Junction of the redox dynamic, orchestra of signaling, and altered metabolism in regulation of T- cell lymphoma by Shantanu Singh, Akhilendra Kumar Maurya

“…Cancer cells rewire the cellular metabolism, persuading it to meet new demands of growth and proliferation. …”
Get full text

Metabolic control of epigenetic rearrangements in B cell pathophysiology by Beatrice Calciolari, Greta Scarpinello, Laura Quotti Tubi, Francesco Piazza, Alessandro Carrer

“…B and T cell precursors reprogram their cellular metabolism across developmental stages, not only to meet ever-changing energetic demands but to impose chromatin accessibility and regulate the function of master transcription factors. …”
Get full text

The Role of Metabolic Plasticity of Tumor-Associated Macrophages in Shaping the Tumor Microenvironment Immunity by Md Nabiul Hasan, Okan Capuk, Shivani M. Patel, Dandan Sun

“…We highlighted the roles of these proteins in modulating the cellular metabolism of TAMs and their potential as therapeutic targets for improving immune checkpoint therapy.…”
Get full text

Synthesis of Hollow Calcium Carbonate Microspheres by a Template Method for DOX Loading and Release with Carbon Dots Photosensitivity by Fuwang Mo, Qiujuan Chen, Xiaohui Zhang

“…In the simulated solutions of cellular metabolism containing various concentrations of reduced glutathione(GSH), the sustained release of DOX was confirmed qualitatively by the luminescence of the CQDs. …”
Get full text

Focusing on Phosphorus Loads: From Healthy People to Chronic Kidney Disease by Mengjing Wang, Jiaying Zhang, Kamyar Kalantar-Zadeh, Jing Chen

“…Phosphorus is an essential micromineral with a key role in cellular metabolism and tissue structure. Serum phosphorus is maintained in a homeostatic range by the intestines, bones, and kidneys. …”
Get full text

Nutrient-Response Pathways in Healthspan and Lifespan Regulation by Aleksandra Dabrowska, Juhi Kumar, Charalampos Rallis

“…In recent years, combinatorial drug treatments combined with mutagenesis, high-throughput screens, as well as multi-omics approaches, have provided unprecedented insights in cellular metabolism, development, differentiation, and aging. …”
Get full text

Monitoring of Current Cancer Therapy by Positron Emission Tomography and Possible Role of Radiomics Assessment by Noboru Oriuchi, Hideki Endoh, Kyoichi Kaira

“…The unique response patterns to therapy with immune-checkpoint inhibitors have facilitated the revision of response evaluation criteria using FDG-PET, because the immune response recalls reactive cells such as activated T-cells and macrophages, which show increased glucose metabolism and apparent progression on morphological imaging. Cellular metabolism and function are critical determinants of the viability of active cells in the tumor microenvironment, which would be novel targets of therapies, such as tumor immunity, metabolism, and genetic mutation. …”
Get full text

RAD001 enhances the potency of BEZ235 to inhibit mTOR signaling and tumor growth. by Beat Nyfeler, Yan Chen, Xiaoyan Li, Maria Pinzon-Ortiz, Zuncai Wang, Anupama Reddy, Elina Pradhan, Rita Das, Joseph Lehár, Robert Schlegel, Peter M Finan, Z Alexander Cao, Leon O Murphy, Alan Huang

“…The mammalian target of rapamycin (mTOR) is regulated by oncogenic growth factor signals and plays a pivotal role in controlling cellular metabolism, growth and survival. Everolimus (RAD001) is an allosteric mTOR inhibitor that has shown marked efficacy in certain cancers but is unable to completely inhibit mTOR activity. …”
Get full text

Role of Metabolism in Bone Development and Homeostasis by Akiko Suzuki, Mina Minamide, Chihiro Iwaya, Kenichi Ogata, Junichi Iwata

“…Here, we aim to provide a comprehensive review of the cellular metabolism involved in bone development and homeostasis, as revealed by mouse genetic studies.…”
Get full text

Trimetazidine, an Anti-Ischemic Drug, Reduces the Antielectroshock Effects of Certain First-Generation Antiepileptic Drugs by Kinga Borowicz-Reutt, Monika Banach

“…Trimetazidine (TMZ), an anti-ischemic drug for improving cellular metabolism, is mostly administered to patients with poorly controlled ischemic heart disease (IHD). …”
Get full text

