Exploring the impact of smartphone addiction on decision-making behavior in college students: an fNIRS study based on the Iowa Gambling Task by Xiaolong Liu, Ruoyi Tian, Xue Bai, Huafang Liu, Tongshu Li, Xinqi Zhou, Yi Lei

“…Notably, the left dlPFC (e.g., channel 4) exhibited significantly higher activation in the addiction group compared to the control group. …”
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Kir4.1 Dysfunction in the Pathophysiology of Depression: A Systematic Review by Stefania Della Vecchia, Maria Marchese, Filippo Maria Santorelli, Federico Sicca

“…Among these, emerging evidence suggests a role for the astrocytic inward rectifier potassium channel 4.1 (Kir4.1) as an important modulator of neuronal excitability and glutamate metabolism. …”
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Designing inhibitors of M2 proton channel against H1N1 swine influenza virus. by Qi-Shi Du, Ri-Bo Huang, Shu-Qing Wang, Kuo-Chen Chou

“…The computer-aided drug design methods are used to calculate the binding free energies, with the computational biology techniques to analyze the interactions between M2 proton channel and adamantine-based inhibitors.1) The NMR structure of M2 proton channel provides a reliable structural basis for rational drug design against influenza virus. 2) The channel gating mechanism and the inhibiting mechanism of M2 proton channel, revealed by the NMR structure of M2 proton channel, provides the new ideas for channel inhibitor design. 3) The newly designed adamantane-based inhibitors based on the modeled structure of H1N1-M2 proton channel have two pharmacophore groups, which act like a "barrel hoop", holding two adjacent helices of the H1N1-M2 tetramer through the two pharmacophore groups outside the channel. 4) The inhibitors with such binding mechanism may overcome the drug resistance problem of influenza A virus to the adamantane-based drugs.…”
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A low-water crossing impacts Northern Hog Sucker Hypentelium nigricans movement in an Ozark stream by Jeffrey M. Williams, Hope R. Dodd, Debra S. Finn

“…The Current River in Missouri (USA) contains a single anthropogenic barrier to longitudinal connectivity: the Cedar Grove low-water crossing, which spans the main channel (10 culverts) and a side channel (4 culverts). In July 2017, we radio-tagged Northern Hog Sucker Hypentelium nigricans upstream (henceforth ‘above’; N = 24) and downstream (henceforth ‘below’; N = 26) of the crossing and followed their movements monthly for a year to assess fish passage and maximum displacement. …”
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Characterizing the role of atrial natriuretic peptide signaling in the development of embryonic ventricular conduction system by Arun Govindapillai, Adam Hotchkiss, Mark Baguma-Nibasheka, Robert A. Rose, Lucile Miquerol, Oliver Smithies, Nobuyo Maeda, Kishore B. S. Pasumarthi

“…The present study showed that treatment of embryonic ventricular cells with ANP or cell permeable 8-Br-cGMP can induce gene expression of important VCS markers such as hyperpolarization-activated cyclic nucleotide-gated channel-4 (HCN4) and connexin 40 (Cx40). Inhibition of protein kinase G (PKG) via Rp-8-pCPT-cGMPS further confirmed the role of ANP/NPRA/cGMP/PKG pathway in the regulation of HCN4 and Cx40 gene expression. …”
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Retinal pigment epithelium-specific CLIC4 mutant is a mouse model of dry age-related macular degeneration by Jen-Zen Chuang, Nan Yang, Nobuyuki Nakajima, Wataru Otsu, Cheng Fu, Howard Hua Yang, Maxwell Ping Lee, Armaan Fazal Akbar, Tudor Constantin Badea, Ziqi Guo, Afnan Nuruzzaman, Kuo-Shun Hsu, Joshua L. Dunaief, Ching-Hwa Sung

“…Here, the authors show that mice lacking chloride intracellular channel 4 in retinal pigment epithelium have defective lipid processing in the eye and pathological features mirroring human AMD, including drusen formation.…”
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4-aminopyridine does not enhance flocculus function in tottering, a mouse model of vestibulocerebellar dysfunction and ataxia. by John S Stahl, Zachary C Thumser

“…Largely based on work in the ataxic mouse mutant tottering (which carries a mutation of the Cacna1a gene of the P/Q voltage-activated calcium channel), 4-AP is hypothesized to function by enhancing excitability or rhythmicity of floccular Purkinje cells. …”
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Pathophysiological mechanisms of bradycardia in patients with anorexia nervosa by Reiner Buchhorn, Christoph Baumann, Christian Willaschek

