Metabolic regulation of proteome stability via N-terminal acetylation controls male germline stem cell differentiation and reproduction by Charlotte M. François, Thomas Pihl, Marion Dunoyer de Segonzac, Chloé Hérault, Bruno Hudry

“…Abstract The molecular mechanisms connecting cellular metabolism with differentiation remain poorly understood. …”
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A Metabolic Mechanism for Anaesthetic Suppression of Cortical Synaptic Function in Mouse Brain Slices—A Pilot Investigation by Logan J. Voss, Jamie W. Sleigh

“…The temporal sequence suggests that the observed synaptic depression—as seen in anaesthesia—may be secondary to a reduction in cellular metabolic capacity.…”
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Metformin and Cancer, an Ambiguanidous Relationship by Sarah J. Skuli, Safwan Alomari, Hallie Gaitsch, A’ishah Bakayoko, Nicolas Skuli, Betty M. Tyler

“…The deregulation of energetic and cellular metabolism is a signature of cancer cells. Thus, drugs targeting cancer cell metabolism may have promising therapeutic potential. …”
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Lysosomes and Their Role in Regulating the Metabolism of Hematopoietic Stem Cells by Tasleem Arif

“…In recent years, lysosomes have emerged as control centers of cellular metabolism, particularly in HSC quiescence, and essential regulators of cell signaling have been found on the lysosomal membrane. …”
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Development of PPARγ Agonists for the Treatment of Neuroinflammatory and Neurodegenerative Diseases: Leriglitazone as a Promising Candidate by Pilar Pizcueta, Cristina Vergara, Marco Emanuele, Anna Vilalta, Laura Rodríguez-Pascau, Marc Martinell

“…Increasing evidence suggests that the peroxisome proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily, plays an important role in physiological processes in the central nervous system (CNS) and is involved in cellular metabolism and repair. Cellular damage caused by acute brain injury and long-term neurodegenerative disorders is associated with alterations of these metabolic processes leading to mitochondrial dysfunction, oxidative stress, and neuroinflammation. …”
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Multilevel Heterogeneity of Colorectal Cancer Liver Metastasis by Hao Chen, Chongya Zhai, Xian Xu, Haidong Wang, Weidong Han, Jiaying Shen

“…Preclinical evidence shows that targeting the EMT process or enhancing cellular metabolism may represent a novel approach to increasing the therapeutic efficacy of CRLM.…”
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Streptococcus pyogenes can support or inhibit growth of Haemophilus influenzae by supplying or restricting extracellular NAD. by Hyunju Lee, Rebecca J Edgar, Ian J Lichtenstein, Jorge J Velarde, Natalia Korotkova, Michael R Wessels

“…Nicotinamide adenine dinucleotide (NAD+) is an essential co-factor for cellular metabolism and serves as a substrate in enzymatic processes. …”
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Ferroptosis in Cancer Cell Biology by Christina M. Bebber, Fabienne Müller, Laura Prieto Clemente, Josephine Weber, Silvia von Karstedt

“…Here, we systematically review current literature on ferroptosis signalling, cross-signalling to cellular metabolism in cancer and a potential role for ferroptosis in tumour suppression and tumour immunology. …”
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The Landscape of the Anti-Kinase Activity of the IDH1 Inhibitors by Katarzyna Malarz, Jacek Mularski, Marcin Pacholczyk, Robert Musiol

“…Isocitrate dehydrogenases constitute a class of enzymes that are crucial for cellular metabolism. The overexpression or mutation of isocitrate dehydrogenases are often found in leukemias, glioblastomas, lung cancers, and ductal pancreatic cancer among others. …”
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Intracellular and Extracellular Antifreeze Protein Significantly Improves Mammalian Cell Cryopreservation by Jonathan A. Sreter, Thomas L. Foxall, Krisztina Varga

“…Upon thawing, cellular viability was determined using trypan blue, cellular damage was assessed by lactate dehydrogenase (LDH) assay, and cellular metabolism was measured using a metabolic activity assay (MTS). …”
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Comparison of phasor analysis and biexponential decay curve fitting of autofluorescence lifetime imaging data for machine learning prediction of cellular phenotypes by Linghao Hu, Blanche Ter Hofstede, Dhavan Sharma, Feng Zhao, Alex J. Walsh

