A randomised double blind placebo controlled phase 2 trial of adjunctive aspirin for tuberculous meningitis in HIV-uninfected adults حسب Mai, N, Day, J, Dobbs, N, Phu, N, Colas, R, Thao, L, Thuong, N, Nghia, H, Hanh, N, Hang, N, Heemskerk, A, Ly, L, Thu, D, Thwaites, G, Kestelyn, E, Merson, L, Wolbers, M, Wolbers, M, Geskus, G, Dalli, J, Summers, D

"…Secondary endpoints included 8-month survival and neuro-disability; the number of grade 3&4 and serious adverse events; and cerebrospinal fluid (CSF) inflammatory lipid mediator profiles.…"

Deaths attributed to respiratory syncytial virus in young children in high–mortality rate settings: report from child health and mortality prevention surveillance (CHAMPS) حسب Blau, DM, Baillie, VL, Els, T, Mahtab, S, Mutevedzi, P, Keita, AM, Kotloff, KL, Mehta, A, Sow, SO, Tapia, MD, Tippett Barr, BA, Oluoch, BO, Onyango, C, Revathi, G, Verani, JR, Abayneh, M, Assefa, N, Madrid, L, Oundo, JO, Scott, JAG, Bassat, Q, Mandomando, I, Sitoe, A, Valente, M, Varo, R, Bassey, I-A, Cain, CJ, Jambai, A, Ogbuanu, I, Ojulong, J, Alam, M, El Arifeen, S, Gurley, ES, Rahman, A, Rahman, M, Waller, JL, Dewey, B, Breiman, RF, Whitney, CG, Madhi, SA

"…Panels determined causes of deaths by reviewing all available data including pathological results from minimally invasive tissue sampling, polymerase chain reaction screening for multiple infectious pathogens in lung tissue, nasopharyngeal swab, blood, and cerebrospinal fluid samples, clinical information from medical records, and verbal autopsies. …"

Increased interleukin-6 correlates with myelin oligodendrocyte glycoprotein antibodies in pediatric monophasic demyelinating diseases and multiple sclerosis حسب Horellou, P, Wang, M, Keo, V, Chrétien, P, Serguera, C, Waters, P, Deiva, K

"…Recently, in adult NMO patients, C5a levels were shown to be elevated in cerebrospinal fluid (CSF) during acute exacerbation. We investigated the CSF levels of anaphylatoxins and pro-inflammatory cytokines, and plasma MOG antibodies in onset samples from children with ADS. …"

Central role of JC virus-specific CD4+ lymphocytes in progressive multi-focal leucoencephalopathy-immune reconstitution inflammatory syndrome. حسب Aly, L, Yousef, S, Schippling, S, Jelcic, I, Breiden, P, Matschke, J, Schulz, R, Bofill-Mas, S, Jones, L, Demina, V, Linnebank, M, Ogg, G, Girones, R, Weber, T, Sospedra, M, Martin, R

"…Due to initially negative JC viral deoxyribonucleic acid testing in the cerebrospinal fluid, a diagnostic brain biopsy was performed in one patient. …"

Biological effects of sodium phenylbutyrate and taurursodiol in Alzheimer's disease حسب Arnold, SE, Hendrix, S, Nicodemus‐Johnson, J, Knowlton, N, Williams, VJ, Burns, JM, Crane, M, McManus, AJ, Vaishnavi, SN, Arvanitakis, Z, Neugroschl, J, Bell, K, Trombetta, BA, Carlyle, BC, Kivisäkk, P, Dodge, HH, Tanzi, RE, Yeramian, PD, Leslie, K

"…Secondary clinical outcomes included various cognitive, functional, and neuropsychiatric assessments. Cerebrospinal fluid (CSF) biomarkers spanning multiple pathophysiological pathways in AD were evaluated in participants with both baseline and Week 24 samples (exploratory outcome). …"

The adult neural stem cell niche in ischaemic stroke حسب Young, C

"…This was associated with focal planar cell polarity misalignment, and turbulent and decreased rate of cerebrospinal fluid flow. These findings demonstrate significant changes in multiple SVZ cell types which are positioned to influence post-stroke neurogenesis and regulation of the neural stem cell niche</p> <p>Gal-3 was up-regulated in the ischaemic brain and ipsilateral SVZ. …"

