Andrographolide, an Anti-Inflammatory Multitarget Drug: All Roads Lead to Cellular Metabolism by Rafael Agustín Burgos, Pablo Alarcón, John Quiroga, Carolina Manosalva, Juan Hancke

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Behind Protein Synthesis: Amino Acids—Metabokine Regulators of Both Systemic and Cellular Metabolism by Evasio Pasini, Giovanni Corsetti, Francesco S. Dioguardi

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Bacteria employ lysine acetylation of transcriptional regulators to adapt gene expression to cellular metabolism by Magdalena Kremer, Sabrina Schulze, Nadja Eisenbruch, Felix Nagel, Robert Vogt, Leona Berndt, Babett Dörre, Gottfried J. Palm, Jens Hoppen, Britta Girbardt, Dirk Albrecht, Susanne Sievers, Mihaela Delcea, Ulrich Baumann, Karin Schnetz, Michael Lammers

“…By detecting cellular acetyl-CoA, NAD+ and acetyl-phosphate, bacteria apply lysine acetylation of transcriptional regulators to sense the cellular metabolic state directly adjusting gene expression to changing environmental conditions.…”
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lncRNA PRADX is a Mesenchymal Glioblastoma Biomarker for Cellular Metabolism Targeted Therapy by Can Xu, Can Xu, Jixing Zhao, Jixing Zhao, Jia Song, Jia Song, Menglin Xiao, Menglin Xiao, Xiaoteng Cui, Xiaoteng Cui, Lei Xin, Lei Xin, Jianglong Xu, Jianglong Xu, Yuhao Zhang, Yuhao Zhang, Kaikai Yi, Kaikai Yi, Biao Hong, Biao Hong, Fei Tong, Fei Tong, Shaohui Tian, Shaohui Tian, Yanli Tan, Yanli Tan, Chunsheng Kang, Chunsheng Kang, Chuan Fang, Chuan Fang

“…Finally, we determined that combined of ACSL1 and CPT1 inhibitors could reverse the accelerated cellular metabolism and tumor growth induced by PRADX overexpression in vivo and in vitro. …”
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Myeloid cell ACE shapes cellular metabolism and function in PCSK-9 induced atherosclerosis by DuoYao Cao, Suguru Saito, LiMin Xu, Wei Fan, Xiaomo Li, Faizan Ahmed, Predrag Jovanovic, Tomohiro Shibata, Mingtian Che, Ellen A. Bernstein, Jorge Gianni, Jorge Gianni, Ajit S. Divakaruni, Derick Okwan-Duodu, Zakir Khan, Zakir Khan, Celine E. Riera, Fanfan Chen, Kenneth E. Bernstein, Kenneth E. Bernstein

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Regular exercise delays microvascular endothelial dysfunction by regulating antioxidant capacity and cellular metabolism by Giorgia Scarfò, Simona Daniele, Elisa Chelucci, Antonio Rizza, Jonathan Fusi, Giancarlo Freggia, Barbara Costa, Sabrina Taliani, Paolo Artini, Claudia Martini, Ferdinando Franzoni

“…Finally, regular PA enhanced plasma level of SIRT1 and miR29, suggested as epigenetic regulators of redox balance and cellular metabolism. In addition, stimulated local blood flow was directly related to plasma antioxidant capacity, and SIRT1 and miR29 levels. …”
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The Role of Cellular Metabolism in Maintaining the Function of the Dentine-Pulp Complex: A Narrative Review by Kacper Nijakowski, Martyna Ortarzewska, Jakub Jankowski, Anna Lehmann, Anna Surdacka

“…The cellular metabolic processes ensure the physiological integrity of the dentine-pulp complex. …”
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Stem Cell Theory of Cancer: Clinical Implications for Cellular Metabolism and Anti-Cancer Metabolomics by Shi-Ming Tu, Jim Z. Chen, Sunny R. Singh, Sanjay Maraboyina, Neriman Gokden, Ping-Ching Hsu, Timothy Langford

“…In this perspective, we re-examine different types of cellular metabolism, e.g., glycolytic vs. mitochondrial, of glucose, glutamine, arginine, and fatty acids in CSCs and non-CSCs. …”
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Rewired Cellular Metabolic Profiles in Response to Metformin under Different Oxygen and Nutrient Conditions by Shan Liu, Jumpei Washio, Satoko Sato, Yuki Abiko, Yuta Shinohara, Yuri Kobayashi, Haruki Otani, Shiori Sasaki, Xiaoyi Wang, Nobuhiro Takahashi

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Targeting Cellular Metabolism With CPI-613 Sensitizes Pancreatic Cancer Cells to Radiation Therapy by Husain Yar Khan, PhD, Mandana Kamgar, MD, Amro Aboukameel, MS, Sahar Bannoura, MS, Brian Y. Chung, PhD, Yiwei Li, MD, Mohammed Najeeb Al Hallak, MD, Philip A. Philip, MD, PhD, Susan Tsai, MD, Sanjeev Luther, MBA, William A. Hall, MD, Asfar S. Azmi, PhD

