Interplay of Vitamin D and SIRT1 in Tissue-Specific Metabolism—Potential Roles in Prevention and Treatment of Non-Communicable Diseases Including Cancer by Zsuzsanna Nemeth, Attila Patonai, Laura Simon-Szabó, István Takács

“…Through their proper regulation, they maintain normal body weight, lipid profile, insulin secretion and sensitivity, balance between the pro- and anti-inflammatory processes under normal conditions and infections, maintain endothelial health; balance cell differentiation, proliferation, and fate; and balance the circadian rhythm of the cellular metabolism. The role of these two molecules is interconnected in the molecular network, and they regulate each other in several layers of the homeostasis of energy and the cellular metabolism. …”
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HIF-1α induces glycolytic reprograming in tissue-resident alveolar macrophages to promote cell survival during acute lung injury by Parker S Woods, Lucas M Kimmig, Kaitlyn A Sun, Angelo Y Meliton, Obada R Shamaa, Yufeng Tian, Rengül Cetin-Atalay, Willard W Sharp, Robert B Hamanaka, Gökhan M Mutlu

“…Cellular metabolism is a critical regulator of macrophage effector function. …”
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Phage-Defense Systems Are Unlikely to Cause Cell Suicide by Laura Fernández-García, Thomas K. Wood

“…As new phage-defense systems (PDs) are discovered, the overlap between their mechanisms and those of toxin/antitoxin systems (TAs) is becoming clear in that both use similar means to reduce cellular metabolism; for example, both systems have members that deplete energetic compounds (e.g., NAD⁺, ATP) and deplete nucleic acids, and both have members that inflict membrane damage. …”
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Methionine Dependence of Cancer by Peter Kaiser

“…Tumorigenesis is accompanied by the reprogramming of cellular metabolism. The shift from oxidative phosphorylation to predominantly glycolytic pathways to support rapid growth is well known and is often referred to as the Warburg effect. …”
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Redox Regulation of Lipid Mobilization in Adipose Tissues by Ursula Abou-Rjeileh, G. Andres Contreras

“…Reactive oxygen and nitrogen species (ROS and RNS) are byproducts of cellular metabolism that exert signaling functions in several cellular processes, including lipolysis and lipogenesis. …”
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Inhibiting the Priming for Cancer in Li-Fraumeni Syndrome by Pan Pantziarka, Sarah Blagden

“…Important factors in the creation of the pre-cancerous niche include disrupted tissue homeostasis, cellular metabolism and chronic inflammation. While druggability of TP53 remains a challenge, there is evidence that drug re-purposing may be able to address aspects of pre-cancerous niche formation and thereby reduce the risk of cancer in individuals with LFS.…”
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Metabolic Rewiring in Adult-Type Diffuse Gliomas by Jong-Whi Park

“…In addition, extensive molecular profiling has revealed activated oncogenes and inactivated tumor suppressors that directly or indirectly impact the cellular metabolism that is associated with the pathogenesis of gliomas. …”
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Immunoregulation: the interplay between metabolism and redox homeostasis by E. Perpiñán, A. Sanchez-Fueyo, N. Safinia

“…Upon activation regulatory T cells rearrange their oxidation-reduction (redox) system, which in turn supports their metabolic reprogramming, adding a layer of complexity to our understanding of cellular metabolism. Here we review the literature surrounding redox homeostasis and metabolism of regulatory T cells to highlight new mechanistic insights of these interlinked pathways in immune regulation.…”
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Polyunsaturated Fatty Acids Drive Lipid Peroxidation during Ferroptosis by Michael S. Mortensen, Jimena Ruiz, Jennifer L. Watts

“…Ferroptosis is a form of regulated cell death that is intricately linked to cellular metabolism. In the forefront of research on ferroptosis, the peroxidation of polyunsaturated fatty acids has emerged as a key driver of oxidative damage to cellular membranes leading to cell death. …”
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Numerical analysis of coupled systems of ODEs and applications to enzymatic competitive inhibition by product by Vinh Quang Mai, Thái Anh Nhan

