Novel biological insights revealed from the investigation of multiscale genome architecture by Tianyi Ding, He Zhang

“…Gene expression and cell fate determination require precise and coordinated epigenetic regulation. …”
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Spatial Genome Organization: From Development to Disease by Aishwarya Sivakumar, Jose I. de las Heras, Eric C. Schirmer

“…We will then elaborate on the dynamics of genome organization during development, and how genome architecture plays an important role in cell fate determination. Finally, we will discuss how misregulation can be a factor in human disease.…”
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An Efficient Antipodal Cell Isolation Method for Screening of Cell Type-Specific Genes in Arabidopsis thaliana. by Xiaobo Yu, An Luo, Meng-Xiang Sun

“…Excluding the antipodal cell, as a model for the study of cell fate determination and cell type specification, the roles of these embryo sac component cells in fertilization and seed formation have been widely investigated. …”
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beta-Catenin regulates intercellular signalling networks and cell-type specific transcription in the developing mouse midbrain-rhombomere 1 region. by Dmitri Chilov, Natalia Sinjushina, Jonna Saarimäki-Vire, Makoto M Taketo, Juha Partanen

“…These results highlight the role of beta-catenin in establishment of neuroectodermal signalling centers, promoting region-specific gene expression and regulation of cell fate determination.…”
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Convergent accelerated evolution of mammal-specific conserved non-coding elements in hibernators by Daiki Nakayama, Takashi Makino

“…We also found that common factors of genes that located near accelerated CNEs and are differentially expressed between normal and hibernation periods related to gene regulation and cell-fate determination. It suggests that the molecular mechanisms controlling hibernation have undergone convergent evolution. …”
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Lactylation, an emerging hallmark of metabolic reprogramming: Current progress and open challenges by Xuelian Liu, Yu Zhang, Wei Li, Xin Zhou, Xin Zhou, Xin Zhou

“…Several studies have identified the pivotal role of protein lactylation in cell fate determination, embryonic development, inflammation, cancer, and neuropsychiatric disorders. …”
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Mitochondrial membrane potential probes and the proton gradient: a practical usage guide by Seth W. Perry, John P. Norman, Justin Barbieri, Edward B. Brown, Harris A. Gelbard

“…Fluorescent probes for monitoring mitochondrial membrane potential are frequently used for assessing mitochondrial function, particularly in the context of cell fate determination in biological and biomedical research. …”
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Epigenetic Control of Muscle Stem Cells: Focus on Histone Lysine Demethylases by Delia Cicciarello, Laurent Schaeffer, Isabella Scionti

“…More globally, cell fate determination involves important changes in the epigenetic landscape of the genome. …”
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Hematopoietic stem cell development and regulatory signaling in zebrafish. by Zhang, C, Patient, R, Liu, F

“…HSC development must be tightly controlled from cell fate determination to self-maintenance during adulthood. …”

BRD4 localization to lineage-specific enhancers is associated with a distinct transcription factor repertoire by Najafova, Z, Tirado-Magallanes, R, Subramaniam, M, Hossan, T, Schmidt, G, Nagarajan, S, Baumgart, S, Mishra, V, Bedi, U, Hesse, E, Knapp, S, Hawse, J, Johnsen, S

“…Proper temporal epigenetic regulation of gene expression is essential for cell fate determination and tissue development. The Bromodomain-containing Protein-4 (BRD4) was previously shown to control the transcription of defined subsets of genes in various cell systems. …”

The imidazoacridinone C-1311 induces p53-dependent senescence or p53-independent apoptosis and sensitizes cancer cells to radiation by Skwarska, A, Ramachandran, S, Dobrynin, G, Leszczynska, K, Hammond, E

“…For the first time we demonstrate that the tumor suppressor, p53 plays a key role in cell fate determination after C-1311 treatment. In the presence of wild-type p53, cells exposed to C-1311 entered senescence. …”

Chirality Regulates Macrophage Polarization for Tissue Regeneration Through Bidirectionally Modulating WTAP‐Mediated m6A Modification by Yue Yang, Xinwei Guo, Chenyan Huang, Chen Chen, Yingying Zhou, Zhengrong Gao, Chuanliang Feng, Shengjie Jiang, Xuliang Deng, Yan Wei

