Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis by Xin Tracy Liu, Yu Huang, Da Liu, Yingxin Celia Jiang, Min Zhao, Long Hoa Chung, Xingxing Daisy Han, Yinan Zhao, Jinbiao Chen, Paul Coleman, Ka Ka Ting, Collin Tran, Yingying Su, Claude Vincent Dennis, Atul Bhatnagar, Ken Liu, Anthony Simon Don, Mathew Alexander Vadas, Mark Douglas Gorrell, Shubiao Zhang, Michael Murray, Mary Meltem Kavurma, Geoffrey William McCaughan, Jennifer Ruth Gamble, Yanfei Qi

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ARHGAP18: A Flow‐Responsive Gene That Regulates Endothelial Cell Alignment and Protects Against Atherosclerosis by Angelina J. Lay, Paul R. Coleman, Ann Formaz‐Preston, Ka Ka Ting, Ben Roediger, Wolfgang Weninger, Martin A. Schwartz, Mathew A. Vadas, Jennifer R. Gamble

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The Fusion of <i>CLEC12A</i> and <i>MIR223HG</i> Arises from a <i>trans</i>-Splicing Event in Normal and Transformed Human Cells by Bijay P. Dhungel, Geoffray Monteuuis, Caroline Giardina, Mehdi S. Tabar, Yue Feng, Cynthia Metierre, Sarah Ho, Rajini Nagarajah, Angela R. M. Fontaine, Jaynish S. Shah, Divya Gokal, Charles G. Bailey, Ulf Schmitz, John E. J. Rasko

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Generation of an induced pluripotent stem cell line from a patient with conduction disease and recurrent ventricular fibrillation with a sodium voltage-gated channel alpha subunit... by Serena Li, Stuart Fraser, Ginell Ranpura, Seakcheng Lim, Emma S. Singer, Jeremy D.K. Parker, Joshua Crowe, Richard D. Bagnall, Zachary Laksman, Christopher Semsarian

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Mitochondria-Targeted Antioxidants as a Therapeutic Strategy for Chronic Obstructive Pulmonary Disease by Lauren H. Fairley, Shatarupa Das, Vivek Dharwal, Nadia Amorim, Karl J. Hegarty, Ridhima Wadhwa, Guntipally Mounika, Philip M. Hansbro

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Ablation of sphingosine kinase 2 suppresses fatty liver-associated hepatocellular carcinoma via downregulation of ceramide transfer protein by Xin Tracy Liu, Long Hoa Chung, Da Liu, Jinbiao Chen, Yu Huang, Jonathan D. Teo, Xingxing Daisy Han, Yinan Zhao, Fiona H. X. Guan, Collin Tran, Jun Yup Lee, Timothy A. Couttas, Ken Liu, Geoffery W. McCaughan, Mark D. Gorrell, Anthony S. Don, Shubiao Zhang, Yanfei Qi

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The burden of splice-disrupting variants in inherited heart disease and unexplained sudden cardiac death by Emma S. Singer, Joshua Crowe, Mira Holliday, Julia C. Isbister, Sean Lal, Natalie Nowak, Laura Yeates, Charlotte Burns, Sulekha Rajagopalan, Ivan Macciocca, Ingrid King, Julie Wacker, Jodie Ingles, Robert G. Weintraub, Christopher Semsarian, Richard D. Bagnall

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The Tumour Vasculature as a Target to Modulate Leucocyte Trafficking by Yang Zhao, Ka Ka Ting, Paul Coleman, Yanfei Qi, Jinbiao Chen, Mathew Vadas, Jennifer Gamble

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A Novel Purification Procedure for Active Recombinant Human DPP4 and the Inability of DPP4 to Bind SARS-CoV-2 by Cecy R Xi, Arianna Di Fazio, Naveed Ahmed Nadvi, Karishma Patel, Michelle Sui Wen Xiang, Hui Emma Zhang, Chandrika Deshpande, Jason K K Low, Xiaonan Trixie Wang, Yiqian Chen, Christopher L D McMillan, Ariel Isaacs, Brenna Osborne, Ana Júlia Vieira de Ribeiro, Geoffrey W McCaughan, Joel P Mackay, W Bret Church, Mark D Gorrell

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Nicotinamide Inhibits T Cell Exhaustion and Increases Differentiation of CD8 Effector T Cells by Sara Alavi, Abdullah Al Emran, Hsin-Yi Tseng, Jessamy C. Tiffen, Helen Marie McGuire, Peter Hersey

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Dipeptidyl Peptidase Inhibition Enhances CD8 T Cell Recruitment and Activates Intrahepatic Inflammasome in a Murine Model of Hepatocellular Carcinoma by James M. Henderson, Michelle S. W. Xiang, Jiali Carrie Huang, Stefanie Wetzel, Linxuan Jiang, Jack H. Lai, Wengen Wu, James G. Kench, William W. Bachovchin, Ben Roediger, Geoffrey W. McCaughan, Hui Emma Zhang, Mark D. Gorrell

