Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases حسب Prakadan, Sanjay M, Alvarez-Breckenridge, Christopher A, Markson, Samuel C, Kim, Albert E, Klein, Robert H, Nayyar, Naema, Navia, Andrew W, Kuter, Benjamin M, Kolb, Kellie E, Bihun, Ivanna, Mora, Joana L, Bertalan, Mia Solana, Shaw, Brian, White, Michael, Kaplan, Alexander, Stocking, Jackson H, Wadsworth, Marc H, Lee, Eudocia Q, Chukwueke, Ugonma, Wang, Nancy, Subramanian, Megha, Rotem, Denisse, Cahill, Daniel P, Adalsteinsson, Viktor A, Miller, Jeffrey W, Sullivan, Ryan J, Carter, Scott L, Brastianos, Priscilla K, Shalek, Alex K

"…Here, we investigate the cellular and molecular features underpinning observed patient trajectories in these trials by applying single-cell RNA and cell-free DNA profiling to longitudinal cerebrospinal fluid (CSF) draws from enrolled patients. …"
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Functional connectivity MRI quality control procedures in CONN حسب Morfini, Francesca, Whitfield-Gabrieli, Susan, Nieto-Castañón, Alfonso

"…Data denoising was performed based on the combination of scrubbing, motion regression, and aCompCor – a principal component characterization of noise from minimally eroded masks of white matter and of cerebrospinal fluid tissues. Participant-level QC procedures included visual inspection of raw-level data and of representative images after each preprocessing step for each run, as well as the computation of automated descriptive QC measures such as average framewise displacement, average global signal change, prevalence of outlier scans, MNI to anatomical and functional overlap, anatomical to functional overlap, residual BOLD timeseries variability, effective degrees of freedom, and global correlation strength. …"
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A Soft Robotic Actuator System for In Vivo Modeling of Normal Pressure Hydrocephalus حسب Flürenbrock, Fabian, Rosalia, Luca, Podgoršak, Anthony, Sapozhnikov, Katherina, Trimmel, Nina Eva, Weisskopf, Miriam, Oertel, Markus Florian, Roche, Ellen, Zeilinger, Melanie N., Korn, Leonie, Daners, Marianne Schmid

"…The intracranial pressure (ICP) affects the dynamics of cerebrospinal fluid (CSF) and its waveform contains information that is of clinical importance in medical conditions such as hydrocephalus. …"
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Evaluating the effect of rapamycin treatment in Alzheimer’s disease and aging using in vivo imaging: the ERAP phase IIa clinical study protocol حسب Svensson, Jonas E., Bolin, Martin, Thor, Daniel, Williams, Pete A., Brautaset, Rune, Carlsson, Marcus, Sörensson, Peder, Marlevi, David, Spin-Neto, Rubens, Probst, Monika, Hagman, Göran, Morén, Anton Forsberg, Kivipelto, Miia, Plavén-Sigray, Pontus

"…Secondary endpoints include changes in cognitive measures, markers in cerebrospinal fluid as well as cerebral blood flow measured using magnetic resonance imaging. …"
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Applying the Kelvin probe to biological tissues: Theoretical and computational analyses حسب Grodzinsky, Alan J., Ahn, Andrew C., Baikie, Iain D., Gow, Brian J., Martinsen, Ørjan G., Zhao, Min

"…These theoretically derived equations are then computationally analyzed using parameters from both theoretical specimens and actual biomaterials—including wet skin, dry skin, cerebrospinal fluid, and tendon. Based on these analyses, a Kelvin probe performs in two distinct ways depending on the charge relaxation rates of the sample: The specimen is treated either as a perfect dielectric or as highly conductive material. …"
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Multiple roles for the Na,K-ATPase subunits, Atp1a1 and Fxyd1, during brain ventricle development حسب Chang, Jessica T., Lowery, Laura Anne, Sive, Hazel L.