Field evaluation of two rapid diagnostic tests for Neisseria meningitidis serogroup A during the 2006 outbreak in Niger. حسب Rose, A, Gerstl, S, Mahamane, A, Sidikou, F, Djibo, S, Bonte, L, Caugant, D, Guerin, P, Chanteau, S

"…Earlier evaluations, performed after heating and centrifugation of cerebrospinal fluid (CSF) samples, under good laboratory conditions, showed high sensitivity and specificity. …"

Phenytoin pharmacokinetics and clinical effects in African children following fosphenytoin and chloramphenicol coadministration. حسب Ogutu, B, Newton, C, Muchohi, SN, Otieno, G, Kokwaro, G

"…Blood pressure, heart rate, respiratory rate, oxygen saturation, level of consciousness and convulsion episodes were monitored. Cerebrospinal fluid (CSF) and plasma phenytoin concentrations were determined. …"

Plasma protein biomarkers for the prediction of CSF amyloid and tau and [18F]-flutemetamol PET scan result حسب Westwood, S, Baird, AL, Hye, A, Ashton, NJ, Nevado-Holgado, AJ, Anand, SN, Liu, B, Newby, D, Bazenet, C, Kiddle, SJ, Ward, M, Newton, B, Desai, K, Hehir, C, Zanette, M, Galimberti, D, Parnetti, L, Lleó, A, Baker, S, Narayan, VA, Van Der Flier, WM, Scheltens, P, Teunissen, CE, Visser, PJ, Lovestone, S

"…<strong>Background:</strong> Blood biomarkers may aid in recruitment to clinical trials of Alzheimer’s disease (AD) modifying therapeutics by triaging potential trials participants for amyloid positron emission tomography (PET) or cerebrospinal fluid (CSF) Aβ and tau tests. <strong>Objective:</strong> To discover a plasma proteomic signature associated with CSF and PET measures of AD pathology. …"

The PREVENT dementia programme: baseline demographic, lifestyle, imaging and cognitive data from a midlife cohort study investigating risk factors for dementia حسب Ritchie, CW, Bridgeman, K, Gregory, S, O’Brien, JT, Danso, SO, Dounavi, M, Carriere, I, Driscoll, D, Hillary, R, Koychev, I, Lawlor, B, Naci, L, Su, L, Low, A, Mak, E, Malhotra, P, Manson, J, Marioni, R, Murphy, L, Ntailianis, G, Stewart, W, Muniz-Terrera, G, Ritchie, K

"…Participants in the PREVENT cohort provide demographic data, biological samples (blood, saliva, urine and optional cerebrospinal fluid), lifestyle and psychological questionnaires, undergo a comprehensive cognitive test battery and are imaged using multi-modal 3-T MRI scanning, with both structural and functional sequences. …"

Diagnostic accuracy of fetal choroid plexus length to head biometry ratio at 11 to 13 weeks for open spina bifida حسب Kalafat, E, Ting, L, Thilaganathan, B, Papageorghiou, AT, Khalil, A

"…The ratio reflects the so-called dry brain effect caused by cerebrospinal fluid leakage and expansion of the choroid plexus into the lateral ventricles. …"

Partial Cyst Resection, Fabrication, Imbrication and Duraplasty of Symptomatic Sacral Tarlov Cysts حسب Loh, Li Loong, Zamzuri Zakaria Mohamad, Mohamed Saufi Awang, Muhammad Wafiuddin Ahmad

"…Tarlov cysts are pathological cerebrospinal fluid-filled sacs located in the space between the perineum and endoneurium of the nerve roots. …"
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Clinical Prediction from Structural Brain MRI Scans: A Large-Scale Empirical Study حسب Konukoglu, Ender, Sabuncu, Mert R

"…We employed three classes of state-of-the-art MVPA algorithms and common types of structural measurements from brain Magnetic Resonance Imaging (MRI) scans to predict an array of clinically relevant variables (diagnosis of Alzheimer’s, schizophrenia, autism, and attention deficit and hyperactivity disorder; age, cerebrospinal fluid derived amyloid-β levels and mini-mental state exam score). …"
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MRI based cerebral oxygenation measures in humans : technical development for use across lifespan حسب Stout, Jeffrey Neil

