Uncoupling Protein 3 Catalyzes the Exchange of C4 Metabolites Similar to UCP2 by Jürgen Kreiter, Tatyana Tyschuk, Elena E. Pohl

“…The expression of UCP3 in tissues mainly dependent on fatty acid oxidation suggests its involvement in cellular metabolism and has drawn attention to its possible transport function beyond the transport of protons in the presence of fatty acids. …”
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Mitochondrial NAD kinase in health and disease by Ren Zhang, Kezhong Zhang

“…Nicotinamide adenine dinucleotide phosphate (NADP), a co-enzyme and an electron carrier, plays crucial roles in numerous biological functions, including cellular metabolism and antioxidation. Because NADP is subcellular-membrane impermeable, eukaryotes compartmentalize NAD kinases (NADKs), the NADP biosynthetic enzymes. …”
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SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein. by Marius Walter, Irene P Chen, Albert Vallejo-Gracia, Ik-Jung Kim, Olga Bielska, Victor L Lam, Jennifer M Hayashi, Andrew Cruz, Samah Shah, Frank W Soveg, John D Gross, Nevan J Krogan, Keith R Jerome, Birgit Schilling, Melanie Ott, Eric Verdin

“…SIRT5 is an NAD-dependent protein deacylase critical for cellular metabolism that removes succinyl and malonyl groups from lysine residues. …”
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Inhibition of mutagenic activation of orthoaminoazotoluene increases its carcinogenicity for mouse liver by V. I. Kaledin, L. P. Ovchinnikova, S. I. Ilnitskaya, T. S. Morozkova, N. A. Popova

“…It is considered that chemically active carcinogens induce mutations (and tumors) directly interacting with DNA, while inactive substances are mutagenically activated in the processes of cellular metabolism in target tissues. The aminoazo dyes was found to be activated by N-hydroxilation and subsequent conjugation with sulfuric acid catalyzed by the enzyme sulfotransferase. …”
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Functions of p53 in pluripotent stem cells by Xuemei Fu, Shouhai Wu, Bo Li, Yang Xu, Jingfeng Liu

“…In addition, the roles of p53 in cellular metabolism might also contribute to genomic stability of PSCs by limiting oxidative stress. …”
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The Role of the Estrogen-Related Receptor Alpha (ERRa) in Hypoxia and Its Implications for Cancer Metabolism by Leslie Chaltel-Lima, Fabiola Domínguez, Lenin Domínguez-Ramírez, Paulina Cortes-Hernandez

“…The estrogen-related receptor alpha (ERRα) is a transcription factor with important roles in the regulation of cellular metabolism that is overexpressed in hypoxia, suggesting that it plays a role in cell survival in this condition. …”
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Mycoplasmas–Host Interaction: Mechanisms of Inflammation and Association with Cellular Transformation by Francesca Benedetti, Sabrina Curreli, Davide Zella

“…In humans, some <i>Mycoplasma</i> species are found as commensal inhabitants, while others have a significant impact on the cellular metabolism and physiology. Mollicutes lack typical bacterial PAMPs (e.g., lipoteichoic acid, flagellin, and some lipopolysaccharides) and consequently the exact molecular mechanisms of Mycoplasmas’ recognition by the cells of the immune system is the subjects of several researches for its pathogenic implications. …”
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Exploring the role of macrophages in the progression from atypical hyperplasia to endometrial carcinoma through single-cell transcriptomics and bulk transcriptomics analysis by Xiaolei Song, Re Na, Nianghai Peng, Wenming Cao, Yan Ke

“…Statistical methods employed included LASSO regression for diagnostic modeling and various clustering algorithms for subtype identification.ResultsWe found that subtype B was closely related to cellular metabolism. A diagnostic model was established using LASSO regression and was based on the genes CDH18, H19, PAGE2B, PXDN, and THRB. …”
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Thermal adaptation of decomposer communities in warming soils by Mark Alexander Bradford

“…I argue that controversies over whether soil microbes adapt to warming stem from disregarding the evolutionary physiology of cellular metabolism, and confusion arising from the term thermal acclimation to represent phenomena at the organism- and ecosystem-levels with different underlying mechanisms. …”
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Metabolic Reprogramming of Chemoresistant Cancer Cells and the Potential Significance of Metabolic Regulation in the Reversal of Cancer Chemoresistance by Xun Chen, Shangwu Chen, Dongsheng Yu