"…Formation of the vertebrate brain ventricles requires both production of cerebrospinal fluid (CSF), and its retention in the ventricles. …"
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Amyloid β chaperone — lipocalin-type prostaglandin D synthase acts as a peroxidase in the presence of heme حسب Phillips, Margaret, Kannaian, Bhuvaneswari, Ng, Justin Tze-Yang, Kather, Ralf, Mu, Yuguang, Harmer, Jeffrey R., Pervushin, Konstantin

"…In addition to the transporter function, L-PGDS is a key amyloid β chaperone in human cerebrospinal fluid. The presence of high levels of bilirubin and its derivatives, implicated in Alzheimer's disease, by binding to L-PGDS may reduce its chaperone activity. …"
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Early‑onset neonatal sepsis and antibiotic use in Indonesia: a descriptive, cross‑sectional study حسب Salsabila, Khansa, Toha, Nadira Mohammad Ali, Rundjan, Lily, Pattanittum, Porjai, Sirikarn, Prapassara, Rohsiswatmo, Rinawati, Wandita, Setya, Hakimi, Mohammad, Lumbiganon, Pagakrong, Green, Sally, Turner, Tari

"…Culture-proven EOS was defined as positive blood or cerebrospinal fluid culture. Type and duration of antibiotics used were also documented. …"
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Paediatric autoimmune encephalopathies: clinical features, laboratory investigations and outcomes in patients with or without antibodies to known central nervous system autoantigen... حسب Hacohen, Y, Wright, S, Waters, P, Agrawal, S, Carr, L, Cross, H, De Sousa, C, Devile, C, Fallon, P, Gupta, R, Hedderly, T, Hughes, E, Kerr, T, Lascelles, K, Lin, J, Philip, S, Pohl, K, Prabahkar, P, Smith, M, Williams, R, Clarke, A, Hemingway, C, Wassmer, E, Vincent, A, Lim, M

"…An acute infective organism (15%) or abnormal cerebrospinal fluid (32%), EEG (70%) or MRI (37%) abnormalities were found. …"

Adjunctive dexamethasone in HIV-associated cryptococcal meningitis حسب Beardsley, J, Wolbers, M, Kibengo, F, Ggayi, A, Kamali, A, Cuc, N, Binh, T, Chau, N, Farrar, J, Merson, L, Phuong, L, Thwaites, G, Van Kinh, N, Thuy, P, Chierakul, W, Siriboon, S, Thiansukhon, E, Onsanit, S, Supphamongkholchaikul, W, Chan, A, Heyderman, R, Mwinjiwa, E, van Oosterhout, J, Imran, D, Basri, H, Mayxay, M, Dance, D, Phimmasone, P, Rattanavong, S, Lalloo, D, Day, J

"…Fungal clearance in cerebrospinal fluid was slower in the dexamethasone group. …"

Enterovirus and parechovirus meningitis in infants younger than 90 days old in the UK and Republic of Ireland: a British Paediatric Surveillance Unit study حسب Kadambari, S, Braccio, S, Ribeiro, S, Allen, DJ, Pebody, R, Brown, D, Cunney, R, Sharland, M, Ladhani, S

"…Nearly all cases (678/703, 96%) were confirmed by cerebrospinal fluid (CSF) PCR, with 52% (309/600) having normal CSF white cell count for age. …"

CDH6 and HAGH protein levels in plasma associate with Alzheimer’s disease in APOE ε4 carriers حسب Ahmad, S, del Campo Milan, M, Hansson, O, Demirkan, A, Agustin, R, Sáez, ME, Giagtzoglou, N, Cabrera-Socorro, A, Bakker, MHM, Ramirez, A, Hankemeier, T, Stomrud, E, Mattsson-Carlgren, N, Scheltens, P, van der Flier, WM, Ikram, MA, Malarstig, A, Teunissen, CE, Amin, N, van Duijn, CM

"…We further evaluated the correlation of these protein biomarkers with total tau (t-tau), phosphorylated tau (p-tau) and amyloid-beta (Aβ) 42 levels in cerebrospinal fluid (CSF) in the Amsterdam Dementia Cohort (N = 441). …"

Magnetic resonance imaging of cerebrovascular anatomy and physiology at 7 Tesla حسب Viessmann, O

"…The readout scheme was specifically optimised for high resolution wall depiction and enhanced suppression of cerebrospinal fluid to produce vessel wall contrast in the major intracranial arteries at 7T. …"