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State-space Modeling of Neural Oscillations: Toward Assessing Alzheimer’s Disease Neuropathology with Sleep EEG حسب He, Mingjian

"…Third, a semi-automated pipeline is developed to build realistic four-layer forward models including the cerebrospinal fluid in each individual to account for cortical atrophy. …"
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The formation and function of the brain ventricular system حسب Chang, Jessica T. (Jessica Tzung-Min)

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Amyloid-tau-neurodegeneration profiles and longitudinal cognition in sporadic young-onset dementia حسب Vipin, Ashwati, Koh, Chen Ling, Wong, Benjamin Yi Xin, Zailan, Fatin Zahra, Tan, Jayne Yi, Soo, See Ann, Satish, Vaynii, Kumar, Dilip, Wang, Brian Zhiyang, Ng, Adeline Su Lyn, Chiew, Hui Jin, Ng, Kok Pin, Kandiah, Nagaendran

"…They were stratified into A+N+, A- N+, and A- N- profiles via cerebrospinal fluid amyloid-β1-42 (A), phosphorylated-tau (T), MRI medial temporal atrophy (neurodegeneration- N), and confluent white matter hyperintensities cerebrovascular disease (CVD). …"
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Mass spectrometry imaging highlights dynamic patterns of lipid co-expression with Aβ plaques in mouse and human brains حسب Huang, Helen Xuexia, Inglese, Paolo, Tang, Jiabin, Yagoubi, Riad, Correia, Gonçalo D. S., Horneffer-van der Sluis, Verena M., Camuzeaux, Stephane, Wu, Vincen, Kopanitsa, Maksym V., Willumsen, Nanet, Jackson, Johanna S., Barron, Anna M., Saito, Takashi, Saido, Takaomi C., Gentlemen, Steve, Takats, Zoltan, Matthews, Paul M.

"…Lipids play crucial roles in the susceptibility and brain cellular responses to Alzheimer's disease (AD) and are increasingly considered potential soluble biomarkers in cerebrospinal fluid (CSF) and plasma. To delineate the pathological correlations of distinct lipid species, we conducted a comprehensive characterization of both spatially localized and global differences in brain lipid composition in AppNL-G-F mice with spatial and bulk mass spectrometry lipidomic profiling, using human amyloid-expressing (h-Aβ) and WT mouse brains controls. …"
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Neuronal antibodies in pediatric epilepsy: Clinical features and long-term outcomes of a historical cohort not treated with immunotherapy. حسب Wright, S, Geerts, A, Jol-van der Zijde, C, Jacobson, L, Lang, B, Waters, P, van Tol, M, Stroink, H, Neuteboom, R, Brouwer, O, Vincent, A

"…All sera were tested for serum N-methyl-d-aspartate receptor (NMDAR), alpha amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor, leucine rich glioma inactivated 1, contactin associated protein like 2 (CASPR2), contactin-2, glutamic acid decarboxylase, and voltage gated potassium channel (VGKC)-complex antibodies by standard techniques. No cerebrospinal fluid (CSF) samples were available. Results were correlated with clinical data collected over 15 years.Seventeen patients (9.5%) were positive for VGKC complex (n = 3), NMDAR (n = 7), CASPR2 (n = 4), and contactin-2 (n = 3), compared to three (3/112; 2.6%) healthy controls (VGKC complex [n = 1], NMDAR [n = 2]; p = 0.03; Fisher's exact test). …"

Pharmacokinetics and clinical effect of phenobarbital in children with severe falciparum malaria and convulsions. حسب Kokwaro, G, Ogutu, B, Muchohi, SN, Otieno, G, Newton, C

"…Vital signs were monitored. Plasma and cerebrospinal fluid (CSF) phenobarbital concentrations were measured with an Abbott TDx FLx fluorescence polarisation immunoassay analyser (Abbott Laboratories, Diagnostic Division, Abbott Park, IL, USA). …"