Copper concentration in multiple sclerosis: a systematic review and meta-analysis по Sarmadi, M, Bidel, Z, Najafi, F, Ramakrishnan, R, Teymoori, F, Zarmehri, HA, Nazarzadeh, M

“...Observational studies that assessed copper as exposure in serum, plasma, whole blood, and cerebrospinal fluid were included. Standardized mean differences (SMD), comparing the mean of copper concentration in multiple sclerosis patients versus healthy controls, were considered as the measure of association. ...”

AIDS-associated Penicillium marneffei infection of the central nervous system. по Le, T, Huu Chi, N, Kim Cuc, N, Manh Sieu, T, Shikuma, C, Farrar, J, Day, J

“...We report the first case series of 21 human immunodeficiency virus-infected patients who presented with a syndrome consistent with acute central nervous system infection and who had Penicillium marneffei isolated from cerebrospinal fluid....”

Fifteen-minute consultation: Enterovirus meningitis and encephalitis: When can we stop the antibiotics? по Drysdale, S, Kelly, D

“...Obtaining an EV-positive cerebrospinal fluid result usually allows antimicrobial treatment to be stopped. ...”

Standardizing surveillance of pneumococcal disease. по Knoll, MD, Moïsi, J, Muhib, F, Wonodi, C, Lee, E, Grant, L, Gilani, Z, Anude, C, O'Brien, K, Cherian, T, Levine, O

“...Antigen testing and polymerase chain reaction increased the proportion of cerebrospinal fluid specimens with pneumococcus identified by 1.3-5.5-fold, compared with culture alone. ...”

Inflammation-related plasma and CSF biomarkers for multiple sclerosis по Huang, J, Khademi, M, Fugger, L, Lindhe, Ö, Novakova, L, Axelsson, M, Malmeström, C, Constantinescu, C, Lycke, J, Piehl, F, Olsson, T, Kockum, I

“...We have investigated a broad set of protein biomarkers in cerebrospinal fluid (CSF) and plasma using a highly sensitive proteomic immunoassay. ...”

Evaluation of GeneXpert MTB/RIF for diagnosis of tuberculous meningitis по Nhu, N, Heemskerk, D, Thu, D, Chau, T, Mai, N, Nghia, H, Loc, P, Ha, D, Merson, L, Thinh, T, Day, J, Chau, N, Wolbers, M, Farrar, J, Caws, M

“...Meticulous examination of a smear from a large volume of cerebrospinal fluid (CSF) remains the most sensitive technique but is not practical in most laboratories. ...”

Evaluation of GeneXpert MTB/RIF for diagnosis of tuberculous meningitis. по Nhu, N, Heemskerk, D, Thu, D, Chau, T, Mai, N, Nghia, H, Loc, P, Ha, D, Merson, L, Thinh, T, Day, J, Chau, N, Wolbers, M, Farrar, J, Caws, M

“...Meticulous examination of a smear from a large volume of cerebrospinal fluid (CSF) remains the most sensitive technique but is not practical in most laboratories. ...”

Valacyclovir for herpes simplex encephalitis. по Pouplin, T, Pouplin, J, Van Toi, P, Lindegardh, N, Rogier van Doorn, H, Hien, T, Farrar, J, Török, M, Chau, T

“...We report the penetration of acyclovir into the cerebrospinal fluid (CSF) in patients with HSE, treated with the oral prodrug valacyclovir at 1,000 mg three times daily. ...”

Acute encephalopathy associated with influenza A infection in adults. по Lee, N, Wong, C, Chan, P, Lindegardh, N, White, N, Hayden, F, Wong, E, Wong, K, Cockram, C, Sung, J, Hui, D

“...We detected high cerebrospinal fluid (CSF) and plasma concentrations of CXCL8/IL-8 and CCL2/MCP-1 (CSF/plasma ratios > or =3), and interleukin-6, CXCL10/IP-10, but no evidence of viral neuroinvasion. ...”

Cerebellar ataxia in non-paraneoplastic Lambert-Eaton myasthenic syndrome. по Lorenzoni, P, Scola, R, Lang, B, Kay, C, Teive, H, Kowacs, P, Werneck, L

“...We describe two patients with non-paraneoplastic LEMS associated with CA who showed high levels of anti-P/Q-type voltage-gated calcium channels antibodies in the serum and cerebrospinal fluid, and reduced CMAP with increment after brief maximum voluntary contraction in electrophysiological studies. ...”

Interactions between Neisseria meningitidis and human cells that promote colonisation and disease. по Corbett, A, Exley, R, Bourdoulous, S, Tang, C

“...Multiple steps are involved during the pathogenesis of infection, including the colonisation of healthy individuals and invasion of the bacterium into the cerebrospinal fluid. The bacterium is capable of adhering to, and entering into, a range of human cell types, which facilitates its ability to cause disease. ...”