“…Introduction: Autofluorescence imaging of the coenzymes reduced nicotinamide (phosphate) dinucleotide (NAD(P)H) and oxidized flavin adenine dinucleotide (FAD) provides a label-free method to detect cellular metabolism and phenotypes. Time-domain fluorescence lifetime data can be analyzed by exponential decay fitting to extract fluorescence lifetimes or by a fit-free phasor transformation to compute phasor coordinates.Methods: Here, fluorescence lifetime data analysis by biexponential decay curve fitting is compared with phasor coordinate analysis as input data to machine learning models to predict cell phenotypes. …”
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Involvement of Gut Microbiota, Microbial Metabolites and Interaction with Polyphenol in Host Immunometabolism by Andy W.C. Man, Yawen Zhou, Ning Xia, Huige Li

“…Manipulation of cellular metabolism could be beneficial to immunity and prevent metabolic and degenerative diseases including obesity, diabetes, and cancer. …”
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Biomolecular Pathways of Cryoinjuries in Low-Temperature Storage for Mammalian Specimens by Ying Fu, Wenjun Dang, Xiaocong He, Feng Xu, Haishui Huang

“…Low-temperature preservation could effectively extend in vitro storage of biological materials due to delayed or suspended cellular metabolism and decaying as illustrated by the Arrhenius model. …”
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Mitochondria as a target of micro- and nanoplastic toxicity by Fulya Dal Yöntem, Müfide Aydoğan Ahbab

“…MPs/NPs can cross through the biological barriers in the human body and be internalized by the cells, potentially altering mitochondrial dynamics, bioenergetics, and signaling pathways, thus impacting cellular metabolism and function. This review states the effects of MPs/NPs on mitochondrial homeostasis and function as well as on mitochondrial membrane dynamics, mitophagy, and mitochondrial apoptosis are discussed.…”
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Metabolic Reprogramming: A Friend or Foe to Cancer Therapy? by Christopher McCann, Emma M. Kerr

“…However, an increasing understanding of the crosstalk between cancer hallmarks has highlighted the complexity of the mechanisms of drug resistance, co-opting pathways outside of the canonical “cell death” machinery to facilitate cell survival in the face of cytotoxic stress. Rewiring of cellular metabolism is vital to drive and support increased proliferative demands in cancer cells, and recent discoveries in the field of cancer metabolism have uncovered a novel role for these programs in facilitating drug resistance. …”
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Prevalent and dynamic binding of the cell cycle checkpoint kinase Rad53 to gene promoters by Yi-Jun Sheu, Risa Karakida Kawaguchi, Jesse Gillis, Bruce Stillman

“…Replication of the genome must be coordinated with gene transcription and cellular metabolism, especially following replication stress in the presence of limiting deoxyribonucleotides. …”
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Gut Microbiomes of Freshwater Mussels (Unionidae) Are Taxonomically and Phylogenetically Variable across Years but Remain Functionally Stable by Mark McCauley, Marlène Chiarello, Carla L. Atkinson, Colin R. Jackson

“…Inferred biosynthesis pathways showed temporal variation in pathways involved in degradation, while pathways involved in cellular metabolism were stable. There was no evidence for phylosymbiosis across any facet of microbiome biodiversity. …”
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Continuous protein supplementation reduces acute exercise-induced stress markers in athletes performing marathon by Röhling, Martin, McCarthy, H. David, Berg, Aloys

“…In conclusion, supplementary protein intake may influence exercise-induced muscle stress reactions by changing cellular metabolism and inflammatory pathways.…”
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Transcriptome sequencing, microarray, and proteomic analyses reveal cellular and metabolic impact of hepatitis C virus infection in vitro. by Woodhouse, S, Narayan, R, Latham, S, Lee, S, Antrobus, R, Gangadharan, B, Luo, S, Schroth, G, Klenerman, P, Zitzmann, N

“…HCV infection had a broad effect on cellular metabolism, leading to increases in cellular cholesterol and free fatty acid levels, associated with a profound and specific decrease in cellular glucose levels.RNA-Seq technology, especially when combined with established methods, demonstrated that HCV infection has potentially wide-ranging effects on cellular gene and protein expression. …”

Human MAIT cells show metabolic quiescence with rapid glucose-dependent upregulation of granzyme B upon stimulation by Zinser, ME, Highton, AJ, Kurioka, A, Kronsteiner, B, Hagel, J, Leng, T, Marchi, E, Phetsouphanh, C, Willberg, CB, Dunachie, SJ, Klenerman, P

“…T cells profoundly change their cellular metabolism during their maturation and activation. …”