Review: Synovial cell mtabolism and chronic inflammation in rheumatoid arthritis by Falconer, J, Murphy, A, Young, S, Clark, A, Tiziani, S, Guma, M, Buckley, C

“…Finally, it is not yet known whether metabolic change is a consequence of disease or whether primary changes to cellular metabolism might underlie or contribute to the pathogenesis of early‐stage disease. …”

Factors influencing the oxygen concentration gradient from the synovial surface of articular cartilage to the cartilage-bone interface: a modeling study. by Zhou, S, Cui, Z, Urban, J

“…Cartilage is usually regarded as hypoxic, even though cellular metabolism is inhibited at low oxygen concentrations. …”

Anticancer imidazoacridinone C-1311 is effective in androgen-dependent and androgen-independent prostate cancer cells by Niemira, M, Borowa-Mazgaj, B, Bader, SB, Moszyńska, A, Ratajewski, M, Karaś, K, Kwaśniewski, M, Krętowski, A, Mazerska, Z, Hammond, EM, Skwarska, A

“…In contrast, in AR-independent PCa cells, C-1311 targeted the cellular metabolism and inhibited the genes regulating glycolysis and gluconeogenesis. …”

Sensitivity of the plant vacuolar malate channel to pH, Ca2+ and anion-channel blockers. by Pantoja, O, Smith, J

“…Transport of malate across the vacuolar membrane is important for the regulation of cytoplasmic pH and the control of cellular metabolism, particularly in plants showing crassulacean acid metabolism (CAM), in which large fluxes of malate occur during the day/night cycle. …”

Protein O-GlcNAcylation promotes trophoblast differentiation at implantation by Ruane, PT, Tan, CMJ, Adlam, DJ, Kimber, SJ, Brison, DR, Aplin, JD, Westwood, M

“…Dynamic protein modification with O-linked β-N-acetylglucosamine (O-GlcNAcylation) is mediated by O-GlcNAc transferase and O-GlcNAcase (OGA), and couples cellular metabolism to stress adaptation. O-GlcNAcylation is essential for blastocyst formation, but whether there is a role for this system at implantation remains unexplored. …”

The balance between inactivation and activation of the Na+−K+ pump underlies the triphasic accumulation of extracellular K+ during myocardial ischemia by Terkildsen, J, Crampin, E, Smith, N

“…These ischemia-induced electrophysiological changes are driven by an impaired cellular metabolism. However, the relative contributions of these mechanisms, as well as the origin of the triphasic profile, have proven to be difficult to determine experimentally. …”

Purine nucleotide metabolism regulates expression of the human immune ligand MICA by McCarthy, MT, Moncayo, G, Hiron, TK, Jakobsen, NA, Vali, A, Soga, T, Adam, J, O'Callaghan, CA

“…Here we use metabolic interventions and metabolomic analyses to show that the transition from quiescent cellular metabolism to a “Warburg” or biosynthetic metabolic state induces MICA expression. …”

The role of initiator tRNA I met in fidelity of initiation of protein synthesis by Monajemi, H., Abdullah, W.A.T.W., Zain, Sharifuddin Md, Daud, M.N., Omar, N.Y.M.

“…The proper arrangement of amino acids in a protein determines its proper function, which is vital for the cellular metabolism. This indicates that the process of peptide bond formation requires high fidelity. …”

Study of Structure–Activity Relationships of the Marine Alkaloid Fascaplysin and Its Derivatives as Potent Anticancer Agents by Maxim E. Zhidkov, Moritz Kaune, Alexey V. Kantemirov, Polina A. Smirnova, Pavel V. Spirin, Maria A. Sidorova, Sergey A. Stadnik, Elena Y. Shyrokova, Dmitry N. Kaluzhny, Oleg A. Tryapkin, Tobias Busenbender, Jessica Hauschild, Tina Rohlfing, Vladimir S. Prassolov, Carsten Bokemeyer, Markus Graefen, Gunhild von Amsberg, Sergey A. Dyshlovoy

“…Their selectivity towards human prostate cancer versus non-cancer cells, as well as the effects on cellular metabolism, membrane integrity, cell cycle progression, apoptosis induction and their ability to intercalate into DNA were investigated. …”
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Effects of the Novel PFKFB3 Inhibitor KAN0438757 on Colorectal Cancer Cells and Its Systemic Toxicity Evaluation In Vivo by Tiago De Oliveira, Tina Goldhardt, Marcus Edelmann, Torben Rogge, Karsten Rauch, Nikola Dobrinov Kyuchukov, Kerstin Menck, Annalen Bleckmann, Joanna Kalucka, Shawez Khan, Jochen Gaedcke, Martin Haubrock, Tim Beissbarth, Hanibal Bohnenberger, Mélanie Planque, Sarah-Maria Fendt, Lutz Ackermann, Michael Ghadimi, Lena-Christin Conradi

