N-methyl-D-aspartate receptor antibodies in post-herpes simplex virus encephalitis neurological relapse. by Hacohen, Y, Deiva, K, Pettingill, P, Waters, P, Siddiqui, A, Chretien, P, Menson, E, Lin, J, Tardieu, M, Vincent, A, Lim, M

“…Seven children who had a neurological relapse following their initial encephalitis, identified from 20 cases of pediatric HSVE, were studied. Serum and/or cerebrospinal fluid (CSF) were tested for N-methyl-D-aspartate receptor (NMDAR) and other antibodies previously reported in central nervous system autoimmunity. …”

Physiological noise in brainstem FMRI. by Brooks, J, Faull, O, Pattinson, K, Jenkinson, M

“…However, the brainstem's location close to major arteries and adjacent pulsatile cerebrospinal fluid filled spaces, means that it is difficult to reliably record functional magnetic resonance imaging (fMRI) data from. …”

Correlation of susceptibility of Cryptococcus neoformans to amphotericin B with clinical outcome. by Larsen, R, Bauer, M, Pitisuttithum, P, Sanchez, A, Tansuphaswadikul, S, Wuthiekanun, V, Peacock, S, Simpson, A, Fothergill, A, Rinaldi, MG, Bustamante, B, Thomas, A, Altomstone, R, Day, N, White, N

“…This report describes a modified quantitative broth macrodilution susceptibility method showing a correlation with both the patient's quantitative biological response in the cerebrospinal fluid (CSF) and the survival of 85 patients treated with amphotericin B (AMB). …”

Leptomeningeal metastasis: survival and prognostic factors in 155 patients. by Herrlinger, U, Förschler, H, Küker, W, Meyermann, R, Bamberg, M, Dichgans, J, Weller, M

“…Univariate Cox regression analysis revealed that age >60 and elevated cerebrospinal fluid (CSF) albumin or lactate levels were therapy-independent predictors of poor survival in the entire cohort as well as in the subgroup of patients with systemic primary tumors (n=105). …”

Spectrum of movement disorders and neurotransmitter abnormalities in paediatric POLG disease by Papandreou, A, Rahman, S, Fratter, C, Ng, J, Meyer, E, Carr, LJ, Champion, M, Clarke, A, Gissen, P, Hemingway, C, Hussain, N, Jayawant, S, King, MD, Lynch, BJ, Mewasingh, L, Patel, J, Prabhakar, P, Neergheen, V, Pope, S, Heales, SJR, Poulton, J, Kurian, MA

“…<p><strong>Objectives</strong> To describe the spectrum of movement disorders and cerebrospinal fluid (CSF) neurotransmitter profiles in paediatric patients with <em>POLG</em> disease.…”

Aβ42/Aβ40 and Aβ42/Aβ38 ratios are associated with measures of gait variability and activities of daily living in mild Alzheimer's disease: a pilot study by Koychev, I, Galna, B, Zetterberg, H, Lawson, J, Zamboni, G, Ridha, BH, Rowe, J, Thomas, A, Howard, R, Malhotra, P, Ritchie, C, Lovestone, S, Rochester, L

“…In this study we compared gait-related measures with cerebrospinal fluid (CSF) markers of AD pathology. We recruited seventeen participants with mild AD in a multi-site study and performed gait assessment as well as lumbar punctures to obtain CSF. …”

Pharmacokinetics and pharmacodynamics of intensive antituberculosis treatment of tuberculous meningitis by Ding, J, Thuy Thuong Thuong, N, Pham, TV, Heemskerk, D, Pouplin, T, Tran, CTH, Nguyen. MTH, Nguyen, PH, Phan, LP, Nguyen, CVV, Thwaites, G, Tarning, J

“…Rifampin 15 mg/kg increased plasma and cerebrospinal fluid (CSF) exposures compared with 10 mg/kg: day 14 exposure increased from 48.2 hour·mg/L (range 18.2–93.8) to 82.5 hour·mg/L (range 8.7–161.0) in plasma and from 3.5 hour·mg/L (range 1.2–9.6) to 6.0 hour·mg/L (range 0.7–15.1) in CSF. …”

Immunotherapy in autoimmune encephalitis by Trewin, BP, Freeman, I, Ramanathan, S, Irani, SR

“…<p><strong>Purpose of review </strong></p> Autoimmune encephalitis (AE) refers to immune-mediated neurological syndromes often characterised by the detection of pathogenic autoantibodies in serum and/or cerebrospinal fluid which target extracellular epitopes of neuroglial antigens. …”

Cortical overgrowth in fetuses with isolated ventriculomegaly. by Kyriakopoulou, V, Vatansever, D, Elkommos, S, Dawson, S, McGuinness, A, Allsop, J, Molnár, Z, Hajnal, J, Rutherford, M

“…The extracerebral cerebrospinal fluid and third and fourth ventricles were also enlarged. …”

Inhibition of β-glucocerebrosidase activity preserves motor unit integrity in a mouse model of amyotrophic lateral sclerosis by Henriques, A, Huebecker, M, Blasco, H, Keime, C, Andres, C, Corcia, P, Priestman, D, Platt, F, Spedding, M, Loeffler, J

“…We report here altered levels of gangliosides in the cerebrospinal fluid of amyotrophic lateral sclerosis patients in early disease stage. …”

Effect of antituberculosis drug resistance on response to treatment and outcome in adults with tuberculous meningitis. by Thwaites, G, Lan, N, Dung, N, Quy, H, Oanh, D, Thoa, N, Hien, N, Thuc, N, Hai, N, Bang, N, Lan, N, Duc, N, Tuan, V, Hiep, C, Chau, T, Mai, P, Dung, N, Stepniewska, K, White, N, Hien, T, Farrar, J

