Oxidative Stress and Inflammation in B-Cell Lymphomas by Mário Sousa-Pimenta, Maria Manuela Estevinho, Miguel Sousa Dias, Ângelo Martins, Letícia M. Estevinho

“…Reactive oxygen species (ROSs) are by-products of cellular metabolism able to modulate cell signaling and fate. …”
Get full text

A Model of Lipid Monolayer–Bilayer Fusion of Lipid Droplets and Peroxisomes by Maksim A. Kalutsky, Timur R. Galimzyanov, Rodion J. Molotkovsky

“…In some processes of cellular metabolism, lipid droplets interact with peroxisomes resulting in the fusion of their envelopes and the formation of protrusions of the peroxisome monolayer, called pexopodia. …”
Get full text

Mitochondrial Dynamics and Microglia as New Targets in Metabolism Regulation by Martina Chiurazzi, Martina Di Maro, Mauro Cozzolino, Antonio Colantuoni

“…Mitochondria are cellular organelles that are involved in dynamic processes; their dysfunction has been associated with many diseases, such as obesity and type 2 diabetes, indicating their importance in cellular metabolism and bioenergetics. Food intake excess can induce mitochondrial dysfunction with consequent production of reactive oxygen species (ROS) and oxidative stress. …”
Get full text

Shifting the Gears of Metabolic Plasticity to Drive Cell State Transitions in Cancer by Zhengwei Wu, Yi Fei Lee, Xun Hui Yeo, Ser Yue Loo, Wai Leong Tam

“…It is increasingly appreciated that cancer cells need to appropriately reprogram their cellular metabolism in a timely manner to support the changes associated with new phenotypic cell states. …”
Get full text

Lysosomes in Stem Cell Quiescence: A Potential Therapeutic Target in Acute Myeloid Leukemia by Vaibhav Jain, Swaroop Bose, Awadhesh K. Arya, Tasleem Arif

“…Therefore, lysosomes connect cellular metabolism and signaling pathways. Lysosome’s involvement in the critical biological processes has rekindled clinical interest towards this organelle for treating various diseases, including cancer. …”
Get full text

Transcriptome sequencing and annotation for the Jamaican fruit bat (Artibeus jamaicensis). by Timothy I Shaw, Anuj Srivastava, Wen-Chi Chou, Liang Liu, Ann Hawkinson, Travis C Glenn, Rick Adams, Tony Schountz

“…Annotated genes are involved in a broad range of activities ranging from cellular metabolism to genome regulation through ncRNAs. …”
Get full text

Amino Acid Metabolism in Leukocytes Showing In Vitro IgG Memory from SARS-CoV2-Infected Patients by Giuseppina Fanelli, Veronica Lelli, Sara Rinalducci, Anna Maria Timperio

“…COVID-19 is a disease that affects the entire body and can significantly impact cellular metabolism. Recent studies have focused their analysis on the potential connections between post-infection stages of SARS-CoV2 and different metabolic pathways. …”
Get full text

FOXM1: A Multifunctional Oncoprotein and Emerging Therapeutic Target in Ovarian Cancer by Cassie Liu, Carter J. Barger, Adam R. Karpf

“…As a master transcriptional regulator, FOXM1 promotes critical oncogenic phenotypes in ovarian cancer, including: (1) cell proliferation, (2) invasion and metastasis, (3) chemotherapy resistance, (4) cancer stem cell (CSC) properties, (5) genomic instability, and (6) altered cellular metabolism. We additionally discuss the evidence for FOXM1 as a cancer biomarker, describe the rationale for FOXM1 as a cancer therapeutic target, and provide an overview of therapeutic strategies used to target FOXM1 for cancer treatment.…”
Get full text

Detection of nitric oxide-mediated metabolic effects using real-time extracellular flux analysis. by Bay Vagher, Eyal Amiel

“…Historically, acute metabolic reprogramming and NO-mediated effects on cellular metabolism have been studied at specific timepoints during the DC activation process, namely at times before and after NO production. …”
Get full text

Emerging Roles of Hedgehog Signaling in Cancer Immunity by Alessandro Giammona, Enrica Crivaro, Barbara Stecca

“…Activation of HH signaling sustains proliferation, suppresses cell death signals, enhances invasion and metastasis, deregulates cellular metabolism and promotes angiogenesis and tumor inflammation. …”
Get full text

