Shape-memory surfaces for cell mechanobiology by Mitsuhiro Ebara

“…The goal for these endeavors is to mimic the surrounding mechanical cues of extracellular environments which have been considered as critical parameters in cell fate determination. The untapped potential of SMSs makes them one of the most exciting interfaces of materials science and cell mechanobiology.…”
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Disrupting the interaction between retinoblastoma protein and Raf-1 leads to defects in progenitor cell proliferation and survival during early inner ear development. by Wenyan Li, Shan Sun, Yan Chen, Huiqian Yu, Zheng-Yi Chen, Huawei Li

“…The retinoblastoma protein (pRb) is required for cell-cycle exit of embryonic mammalian hair cells but is not required for hair cell fate determination and early differentiation, and this provides a strategy for hair cell regeneration by manipulating the pRb pathway. …”
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The Multiple Interactions of RUNX with the Hippo–YAP Pathway by Linda Shyue Huey Chuang, Yoshiaki Ito

“…Similarly, master regulators of development RUNX transcription factors have been shown to play critical roles in proliferation, differentiation, apoptosis and cell fate determination. In this review, we discuss the multiple interactions of RUNX with the Hippo–YAP pathway, their shared collaborators in Wnt, TGFβ, MYC and RB pathways, and their overlapping functions in development and tumorigenesis.…”
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Enhanced transcriptional heterogeneity mediated by NF-κB super-enhancers. by Johannes N Wibisana, Takehiko Inaba, Hisaaki Shinohara, Noriko Yumoto, Tetsutaro Hayashi, Mana Umeda, Masashi Ebisawa, Itoshi Nikaido, Yasushi Sako, Mariko Okada

“…The transcription factor NF-κB, which plays an important role in cell fate determination, is involved in the activation of super-enhancers (SEs). …”
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Structural analysis uncovers lipid-binding properties of Notch ligands. by Chillakuri, C, Sheppard, D, Ilagan, M, Holt, L, Abbott, F, Liang, S, Kopan, R, Handford, P, Lea, S

“…The Notch pathway is a core cell-cell signaling system in metazoan organisms with key roles in cell-fate determination, stem cell maintenance, immune system activation, and angiogenesis. …”

Non-muscle myosin II is required for correct fate specification in the Caenorhabditis elegans seam cell divisions by Ding, S, Woollard, A

“…This reveals a role for nmy-2 in cell fate determination not obviously linked to the primary polarity determination mechanisms it has been previously associated with.…”

High expression of new genes in trochophore enlightening the ontogeny and evolution of trochozoans by Xu, F, Domazet-Lošo, T, Fan, D, Dunwell, T, Li, L, Fang, X, Zhang, G

“…In addition to exhibiting spiral cleavage and early cell fate determination, trochozoans typically undergo indirect development, which contributes to the most unique characteristics of their ontogeny. …”

Non-linear and flexible regions of the human Notch-1 extracellular domain revealed by high-resolution structural studies by Redfield, C, Weisshuhn, P, Handford, P, Lea, S, Sheppard, D, Whiteman, P, Taylor, P

“…This results in a short-range signal with profound effects on cell-fate determination, cell proliferation and cell death. …”

Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway. by Goberdhan, D, Paricio, N, Goodman, E, Mlodzik, M, Wilson, C

“…Surprisingly, although DPTEN does not generally affect cell fate determination, it does appear to regulate the subcellular organization of the actin cytoskeleton in multiple cell types. …”

mTOR hypoactivity leads to trophectoderm cell failure by enhancing lysosomal activation and disrupting the cytoskeleton in preimplantation embryo by Chiyuan Ma, Qin Li, Yuxin Yang, Lei Ge, Jiaxuan Cai, Juan Wang, Maoxian Zhu, Yue Xiong, Wenya Zhang, Jingtong Xie, Yujing Cao, Huashan Zhao, Qing Wei, Chen Huang, Junchao Shi, Jian V. Zhang, Enkui Duan, Xiaohua Lei

