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481
Genome-epigenome interactions associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Published 2018-12-01“…These methylation anomalies are in close proximity to genes involved with immune function and cellular metabolism. Finally, we found significant correlations of genotypes with methylation modifications associated with ME/CFS. …”
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482
GPT2 Is Induced by Hypoxia-Inducible Factor (HIF)-2 and Promotes Glioblastoma Growth
Published 2022-08-01“…Hypoxia-inducible factor (HIF) directly activates the transcription of metabolic enzymes in response to hypoxia to reprogram cellular metabolism required for tumor cell proliferation. …”
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483
Telomere Homeostasis: Interplay with Magnesium
Published 2018-01-01“…Telomere homeostasis is tightly linked to cellular metabolism, and in particular with mitochondrial physiology, which is also diminished during cellular senescence and normative physiological ageing. …”
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484
Association of prooxidant-antioxidant disorders with the development of morphofunctional disorders in rats with subtotal cerebral ischemia
Published 2020-08-01“…Brain ischemia has been followed by oxidative stress in brain tissue. The cellular metabolism has been disturbed under the oxidative stress that leads to a water-electrolyte imbalance, manifested by deformation of neuron bodies, wrinkling, and swelling. …”
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485
The Ragulator complex: delving its multifunctional impact on metabolism and beyond
Published 2023-05-01“…Of note, lysosomes contribute to the activation of mammalian target of rapamycin complex 1 (mTORC1), a key regulator of cellular metabolism. The Ragulator complex, a protein complex anchored on the lysosomal membrane, was initially shown to tether the mTORC1 complex to lysosomes. …”
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486
Using stable isotope tracing to unravel the metabolic components of neurodegeneration: Focus on neuron-glia metabolic interactions
Published 2023-06-01“…Elucidating the mechanistic involvement of altered brain metabolism in disease progression has been aided by the advance of techniques to monitor cellular metabolism, in particular by mapping metabolism of substrates containing stable isotopes, a technique known as isotope tracing. …”
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487
Glycosylation: Rising Potential for Prostate Cancer Evaluation
Published 2021-07-01“…A wide range of glycosylation alterations in prostate cancer cells, including increased sialylation and fucosylation, can modify protein function and play a crucial role in many important biological processes in cancer, including cell signalling, adhesion, migration, and cellular metabolism. In this review, we summarize studies evaluating the prostate cancer associated glycosylation related alterations in sialylation, mainly α2,3-sialylation, core fucosylation, branched N-glycans, LacdiNAc group and presence of truncated O-glycans (sTn, sT antigen). …”
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488
Cognitive Impairment in Multiple Sclerosis
Published 2023-07-01“…These pathways are intertwined at multiple levels and can involve metabolic oversight with cellular metabolism dependent upon nicotinamide adenine dinucleotide (NAD+). …”
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489
Telomerase in Cancer: Function, Regulation, and Clinical Translation
Published 2022-02-01“…Additionally, telomerase exhibits telomere-independent regulation of cancer cell growth by participating directly in cellular metabolism, signal transduction, and the regulation of gene expression in ways that are critical for tumorigenesis. …”
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490
Fatty Acid Metabolism and T Cells in Multiple Sclerosis
Published 2022-05-01“…Cellular metabolic remodeling is intrinsically linked to the development, activation, differentiation, function, and survival of T cells. …”
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491
Conventional culture media enriched with extracts of quinoa, amaranth and chia promotes the Staphylococcus aureus growth
Published 2017-08-01“…Results show that adding these extracts, at low concentrations, have a protective effect against the cytotoxicity that could be generated by the oxidative stress product of the cellular metabolism of the bacteria growing in vitro and significantly increase the bacterial growth. …”
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492
Transcranial Photobiomodulation Therapy for Sexual Dysfunction Associated with Depression or Induced by Antidepressant Medications
Published 2022-05-01“…Transcranial PBM (tPBM) targets the cellular metabolism—through the mitochondrial respiratory enzyme, cytochrome c oxidase—and has numerous cellular and physiological beneficial effects on the central nervous system. …”
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493
Exploring Molecular Targets for Mitochondrial Therapies in Neurodegenerative Diseases
Published 2023-08-01“…The progressive deterioration of function and structure of brain cells in neurodegenerative diseases is accompanied by mitochondrial dysfunction, affecting cellular metabolism, intracellular signaling, cell differentiation, morphogenesis, and the activation of programmed cell death. …”
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494
The AirSR Two-component System Contributes to Staphylococcus aureus Survival in Human Blood and Transcriptionally Regulates sspABC operon
Published 2015-07-01“…It is well accepted that the state of cellular metabolism impacts the expression of virulence factors in Staphylococcus aureus. …”
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495
Altered metabolism for neuroprotection provided by mesenchymal stem cells
Published 2019-01-01“…A complete understanding of how MSCs' cellular metabolism affects their function is necessary for their employment in cellular therapy, as MSCs have been demonstrated to have pro- and anti-inflammatory functions. …”
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496
Metabolic reprogramming in the tumor microenvironment of liver cancer
Published 2024-01-01“…Overwhelming evidence has illustrated that dysregulated cellular metabolism can, in turn, promote anabolic growth and tumor propagation in a hostile microenvironment. …”
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497
The polyketide to fatty acid transition in the evolution of animal lipid metabolism
Published 2024-01-01“…The evolutionary origin of the animal FAS and its relationship to the diversity of PKSs remain unclear despite the critical role of lipid synthesis in cellular metabolism. Recently, an animal FAS-like PKS (AFPK) was identified in sacoglossan molluscs. …”
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498
Receptors that bind to PEDF and their therapeutic roles in retinal diseases
Published 2023-04-01“…Understanding the interactions between PEDF and PEDF receptors, their roles in normal cellular metabolism and the response the initiate in disease will be accommodating for elucidating the ways in which inflammation, angiogenesis, and neurodegeneration exacerbate disease pathology. …”
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499
Effect of gamma irradiation, high sugar content and antimicrobials on survival of Escherichia coli: A review
Published 2023-08-01“…Radiation and antimicrobials have been shown to cause an SOS response in E. coli, which affects cellular metabolism, such as the enhanced ability to repair DNA and mutagenesis. …”
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500
Effects of Noonan Syndrome-Germline Mutations on Mitochondria and Energy Metabolism
Published 2022-10-01“…The RAS pathway regulates cellular metabolism by controlling mitochondrial homeostasis, dynamics, and energy production; however, little is known about the role of mitochondrial metabolism in NS and NSML. …”
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