Targeted sequencing from cerebrospinal fluid for rapid identification of drug-resistant tuberculous meningitis Tekijä Tram, TTB, Trieu, LPT, Nhat, LTH, Thu, DDA, Quang, NL, Bang, ND, Chau, TTH, Thwaites, GE, Walker, TM, Ha, VTN, Thuong, NTT

“…We applied Deeplex Myc-TB-a tNGS assay-to cerebrospinal fluid (CSF) samples from 72 adults with microbiologically confirmed TBM and compared its genomic drug susceptibility predictions to a composite reference standard of phenotypic susceptibility testing (pDST) and whole genome sequencing, as well as to clinical outcomes. …”

Juvenile-onset normal tension glaucoma from chronic, recurrent low cerebrospinal fluid pressure. Tekijä Yusuf, I, Ratnarajan, G, Kerr, R, Salmon, J

“… <h4>Introduction</h4> <p>The evidence for low cerebrospinal fluid pressure (CSFP) as a key parameter in the pathogenesis of glaucoma is increasing. …”

Proresolving mediator profiles in cerebrospinal fluid are linked with disease severity and outcome in adults with tuberculous meningitis Tekijä Colas, RA, Nhat, LTH, Thuong, NTT, Gómez, EA, Ly, L, Thanh, HH, Mai, NTH, Phu, NH, Thwaites, GE, Dalli, J

“…Proresolving mediator profiles in cerebrospinal fluid are linked with disease severity and outcome in adults with tuberculous meningitis.…”

Immune activation and HIV-specific CD8+ T cells in cerebrospinal fluid of HIV controllers and noncontrollers Tekijä Ganesh, A, Lemongello, D, Lee, E, Peterson, J, McLaughlin, B, Ferre, A, Gillespie, G, Fuchs, D, Deeks, S, Hunt, P, Price, R, Spudich, S, Shacklett, B

“…The central nervous system (CNS) is an important target of HIV, and cerebrospinal fluid (CSF) can provide a window into host–virus interactions within the CNS. …”

Cerebrospinal fluid/serum gradient of IgG is associated with disability at acute attacks of neuromyelitis optica. Tekijä Kim, S, Waters, P, Vincent, A, Go, M, Park, K, Sung, J, Lee, K

“…The purpose of the study was to evaluate the clinical significance of BBB disruption and the subsequent cerebrospinal fluid (CSF)/serum IgG gradient in NMO. Retrospective analysis was made of acute-stage CSF samples from NMO (n = 40) and multiple sclerosis (MS; n = 26) patients. …”

Proteins of rat serum, urine, and cerebrospinal fluid: VI. Further protein identifications and interstrain comparison. Tekijä Wait, R, Gianazza, E, Eberini, I, Sironi, L, Dunn, M, Gemeiner, M, Miller, I

“…We have investigated the biological fluids--serum, cerebrospinal fluid, and urine--of three strains of rats; the present data extend our database (also available on-line) and may be of interest for pharmacological and toxicological investigation. …”

Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections. Tekijä Tan, L, van Doorn, H, Nghia, H, Chau, T, Tu, L, de Vries, M, Canuti, M, Deijs, M, Jebbink, M, Baker, S, Bryant, J, Tham, N, BKrong, N, Boni, M, Loi, T, Phuong, LT, Verhoeven, J, Crusat, M, Jeeninga, R, Schultsz, C, Chau, N, Hien, T, van der Hoek, L, Farrar, J, Jong, d

“…We identified and characterized the full genome of a novel cyclovirus (tentatively named cyclovirus-Vietnam [CyCV-VN]) in cerebrospinal fluid (CSF) specimens of two Vietnamese patients with CNS infections of unknown etiology. …”

Integrative biochemical, proteomics and metabolomics cerebrospinal fluid biomarkers predict clinical conversion to multiple sclerosis Tekijä Probert, F, Yeo, T, Zhou, Y, Sealey, M, Arora, S, Palace, J, Claridge, TDW, Hillenbrand, R, Oechtering, J, Leppert, D, Kuhle, J, Anthony, DC

“…An integrative multi-variate approach was applied to the analysis of cerebrospinal fluid samples taken from 54 individuals at the point of clinically isolated syndrome with 2-10&#x2009;years of subsequent follow-up enabling stratification into clinical converters and non-converters. …”

A unique androgen excess signature in idiopathic intracranial hypertension is linked to cerebrospinal fluid dynamics Tekijä O'Reilly, M, Westgate, C, Hornby, C, Botfield, H, Taylor, A, Markey, K, Mitchell, J, Scotton, W, Mollan, S, Yiangou, A, Jenkinson, C, Gilligan, L, Sherlock, M, Gibney, J, Tomlinson, J, Lavery, G, Hodson, D, Arlt, W, Sinclair, A

“…In this study, we comprehensively examined the systemic and cerebrospinal fluid (CSF) androgen metabolome in women with IIH in comparison with sex-, BMI-, and age-matched control groups with either simple obesity or PCOS (i.e., obesity and androgen excess). …”

Fabrication of nanoemulsion loaded with cefuroxime for efficient translocation across the blood brain barrier Tekijä Harun, Siti Norhawani

Aiheet: “…Meningitis - Cerebrospinal fluid…”
Hae kokoteksti

Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development Tekijä Xu, Huixin, Fame, Ryann M., Sutin, Jason, Naranjo, Christopher, Syau, Della, Cui, Jin, Shipley, Frederick B., Vernon, Amanda, Gao, Fan, Yong, Zhang, Holtzman, Michael J., Heiman, Myriam, Warf, Benjamin C., Lin, Pei-Yi, Lehtinen, Maria K.