Research Progress towards the Effects of Fatty Acids on the Differentiation and Maturation of Human Induced Pluripotent Stem Cells into Cardiomyocytes by Zhen GAO, Fan ZHOU, Junsheng MU

“…Recent studies have shown that for differentiation and maturation of hiPSCs into CMs, fatty acids have a strong influence on cellular metabolism, organelle development, expression of specific genes, and functional performance. …”
Get full text

Sirt4: A Multifaceted Enzyme at the Crossroads of Mitochondrial Metabolism and Cancer by Daniela Tomaselli, Clemens Steegborn, Antonello Mai, Dante Rotili

“…Sirtuins are NAD+-dependent deacylases that play crucial roles in the regulation of cellular metabolism, and as a result, are implicated in several diseases. …”
Get full text

Interaction of Klotho and sirtuins by Farzaneh Rostamzadeh, Yasamin Moosavi-Saeed, Mahboobeh Yeganeh-Hajahmadi

“…Sirtuins play a role in regulating the function of various cellular processes such as cellular metabolism, oxidative stress, apoptosis, and inflammation. …”
Get full text

NOX Dependent ROS Generation and Cell Metabolism by Tiziana Pecchillo Cimmino, Rosario Ammendola, Fabio Cattaneo, Gabriella Esposito

“…In particular, we dissect the contribute of NOX1, NOX2, and NOX4 enzymes in the modulation of cellular metabolism and highlight their potential role as a new therapeutic target for tumor metabolism rewiring.…”
Get full text

A versatile LC-MS/MS approach for comprehensive, quantitative analysis of central metabolic pathways [version 1; referees: 2 approved] by Adhish Walvekar, Zeenat Rashida, Hemanth Maddali, Sunil Laxman

“…Liquid chromatography-mass spectrometry (LC-MS/MS) based approaches are widely used for the identification and quantitation of specific metabolites, and are a preferred approach towards analyzing cellular metabolism. Most methods developed come with specific requirements such as unique columns, ion-pairing reagents and pH conditions, and typically allow measurements in a specific pathway alone. …”
Get full text

Understanding the molecular mechanisms of macrophage polarization and metabolic reprogramming in endometriosis: A narrative review by Hiroshi Kobayashi, Shogo Imanaka

“…A review article focused on the unique aspect of cellular metabolic reprogramming of endometriotic cells has been reported. …”
Get full text

Mir-190b negatively contributes to the Trypanosoma cruzi- infected cell survival by repressing PTEN protein expression by Cíntia Júnia Monteiro, Suianne Letícia Antunes Mota, Lívia de Figueiredo Diniz, Maria Terezinha Bahia, Karen CM Moraes

“…Previous studies have reported that the establishment of parasitism is connected to the activation of the phosphatidylinositol-3 kinase (PI3K), which controls important steps in cellular metabolism by regulating the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate. …”
Get full text

Mitochondria in innate immunity signaling and its therapeutic implications in autoimmune diseases by Yuhao Jiao, Zhiyu Yan, Zhiyu Yan, Aiming Yang

“…In this review, we aim to summarize recent findings on the function of mitochondria in the innate immune response and its aberrancy in autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, etc., mainly focusing on its direct impact on cellular metabolism and its machinery on regulating immune response signaling pathways. …”
Get full text

Reversing the Warburg effect to control cancer: a review of diet-based solutions by Hassan Bahrami, Majid Tafrihi, Sorayya Mohamadzadeh

“…Warburg effect is a form of cellular metabolism commonly used by cancer cells, in which, consumption of glucose and production of acidic cell metabolic wastes take place at a considerably higher rate. …”
Get full text

Assessment of the salivary level of superoxide dismutase and melatonin in localized periodontitis versus generalized periodontitis by Alla Ali Jan Miran, Hadeel Mazin Akram

“…In order to defend themselves from the action of oxygen-free radicals, Organisms that use oxygen in their cellular metabolism are supplied with defense systems. The term "the system's antioxidative barrier" is frequently used to describe them. superoxide dismutase (SOD) is one of the enzymatic antioxidants that preserves the cell against reactive oxygen species by removing superoxide radicals and hydrogen peroxide, Melatonin is natural hormone in the body with antioxidant effects. …”
Get full text