Health & Physical Activity by Scheer V, 2, Hoffman MD, 3

“…Without proper intervention, cerebral edema with life-threatening symptoms such as confusion, agitation, seizures and coma (exercise-associated hyponatremia encephalopathy (EAHE)) may develop.Treatment: Asymptomatic EAH can be treated by fluid restriction until onset of urination, mild symptomatic cases of EAH by oralhypertonic saline solutions, while intravenous infusion of hypertonic saline can be life-saving in moderate to severe EAH and EAHE.Prevention: Proper hydration strategies like drinkinglimitedto thirst can generally prevent EAH. …”
Get full text

The lymphatic drainage systems in the brain: a novel target for ischemic stroke? by Ying-Jie Wang, Yan-Rong Sun, Yan-Hong Pei, Hao-Wen Ma, Ya-Kun Mu, Li-Hua Qin, Jun-Hao Yan

“…After ischemic stroke, impairment of these systems could lead to cerebral edema, accumulation of toxic factors, and activation of neuroinflammation, while restoration of their normal functions can improve neurological outcomes. …”
Get full text

Neuroprotective Effects of Allicin on Neurological Scores, Blood Brain Barrier Permeability and Brain Edema Following Severe Traumatic Brain Injury in Male Rats: A Behavioral, Bioc... by Seyed Reza Seyedin, Moslem Mohammadi, Ali Siahposht-Khachaki

“…Conclusion: Allicin showed neuroprotective effects in the brain and can affect the consequences of trauma, reduce cerebral edema, accelerate improvement of blood-brain barrier, and improve neurological scores and the function of vestibular system.…”
Get full text

Single ⁃ center study on endovascular treatment of acute ischemic stroke with large vessel occlusion caused by carotid artery dissection by Jun⁃jie LIU, Zhi⁃rong ZHANG, Liang ZHANG, Kai⁃feng LI, Xiong⁃jun HE, Ya⁃jie LIU

“…Patients with postoperative complications were: one case of death caused by cerebral hernia, one case of cerebral edema due to a large cerebral infarction, one case had a small amount of cerebral hemorrhage, one case of subarachnoid hemorrhage. …”
Get full text

The Efficacy and Safety of Preoperative Lumbar Drain Placement in Anterior Skull Base Surgery by Paul D. Ackerman, Drew A. Spencer, Vikram C. Prabhu

“…Other complications were rare, but we encountered two instances of delayed malignant cerebral edema in the open ASB cohort that are discussed in detail. …”
Get full text

Steroid utility, immunotherapy, and brain tumor management: an update on conflicting therapies by Matthew Goldman, Brandon Lucke-Wold, Meleine Martinez-Sosa, Jason Katz, Yusuf Mehkri, Jeff Valisno, Stephan Quintin

“…This further emphasizes the need for alternative agents to effectively treat tumor-induced cerebral edema. This review highlights the current clinical utility of steroids to treat brain tumor-related edema and the underlying pathophysiology. …”
Get full text

Endothelial edema precedes blood-brain barrier breakdown in early time points after experimental focal cerebral ischemia by Martin Krueger, Bianca Mages, Constance Hobusch, Dominik Michalski

“…Abstract In the setting of stroke, ischemia-related blood-brain barrier (BBB) dysfunction aggravates the cerebral edema, which critically impacts on the clinical outcome. …”
Get full text

High altitude retinopathy: An overview and new insights by Cong Han, Xing-Xing Zheng, Wen-Fang Zhang

“…Various studies have demonstrated the correlation of HAR with acute mountain sickness (AMS) and high-altitude cerebral edema (HACE), so a deeper understanding of HAR is important. …”
Get full text

Rates and Risk Factors of Acute Ischemic Stroke Mortality [A Multi-Center Prospective Cohort Study] by Mohamed Elsaed, Mahrous Seddeek, Ahmed Elsheshiny

“…Development of hemorrhagic transformation, cerebral edema, pneumonia, GIT bleeding at admission appears to be associated with in-hospital mortality.…”
Get full text

Critical Care for Patients with Massive Ischemic Stroke by Sang-Beom Jeon, Younsuck Koh, H. Alex Choi, Kiwon Lee

“…Malignant cerebral edema following ischemic stroke is life threatening, as it can cause inadequate blood flow and perfusion leading to irreversible tissue hypoxia and metabolic crisis. …”
Get full text

Ureidobenzenesulfonamides as Selective Carbonic Anhydrase I, IX, and XII Inhibitors by Toni C. Denner, Andrea Angeli, Marta Ferraroni, Claudiu T. Supuran, René Csuk

“…Thereby, biphenyl- and benzylphenyl-substituted sulfonamides showed high selectivity against hCA IX and hCA XII; these enzymes are common targets in the treatment of hypoxic cancers, and noteworthy inhibitory activity was observed for several compounds toward hCA I that might be of interest for future applications to treat cerebral edema. Compound <b>3</b> (4-[3-(2-benzylphenyl)ureido]benzenesulfonamide) held an exceptionally low K_i value of 1.0 nM for hCA XII.…”
Get full text

