Ablation of coactivator Med1 switches the cell fate of dental epithelia to that generating hair. by Keigo Yoshizaki, Lizhi Hu, Thai Nguyen, Kiyoshi Sakai, Bing He, Chak Fong, Yoshihiko Yamada, Daniel D Bikle, Yuko Oda

“…Here we provide evidence that the transcriptional coactivator, Mediator 1 (Med1), is essential for the cell fate determination of ectodermal epithelia. Conditional deletion of Med1 in vivo converted dental epithelia into epidermal epithelia, causing defects in enamel organ development while promoting hair formation in the incisors. …”
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RNA editing enzyme ADAR1 is required for early T cell development by Richard Xufeng, Daibang Nie, Qiong Yang, Wang Wang, Tao Cheng, Qingde Wang

“…This study demonstrated an essential role for the RNA editing enzyme ADAR1 as a potential regulator for T-cell fate determination during clonal selection, which, in turn, contributes to immunologic homeostasis.…”
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Notch Signaling Pathway and Human Placenta by Wei-Xiu Zhao, Jian-Hua Lin

“…<p>Notch signaling was evolutionarily conserved and critical for cell-fate determination, differentiation and many other biological processes. …”
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The Crosstalk between Cancer Stem Cells and Microenvironment Is Critical for Solid Tumor Progression: The Significant Contribution of Extracellular Vesicles by Chiara Ciardiello, Alessandra Leone, Alfredo Budillon

“…Accordingly, a number of studies led to the recognition of stem cell-associated EVs as new complexes able to contribute to cell fate determination of either normal or tumor cells. In this review, we aim to highlight an existing bidirectional role of EV-mediated communication—from cancer stem cells to microenvironment and also from microenvironment to cancer stem cells—in the most widespread solid cancers as prostate, breast, lung, and colon tumors.…”
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Regulation of differentiation by rhogtpases in mouse embryonic stem cells by Tan, Mei Hua

“…Taken together, we have discovered a new role of RhoA in the regulation of cell fate determination during differentiation of mESCs.…”
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Comprehensive identification of arginine methylation in primary T cells reveals regulatory roles in cell signalling by Geoghegan, V, Guo, A, Trudgian, D, Thomason, B, Acuto, O

“…We find that components of T cell antigen receptor signal machinery and several key transcription factors that regulate T cell fate determination are methylated on arginine. Moreover, we demonstrate changes in arginine methylation stoichiometry during cellular stimulation in a subset of proteins critical to T cell differentiation. …”

Redefining the expression and function of the inhibitor of differentiation 1 in mammary gland development. by Radhika Nair, Simon Junankar, Sandra O'Toole, Jaynish Shah, Alexander D Borowsky, J Michael Bishop, Alexander Swarbrick

“…Together, these data demonstrate that there is no luminal cell-autonomous role for Id1 in mammary epithelial cell fate determination, ductal morphogenesis and terminal differentiation.…”
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Long Noncoding RNA Mediated Regulation in Human Embryogenesis, Pluripotency, and Reproduction by Lei Liu, Fang Fang

“…They contribute to cell fate determination through interacting with almost all classes of cellular biomolecules, including proteins, DNA, mRNAs, and microRNAs. …”
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Protein ubiquitination in T cell development by Ting Zhong, Kang Lei, Xiaoxi Lin, Zhiguo Xie, Shuoming Luo, Zhiguang Zhou, Bin Zhao, Xia Li

“…Understanding how T cell development is regulated by ubiquitination and deubiquitination will not only enhance our understanding of cell fate determination via gene regulatory networks but also provide potential novel therapeutic strategies for treating autoimmune diseases and cancer.…”
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Epigenetic control of dental stem cells: progress and prospects in multidirectional differentiation by Yan Li, Xinwei Guo, Hua Yao, Zhimin Zhang, Hongyan Zhao

“…Epigenetic mechanisms are widely involved in processes such as bone homeostasis, embryogenesis, stem cell fate determination, and disease development. Recently, the epigenetic regulation of dental stem cells has attracted considerable research attention. …”
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Pathways and mechanisms of transmembrane calcium ions exchange in the cell nucleus by T. O. Veklich, Yu. V. Nikonishyna, S. O. Kosterin

