Regulation of Gastrointestinal Immunity by Metabolites by Bon-Hee Gu, Myunghoo Kim, Cheol-Heui Yun

“…Metabolites, especially those derived from the microbiota, regulate immune cell functions in various ways, including the recognition and activation of cell surface receptors, the control of gene expression by epigenetic regulation, and the integration of cellular metabolism. These mucosal immune regulations are key to understanding the mechanisms underlying the development of gastrointestinal disorders. …”
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Lights at night: does photobiomodulation improve sleep? by Audrey Valverde, Catherine Hamilton, Cécile Moro, Malvina Billeres, Pierre Magistretti, John Mitrofanis

“…It impacts every organ and system of our body, from the brain to the heart and from cellular metabolism to immune function. A consistent daily schedule of quality of sleep makes a world of difference to our health and well-being. …”
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Galectins Are Central Mediators of Immune Escape in Pancreatic Ductal Adenocarcinoma by Zhengting Jiang, Wenjie Zhang, Gengyu Sha, Daorong Wang, Dong Tang

“…It further promotes fibrosis of tissues surrounding PDAC, enhances local cellular metabolism, and ultimately constructs tumor immune privileged areas to induce immune evasion behavior of tumor cells. …”
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Tumor Microenvironment-Induced Immunometabolic Reprogramming of Natural Killer Cells by Andrea M. Chambers, Kyle B. Lupo, Sandro Matosevic, Sandro Matosevic

“…At the same time, cellular metabolism also mediates immune cell survival, proliferation and cytotoxic responses within the tumor microenvironment. …”
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The Role of Mitochondria in Cardiovascular Diseases by Anastasia V. Poznyak, Ekaterina A. Ivanova, Igor A. Sobenin, Shaw-Fang Yet, Alexander N. Orekhov

“…As a central player in the regulation of cellular metabolism and a powerful controller of cellular fate, mitochondria appear to comprise an interesting potential therapeutic target. …”
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Immunometabolism of Immune Cells in Mucosal Environment Drives Effector Responses against <i>Mycobacterium tuberculosis</i> by Mohd Hatimi Tukiman, Mohd Nor Norazmi

“…The immune cells are not only reliant on immune signalling to mount an effective response to Mtb invasion but can also be orchestrated by their metabolic state. Cellular metabolism was often overlooked in the past but growing evidence of its importance in the functions of immune cells suggests that it can no longer be ignored. …”
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Folate and retinal vascular diseases by Jinyue Gu, Chunyan Lei, Meixia Zhang

“…Abstract Folate, a pteroylglutamic acid derivative, participates in fundamental cellular metabolism. Homocysteine, an amino acid, serves as an intermediate of the methionine cycle and can be converted back to methionine. …”
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Decisions, decisions, decisions by Tyers, Mike, Amon, Angelika B

“…A building ueber-theme is the unexpectedly deep integration of division, growth and death not only with each other, but with cellular metabolism. As covered in this Current Opinion in Cell Biology, this full-on system-wide view of the cell is poised to address both the how and why of big decisions in the life of a cell.…”
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The Succinated Proteome of FH-Mutant Tumours. by Yang, M, Ternette, N, Su, H, Dabiri, R, Kessler, B, Adam, J, Teh, B, Pollard, P

“…Previous studies have demonstrated that succination of proteins including glyceraldehyde 3-phosphate dehydrogenase (GAPDH), kelch-like ECH-associated protein 1 (KEAP1) and mitochondrial aconitase (ACO2) can have profound effects on cellular metabolism. Furthermore, immunostaining for 2SC is a sensitive and specific biomarker for HLRCC tumours. …”

Quantification of cell-bubble interactions in a 3D engineered tissue phantom by Walsh, C, Ovenden, N, Stride, E, Cheema, U

“…These results show that bubble nucleation is dominated by DO concentration (affected by cellular metabolism), rather than potential nucleation sites provided by cell-surfaces. …”

Monitoring of metabolite gradients in tissue-engineered constructs. by Boubriak, O, Urban, J, Cui, Z

“…Here, we describe the use of microdialysis for detecting local changes in cellular metabolism within a tissue-engineered construct. …”