Acute foramen magnum syndrome from acquired Chiari I malformation relieved by ventriculoperitoneal shunt revision. по Pereira, E, Qadri, SR, Cadoux-Hudson, T, Green, A

“...Theories regarding the formation of acquired Chiari I malformations, alongside the possible synergistic roles of intracranial pathologies and cerebrospinal fluid drainage in the development of this entity are discussed....”

A randomized, double-blind, placebo-controlled trial of acetazolamide for the treatment of elevated intracranial pressure in cryptococcal meningitis. по Newton, P, Thai, L, Tip, N, Short, J, Chierakul, W, Rajanuwong, A, Pitisuttithum, P, Chasombat, S, Phonrat, B, Maek-A-Nantawat, W, Teaunadi, R, Lalloo, D, White, N

“...We conducted a trial of oral acetazolamide for the treatment of cryptococcal meningitis in 22 Thai adults with headache and an opening cerebrospinal fluid pressure of >/=200 mm H(2)0. The trial was terminated prematurely because patients who received acetazolamide developed significantly lower venous bicarbonate levels and higher chloride levels and had more-frequent serious adverse events than did subjects who received placebo....”

Immunological and biochemical correlates of adjunctive dexamethasone in Vietnamese adults with bacterial meningitis. по Mai, N, Tuan, T, Wolbers, M, Hoang, D, Nga, T, Chau, T, Chuong, L, Sinh, D, Nghia, H, Phong, N, Phu, N, Diep, T, Hang, H, Chau, N, Farrar, J, Schultsz, C, Hien, T, Simmons, C

“...Among Vietnamese patients with bacterial meningitis, cerebrospinal fluid (CSF) opening pressure and CSF:plasma glucose ratios were significantly improved and levels of CSF cytokines interleukin (IL)-6, IL-8, and IL-10 and were all statistically significantly lower after treatment in patients who were randomized to dexamethasone, compared with levels in patients who received placebo....”

Lipid arrays identify myelin-derived lipids and lipid complexes as prominent targets for oligoclonal band antibodies in multiple sclerosis. по Brennan, K, Galban-Horcajo, F, Rinaldi, S, O'Leary, C, Goodyear, C, Kalna, G, Arthur, A, Elliot, C, Barnett, S, Linington, C, Bennett, J, Owens, G, Willison, H

“...The presence of oligoclonal bands of IgG (OCB) in cerebrospinal fluid (CSF) is used to establish a diagnosis of multiple sclerosis (MS), but their specificity has remained an enigma since its first description over forty years ago. ...”

Elevated matrix metalloproteinase concentrations offer novel insight into their role in pediatric tuberculous meningitis по Li, YJ, Wilkinson, KA, Wilkinson, RJ, Figaji, AA, Rohlwink, UK

“...We collected lumbar and ventricular cerebrospinal fluid and serum from 40 children treated for tuberculous meningitis and measured the concentrations of gelatinases and their inhibitors. ...”

Successful outcome of Epstein-Barr virus encephalitis managed with bilateral craniectomy, corticosteroids and aciclovir. по Hayton, E, Wakerley, B, Bowler, I, Bogdanovic, M, Adcock, J

“...Serology, bone marrow aspirate and PCR of blood and cerebrospinal fluid confirmed the diagnosis. She was treated with corticosteroids and aciclovir. ...”

Childhood neurological presentation of a novel mitochondrial tRNA(Val) gene mutation. по Blakely, E, Poulton, J, Pike, M, Wojnarowska, F, Turnbull, D, McFarland, R, Taylor, R

“...We describe a young girl with a novel 1659T>C mutation in the tRNA(Val) gene of mitochondrial DNA (mtDNA) who presented with learning difficulties, hemiplegia, and a movement disorder, together with a raised cerebrospinal fluid (CSF) lactate. The mutation, which was present at high levels of heteroplasmy in patient tissues, interrupts a conserved Watson-Crick basepair in the TPsiC stem and has not previously been described in controls. ...”

Glucose-powered neuroelectronics по Rapoport, Benjamin Isaac

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A modified footplate for the Kerrison rongeur по Mitha, Alim P., Ahmad, Mohamed S., Cohen, Sarah J., Lieberman, Janet S., Udengaard, Martin R., Slocum, Alexander H., Coumans, Jean-Valery C. E.

“...Use of the Kerrison rongeur for bone removal in spinal surgery is associated with dural tears and cerebrospinal fluid (CSF) leaks. We report a modification of the Kerrison rongeur footplate designed to reduce the risk of dural tears. ...”
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