adhesion and Survival by Conway, Anne E., Van Nostrand, Eric L., Pratt, Gabriel A., Aigner, Stefan, Wilbert, Melissa L., Sundararaman, Balaji, Lambert, Nicole J., Sathe, Shashank, Liang, Tiffany Y., Essex, Anthony, Landais, Severine, Burge, Christopher B., Jones, D. Leanne, Yeo, Gene W., Freese, Peter Dale, Lambert, Nicole, Burge, Christopher B

“…We observe that IMP1 loss in hPSCs recapitulates IMP1 phenotypes, including a reduction in cell adhesion and increase in cell death. For cell adhesion, we find IMP1 maintains levels of integrin mRNA specifically regulating RNA stability of ITGB5 in hPSCs. …”
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RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction by Sager, H. B., Dutta, P., Hulsmans, M., Courties, G., Sun, Y., Heidt, T., Vinegoni, C., Borodovsky, A., Fitzgerald, K., Wojtkiewicz, G. R., Iwamoto, Y., Tricot, B., Libby, P., Weissleder, R., Swirski, F. K., Nahrendorf, M., Xing, Yiping, Shaw, Taylor E., Langer, Robert S, Anderson, Daniel Griffith, Khan, Omar Fizal, Kauffman, Kevin John, Dahlman, James E.

“…Simultaneously encapsulating small interfering RNA (siRNA)–targeting intercellular cell adhesion molecules 1 and 2 (Icam1 and Icam2), vascular cell adhesion molecule 1 (Vcam1), and E- and P-selectins (Sele and Selp) into polymeric endothelial-avid nanoparticles reduced post-MI neutrophil and monocyte recruitment into atherosclerotic lesions and decreased matrix-degrading plaque protease activity. …”
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Modulation of cell-cell interactions for neural tissue engineering : potential therapeutic applications of cell adhesion molecules in nerve regeneration by Chooi, Wai Hon, Chew, Sing Yian

“…Therefore, modulating cell-cell interactions through cell adhesion molecules (CAMs) such as cadherins, neural cell adhesion molecules (NCAM) and L1, may be a potential alternative to improve nerve regeneration. …”
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Engineering a surface to enhance endothelial cell adhesion towards creating a 'roll-up' blood vessel prosthesis by Chua, Hui Yee.

“…This project investigated the technical feasibility of creating an adherent layer of endothelial cells with improved adhesive strength to produce a synthetic vascular graft using “cutting edge” technologies such as electrospinning and robotic free form fabrication (FFF). Firstly, cell adhesion on the modified surface of electrospun Polycaprolactone (PCL) fibers improved significantly, after verification using the centrifugation assisted cell adhesion assay. …”
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CXCR4 and vascular cell adhesion molecule 1 are key chemokine/adhesion receptors in the migration of cytokine-activated T cells. by Bryant, J, Ahern, D, Brennan, F

“…Levels of vascular cell adhesion molecule 1 (VCAM-1) were measured by sandwich enzyme-linked immunosorbent assay. …”

Female receptivity phenotype of icebox mutants caused by a mutation in the L1-type cell adhesion molecule neuroglian. by Carhan, A, Allen, F, Armstrong, J, Hortsch, M, Goodwin, S, O'Dell, K

“…We have shown that the ibx mutation maps to the 7F region of the Drosophila X chromosome to form a complex complementation group with both lethal and viable alleles of neuroglian (nrg). The L1-type cell adhesion molecule encoded by nrg consists of six immunoglobulin-like domains, five fibronectin-like domains, one transmembrane domain and one alternatively spliced intracellular domain. …”

Estimation of the dissociation constant of the cell adhesion molecules srCD2 and srCD48 using analytical ultracentrifugation. by Silkowski, H, Byron, O, Davis, S, Barclay, A, Davies, E, Rowe, A, Harding, SE

Affinity and kinetic analysis of L-selectin (CD62L) binding to glycosylation-dependent cell-adhesion molecule-1. by Nicholson, M, Barclay, A, Singer, MS, Rosen, S, Van Der Merwe, P

“…The selectin family of cell adhesion molecules mediates the tethering and rolling of leukocytes on blood vessel endothelium. …”

Characterisation of the low affinity interaction between rat cell adhesion molecules CD2 and CD48 by analytical ultracentrifugation. by Silkowski, H, Davis, S, Barclay, A, Rowe, A, Harding, SE, Byron, O

“…CD2 is a cell adhesion molecule found on the plasma membrane of T-lymphocytes. …”

Impaired insulin exocytosis in neural cell adhesion molecule-/- mice due to defective reorganization of the submembrane F-actin network. by Olofsson, C, Håkansson, J, Salehi, A, Bengtsson, M, Galvanovskis, J, Partridge, C, SörhedeWinzell, M, Xian, X, Eliasson, L, Lundquist, I, Semb, H, Rorsman, P

“…The neural cell adhesion molecule (NCAM) is required for cell type segregation during pancreatic islet organogenesis. …”

Correlation of blood levels of soluble vascular cell adhesion molecule-1 with disease activity in systemic lupus erythematosus and vasculitis. by Janssen, B, Luqmani, R, Gordon, C, Hemingway, I, Bacon, P, Gearing, A, Emery, P

“…In patients with SLE and vasculitis, serum levels of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-Selection were determined by ELISA during different stages of disease activity. …”

Quantification and modeling of tripartite CD2-, CD58FC chimera (alefacept)-, and CD16-mediated cell adhesion. by Dustin, M, Starr, T, Coombs, D, Majeau, G, Meier, W, Hochman, P, Douglass, A, Vale, R, Goldstein, B, Whitty, A

The lymphocyte function-associated LFA-1, CD2, and LFA-3 molecules: cell adhesion receptors of the immune system. by Springer, T, Dustin, M, Kishimoto, T, Marlin, S