Enhanced transcriptional heterogeneity mediated by NF-κB super-enhancers. by Johannes N Wibisana, Takehiko Inaba, Hisaaki Shinohara, Noriko Yumoto, Tetsutaro Hayashi, Mana Umeda, Masashi Ebisawa, Itoshi Nikaido, Yasushi Sako, Mariko Okada

“…The transcription factor NF-κB, which plays an important role in cell fate determination, is involved in the activation of super-enhancers (SEs). …”
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Structural analysis uncovers lipid-binding properties of Notch ligands. by Chillakuri, C, Sheppard, D, Ilagan, M, Holt, L, Abbott, F, Liang, S, Kopan, R, Handford, P, Lea, S

“…The Notch pathway is a core cell-cell signaling system in metazoan organisms with key roles in cell-fate determination, stem cell maintenance, immune system activation, and angiogenesis. …”

Non-muscle myosin II is required for correct fate specification in the Caenorhabditis elegans seam cell divisions by Ding, S, Woollard, A

“…This reveals a role for nmy-2 in cell fate determination not obviously linked to the primary polarity determination mechanisms it has been previously associated with.…”

High expression of new genes in trochophore enlightening the ontogeny and evolution of trochozoans by Xu, F, Domazet-Lošo, T, Fan, D, Dunwell, T, Li, L, Fang, X, Zhang, G

“…In addition to exhibiting spiral cleavage and early cell fate determination, trochozoans typically undergo indirect development, which contributes to the most unique characteristics of their ontogeny. …”

Non-linear and flexible regions of the human Notch-1 extracellular domain revealed by high-resolution structural studies by Redfield, C, Weisshuhn, P, Handford, P, Lea, S, Sheppard, D, Whiteman, P, Taylor, P

“…This results in a short-range signal with profound effects on cell-fate determination, cell proliferation and cell death. …”

Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway. by Goberdhan, D, Paricio, N, Goodman, E, Mlodzik, M, Wilson, C

“…Surprisingly, although DPTEN does not generally affect cell fate determination, it does appear to regulate the subcellular organization of the actin cytoskeleton in multiple cell types. …”

mTOR hypoactivity leads to trophectoderm cell failure by enhancing lysosomal activation and disrupting the cytoskeleton in preimplantation embryo by Chiyuan Ma, Qin Li, Yuxin Yang, Lei Ge, Jiaxuan Cai, Juan Wang, Maoxian Zhu, Yue Xiong, Wenya Zhang, Jingtong Xie, Yujing Cao, Huashan Zhao, Qing Wei, Chen Huang, Junchao Shi, Jian V. Zhang, Enkui Duan, Xiaohua Lei

“…Abstract Background Metabolic homeostasis is closely related to early impairment of cell fate determination and embryo development. The protein kinase mechanistic target of rapamycin (mTOR) is a key regulator of cellular metabolism in the body. …”
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The Wnt Co-Receptor PTK7/Otk and Its Homolog Otk-2 in Neurogenesis and Patterning by Qian Hui Tan, Agimaa Otgonbaatar, Prameet Kaur, Angelica Faye Ga, Nathan P. Harmston, Nicholas S. Tolwinski

“…Wnt signaling is a highly conserved metazoan pathway that plays a crucial role in cell fate determination and morphogenesis during development. …”
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MiR-7 in Cancer Development by Petra Korać, Mariastefania Antica, Maja Matulić

“…In some types of lung and oral carcinoma, it can act as oncomir. miR-7 roles in cell fate determination and maintenance of cell homeostasis are still to be discovered, as well as the possibilities of its use as a specific biotherapeutic.…”
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Laser microdissection of sensory organ precursor cells of Drosophila microchaetes. by Eulalie Buffin, Michel Gho

