Metabolic Dysfunction in Motor Neuron Disease: Shedding Light through the Lens of Autophagy by Subhavi De Silva, Bradley J. Turner, Nirma D. Perera

“…Therefore, autophagy is tightly coupled to cellular metabolism. We review evidence that the delicate balance between autophagy and metabolism is aberrant in ALS, giving rise to intracellular and systemic pathophysiology observations. …”
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Research progress of autophagy in retinal and eye diseases by Si-Yu Zeng, Lei Du, Yi-Qiao Xing

“…It promotes the degradation of cell components to provide nutrients and energy for cellular metabolism in stress response. The retina is a light-sensitive tissue that transduces and processes visual images in the eye, and it has a high demand for substances and energy. …”
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Metabolism of NK cells during viral infections by Kenia Y. Osuna-Espinoza, Adrián G. Rosas-Taraco

“…Cellular metabolism is essential for the correct function of immune system cells, including Natural Killer cells (NK). …”
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Targeting the lactic acid metabolic pathway for antitumor therapy by Zhi Li, Jiuwei Cui

“…Lactic acid is one of the most abundant products of cellular metabolism and has historically been considered a cell-damaging metabolic product. …”
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Strengths and Weaknesses of Cell Synchronization Protocols Based on Inhibition of DNA Synthesis by Anna Ligasová, Karel Koberna

“…Synchronous cell populations are commonly used for the analysis of various aspects of cellular metabolism at specific stages of the cell cycle. …”
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Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter by Danielle L. Schmitt, Stephanie D. Curtis, Anne C. Lyons, Jin-fan Zhang, Mingyuan Chen, Catherine Y. He, Sohum Mehta, Reuben J. Shaw, Jin Zhang

“…AMP activated protein kinase (AMPK) is a master regulator of cellular metabolism, but how AMPK activity is spatiotemporally regulated remains unclear. …”
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Targeting Metabolic Reprogramming in Acute Myeloid Leukemia by Isabel Castro, Belém Sampaio-Marques, Paula Ludovico

“…Here, we review the complexity of acute myeloid leukemia (AML) metabolism and discuss how therapies targeting different aspects of cellular metabolism have demonstrated efficacy and how they provide a therapeutic window that should be explored to target the metabolic requirements of AML cells.…”
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Mitochondrial Redox Metabolism: The Epicenter of Metabolism during Cancer Progression by Feroza K. Choudhury

“…Mitochondrial redox metabolism is the central component in the cellular metabolic landscape, where anabolic and catabolic pathways are reprogrammed to maintain optimum redox homeostasis. …”
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Transporter-Mediated Drug Delivery by Gergely Gyimesi, Matthias A. Hediger

“…Transmembrane transport of small organic and inorganic molecules is one of the cornerstones of cellular metabolism. Among transmembrane transporters, solute carrier (SLC) proteins form the largest, albeit very diverse, superfamily with over 400 members. …”
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Adaptive Benefits of Storage Strategy and Dual AMPK/TOR Signaling in Metabolic Stress Response. by Benjamin Pfeuty, Quentin Thommen

“…Cellular metabolism must ensure that supply of nutrient meets the biosynthetic and bioenergetic needs. …”
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The Role of PI3K/AKT/mTOR Signaling in Hepatocellular Carcinoma Metabolism by Ling-Yu Tian, Daniel J. Smit, Manfred Jücker

“…In this review, we illustrate mechanisms by which this signaling network is accountable for regulating HCC cellular metabolism, including glucose metabolism, lipid metabolism, amino acid metabolism, pyrimidine metabolism, and oxidative metabolism, and summarize the ongoing clinical trials based on the inhibition of the PI3K/AKT/mTOR pathway in HCC.…”
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Crosstalk between Autophagy and RLR Signaling by Po-Yuan Ke

“…Autophagy plays a homeostatic role in regulating cellular metabolism by degrading unwanted intracellular materials and acts as a host defense mechanism by eliminating infecting pathogens, such as viruses. …”
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Rational and semi-rational engineering of cytochrome P450s for biotechnological applications by Lian-Hua Xu, Yi-Ling Du

“…The cytochrome P450 enzymes are ubiquitous heme-thiolate proteins performing regioselective and stereoselective oxygenation reactions in cellular metabolism. Due to their broad substrate scope and catalytic versatility, P450 enzymes are also attractive candidates for many industrial and biopharmaceutical applications. …”
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Trends and prospects in mitochondrial genome editing by Hong Thi Lam Phan, Hyunji Lee, Kyoungmi Kim

“…Abstract Mitochondria are of fundamental importance in programmed cell death, cellular metabolism, and intracellular calcium concentration modulation, and inheritable mitochondrial disorders via mitochondrial DNA (mtDNA) mutation cause several diseases in various organs and systems. …”
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Emergence of Exopolysaccharides Overproducers Is Linked to Environmental Spatial Structure via Redox State by Maxime Ardré, Maxime Deforet

“…Yet, it is still unclear what role oxygen plays in cellular metabolism under this condition. A. Besse, M.-C. …”
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Cellular Alterations in Carbohydrate and Lipid Metabolism Due to Interactions with Nanomaterials by Ana Martín-Pardillos, Pilar Martin-Duque

“…This review aims to focus on the implications of nanoparticles in cellular metabolism and their outcomes. In particular, some NPs have the ability to modify glucose and lipid metabolism, and this feature is especially interesting to treat diabetes and obesity and to target cancer cells. …”
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Oxidative stress in male infertility and therapeutic approach: A mini-review by Marwa Lahimer, Henda Mustapha, Véronique Bach, Hafida Khorsi-Cauet, Moncef Benkhalifa, Mounir Ajina, Habib Ben Ali

“…The origin of ROS is diverse, including generated normal cellular metabolism, environmental exposure, advanced paternal age and inflammation. …”
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TOR Signaling Pathway in Cardiac Aging and Heart Failure by Nastaran Daneshgar, Peter S. Rabinovitch, Dao-Fu Dai

“…Mechanistic Target of Rapamycin (mTOR) signaling is a key regulator of cellular metabolism, integrating nutrient sensing with cell growth. …”
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Chromatin as a sensor of metabolic changes during early development by David Pladevall-Morera, Jan J. Zylicz

“…Cellular metabolism is a complex network of biochemical reactions fueling development with energy and biomass; however, it can also shape the cellular epigenome. …”
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The Crosstalk of Epigenetics and Metabolism in Herpesvirus Infection by Yonggang Pei, Erle S. Robertson

“…Here, we describe how epigenetic regulation of cellular metabolism affects herpesvirus infection and induces viral diseases. …”
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