Gene Regulatory Network Analysis Reveals Differences in Site-specific Cell Fate Determination in Mammalian Brain by Gokhan eErtaylan, Satoshi eOkawa, Jens Christian Schwamborn, Antonio edel Sol

“…We report thirty-one candidate cell fate determinant gene pairs, ready to be validated. …”
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Chromosome territory reorganization through artificial chromosome fusion is compatible with cell fate determination and mouse development by Yuang Wang, Zhen Qu, Yi Fang, Yulong Chen, Jiayin Peng, Jiawen Song, Jinsong Li, Jiantao Shi, Jin-Qiu Zhou, Yun Zhao

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An atlas of endogenous DNA double-strand breaks arising during human neural cell fate determination by Roberto Ballarino, Britta A. M. Bouwman, Federico Agostini, Luuk Harbers, Constantin Diekmann, Erik Wernersson, Magda Bienko, Nicola Crosetto

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Dynamic network biomarker factors orchestrate cell-fate determination at tipping points during hESC differentiation by Lin Li, Yilin Xu, Lili Yan, Xiao Li, Fei Li, Zhuang Liu, Chuanchao Zhang, Yuan Lou, Dong Gao, Xin Cheng, Luonan Chen

“…We demonstrate that before the tipping points, M-DNB factors are able to maintain the cell states and orchestrate cell-fate determination during hESC (ES)-to-ME and ME-to-DE differentiation processes, which not only leads to better understanding of endodermal specification of hESCs but also reveals the power of the M-DNB model to identify critical transition points with their key factors in diverse biological processes, including cell differentiation and transdifferentiation dynamics.…”
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Plasticity-Related Gene 5 Is Expressed in a Late Phase of Neurodifferentiation After Neuronal Cell-Fate Determination by Isabel Gross, Isabel Gross, Nicola Brandt, Nicola Brandt, Danara Vonk, Danara Vonk, Danara Vonk, Franziska Köper, Franziska Köper, Franziska Köper, Lars Wöhlbrand, Ralf Rabus, Martin Witt, Axel Heep, Axel Heep, Axel Heep, Torsten Plösch, Torsten Plösch, Torsten Plösch, Mark S. Hipp, Mark S. Hipp, Anja U. Bräuer, Anja U. Bräuer, Anja U. Bräuer

“…During adult neurogenesis, PRG5 is specifically expressed in a late phase after neuronal cell-fate determination associated with dendritic spine formation. …”
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Hedgehog signaling via its ligand DHH acts as cell fate determinant during skeletal muscle regeneration by Alessandra M. Norris, Ambili Bai Appu, Connor D. Johnson, Lylybell Y. Zhou, David W. McKellar, Marie-Ange Renault, David Hammers, Benjamin D. Cosgrove, Daniel Kopinke

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Mechanical Signaling in Dental Pulp Stem Cells by Jiahe Zhao, Wen Du, Daimo Guo, Siyi Wang, Wei Du

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Abundant binary promoter switches in lineage-determining transcription factors indicate a digital component of cell fate determination by Hongchuan Li, Md Ahasanur Rahman, Michael Ruesch, Caprice D. Eisele, Erik M. Anderson, Paul W. Wright, Jennie Cao, Shashikala Ratnayake, Qingrong Chen, Chunhua Yan, Daoud Meerzaman, Roshini S. Abraham, Aharon G. Freud, Stephen K. Anderson

“…In the current study, an examination of transcription factor genes defines an abundance of convergent and divergent sense/antisense promoter pairs, suggesting that competing promoters may control cell fate determination. Differentiation of CD34+ hematopoietic progenitors in vitro shows that cells with GATA1 antisense transcription have enhanced GATA2 transcription and a mast cell phenotype, whereas cells with GATA2 antisense transcription have increased GATA1 transcripts and an erythroblast phenotype. …”
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A model-based factorization method for scRNA data unveils bifurcating transcriptional modules underlying cell fate determination by Jun Ren, Ying Zhou, Yudi Hu, Jing Yang, Hongkun Fang, Xuejing Lyu, Jintao Guo, Xiaodong Shi, Qiyuan Li

