Hematopoietic stem cell development and regulatory signaling in zebrafish. by Zhang, C, Patient, R, Liu, F

“…HSC development must be tightly controlled from cell fate determination to self-maintenance during adulthood. …”

BRD4 localization to lineage-specific enhancers is associated with a distinct transcription factor repertoire by Najafova, Z, Tirado-Magallanes, R, Subramaniam, M, Hossan, T, Schmidt, G, Nagarajan, S, Baumgart, S, Mishra, V, Bedi, U, Hesse, E, Knapp, S, Hawse, J, Johnsen, S

“…Proper temporal epigenetic regulation of gene expression is essential for cell fate determination and tissue development. The Bromodomain-containing Protein-4 (BRD4) was previously shown to control the transcription of defined subsets of genes in various cell systems. …”

The imidazoacridinone C-1311 induces p53-dependent senescence or p53-independent apoptosis and sensitizes cancer cells to radiation by Skwarska, A, Ramachandran, S, Dobrynin, G, Leszczynska, K, Hammond, E

“…For the first time we demonstrate that the tumor suppressor, p53 plays a key role in cell fate determination after C-1311 treatment. In the presence of wild-type p53, cells exposed to C-1311 entered senescence. …”

Chirality Regulates Macrophage Polarization for Tissue Regeneration Through Bidirectionally Modulating WTAP‐Mediated m6A Modification by Yue Yang, Xinwei Guo, Chenyan Huang, Chen Chen, Yingying Zhou, Zhengrong Gao, Chuanliang Feng, Shengjie Jiang, Xuliang Deng, Yan Wei

“…Thus, a mechano‐epigenetic mechanism of chirality‐mediated cell‐fate determination is unveiled, which holds remarkable promise in the realm of assisted regenerative material design.…”
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Nucleoredoxin Knockdown in SH-SY5Y Cells Promotes Cell Renewal by Lucie Valek, Irmgard Tegeder

“…Deficiency in mice leads to cranial dysmorphisms and defects of heart, brain, and bone, suggesting defects of cell fate determination. We used shRNA-mediated knockdown of NXN in SH-SY5Y neuroblastoma cells to study its impact on neuronal cells. …”
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Neuronal cell fate diversification controlled by sub-temporal action of Kruppel by Johannes Stratmann, Hugo Gabilondo, Jonathan Benito-Sipos, Stefan Thor

“…Here, we find that the late temporal gene castor sub-divides its large window in neuroblast 5–6 by simultaneously activating two cell fate determination cascades and a sub-temporal regulatory program. …”
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High incidence of non-random template strand segregation and asymmetric fate determination in dividing stem cells and their progeny. by Michael J Conboy, Ariela O Karasov, Thomas A Rando

“…These data provide compelling evidence of template strand co-segregation based on template age and associated with cell fate determination, suggest that template strand age is monitored during stem cell lineage progression, and raise important caveats for the interpretation of label-retaining cells.…”
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Atrial natriuretic peptide signaling co-regulates lipid metabolism and ventricular conduction system gene expression in the embryonic heart by Abhishek Mishra, Mahtab Tavasoli, Stanislav Sokolenko, Christopher R. McMaster, Kishore B.S. Pasumarthi

“…In this study, histological sections and primary cultures obtained from E11.5 mouse ventricles were analyzed to determine the role of metabolic adaptations in VCS cell fate determination and maturation. Exogenous treatment of E11.5 ventricular cells with ANP revealed a significant increase in lipid droplet accumulation, FAO and higher expression of VCS marker Cx40. …”
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The Dkk3 gene encodes a vital intracellular regulator of cell proliferation. by Jack L Leonard, Deborah M Leonard, Scot A Wolfe, Jilin Liu, Jaime Rivera, Michelle Yang, Ryan T Leonard, Jacob P S Johnson, Prashant Kumar, Kate L Liebmann, Amanda A Tutto, Zhongming Mou, Karl J Simin

“…Members of the Dickkopf (Dkk) family of Wnt antagonists interrupt Wnt-induced receptor assembly and participate in axial patterning and cell fate determination. One family member, DKK3, does not block Wnt receptor activation. …”
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Capillary Isoelectric Focusing Immunoassay for Fat Cell Differentiation Proteomics. by Mary G Johlfs, Priyatham Gorjala, Yasuyo Urasaki, Thuc T Le, Ronald R Fiscus