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Target of Rapamycin Signaling Involved in the Regulation of Photosynthesis and Cellular Metabolism in <i>Chlorella sorokiniana</i> by Linxuan Li, Tingting Zhu, Lele Huang, Maozhi Ren

“…These observations suggested that CsTOR plays an important role in photosynthesis and cellular metabolism, and provide new insights into the function of CsTOR in <i>Chlorella sorokiniana</i>.…”
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Effects of in vitro Brevetoxin Exposure on Apoptosis and Cellular Metabolism in a Leukemic T Cell Line (Jurkat) by John W. Sleasman, Richard H. Pierce, Kathryn Strohbehn, Stephanie R. Leggett, Catherine J. Walsh

“…Using MTT, cellular metabolic activity was decreased in Jurkat cells exposed to 5 - 10 μg/ml PbTx-2 or PbTx-6. …”
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Response of Coral Reef Dinoflagellates to Nanoplastics under Experimental Conditions Suggests Downregulation of Cellular Metabolism by Christina Ripken, Konstantin Khalturin, Eiichi Shoguchi

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Cellular Metabolism and Bioenergetic Function in Human Fibroblasts and Preadipocytes of Type 2 Familial Partial Lipodystrophy by Cristina Algieri, Chiara Bernardini, Fabiana Trombetti, Elisa Schena, Augusta Zannoni, Monica Forni, Salvatore Nesci

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Urolithin A and B Alter Cellular Metabolism and Induce Metabolites Associated with Apoptosis in Leukemic Cells by Abdulaziz Musa Alzahrani, Mohammed Razeeth Shait Mohammed, Raed Ahmed Alghamdi, Abrar Ahmad, Mazin A. Zamzami, Hani Choudhry, Mohammad Imran Khan

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GSDMA3 deficiency reprograms cellular metabolism and modulates BCR signaling in murine B cells by Fei Guan, Xi Luo, Ju Liu, Yanmei Huang, Qi Liu, Jiang Chang, Guofeng Fang, Danqing Kang, Heng Gu, Li Luo, Lu Yang, Zhaoyu Lin, Xiang Gao, Chaohong Liu, Jiahui Lei

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Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase by Cantor, Jason R., Abu-Remaileh, Monther, Kanarek, Naama, Freinkman, Elizaveta, Gao, Xin, Louissaint, Abner, Lewis, Caroline A., Sabatini, David

“…Culture in HPLM, relative to that in traditional media, had widespread effects on cellular metabolism, including on the metabolome, redox state, and glucose utilization. …”
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Altered cellular metabolism following traumatic brain injury: a magnetic resonance spectroscopy study. by Garnett, MR, Corkill, R, Blamire, A, Rajagopalan, B, Manners, D, Young, J, Styles, P, Cadoux-Hudson, T

“…We therefore performed phosphorus magnetic resonance spectroscopy on seven patients in the subacute stage (mean 9 days postinjury) following traumatic brain injury to assess cellular metabolism. In areas of normal-appearing white matter, the pH was significantly alkaline (patients 7.09 +/- 0.04 [mean +/- SD], controls 7.01 +/- 0.04, p = 0.008), the phosphocreatine to inorganic phosphate ratio (PCr/Pi) was significantly increased (patients 4.03 +/- 1.18, controls 2.64 +/- 0.71, p = 0.03), the inorganic phosphate to adenosine triphosphate ratio (Pi/ATP) was significantly reduced (patients 0.37 +/- 0.10, controls 0.56 +/- 0.19, p = 0.04), and the PCr/ATP ratio was nonsignificantly increased (patients 1.53 +/- 0.29, controls 1.34 +/- 0.19, p = 0.14) in patients compared to controls. …”

Linking the FTO obesity rs1421085 variant circuitry to cellular, metabolic, and organismal phenotypes in vivo by Laber, S, Forcisi, S, Bentley, L, Petzold, J, Moritz, F, Smirnov, KS, Al Sadat, L, Williamson, I, Strobel, S, Agnew, T, Sengupta, S, Nicol, T, Grallert, H, Heier, M, Honecker, J, Mianne, J, Teboul, L, Dumbell, R, Long, H, Simon, M, Lindgren, C, Bickmore, WA, Hauner, H, Schmitt-Kopplin, P, Claussnitzer, M, Cox, RD

“…Together, our data establish cross-species conservation of the rs1421085 regulatory circuitry at the molecular, cellular, metabolic, and organismal level, revealing previously unknown contextual dependence of the variant’s action. …”

Persistent β-Hexachlorocyclohexane Exposure Impacts Cellular Metabolism with a Specific Signature in Normal Human Melanocytes by Federica Papaccio, Silvia Caputo, Alessandra Iorio, Paola De Simone, Monica Ottaviani, Antonella Del Brocco, Pasquale Frascione, Barbara Bellei

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