“…M. tuberculosis was cultured from the cerebrospinal fluid (CSF) of all patients and was tested for susceptibility to first-line antituberculosis drugs. …”

White matter hyperintensities are associated with disproportionate progressive hippocampal atrophy. by Fiford, C, Manning, E, Bartlett, J, Cash, D, Malone, I, Ridgway, G, Lehmann, M, Leung, K, Sudre, C, Ourselin, S, Biessels, G, Carmichael, O, Fox, N, Cardoso, M, Barnes, J

“…This study investigates relationships between white matter hyperintensity (WMH) volume, cerebrospinal fluid (CSF) Alzheimer's disease (AD) pathology markers, and brain and hippocampal volume loss. …”

Synaptic protein CSF levels relate to memory scores in individuals without dementia by Wesenhagen, KEJ, de Leeuw, DM, Tomassen, J, Gobom, J, Bos, I, Vos, SJB, Martinez-Lage, P, Tainta, M, Popp, J, Peyratout, G, Tsolaki, M, Vandenberghe, R, Freund-Levi, Y, Verhey, F, Lovestone, S, Streffer, J, Dobricic, V, Blennow, K, Scheltens, P, Smit, AB, Bertram, L, Teunissen, CE, Zetterberg, H, Tijms, BM

“…Background: We investigated how cerebrospinal fluid levels of synaptic proteins associate with memory function in normal cognition (CN) and mild cognitive impairment (MCI), and investigated the effect of amyloid positivity on these associations. …”

The membrane chamber: a new type of in vitro recording chamber. by Hill, MR, Greenfield, S

“…The membrane allows for a fast flow of artificial cerebrospinal fluid of up to at least 17 ml/min. Due to a Bernoulli effect, this high speed flow also causes a 64% increase in flow of solution across the membrane on which the slice rests. …”

Invasive Cronobacter species infection in infants and children admitted to a rural Kenyan hospital with a high prevalence of malnutrition by Piper, J, Mwarumba, S, Ngari, M, Mvera, B, Morpeth, S, Berkley, J

“…The KEMRI/Wellcome Trust Research Programme has conducted systematic surveillance for invasive bacterial infections among children admitted to Kilifi County Hospital, Kenya since 1998. 65,426 paediatric blood and cerebrospinal fluid cultures from 52,733 admissions resulted in 3953 with growth of a pathogenic organism. …”

Immune-mediated steroid-responsive epileptic spasms and epileptic encephalopathy associated with VGKC-complex antibodies. by Suleiman, J, Brenner, T, Gill, D, Troedson, C, Sinclair, A, Brilot, F, Vincent, A, Lang, B, Dale, R

“…She had evidence of immune activation in the central nervous system with elevated cerebrospinal fluid neopterin and mirrored oligoclonal bands, which prompted testing for autoantibodies. …”

Mimics and chameleons in Guillain-Barre and Miller Fisher syndromes. by Wakerley, B, Yuki, N

“…The presence of cerebrospinal fluid albuminocytological dissociation (raised protein, normal cell count), antiganglioside antibodies and neurophysiological evidence of axonal or demyelinating neuropathy also support a diagnosis in many cases, but should not be relied upon. …”

Development of screening guidelines and clinical criteria for predementia Alzheimer's disease. The DESCRIPA Study. by Visser, P, Verhey, F, Boada, M, Bullock, R, De Deyn, P, Frisoni, G, Frolich, L, Hampel, H, Jolles, J, Jones, R, Minthon, L, Nobili, F, Olde Rikkert, M, Ousset, P, Rigaud, A, Scheltens, P, Soininen, H, Spiru, L, Touchon, J, Tsolaki, M, Vellas, B, Wahlund, L, Wilcock, G, Winblad, B

“…At baseline, a number of markers and risk factors for AD were collected, including demographic variables, measures of performance in activities of daily living, cognitive, neuroimaging and genetic markers, and serum and cerebrospinal fluid markers. Subjects will be reassessed annually for 2-3 years, and we will evaluate which combination of variables best predicts AD-type dementia at follow-up. …”

Steroid-responsive recurrent limbic encephalitis associated with small cell lung cancer and neuropil antibodies. by Tüzün, E, Yaka, E, Zuliani, L, Içöz, S, Baklan, B, Birişik, O, Kurd, P, Akman-Demir, G, Vincent, A, Akdal, G

“…However, the patient's serum and cerebrospinal fluid IgG, obtained during both exacerbations, immunolabeled cytoplasm and dendrites of Purkinje cells, cerebellar and hippocampal molecular layers, basal ganglia, thalamus, and the surface of cultured hippocampal neurons, in a manner distinct from previously identified neuropil antibodies associated with SCLC. …”

Point-of-Care approaches for meningitis diagnosis in a low-resource setting (Southwestern Uganda) : observational cohort study protocol of the "PI-POC" trial by Gaudenzi, Giulia, Kumbakumba, Elias, Rasti, Reza, Nanjebe, Deborah, Réu, Pedro, Nyehangane, Dan, Mårtensson, Andreas, Nassejje, Milly, Karlsson, Jens, Mzee, John, Nilsson, Peter, Businge, Stephen, Loh, Edmund, Yap, Boum II, Andersson-Svahn, Helene, Gantelius, Jesper, Mwanga-Amumpaire, Juliet, Alfvén, Tobias

“…Participants are recruited at 2 Pediatric clinics in Mbarara, Uganda. Cerebrospinal fluid (for cases only), blood, and nasopharyngeal (NP) swabs (for both cases and controls) sampled at both clinics are analyzed at the Epicentre Research Laboratory through gold-standard methods for CNS infection diagnosis (microscopy, biochemistry, and culture) and a commercially available ME panel for multiplex PCR analyses of the cerebrospinal fluid. …”
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