“…Abstract Background Metabolic homeostasis is closely related to early impairment of cell fate determination and embryo development. The protein kinase mechanistic target of rapamycin (mTOR) is a key regulator of cellular metabolism in the body. …”
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The Wnt Co-Receptor PTK7/Otk and Its Homolog Otk-2 in Neurogenesis and Patterning by Qian Hui Tan, Agimaa Otgonbaatar, Prameet Kaur, Angelica Faye Ga, Nathan P. Harmston, Nicholas S. Tolwinski

“…Wnt signaling is a highly conserved metazoan pathway that plays a crucial role in cell fate determination and morphogenesis during development. …”
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MiR-7 in Cancer Development by Petra Korać, Mariastefania Antica, Maja Matulić

“…In some types of lung and oral carcinoma, it can act as oncomir. miR-7 roles in cell fate determination and maintenance of cell homeostasis are still to be discovered, as well as the possibilities of its use as a specific biotherapeutic.…”
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Laser microdissection of sensory organ precursor cells of Drosophila microchaetes. by Eulalie Buffin, Michel Gho

“…Using this procedure, we found that genes that exhibit a 2-fold or greater expression in SOPs versus epithelial cells were mainly associated with Gene Ontology (GO) terms related with cell fate determination and sensory organ specification. Furthermore, we found that several genes such as pebbled/hindsight, scabrous, miranda, senseless, or cut, known to be expressed in SOP cells by independent procedures, are particularly detected in laser microdissected SOP cells rather than in epithelial cells.…”
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PPARγ and PPARδ as Modulators of Neoplasia and Cell Fate by Robert I. Glazer, Hongyan Yuan, Zhihui Xie, Yuzhi Yin

“…There is now emerging evidence that PPARs regulate tumor suppressor genes and developmental pathways associated with transformation and cell fate determination. This review discusses the role of PPARγ and PPARδ agonists as modulators of these processes.…”
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Robust quantification of cellular mechanics using optical tweezers by Wessel S. Rodenburg, Sven F.A. Ebben, Jorine M. Eeftens

“…The mechanical properties of cells are closely related to function and play a crucial role in many cellular processes, including migration, differentiation, and cell fate determination. Numerous methods have been developed to assess cell mechanics under various conditions, but they often lack accuracy on biologically relevant piconewton-range forces or have limited control over the applied force. …”
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Plasmogamic Paternal Contributions to Early Zygotic Development in Flowering Plants by Yukinosuke Ohnishi, Yukinosuke Ohnishi, Tomokazu Kawashima

“…Especially, it has become more evident that paternal parent-of-origin effects, via sperm cytoplasm contents, not only control canonical early zygotic development, but also activate a biparental signaling pathway critical for cell fate determination after the first cell division. Here, we summarize the plasmogamic paternal contributions via the entry of sperm contents during/after fertilization in flowering plants.…”
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Molecular Mechanisms and Regulation of Mammalian Mitophagy by Vinay Choubey, Akbar Zeb, Allen Kaasik

“…Mitochondria in the cell are the center for energy production, essential biomolecule synthesis, and cell fate determination. Moreover, the mitochondrial functional versatility enables cells to adapt to the changes in cellular environment and various stresses. …”
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Insights into Bone Morphogenetic Protein—(BMP-) Signaling in Ocular Lens Biology and Pathology by Daisy Y. Shu, Frank J. Lovicu

“…Although originally discovered to possess osteogenic properties, BMPs have since been identified as critical regulators of many biological processes, including cell-fate determination, cell proliferation, differentiation and morphogenesis, throughout the body. …”
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Validation of commercial ERK antibodies against the ERK orthologue of the scleractinian coral Stylophora pistillata [version 1; referees: 1 approved, 2 approved with reservations] by Lucile Courtial, Vincent Picco, Gilles Pagès, Christine Ferrier-Pagès

“…The extracellular signal-regulated protein kinase (ERK) signalling pathway controls key cellular processes, such as cell cycle regulation, cell fate determination and the response to external stressors. …”
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Epigenetic mechanisms in stem cell therapies for achilles tendinopathy by Zheyang Yuan, Zheyu Yao, Xufeng Mao, Xiang Gao, Sengyi Wu, Haijiao Mao

“…And epigenetic modifications play an important role in stem cell fate determination and function. In this review, we provided a brief overview of the biological properties of relevant stem cells. …”
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