“…Thus, a mechano‐epigenetic mechanism of chirality‐mediated cell‐fate determination is unveiled, which holds remarkable promise in the realm of assisted regenerative material design.…”
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Nucleoredoxin Knockdown in SH-SY5Y Cells Promotes Cell Renewal by Lucie Valek, Irmgard Tegeder

“…Deficiency in mice leads to cranial dysmorphisms and defects of heart, brain, and bone, suggesting defects of cell fate determination. We used shRNA-mediated knockdown of NXN in SH-SY5Y neuroblastoma cells to study its impact on neuronal cells. …”
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Neuronal cell fate diversification controlled by sub-temporal action of Kruppel by Johannes Stratmann, Hugo Gabilondo, Jonathan Benito-Sipos, Stefan Thor

“…Here, we find that the late temporal gene castor sub-divides its large window in neuroblast 5–6 by simultaneously activating two cell fate determination cascades and a sub-temporal regulatory program. …”
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Atrial natriuretic peptide signaling co-regulates lipid metabolism and ventricular conduction system gene expression in the embryonic heart by Abhishek Mishra, Mahtab Tavasoli, Stanislav Sokolenko, Christopher R. McMaster, Kishore B.S. Pasumarthi

“…In this study, histological sections and primary cultures obtained from E11.5 mouse ventricles were analyzed to determine the role of metabolic adaptations in VCS cell fate determination and maturation. Exogenous treatment of E11.5 ventricular cells with ANP revealed a significant increase in lipid droplet accumulation, FAO and higher expression of VCS marker Cx40. …”
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Capillary Isoelectric Focusing Immunoassay for Fat Cell Differentiation Proteomics. by Mary G Johlfs, Priyatham Gorjala, Yasuyo Urasaki, Thuc T Le, Ronald R Fiscus

“…Profiling cellular proteome is critical to understanding signal integration during cell fate determination. In this study, the capability of capillary isoelectric focusing (cIEF) immunoassays to detect post-translational modifications (PTM) of protein isoforms is demonstrated. cIEF immunoassays exhibit protein detection sensitivity at up to 5 orders of magnitude higher than traditional methods. …”
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Mitochondrial control of innate immune responses by Shasha Chen, Zhiyong Liao, Pinglong Xu, Pinglong Xu, Pinglong Xu

“…Mitochondria are versatile organelles and essential components of numerous biological processes such as energy metabolism, signal transduction, and cell fate determination. In recent years, their critical roles in innate immunity have come to the forefront, highlighting impacts on pathogenic defense, tissue homeostasis, and degenerative diseases. …”
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Buffered EGFR signaling regulated by spitz-to-argos expression ratio is a critical factor for patterning the Drosophila eye. by Nikhita Pasnuri, Manish Jaiswal, Krishanu Ray, Aprotim Mazumder

“…The expression dose of Spitz and Argos early in photoreceptor cell fate determination has been shown to be critical in patterning the Drosophila eye, but the exact identity of the cells expressing these genes in the larval eye disc has been elusive. …”
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AP2γ: A New Player on Adult Hippocampal Neurogenesis Regulation by Antonio Mateus-Pinheiro, Nuno Dinis Alves, Nuno Sousa, Luisa Pinto

“…In a recent study published in Molecular Psychiatry , we demonstrate Activating Protein 2γ (AP2γ), a transcription factor previously implicated in cell fate determination in the developing cortex, as a novel player in the regulation of glutamatergic neurogenesis in the adult hippocampus. …”
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Molecular profiling of basal cell carcinoma of the prostate: A case report and literature review by Luca Bertozzi, Eileen Zhang, Mohadese Behtaj, Olivia Gordon, Michael J. Whalen

“…Upon literature review, we found that prostate BCC mutations disrupt cell growth, epigenetic regulation, and cell fate determination. With no consensus guidelines available, experimental targeted therapies have shown promise for prostate BCC management.…”
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