“…Alterations of cellular metabolism not only contribute to tumor development, but also mediate the resistance of tumor cells to antitumor drugs. …”
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Glutamine‐driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia by Jing Fan, Jurre J Kamphorst, Robin Mathew, Michelle K Chung, Eileen White, Tomer Shlomi, Joshua D Rabinowitz

“…Here, we integrate LC‐MS‐based isotope tracer studies with oxygen uptake measurements in a quantitative redox‐balanced metabolic flux model of mammalian cellular metabolism. We then apply this approach to assess the impact of Ras and Akt activation and hypoxia on energy metabolism. …”
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Role of Mitochondria in Radiation Responses: Epigenetic, Metabolic, and Signaling Impacts by Dietrich Averbeck, Claire Rodriguez-Lafrasse

“…As typical epigenetic-regulated organelles and central power stations of cells, mitochondria play an important pivotal role in those responses. They direct cellular metabolism, energy supply and homeostasis as well as radiation-induced signaling, cell death, and immunological responses. …”
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Crosstalk of Hedgehog and mTORC1 Pathways by Lasse Jonsgaard Larsen, Lisbeth Birk Møller

“…Hedgehog (Hh) signaling and mTOR signaling, essential for embryonic development and cellular metabolism, are both coordinated by the primary cilium. …”
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Therapy experience in alopecia after COVID-19 by O. A. Katkhanova, M. V. Golubchenko

“…The patients received a complex drug for the treatment of alopecia, 1 tablet three times a day for 2 months, and a peptide lotion for cutaneous use with active ingredients, which activate cellular metabolism in hair follicles, encourage the hair follicles to switch to the active growth phase. …”
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Metabolism-Based Therapeutic Strategies Targeting Cancer Stem Cells by Petra Jagust, Beatriz de Luxán-Delgado, Beatriz Parejo-Alonso, Patricia Sancho, Patricia Sancho

“…Thanks to the great advances in the field over the last few years, we know now that cellular metabolism and stemness are highly intertwined in normal development and cancer. …”
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Ubiquitination of Intramitochondrial Proteins: Implications for Metabolic Adaptability by Prasad Sulkshane, Jonathan Ram, Michael H Glickman

“…Hence, constant surveillance is required to closely monitor mitochondrial health for sound maintenance of cellular metabolism and thus, for viability. In addition to internal mitochondrial chaperones and proteases, mitochondrial health is also governed by host cell protein quality control systems. …”
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Viroporins Manipulate Cellular Powerhouses and Modulate Innate Immunity by Leticia Cedillo-Barrón, Julio García-Cordero, Giovani Visoso-Carvajal, Moisés León-Juárez

“…Cumulative data regarding the importance of mitochondria function in multiple processes, such as cellular metabolism, energy production, calcium homeostasis, apoptosis, and mitophagy, have been reported. …”
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Visualizing subcellular changes in the NAD(H) pool size versus redox state using fluorescence lifetime imaging microscopy of NADH by Angela Song, Nicole Zhao, Diana C. Hilpert, Caroline Perry, Joseph A. Baur, Douglas C. Wallace, Patrick M. Schaefer

“…Our results emphasize NADH FLIM’s potential for evaluating cellular metabolism and relative NAD(H) levels with high spatial resolution, providing a crucial tool for our understanding of aging and metabolism.…”
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Harnessing the Induction of CD8+ T-Cell Responses Through Metabolic Regulation by Pathogen-Recognition-Receptor Triggering in Antigen Presenting Cells by Francesco Nicoli, Stéphane Paul, Victor Appay, Victor Appay

“…On the other hand, the engagement of several metabolic processes, at play in APCs and T-cells upon stimulation, implies that modulating cellular metabolism can impact on priming efficacy. Here, we review recent efforts to understand the interplay between PRR mediated signaling and metabolic pathway modulation in this context, through three examples: interplay between TLR4 and fatty acid metabolism, between TLR9 and IDO, and between STING and autophagy. …”
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Stem Cell Metabolism: Powering Cell-Based Therapeutics by Vagner O. C. Rigaud, Robert Hoy, Sadia Mohsin, Mohsin Khan

“…During commitment, there is a shift in cellular metabolism, which alters cell function. Reprogramming stem cell metabolism may represent an attractive strategy to enhance stem cell therapy for cardiac repair. …”
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