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Repression of Somatic Genes by Selective Recruitment of HDAC3 by BLIMP1 Is Essential for Mouse Primordial Germ Cell Fate Determination by Kentaro Mochizuki, Yohei Hayashi, Tamotsu Sekinaka, Kei Otsuka, Yumi Ito-Matsuoka, Hisato Kobayashi, Shinya Oki, Asuka Takehara, Tomohiro Kono, Noriko Osumi, Yasuhisa Matsui

“…. : Mochizuki et al. find that targeted histone deacetylation of somatic genes by HDAC3-BLIMP1 represses gene expression, which ensures primordial germ cell fate determination.…”
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Cell Fate Decision Making through Oriented Cell Division by Evan B. Dewey, Danielle T. Taylor, Christopher A. Johnston

Subjects: “…cell fate determinants…”
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The Evolutionary Conserved SWI/SNF Subunits ARID1A and ARID1B Are Key Modulators of Pluripotency and Cell-Fate Determination by Luca Pagliaroli, Marco Trizzino

“…In this mini-review we therefore discuss the available scientific literature linking ARID1A and ARID1B to cell fate determination, pluripotency maintenance, and organismal development.…”
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Spatiotemporal Analysis of Mesenchymal Stem Cells Fate Determination by Inflammatory Niche Following Soft Tissue Injury at a Single‐Cell Level by Chen Kan, Zhenya Tan, Haitao Wang, Wei Wang, Jiazhao Yang, Ya Zhang, Xiaoling Lu, Qirong Cheng, Lanyi Chai, Chao Peng, Jicheng Zhu, Chenghang Zhu, Hailin Wang, Li Zhan, Keqiong Lin, Yakun Liu, Lingqiang Zhang, Haitao Fan, Hong Zheng

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P386: CELL FATE DETERMINING TRANSCRIPTION FACTORS AS VULNERABILITIES IN CHILDHOOD AND ADULT MLL-REARRANGED AND T(8;16) ACUTE MYELOID LEUKEMIA by S. Arza Apalategi, B. Heuts, S. Bergevoet, S. van Heeringen, J. Jansen, J. Martens, B. van der Reijden

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From diffuse growth to planar polarity in Arabidopsis root epidermal cells by Daria eBalcerowicz, Sébastjen eSchoenaers, Kris eVissenberg

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Temporal perturbation of ERK dynamics reveals network architecture of FGF2/MAPK signaling by Yannick Blum, Jan Mikelson, Maciej Dobrzyński, Hyunryul Ryu, Marc‐Antoine Jacques, Noo Li Jeon, Mustafa Khammash, Olivier Pertz

Subjects: “…cell fate determination…”
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FoxG1 Directly Represses Dentate Granule Cell Fate During Forebrain Development by Xiao Han, Xiaochun Gu, Qianqian Zhang, Qingxia Wang, Yao Cheng, Samuel J. Pleasure, Chunjie Zhao

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Parallel Activin and BMP signaling coordinates R7/R8 photoreceptor subtype pairing in the stochastic Drosophila retina by Brent S Wells, Daniela Pistillo, Erin Barnhart, Claude Desplan

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The LIM protein complex establishes a retinal circuitry of visual adaptation by regulating Pax6 α-enhancer activity by Yeha Kim, Soyeon Lim, Taejeong Ha, You-Hyang Song, Young-In Sohn, Dae-Jin Park, Sun-Sook Paik, Joo-ri Kim-Kaneyama, Mi-Ryoung Song, Amanda Leung, Edward M Levine, In-Beom Kim, Yong Sook Goo, Seung-Hee Lee, Kyung Hwa Kang, Jin Woo Kim

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Sustained expression of unc-4 homeobox gene and unc-37/Groucho in postmitotic neurons specifies the spatial organization of the cholinergic synapses in C. elegans by Mizuki Kurashina, Jane Wang, Jeffrey Lin, Kathy Kyungeun Lee, Arpun Johal, Kota Mizumoto

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