“…Enzymatic inhibition is one of the key regulatory mechanisms in cellular metabolism, especially the enzymatic competitive inhibition by product. …”
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Nanoparticle-Mediated Therapeutic Application for Modulation of Lysosomal Ion Channels and Functions by Dongun Lee, Jeong Hee Hong

“…Understanding of lysosomal functions is essential for enhancing the efficacy of nanoparticles-mediated therapy and reducing the malfunctions of cellular metabolism. The lysosomal function is modulated by the movement of ions through various ion channels. …”
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Biological consequences of structural and functional proteasome diversity by Alexey V. Morozov, Vadim L. Karpov

“…Ubiquitin-proteasome system (UPS) degrades most intracellular proteins and thus, participates in regulation of cellular metabolism. Within the UPS, proteasomes are the elements that perform substrate cleavage. …”
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Mitochondria from the Outside in: The Relationship Between Inter-Organelle Crosstalk and Mitochondrial Internal Organization by Jonathan R. Friedman

“…Mitochondria form MCSs with almost every other organelle in the cell, including the endoplasmic reticulum, lipid droplets, and lysosomes, to coordinate global cellular metabolism with mitochondrial metabolism. However, these MCSs not only facilitate the transport of metabolites between organelles, but also directly impinge on the physical shape and functional organization inside mitochondria. …”
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Functional analysis of mammalian homologues of yeast vrp1p using S. cerevisiae by Meng, Lei

“…The majority of cellular metabolism takes place in the cytosol which consists of enzymes to carry out biochemical reactions as well as proteins with structural functions. …”
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Normothermic organ preservation by Jamieson, R, Friend, P

“…Normothermic preservation provides oxygen delivery at physiologic or near-physiologic temperature and allows maintenance of normal cellular metabolism. There is increasing evidence, mainly from experimental models, that this technique reduces preservation-related organ damage and that it has potential application particularly in the transplantation of marginal donor organs. …”

MT1-MMP-dependent cell migration: proteolytic and non-proteolytic mechanisms by Gifford, V, Itoh, Y

“…It promotes cell migration by degrading extracellular matrix on the cell surface and creates a migration path, by modifying cell adhesion property by shedding cell adhesion molecules to increase cell motility, and by altering cellular metabolism. Thus, MT1-MMP is a multifunctional cell motility enhancer. …”

mTOR signalling and metabolic regulation of T cell differentiation. by Peter, C, Waldmann, H, Cobbold, S

“…It is increasingly evident that the regulation of cellular metabolism is tightly coupled to T cell differentiation that ultimately determines the cellular fate. …”

TGF-β Isoforms Affect the Planar and Subepithelial Fibrogenesis of Human Conjunctival Fibroblasts in Different Manners by Megumi Watanabe, Yuri Tsugeno, Tatsuya Sato, Araya Umetsu, Nami Nishikiori, Masato Furuhashi, Hiroshi Ohguro

“…The findings presented herein suggest that the three TGF-β isoforms induce diverse and distinctly different effects on cellular properties and the expressions of ECM molecules in HconF and that these changes are independent of cellular metabolism, thereby inducing different effects on the epithelial and subepithelial proliferation of human conjunctiva.…”
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Monitoring the Intracellular pH and Metabolic State of Cancer Cells in Response to Chemotherapy Using a Combination of Phosphorescence Lifetime Imaging Microscopy and Fluorescence... by Irina Druzhkova, Anastasiya Komarova, Elena Nikonova, Vadim Baigildin, Artem Mozherov, Yuliya Shakirova, Uliana Lisitsa, Vladislav Shcheslavskiy, Nadezhda Ignatova, Evgeny Shirshin, Marina Shirmanova, Sergey Tunik

“…The extracellular matrix (ECM), in which collagen is the most abundant protein, impacts many aspects of tumor physiology, including cellular metabolism and intracellular pH (pHi), as well as the efficacy of chemotherapy. …”
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Functional photosystem I maintains proper energy balance during nitrogen depletion in Chlamydomonas reinhardtii, promoting triacylglycerol accumulation by Mahmoud Gargouri, Philip D. Bates, Jeong-Jin Park, Helmut Kirchhoff, David R. Gang

“…These results suggested a central role for PSI in controlling cellular metabolism and its implication in regulation of lipid/starch partitioning. …”
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