Metabolic activation and colitis pathogenesis is prevented by lymphotoxin β receptor expression in neutrophils by Riffelmacher, T, Giles, DA, Zahner, S, Dicker, M, Andreyev, AY, McArdle, S, Perez-Jeldres, T, van der Gracht, E, Murray, MP, Hartmann, N, Tumanov, AV, Kronenberg, M

“…Mechanistically, RNA-Seq analysis revealed LIGHT-induced suppression of cellular metabolism, and mitochondrial function, that was dependent on LT&#x3B2;R. …”

The impact of impaired mitochondrial function on retrograde signalling: a meta-analysis of transcriptomic responses. by Schwarzländer, M, König, A, Sweetlove, L, Finkemeier, I

“…Mitochondria occupy a central position in cellular metabolism. Their protein complement must therefore be dynamically adjusted to the metabolic demands of the cell. …”

The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation by Parzych, K, Saavedra-García, P, Valbuena, G, Al-Sadah, H, Robinson, M, Penfold, L, Kuzeva, D, Ruiz-Tellez, A, Loaiza, S, Holzmann, V, Caputo, V, Johnson, D, Kaiser, M, Karadimitris, A, Lam, E, Chevet, E, Feldhahn, N, Keun, H, Auner, H

“…Here, we provide evidence that VCP/p97 acts as a regulator of cellular metabolism. We found that VCP/p97 was tied to multiple metabolic processes on the gene expression level in a diverse range of cancer cell lines and in patient-derived multiple myeloma cells. …”

Dynamic sensitivity of ATP-sensitive K(+) channels to ATP. by Loussouarn, G, Pike, L, Ashcroft, F, Makhina, E, Nichols, C

“…ATP and MgADP regulate K(ATP) channel activity and hence potentially couple cellular metabolism to membrane electrical activity in various cell types. …”

Gene knockout identification using an extension of bees hill flux balance analysis by Yee, Wen Choon, Mohamad, Mohd. Saberi, Deris, Safaai, Chuii, Khim Chong, Omatu, Sigeru, Manuel, Corchado Juan

“…Furthermore, a vast number of reactions in cellular metabolism often lead to a combinatorial problem in obtaining optimal gene knockout. …”

Hybrid approach for metabolites production using differential evolution and minimization of metabolic adjustment by Mazlan, Noor Ameera

“…Minimization of Metabolic Adjustment (MOMA) is one of the constraint based algorithms which act to simulate the cellular metabolism after perturbation (gene knockout) occurred to the metabolic model. …”
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Foci-forming regions of pyruvate kinase and enolase at the molecular surface incorporate proteins into yeast cytoplasmic metabolic enzymes transiently assembling (META) bodies by Ryotaro Utsumi, Yuki Murata, Sayoko Ito-Harashima, Misaki Akai, Natsuko Miura, Kouichi Kuroda, Mitsuyoshi Ueda, Michihiko Kataoka

“…Spatial reorganization of metabolic enzymes to form the “metabolic enzymes transiently assembling (META) body” is increasingly recognized as a mechanism contributing to regulation of cellular metabolism in response to environmental changes. …”
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The Glycolytic Pathway as a Target for Novel Onco-Immunology Therapies in Pancreatic Cancer by Claudia Curcio, Silvia Brugiapaglia, Sara Bulfamante, Laura Follia, Paola Cappello, Francesco Novelli

“…A platform of onco-immunology targets is represented by molecules that play a role in the reprogrammed cellular metabolism as one hallmark of cancer. Due to the hypoxic tumor microenvironment (TME), PDA cells display an altered glucose metabolism—resulting in its increased uptake—and a higher glycolytic rate, which leads to lactate accumulation and them acting as fuel for cancer cells. …”
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The Context-Dependent Impact of Integrin-Associated CD151 and Other Tetraspanins on Cancer Development and Progression: A Class of Versatile Mediators of Cellular Function and Sign... by Sonia Erfani, Hui Hua, Yueyin Pan, Binhua P. Zhou, Xiuwei H. Yang

“…We also highlight emerging genetic and epigenetic evidence on the intrinsic links between tetraspanins, the epithelial-mesenchymal transition (EMT), cancer stem cells (CSCs), and the Wnt/β-catenin pathway, as well as the dynamics of exosome and cellular metabolism. Finally, we discuss the implications of the highly plastic nature and epigenetic susceptibility of CD151 expression, function, and signaling for clinical diagnosis and therapeutic intervention for human cancer.…”
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