Targeting the Interplay between Cancer Metabolic Reprogramming and Cell Death Pathways as a Viable Therapeutic Path by Elisabetta Iessi, Rosa Vona, Camilla Cittadini, Paola Matarrese

“…Many oncogenes and tumor suppressor genes have a significant effect on cellular metabolism, as there is a close relationship between the pathways activated by these genes and the various metabolic options. …”
Get full text

Emerging role of hypoxia-inducible factor-1α in inflammatory autoimmune diseases: A comprehensive review by Yang-Yang Tang, Da-Cheng Wang, You-Qiang Wang, An-Fang Huang, Wang-Dong Xu

“…HIF-1α signaling regulates cellular metabolism, triggering the release of inflammatory cytokines and inflammatory cells proliferation. …”
Get full text

Next-Generation Genome-Scale Metabolic Modeling through Integration of Regulatory Mechanisms by Carolina H. Chung, Da-Wei Lin, Alec Eames, Sriram Chandrasekaran

“…A diverse set of mechanisms regulate cellular metabolism, enabling organisms to respond to a wide range of conditions. …”
Get full text

A synthetic biosensor to detect peroxisomal acetyl-CoA concentration for compartmentalized metabolic engineering by Herbert M. Huttanus, Ryan S. Senger

“…We expect our synthetic biosensors can be widely used to investigate sub-cellular metabolism and facilitate the “design-build-test” cycle of compartmentalized metabolic engineering.…”
Get full text

Role of Divalent Cations in HIV-1 Replication and Pathogenicity by Nabab Khan, Xuesong Chen, Jonathan D. Geiger

“…Divalent cations are essential for life and are fundamentally important coordinators of cellular metabolism, cell growth, host-pathogen interactions, and cell death. …”
Get full text

Activation mechanism of ATP-sensitive K+ channels explored with real-time nucleotide binding by Michael Puljung, Natascia Vedovato, Samuel Usher, Frances Ashcroft

“…The response of ATP-sensitive K+ channels (KATP) to cellular metabolism is coordinated by three classes of nucleotide binding site (NBS). …”
Get full text

Roles of Autophagy in Oxidative Stress by Hyeong Rok Yun, Yong Hwa Jo, Jieun Kim, Yoonhwa Shin, Sung Soo Kim, Tae Gyu Choi

“…Reactive oxygen species (ROS) are highly reactive molecules that are generated as by-products of cellular metabolism, principally by mitochondria. Mitochondrial ROS (mROS) are beneficial or detrimental to cells depending on their concentration and location. mROS function as redox messengers in intracellular signalling at physiologically low level, whereas excessive production of mROS causes oxidative damage to cellular constituents and thus incurs cell death. …”
Get full text

Structural and Molecular Basis for Mitochondrial DNA Replication and Transcription in Health and Antiviral Drug Toxicity by Joon Park, Noe Baruch-Torres, Y. Whitney Yin

“…While the mitochondrial RNA transcription is carried out by mitochondrial RNA polymerase, mitochondrial transcription factors TFAM and TFB2M, and a transcription elongation factor, TEFM, both RNA transcriptions, and DNA replication machineries are intertwined and control mtDNA copy numbers, cellular energy supplies, and cellular metabolism. In this review, we discuss the mechanisms governing these main pathways and the mtDNA diseases that arise from mutations in transcription and replication machineries from a structural point of view. …”
Get full text

Exploring the Role of Surface and Mitochondrial ATP-Sensitive Potassium Channels in Cancer: From Cellular Functions to Therapeutic Potentials by Dong-Oh Moon

“…Notably responsive to changes in cellular metabolism, KATP channels link metabolic states to electrical activity, a feature that becomes particularly significant in cancer cells. …”
Get full text

Metabolic Biomarkers Differentiate a Surgical Intervertebral Disc from a Nonsurgical Intervertebral Disc by Beata Toczylowska, Michal Woznica, Elzbieta Zieminska, Leszek Krolicki

“…Methods: Nuclear magnetic resonance (NMR) spectroscopy allows the study of biochemistry and cellular metabolism in vitro. Hydrophilic and hydrophobic compounds were extracted from the NP of the intervertebral disc. …”
Get full text