“…A variety of nuclear calcium functions includes regulations of gene transcription and permeability of nuclear pore complexes, activation of numerous enzymes involved in the apoptosis, and therefore cell fate determination. Thus, the pathways of Ca2+ entry into the nucleus, the interplay between nuclear and cytosolic calcium signals, calcium accumulation in the nuclear depot, extrusion and subsequent destinies are of particular interest. …”
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Coordinating cell polarity and cell cycle progression: what can we learn from flies and worms? by Anna Noatynska, Nicolas Tavernier, Monica Gotta, Lionel Pintard

“…Key cell cycle regulators control cell polarity, and thus influence cell fate determination and/or differentiation, whereas some factors involved in cell polarity regulate cell cycle timing and proliferation potential. …”
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Advances in the Regulation of Epidermal Cell Development by C2H2 Zinc Finger Proteins in Plants by Guoliang Han, Yuxia Li, Ziqi Qiao, Chengfeng Wang, Yang Zhao, Jianrong Guo, Min Chen, Baoshan Wang

“…Plant epidermal cells, such as trichomes, root hairs, salt glands, and stomata, play pivotal roles in the growth, development, and environmental adaptation of terrestrial plants. Cell fate determination, differentiation, and the formation of epidermal structures represent basic developmental processes in multicellular organisms. …”
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dachshund Potentiates Hedgehog Signaling during Drosophila Retinogenesis. by Catarina Brás-Pereira, Delphine Potier, Jelle Jacobs, Stein Aerts, Fernando Casares, Florence Janody

“…This process is driven by the dynamic changes in signaling activity of the conserved Hedgehog (Hh) pathway, which coordinates cell fate determination, cell cycle and tissue morphogenesis. …”
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Twist1 controls a cell-specification switch governing cell fate decisions within the cardiac neural crest. by Joshua W Vincentz, Beth A Firulli, Andrea Lin, Douglas B Spicer, Marthe J Howard, Anthony B Firulli

“…These data demonstrate that Twist1 functions in post-migratory neural crest cells to repress pro-neural factors and thereby regulate cell fate determination between ectodermal and mesodermal lineages.…”
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Cell Fate Control by Translation: mRNA Translation Initiation as a Therapeutic Target for Cancer Development and Stem Cell Fate Control by Hyun-Jung Kim

“…In addition, the machinery that is involved in protein synthesis plays critical roles in stem cell fate determination. In the current review, recent advances in the understanding of translational control, especially translational initiation in cancer development and stem cell fate control, are described. …”
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TRAF1 from a Structural Perspective by Hyunseok Jang, Subin Kim, Do Yeon Kim, Ju Hee Han, Hyun Ho Park

“…Tumor necrosis factor receptor-associated factor (TRAF) proteins play pivotal roles in a multitude of cellular signaling pathways, encompassing immune response, cell fate determination, development, and thrombosis. Their involvement in these processes hinges largely on their ability to interact directly with diverse receptors via the TRAF domain. …”
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Cytoskeletal Protein 4.1R in Health and Diseases by Jiaojiao Liu, Cong Ding, Xin Liu, Qiaozhen Kang

“…It has been found to play a crucial role in various biological processes, such as cell fate determination, cell cycle regulation, cell proliferation, and cell motility. …”
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Mitochondrial Quality Control in COPD and IPF by Hiromichi Hara, Kazuyoshi Kuwano, Jun Araya

“…Mitochondria play important roles in the maintenance of intracellular homeostasis; hence, the quality control of mitochondria is crucial for cell fate determination. Mitochondria dynamics and mitochondria-specific autophagy, known as mitophagy, are two main quality control systems in cells. …”
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Rcor2 Is Required for Somatic Differentiation and Represses Germline Cell Fate by Lijuan Pei, Hongjie Zhang, Meihui Zhang, Yixuan Wang, Ke Wei

“…Our results suggest that Rcor2 plays an important role in somatic cell fate determination by suppressing PGC differentiation through regulating epigenetic modifications of PGC specific genes.…”
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