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Exploring Viral–Host Protein Interactions as Antiviral Therapies: A Computational Perspective by Sobia Idrees, Hao Chen, Nisha Panth, Keshav Raj Paudel, Philip M. Hansbro

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A single dose, BCG-adjuvanted COVID-19 vaccine provides sterilising immunity against SARS-CoV-2 infection by Claudio Counoupas, Matt D. Johansen, Alberto O. Stella, Duc H. Nguyen, Angela L. Ferguson, Anupriya Aggarwal, Nayan D. Bhattacharyya, Alice Grey, Owen Hutchings, Karishma Patel, Rezwan Siddiquee, Erica L. Stewart, Carl G. Feng, Nicole G. Hansbro, Umaimainthan Palendira, Megan C. Steain, Bernadette M. Saunders, Jason K. K. Low, Joel P. Mackay, Anthony D. Kelleher, Warwick J. Britton, Stuart G. Turville, Philip M. Hansbro, James A. Triccas

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A hepatic network of dendritic cells mediates CD4 T cell help outside lymphoid organs by Kieran English, Rain Kwan, Lauren E. Holz, Claire McGuffog, Jelte M. M. Krol, Daryan Kempe, Tsuneyasu Kaisho, William R. Heath, Leszek Lisowski, Maté Biro, Geoffrey W. McCaughan, David G. Bowen, Patrick Bertolino

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A Novel Function of Sphingosine Kinase 2 in the Metabolism of Sphinga-4,14-Diene Lipids by Timothy Andrew Couttas, Yepy Hardi Rustam, Huitong Song, Yanfei Qi, Jonathan David Teo, Jinbiao Chen, Gavin Edmund Reid, Anthony Simon Don

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Generation of an induced pluripotent stem cell line from a hypertrophic cardiomyopathy patient with a pathogenic myosin binding protein C (MYBPC3) p.Arg502Trp mutation by Mira Holliday, Samantha Barratt Ross, Seakcheng Lim, Christopher Semsarian

“…This line is a useful resource for studying and modeling hypertrophic cardiomyopathy.Resource tableUnlabelled TableUnique stem cell line identifierMCCI0003i-HCMAlternative name(s) of stem cell lineIK1InstitutionCentenary InstituteContact information of distributorChristopher Semsarian; c.semsarian@centenary.org.auType of cell lineiPSCOriginHumanAdditional origin infoAge: 58Sex: maleEthnicity: North-west EuropeanCell sourcePeripheral blood mononuclear cellsClonalityClonalMethod of reprogrammingTransgene free (episomal vectors)Genetic modificationNAType of modificationNAAssociated diseaseHypertrophic CardiomyopathyGene/locusMYBPC3 c.1504C > T p.Arg502Trp, Chr11: 47364249 (on Assembly GRCh37)Method of modificationNAName of transgene or resistanceNAInducible/constitutive systemNADate archived/stock date2017Cell line repository/bankNAEthical approvalPatient informed consent obtained, and ethics review board-competent authority approval obtained through the Ethics Review Committee, Sydney Local Health District.Protocol No X13-0069 and HREC/13/RPAH/93…”
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Towards resolution of the intron retention paradox in breast cancer by Jaynish S. Shah, Michael J. G. Milevskiy, Veronika Petrova, Amy Y. M. Au, Justin J. L. Wong, Jane E. Visvader, Ulf Schmitz, John E. J. Rasko

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DPP9: Comprehensive In Silico Analyses of Loss of Function Gene Variants and Associated Gene Expression Signatures in Human Hepatocellular Carcinoma by Jiali Carrie Huang, Abdullah Al Emran, Justine Moreno Endaya, Geoffrey W. McCaughan, Mark D. Gorrell, Hui Emma Zhang

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Mucosal TLR2-activating protein-based vaccination induces potent pulmonary immunity and protection against SARS-CoV-2 in mice by Anneliese S. Ashhurst, Matt D. Johansen, Joshua W. C. Maxwell, Skye Stockdale, Caroline L. Ashley, Anupriya Aggarwal, Rezwan Siddiquee, Stefan Miemczyk, Duc H. Nguyen, Joel P. Mackay, Claudio Counoupas, Scott N. Byrne, Stuart Turville, Megan Steain, James A. Triccas, Philip M. Hansbro, Richard J. Payne, Warwick J. Britton

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Widespread Aberrant Alternative Splicing despite Molecular Remission in Chronic Myeloid Leukaemia Patients by Ulf Schmitz, Jaynish S. Shah, Bijay P. Dhungel, Geoffray Monteuuis, Phuc-Loi Luu, Veronika Petrova, Cynthia Metierre, Shalima S. Nair, Charles G. Bailey, Verity A. Saunders, Ali G. Turhan, Deborah L. White, Susan Branford, Susan J. Clark, Timothy P. Hughes, Justin J.-L. Wong, John E.J. Rasko

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