Orientia, rickettsia, and leptospira pathogens as causes of CNS infections in Laos: a prospective study حسب Dittrich, S, Rattanavong, S, Lee, SJ, Panyanivong, P, Craig, SB, Tulsiani, SM, Blacksell, SD, Dance, DAB, Dubot-Pérès, A, Sengduangphachanh, A, Phoumin, P, Paris, DH, Newton, PN

"…Microbiological examinations (culture, PCR, and serology) targeted so-called conventional bacterial infections (Streptococcus pneumoniae, Neisseria meningitidis, Haemophilus influenzae, S suis) and O tsutsugamushi, Rickettsia typhi/Rickettsia spp, and Leptospira spp infections in blood or cerebrospinal fluid (CSF). We analysed and compared causes and clinical and CSF characteristics between patient groups. …"

Decline of meticillin-resistant Staphylococcus aureus in Oxfordshire hospitals is strain-specific and preceded infection-control intensification حسب Wyllie, D, Walker, A, Miller, R, Moore, C, Williamson, SR, Schlackow, I, Finney, J, O'Connor, L, Peto, T, Crook, D

"…Isolation rates were modelled using segmented negative binomial regression for three groups of isolates: from blood cultures, from samples suggesting invasion (eg, cerebrospinal fluid, joint fluid, pus samples) and from surface swabs (eg, from wounds). …"

Paediatric autoimmune encephalopathies: Clinical features, laboratory investigations and outcomes in patients with or without antibodies to known central nervous system autoantigen... حسب Hacohen, Y, Wright, S, Waters, P, Agrawal, S, Carr, L, Cross, H, De Sousa, C, DeVile, C, Fallon, P, Gupta, R, Hedderly, T, Hughes, E, Kerr, T, Lascelles, K, Lin, J, Philip, S, Pohl, K, Prabahkar, P, Smith, M, Williams, R, Clarke, A, Hemingway, C, Wassmer, E, Vincent, A, Lim, M

"…An acute infective organism (15%) or abnormal cerebrospinal fluid (32%), EEG (70%) or MRI (37%) abnormalities were found. …"

Human brain acetylcholinesterase حسب Novales-Li, P

"…Chromatofocussing showed caudate nucleus and cerebrospinal fluid (CSF) AChE eluting between isoelectric points (pi) of 5.2 - 5.57, whilst isoelectric focussing (IEF) revealed heterogeneous AChE isoforms migrating between pI 4.5 - 6. …"

Gene therapy restores dopamine transporter expression and ameliorates pathology in iPSC and mouse models of infantile parkinsonism حسب Ng, J, Barral, S, De La Fuente Barrigon, C, Lignani, G, Erdem, FA, Wallings, R, Privolizzi, R, Rossignoli, G, Alrashidi, H, Heasman, S, Meyer, E, Ngoh, A, Pope, S, Karda, R, Perocheau, D, Baruteau, J, Suff, N, Antinao Diaz, J, Schorge, S, Vowles, J, Marshall, LR, Cowley, SA, Sucic, S, Freissmuth, M, Counsell, JR, Wade-Martins, R, Heales, SJR, Rahim, AA, Bencze, M, Waddington, SN, Kurian, MA

"…Patients present with early infantile hyperkinesia, severe progressive childhood parkinsonism, and raised cerebrospinal fluid dopamine metabolites. The absence of effective treatments and relentless disease course frequently leads to death in childhood. …"

Assessment of physiological noise modelling methods for functional imaging of the spinal cord. حسب Kong, Y, Jenkinson, M, Andersson, J, Tracey, I, Brooks, J

"…Two general techniques were compared: physiological noise model (PNM) and selective averaging filter (SAF), along with regressors designed to account for specific signal compartments and physiological processes: cerebrospinal fluid (CSF), motion correction (MC) parameters, heart rate (HR), respiration volume per time (RVT), and the associated cardiac and respiratory response functions. …"

Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson’s disease حسب Huebecker, M, Moloney, EB, van der Spoel, AC, Priestman, DA, Isacson, O, Hallett, PJ, Platt, FM

"…In addition, glycosphingolipid levels in cerebrospinal fluid and serum were analysed as possible biomarkers for PD.…"