High altitude illness in pilgrims after rapid ascent to 4380 M. by Zafren, K, Pun, M, Regmi, N, Bashyal, G, Acharya, B, Gautam, S, Jamarkattel, S, Lamichhane, S, Acharya, S, Basnyat, B

“…Acute Mountain Sickness (AMS) was LLS≥3. High Altitude Cerebral Edema (HACE) was AMS with ataxia or altered mental status.…”

A case report of fatal outcome of cerebral venous sinus thrombosis with cerebral hemorrhage during early pregnancy secondary to antithrombin III deficiency by Elias, Nurezwana, Murajrajamany, Kavitha, Noor Azmi, Mat Adenan

“…A repeated brain CT scan showed worsening intraparenchymal hemorrhages with midline shift, subfalcine herniation and cerebral edema. An emergency bilateral craniectomy was performed to relieve the intracranial pressure. …”

Neuroprotective Effects of Allicin on Neurological Scores, Blood Brain Barrier Permeability and Brain Edema Following Severe Traumatic Brain Injury in Male Rats: A Behavioral, Bioc... by Seyed Reza Seyedin, Moslem Mohammadi, Ali Siahposht-Khachaki

“…Conclusion: Allicin showed neuroprotective effects in the brain and can affect the consequences of trauma, reduce cerebral edema, accelerate improvement of blood-brain barrier, and improve neurological scores and the function of vestibular system.…”
Get full text

Alternative management of diabetic ketoacidosis in a Brazilian pediatric emergency department by Savoldelli Roberta D, Farhat Sylvia CL, Manna Thais D

“…DKA treatment guidelines include: restoration of circulating volume and electrolyte replacement; correction of insulin deficiency aiming at the resolution of metabolic acidosis and ketosis; reduction of risk of cerebral edema; avoidance of other complications of therapy (hypoglycemia, hypokalemia, hyperkalemia, hyperchloremic acidosis); identification and treatment of precipitating events. …”
Get full text

A Diagnostic Dilemma: Metastatic Testicular Cancer and Systemic Sarcoidosis – A Review of the Literature by R. Gupta, V. Senadhi

“…Additionally, the patient’s skin and central nervous system (CNS) lesions improved on steroids that had been started for cerebral edema. Given the predilection of testicular cancer for CNS metastasis, neurosarcoidosis can also be mistaken for testicular cancer metastasis to the CNS, as seen in our case. …”
Get full text

ASPHYXIA AND DEVELOPMENTAL OUTCOME IN HIGH RISK INFANTS by Valentina DUKOVSKA, Aspazija SOFIJANOVA, Filip DUMA, Zhivko JUZEVSKI

“…Asphyxia is a risk factor that is very often related to neuro-developmental issues in high risk infants and equally affects preterm and term infants, however its outcome on the developed brain differs from the outcome on the preterm brain.In preterm infants, asphyxia usually exerts a hemorrhagic or ischaemic event and periventricular leukomalacia.In term infants, asphyxia leads to cerebral edema and atrophy of the brain, which may later lead to hypoxic ischaemic encephalopathy (HIE).The number of term infants with HIE who have survived is lower than those of preterm infants, while the percentage of term infants with HIE who have neuro-developmental issues is higher. …”
Get full text

Hypertonic saline infusion suppresses apoptosis of hippocampal cells in a rat model of cardiopulmonary resuscitation by Xiang Zhou, Yong Liu, Yang Huang, ShuiBo Zhu, Jian Zhu, RongPing Wang

“…Abstract Hypertonic saline (HS) attenuates cerebral edema, improves microcirculation perfusion and alleviates inflammation. …”
Get full text

Pain in the back after a brain trauma—The revelation of a spinal subdural hematoma: A case report with a literature review by Hajar Andour, Zakaria Abide, Amine Cherraqi, Mohamed Mouhassani, Issam En-Nafaa, Jamal Fenni, Mohamed Lahkim

“…We report the case of a 45-year-old man who has been a victim of a brain trauma which resulted in a cerebral edema. A week later, the patient came to the emergency department for disabling abdominal pain, predominant in the back. …”
Get full text

Prediction of the development and susceptibility to acute mountain sickness (AMS) by monitoring oxygen saturation (SpO2) – literature review by Karol Mazur, Dominik Machaj, Sandra Jastrzębska, Alicja Płaczek, Dominika Mazur

“…<p>The hypoxia is the main cause of altitude sickness, that usually starts from the benign form - acute mountain sickness (AMS), that being untreated can progress to the life-threatening states, like high altitude pulmonary edema (HAPE) and high altitude cerebral edema (HACE).</p><p>The aim of this study was to evaluate the role of monitoring oxygen saturation in prediction of the of the development and susceptibility to acute mountain sickness (AMS). …”
Get full text