“…Using this procedure, we found that genes that exhibit a 2-fold or greater expression in SOPs versus epithelial cells were mainly associated with Gene Ontology (GO) terms related with cell fate determination and sensory organ specification. Furthermore, we found that several genes such as pebbled/hindsight, scabrous, miranda, senseless, or cut, known to be expressed in SOP cells by independent procedures, are particularly detected in laser microdissected SOP cells rather than in epithelial cells.…”
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Role of Diet in Stem and Cancer Stem Cells by Francesca Puca, Monica Fedele, Debora Rasio, Sabrina Battista

“…In this context, diet-induced metabolic changes can have a profound impact on stem cell fate determination, lineage specification and differentiation. …”
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FTO Knockout Causes Chromosome Instability and G2/M Arrest in Mouse GC-1 Cells by Tao Huang, Qiang Gao, Tongying Feng, Yi Zheng, Jiayin Guo, Wenxian Zeng

“…Increasing studies have uncovered the significance of m6A in various biological processes such as stem cell fate determination, carcinogenesis, adipogenesis, stress response, etc, which put forwards a novel conception called epitranscriptome. …”
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Plasmogamic Paternal Contributions to Early Zygotic Development in Flowering Plants by Yukinosuke Ohnishi, Yukinosuke Ohnishi, Tomokazu Kawashima

“…Especially, it has become more evident that paternal parent-of-origin effects, via sperm cytoplasm contents, not only control canonical early zygotic development, but also activate a biparental signaling pathway critical for cell fate determination after the first cell division. Here, we summarize the plasmogamic paternal contributions via the entry of sperm contents during/after fertilization in flowering plants.…”
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Quercetin and lithium chloride modulate Wnt signaling in pluripotent embryonal carcinoma NT2/D1 cells by Mojsin Marija, Topalović Vladanka, Marjanović Jelena, Stevanović Milena

“…Wnt signaling functions in numerous cellular activities such as cell fate determination, patterning, and migration in embryogenesis, apoptosis, etc. …”
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Shaping of Dendritic Cell Function by the Metabolic Micro-Environment by Eline Constance Brombacher, Bart Everts

“…Nutrients are required for growth and survival of all cells, but are also crucially involved in cell fate determination of many cell types, including immune cells. …”
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JMJD3: a critical epigenetic regulator in stem cell fate by Yuanjie Ding, Yuanchun Yao, Xingmu Gong, Qi Zhuo, Jinhua Chen, Miao Tian, Maryam Farzaneh

“…Recent studies have illustrated that JMJD3 plays a major role in cell fate determination of pluripotent and multipotent stem cells (MSCs). …”
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Molecular Mechanisms and Regulation of Mammalian Mitophagy by Vinay Choubey, Akbar Zeb, Allen Kaasik

“…Mitochondria in the cell are the center for energy production, essential biomolecule synthesis, and cell fate determination. Moreover, the mitochondrial functional versatility enables cells to adapt to the changes in cellular environment and various stresses. …”
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Protocol for Establishing Mouse Embryonic Stem Cells to Study Histone Inheritance Pattern at Single-Cell Resolution by Binbin Ma, Tung-Jui Trieu, Shukry J. Habib, Xin Chen

“…Summary: Asymmetric histone inheritance can regulate cell-fate determination in Drosophila male germline stem cells. …”
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Insights into Bone Morphogenetic Protein—(BMP-) Signaling in Ocular Lens Biology and Pathology by Daisy Y. Shu, Frank J. Lovicu

“…Although originally discovered to possess osteogenic properties, BMPs have since been identified as critical regulators of many biological processes, including cell-fate determination, cell proliferation, differentiation and morphogenesis, throughout the body. …”
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Validation of commercial ERK antibodies against the ERK orthologue of the scleractinian coral Stylophora pistillata [version 1; referees: 1 approved, 2 approved with reservations] by Lucile Courtial, Vincent Picco, Gilles Pagès, Christine Ferrier-Pagès

“…The extracellular signal-regulated protein kinase (ERK) signalling pathway controls key cellular processes, such as cell cycle regulation, cell fate determination and the response to external stressors. …”
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