“…Profiling cellular proteome is critical to understanding signal integration during cell fate determination. In this study, the capability of capillary isoelectric focusing (cIEF) immunoassays to detect post-translational modifications (PTM) of protein isoforms is demonstrated. cIEF immunoassays exhibit protein detection sensitivity at up to 5 orders of magnitude higher than traditional methods. …”
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Mitochondrial control of innate immune responses by Shasha Chen, Zhiyong Liao, Pinglong Xu, Pinglong Xu, Pinglong Xu

“…Mitochondria are versatile organelles and essential components of numerous biological processes such as energy metabolism, signal transduction, and cell fate determination. In recent years, their critical roles in innate immunity have come to the forefront, highlighting impacts on pathogenic defense, tissue homeostasis, and degenerative diseases. …”
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Buffered EGFR signaling regulated by spitz-to-argos expression ratio is a critical factor for patterning the Drosophila eye. by Nikhita Pasnuri, Manish Jaiswal, Krishanu Ray, Aprotim Mazumder

“…The expression dose of Spitz and Argos early in photoreceptor cell fate determination has been shown to be critical in patterning the Drosophila eye, but the exact identity of the cells expressing these genes in the larval eye disc has been elusive. …”
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AP2γ: A New Player on Adult Hippocampal Neurogenesis Regulation by Antonio Mateus-Pinheiro, Nuno Dinis Alves, Nuno Sousa, Luisa Pinto

“…In a recent study published in Molecular Psychiatry , we demonstrate Activating Protein 2γ (AP2γ), a transcription factor previously implicated in cell fate determination in the developing cortex, as a novel player in the regulation of glutamatergic neurogenesis in the adult hippocampus. …”
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Molecular profiling of basal cell carcinoma of the prostate: A case report and literature review by Luca Bertozzi, Eileen Zhang, Mohadese Behtaj, Olivia Gordon, Michael J. Whalen

“…Upon literature review, we found that prostate BCC mutations disrupt cell growth, epigenetic regulation, and cell fate determination. With no consensus guidelines available, experimental targeted therapies have shown promise for prostate BCC management.…”
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PINK1/Parkin-Mediated Mitophagy Promotes Resistance to Sonodynamic Therapy by Lin Song, Yongmin Huang, Xuandi Hou, Yaoheng Yang, Shashwati Kala, Zhihai Qiu, Rui Zhang, Lei Sun

“…In SDT, mitochondria played a crucial role in cell fate determination. However, mitochondrial activities and their response to SDT remain elusive. …”
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Histone lactylation regulates cancer progression by reshaping the tumor microenvironment by Junxing Qu, Peizhi Li, Zhiheng Sun

“…As a major product of glycolysis and a vital signaling molecule, many studies have reported the key role of lactate in tumor progression and cell fate determination. Lactylation is a newly discovered post-translational modification induced by lactate. …”
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The role of regulated mRNA stability in establishing bicoid morphogen gradient in Drosophila embryonic development. by Wei Liu, Mahesan Niranjan

“…The Bicoid morphogen is amongst the earliest triggers of differential spatial pattern of gene expression and subsequent cell fate determination in the embryonic development of Drosophila. …”
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A Network of Chromatin Factors Is Regulating the Transition to Postembryonic Development in Caenorhabditis elegans by Peter Erdelyi, Xing Wang, Marina Suleski, Chantal Wicky

“…In Caenorhabditis elegans, the let-418 gene encodes one of the two Mi2 homologs, which is part of at least two chromatin complexes, namely the Nucleosome Remodeling and histone Deacetylase (NuRD) complex and the MEC complex, and functions in larval development, vulval morphogenesis, lifespan regulation, and cell fate determination. To explore the mechanisms involved in the action of LET-418/Mi2, we performed a genome-wide RNA interference (RNAi) screen for suppressors of early larval arrest associated with let-418 mutations. …”
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Glycan profiling shows unvaried N-glycomes in MSC clones with distinct differentiation potentials by Katherine Mary Wilson, Jane Elizabeth Thomas-Oates, Paul eGenever, Daniel eUngar

“…Thus N-glycans may instead be important for self-renewal rather than for cell fate determination.…”
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Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor. by Schoen W Kruse, Kelly Suino-Powell, X Edward Zhou, Jennifer E Kretschman, Ross Reynolds, Clemens Vonrhein, Yong Xu, Liliang Wang, Sophia Y Tsai, Ming-Jer Tsai, H Eric Xu

“…The chicken ovalbumin upstream promoter-transcription factors (COUP-TFI and II) make up the most conserved subfamily of nuclear receptors that play key roles in angiogenesis, neuronal development, organogenesis, cell fate determination, and metabolic homeostasis. Although the biological functions of COUP-TFs have been studied extensively, little is known of their structural features or aspects of ligand regulation. …”
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