“…Cerebrospinal fluid (CSF) provides vital support for the brain. …”
Hae kokoteksti

Identification of SPARC-like 1 protein as part of a biomarker panel for Alzheimer's disease in cerebrospinal fluid. Tekijä Vafadar-Isfahani, B, Ball, G, Coveney, C, Lemetre, C, Boocock, D, Minthon, L, Hansson, O, Miles, A, Janciauskiene, S, Warden, D, Smith, A, Wilcock, G, Kalsheker, N, Rees, R, Matharoo-Ball, B, Morgan, K

“…Samples of lumbar cerebrospinal fluid (CSF) from clinically-diagnosed AD cases (n = 33), age-matched controls (n = 20), and mild cognitive impairment (MCI) patients (n = 10) were used to obtain proteomic profiles, followed by bioinformatic analysis that generated a set of potential biomarkers in CSF samples that could discriminate AD cases from controls. …”

Deep proteomics network and machine learning analysis of human cerebrospinal fluid in Japanese encephalitis virus infection Tekijä Bharucha, T, Gangadharan, B, Kumar, A, Myall, A, Ayhan, N, Pastorino, B, Chanthongthip, A, Vongsouvath, M, Mayxay, M, Sengvilaipaseuth, O, Phonemixay, O, Rattanavong, S, O'Brien, D, Vendrell, I, Fischer, R, Kessler, B, Turtle, L, de Lamballerie, X, Dubot-Peres, A, Newton, P, Zitzmann, N

“…We aimed to test the hypothesis of a Japanese encephalitis (JE) protein signature in human cerebrospinal fluid (CSF) that could be harnessed in a rapid diagnostic test (RDT), contribute to understanding the host response and predict outcome during infection. …”

CACNA1H antibodies associated with headache with neurological deficits and cerebrospinal fluid lymphocytosis (HaNDL). Tekijä Kürtüncü, M, Kaya, D, Zuliani, L, Erdağ, E, Içöz, S, Uğurel, E, Cavuş, F, Ayşit, N, Birişik, O, Vincent, A, Eraksoy, M, Vural, B, Akman-Demir, G, Tüzün, E

“… BACKGROUND: Patients with the syndrome of headache with neurological deficits and lymphocytosis (HaNDL) typically present with recurrent and temporary attacks of neurological symptoms and cerebrospinal fluid lymphocytosis. AIM AND METHODS: To identify potential HaNDL-associated antibodies directed against neuronal surface and/or synapse antigens, sera of four HaNDL patients and controls were screened with indirect immunohistochemistry, immunofluorescence, cell-based assay, radioimmunoassay, protein macroarray and enzyme-linked immunosorbent assay (ELISA). …”

Direct detection of the multidrug resistance genome of Haemophilus influenzae in cerebrospinal fluid of children: implications for treatment of meningitis. Tekijä Saha, S, Darmstadt, G, Baqui, A, Islam, N, Qazi, S, Islam, M, El Arifeen, S, Santosham, M, Black, R, Crook, D

Distinguishing neurosarcoidosis from multiple sclerosis based on cerebrospinal fluid analysis: A retrospective cohort study Tekijä Arun, T, Pattison, L, Palace, J

The effect of head orientation on subarachnoid cerebrospinal fluid distribution and its implications for neurophysiological modulation and recording techniques. Tekijä Bijsterbosch, J, Lee, K, Hunter, MD, Wilkinson, I, Farrow, T, Barker, A, Woodruff, P

“…Gravitational forces may lead to local changes in subarachnoid cerebrospinal fluid (CSF) layer thickness, which has important implications for neurophysiological modulation and recording techniques. …”

How many patients with anti-JEV IgM in cerebrospinal fluid really have Japanese encephalitis? Tekijä Dubot-Pérès, A, Sengvilaipaseuth, O, Chanthongthip, A, Newton, P, de Lamballerie, X

Association of altered liver enzymes with Alzheimer disease diagnosis, cognition, neuroimaging measures, and cerebrospinal fluid biomarkers Tekijä Nho, K, Kueider-Paisley, A, Ahmad, S, Mahmoudiandehkordi, S, Arnold, M, Risacher, S, Louie, G, Blach, C, Baillie, R, Han, X, Kastenmüller, G, Trojanowski, J, Shaw, L, Weiner, M, Doraiswamy, P, Van Duijn, C, Saykin, A, Kaddurah-Daouk, R

“…Design, Setting, and Participants:In this cohort study, serum-based liver function markers were measured from September 1, 2005, to August 31, 2013, in 1581 AD Neuroimaging Initiative participants along with cognitive measures, cerebrospinal fluid (CSF) biomarkers, brain atrophy, brain glucose metabolism, and amyloid-β accumulation. …”

Meta-transcriptomic identification of hepatitis B virus in cerebrospinal fluid in patients with central nervous system disease Tekijä Pettersson, J, Piorkowski, G, Mayxay, M, Rattanavong, S, Vongsouvath, M, Davong, V, Alfsnes, K, Eldholm, V, De Lamballerie, X, Holmes, E, Newton, P, Dubot-Pérès, A

“…Using RNA sequencing, we aimed to identify microbes present in cerebrospinal fluid (CSF) of two patients suffering CNS infection, previously diagnosed with Cryptococcus sp. and Streptococcus pneumoniae infection, respectively. …”