Molecular mechanisms of cerebrospinal fluid production. by Brown, P, Davies, S, Speake, T, Millar, I

“…The epithelial cells of the choroid plexuses secrete cerebrospinal fluid (CSF), by a process which involves the transport of Na(+), Cl(-) and HCO(3)(-) from the blood to the ventricles of the brain. …”

Optimisation of ExoCounter technology for use in cerebrospinal fluid and investigation of placenta-derived exosomes within cerebrospinal fluid by Davies, B

“…This project did not find evidence that placenta-derived exosomes are present in cerebrospinal fluid. No difference was seen in plasma or cerebrospinal fluid counts between the three clinical groups, but this was affected by small samples sizes and unmatched gestational age between groups. …”

Parameter estimations for the cerebrospinal fluid infusion test by Eisentrager, A, Sobey, I, Czosnyka, M

Parameter estimations for cerebrospinal fluid infusion test by Eisentraeger, A, Sobey, I, Czosnyka, M

“…We consider a single compartment model for a cerebrospinal fluid infusion test using first, an inverse power law cerebral compliance with constant elastance and second, a more recently developed compliance model with elastance depending on intracranial pressure (ICP). …”

Analysis of the Cerebrospinal Fluid Flow in the Stenosed Aqueduct of Sylvius by H, Edi Azali, A G, Ahmad Lutfi, S, Amir Hamzah, Osman, Kahar, A K, Mohammed Rafiq, Abd. Aziz, Azian, Sa'at@Yusof, Azlin

“…Objective: To analyze cerebrospinal fluid flow through the region of interest i.e.Aqueduct of Sylvius. …”
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Allostasis of cerebral water: modelling the transport of cerebrospinal fluid by Tully, B, Brett Tully

“…</p><p>By modelling the transport of cerebrospinal fluid (CSF) between the ventricular system, cerebral tissue and blood networks, we find that changes to the biophysical properties of the brain (rather than structural changes such as aqueduct obstruction) are capable of producing clinically relevant ventriculomegaly in the absence of any obstruction to CSF flowthrough the ventricular system. …”

Normal-tension glaucoma and low cerebrospinal fluid pressure. by Yusuf, I, Ratnarajan, G, Kerr, R, Salmon, J

“…We can report that since the implantation of the ProGAV cerebrospinal fluid (CSF) shunt, his recurrent left optic disc hemorrhages have not recurred. …”

Molecular typing of bacteria directly from cerebrospinal fluid. by Enright, M, Knox, K, Griffiths, D, Crook, D, Spratt, BG

“…Using Streptococcus pneumoniae as an example, the ability of multilocus sequence typing (MLST) to characterise isolates directly from cerebrospinal fluid (CSF) was investigated. A nested multiplex polymerase chain reaction method that amplifies the seven housekeeping gene fragments used for pneumococcal MLST was applied to 30 CSF samples from suspected cases of bacterial meningitis. …”

Cerebrospinal fluid macrophage biomarkers in amyotrophic lateral sclerosis by Thompson, A, Gray, E, Thézénas, M, Charles, P, Evetts, S, Hu, M, Talbot, K, Fischer, R, Kessler, B, Turner, M

“…We sought to use a high-throughput proteomic method to identify novel biomarkers in individual cerebrospinal fluid samples. </p><p><b>Methods:</b> Liquid chromatography-tandem mass spectrometry with label-free quantification was used to identify cerebrospinal fluid proteins using samples from a well-characterised longitudinal cohort comprising patients with ALS (n=43), the upper motor neuron variant primary lateral sclerosis (PLS, n=6), cross-sectional healthy (n=20) and disease controls (Parkinsons’s n=20, ALS mimic disorders n=12). …”

Cerebrospinal fluid biomarker development in amyotrophic lateral sclerosis by Thompson, AG

“…The experiments described in this thesis aim to develop novel biomarkers using mass spectrometrybased proteomic analysis of cerebrospinal fluid (CSF) and, to provide improved access to the intracellular compartment of central nervous system (CNS) cells, CSF-derived extracellular vesicles (EVs).…”

Profiling of metalloprotease activities in cerebrospinal fluids of patients with neoplastic meningitis by Conrad, Catharina, Dorzweiler, Kristina, Strik, Herwig, Bartsch, Jörg W., Miller, Miles Aaron, Lauffenburger, Douglas A

“…Identification of malignant involvement of the cerebrospinal fluid (CSF) early in the disease course has crucial prognostic and therapeutic implications, but remains challenging. …”
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Cerebrospinal fluid studies in children with cerebral malaria: an excitotoxic mechanism? by Dobbie, M, Crawley, J, Waruiru, C, Marsh, K, Surtees, R

“…One hypothesis is that activation of microglia and astrocytes in the brain might cause the cerebral symptoms by excitotoxic mechanisms. Cerebrospinal fluid was sampled in 97 Kenyan children with cerebral malaria, 85% within 48 hr of admission. …”

Immunoglobulin and other proteins in the cerebrospinal fluid of patients with Alzheimer's disease. by Chapel, H, Esiri, M, Wilcock, G

“…Immunoglobulin has been measured and studied electrophoretically in cerebrospinal fluid (CSF) from 14 patients with Alzheimer's disease and 25 undemented controls. …”

Frequency of MOG-IgG in cerebrospinal fluid versus serum by Pace, S, Orrell, M, Woodhall, M, Palace, J, Leite, MI, Irani, S, Waters, P, Handel, AE

Pathophysiological and prognostic significance of cerebrospinal-fluid lactate in cerebral malaria. by White, N, Warrell, D, Looareesuwan, S, Chanthavanich, P, Phillips, R, Pongpaew, P

“…Cerebrospinal-fluid (CSF) lactate concentrations were elevated in all but 1 of 45 patients with cerebral malaria. …”

The longitudinal cerebrospinal fluid metabolomic profile of amyotrophic lateral sclerosis. by Gray, E, Larkin, J, Claridge, T, Talbot, K, Sibson, N, Turner, M

“…Metabolomic analysis of cerebrospinal fluid (CSF) using proton nuclear magnetic resonance ((1)H-NMR) spectroscopy is a highly sensitive method capable of revealing nervous system cellular pathology. …”

Total lactate dehydrogenase in cerebrospinal fluid for identification of bacterial meningitis. by Quaglia, A, Karlsson, M, Larsson, M, Taylor, W, Diep, N, Trinh, D, Trung, N, Van Kinh, N, Wertheim, H

Cerebrospinal Fluid Studies in Kenyan Children with Severe Falciparum Malaria. by Mturi, N, Keir, G, Maclennan, C, Ross, A, Willis, A, Elford, B, Berkley, J, Newton, C

“…We measured proteins and amino acids in paired plasma and cerebrospinal fluid (CSF) samples in children with severe falciparum malaria, to assess the integrity of the blood brain barrier (BBB), and look for evidence of intrathecal synthesis of immunoglobulins, excitotoxins and brain damage. …”

The predictive value of cerebrospinal fluid electrophoresis in 'possible' multiple sclerosis. by Moulin, D, Paty, D, Ebers, G

Directional cerebrospinal fluid movement between brain ventricles in larval zebrafish by Hong, Alex, Fame, Ryann M., Chang, Jessica T., Aponte Santiago, Nicole Ann, Sive, Hazel L.

“…Background Cerebrospinal fluid (CSF) contained within the brain ventricles contacts neuroepithelial progenitor cells during brain development. …”
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