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Metabolic modeling-based drug repurposing in Glioblastoma by Claudio Tomi-Andrino, Alina Pandele, Klaus Winzer, John King, Ruman Rahman, Dong-Hyun Kim

“…Specifically, the reprogramming of cellular metabolism has been identified as a source of potential drug targets. …”
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The Role of Lipid Metabolism in T Lymphocyte Differentiation and Survival by Duncan Howie, Annemieke Ten Bokum, Andra Stefania Necula, Stephen Paul Cobbold, Herman Waldmann

“…The differentiation and effector functions of both the innate and adaptive immune system are inextricably linked to cellular metabolism. The features of metabolism which affect both arms of the immune system include metabolic substrate availability, expression of enzymes, transport proteins, and transcription factors which control catabolism of these substrates, and the ability to perform anabolic metabolism. …”
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Toward Systems-Level Metabolic Analysis in Endocrine Disorders and Cancer by Aliya Lakhani, Da Hyun Kang, Yea Eun Kang, Junyoung O. Park

“…In tumorigenesis, cancer-specific mutations and nutrient availability in the tumor microenvironment reprogram cellular metabolism to meet increased energy and biosynthesis needs. …”
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Mitochondrial Dynamics and Mitophagy in Cardiometabolic Disease by Jianguo Lin, Jianguo Lin, Jinlong Duan, Qingqing Wang, Siyu Xu, Siyu Xu, Simin Zhou, Kuiwu Yao, Kuiwu Yao

“…Mitochondria play a key role in cellular metabolism. Mitochondrial dynamics (fusion and fission) and mitophagy, are critical to mitochondrial function. …”
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Functional Regulation of KATP Channels and Mutant Insight Into Clinical Therapeutic Strategies in Cardiovascular Diseases by Zhicheng Wang, Weikang Bian, Yufeng Yan, Dai-Min Zhang, Dai-Min Zhang

“…ATP-sensitive potassium channels (KATP channels) play pivotal roles in excitable cells and link cellular metabolism with membrane excitability. The action potential converts electricity into dynamics by ion channel-mediated ion exchange to generate systole, involved in every heartbeat. …”
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Succinylation and redox status in cancer cells by Xiaofeng Dai, Yanyan Zhou, Fei Han, Jitian Li

“…Taken together, we emphasize the central role of succinylation in bridging the gap between cellular metabolism and redox status, and its clinical relevance as a mark for cancer diagnosis as well as a target in onco-therapeutics.…”
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The Impact of Anthocyanins and Iridoids on Transcription Factors Crucial for Lipid and Cholesterol Homeostasis by Maciej Danielewski, Agnieszka Matuszewska, Adam Szeląg, Tomasz Sozański

“…Transcription factors directly affect a number of parameters of cell functions and cellular metabolism. In the context of lipid and cholesterol metabolism, five particularly important transcription factors can be distinguished: liver X receptor (LXR), peroxisome proliferator-activated receptor-α (PPAR-α), peroxisome proliferator-activated receptor-γ (PPAR-γ), CCAAT/enhancer binding protein α (C/EBPα) and sterol regulatory element-binding protein 1c (SREBP-1c). …”
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Short chain fatty acids: key regulators of the local and systemic immune response in inflammatory diseases and infections by Lisa-Marie Ney, Maximilian Wipplinger, Martha Grossmann, Nicole Engert, Valentin D. Wegner, Alexander S. Mosig

“…In this review, we provide an overview of the various functions of SCFAs in regulating cellular metabolism, emphasizing the orchestration of the immune response along the gut–brain, the gut–lung and the gut–liver axes. …”
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Pathogenetic Mechanisms of Formation of External Genital Endometriosis and Its Relapses in Patients of Reproductive Age by N. V. Ermolova, N. A. Drukker, L. V. Kolesnikova, A. V. Busarova, A. V. Shiring

“…The increase of VEGF production on systemic level and high content of solutable receptor of VEGF, NO and NO- syntaze on the local level (the peritoneal fluid) are typical for relapsing of EGE.Summary: The switсhing of disorder of regulatory control of the cellular metabolism from one growth factors to another is happened in different stages of external genital endometriosis formation.…”
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Group II Intron-Encoded Proteins (IEPs/Maturases) as Key Regulators of Nad1 Expression and Complex I Biogenesis in Land Plant Mitochondria by Ron Mizrahi, Sofia Shevtsov-Tal, Oren Ostersetzer-Biran

“…Mitochondria are semi-autonomous organelles that produce much of the energy required for cellular metabolism. As descendants of a bacterial symbiont, most mitochondria harbor their own genetic system (mtDNA/mitogenome), with intrinsic machineries for transcription and protein translation. …”
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