“…Abstract Background The purpose of this investigation was to examine heart rate variability (HRV), interbeat interval (IBI), and their interrelationship in healthy controls, bradycardic hyperpolarization‐activated cyclic nucleotide‐gated channel 4 (HCN4) mutation carriers, and patients with anorexia nervosa (AN). …”
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Analysis of the Structure, Conduct and Performance of the Chrysanthemum Flower Market in Pasuruan Regency (Study Case in Tutur Village) by Zakia Putri Sulaiman, Ratya Anindita, Abdul Wahib Muhaimin

“…Following an investigation into market performance in Tutur Village, it has been discovered that channel 4 has the largest overall margin, followed by channel 5. …”
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Blockage of transdifferentiation from fibroblast to myofibroblast in experimental ovarian cancer models by Dai Shuzhen, Good David A, Yang Qifeng, Qu Xun, Yao Qin, Kong Beihua, Wei Ming Q

“…Chloride intracellular channel 4 (CLIC4) and reactive oxygen species (ROS) have been linked with promoting stromal cell transdifferentiation in various cancers, but little is known of their roles in ovarian cancer. …”
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Simulation study on the influence of metal contact and MOS interface trap states on the electrical characteristics of SiC IGBT by Lingqin Huang, Xinchao Liu, Jing Zhu, Yaohua Wang

“…A 13 kV class n-channel 4H–SiC trench gate insulated gate bipolar transistor (IGBT) structure is designed based on Silvaco TCAD device simulator tool. …”
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ALA- or Ce6-PDT induced phenotypic change and suppressed migration in surviving cancer cells by Pei-Tzu Li, En-Sheng Ke, Pei-Chi Chiang, Tsuimin Tsai

“…Gene expression related to metastasis including matrix metalloproteinases (MMPs) and chloride intracellular channel 4 (CLIC4) was also reduced. In addition, in the animal tumor model, mRNA expression of MMP9 and CLIC4 was also noticeably decreased. …”
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A comparative study on the difference of CFD simulations based on a simplified geometry and a more refined BIM based geometry by Fusuo Xu, Jianzhi Yang, Xiaowei Zhu

“…The wind velocity difference is as high as 2.65 m/s at the central channel, 4 m/s at the roof garden, and 3.69 m/s at the overhead corridor. …”
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A New Water Level Measurement Method Combining Infrared Sensors and Floats for Applications on Laboratory Scale Channel under Unsteady Flow Regime by Samer Majdalani, Jean-Philippe Chazarin, Roger Moussa

“…In this paper, we studied water transport under an unsteady flow regime in an experimental channel (4 m in length; 3 cm in width). Our experiments implicated some measuring requirements, specifically, a water level (WL) detection technique that is able to measure WL in a range of 2 cm with a precision of 1 mm. …”
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PENGGUNAAN CITRA LANDSAT MULTI-TEMPORAL UNTUK KAJIAN PERUBAHAN GARIS PANTAI DI JAWA by , Imam Bachrodin, , Prof. Dr. Hartono, DEA, DESS

“…Research has show that Landsat MSS, TM and ETM+ image with single band on channel 4 in the TM and ETM+, channel 7 on the MSS which enables to determine sea and land has ability to show Coastline changing up to 1:150.000 scale. …”

Current situation of stakeholders’ characteristics in Chu-mango supply chain by Vo Tuan Truong, Kiet Hong, Sidique, Shaufique Fahmi

“…The transaction takes place in cash for channel 2, bank transfer for channel 3, and both for channel 4. Processing firms play an essential role in the consumption of Chu-mango grades 3 and 4 of farmers and create value-added products for consumers. …”

A multi-focus image fusion technique for RGB color images using discrete cosine transform (DCT) by Waheed, Safa Riyadh

“…The proposed scheme is performed in five steps: (1) RGB colour image (input image) is split into three channels R, G, and B for both images.(2) DCT algorithm is applied to each channel (R, G and B) for image1 and image2 respectively. (3) The variance values are computed for the corresponding 8x8 blocks of each channel. (4) Each block of R (image 1) is compared with each block of R (image2) based on the variance value and then the block having maximum variance value is selected to be the block in the new image. …”
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Tobacco industry influence in low- and middle-income countries in the ASEAN region: Qualitative interviews with tobacco control experts during the COVID-19 pandemic by Thomas Stubbs, Victoria White, Hua-Hie Yong, John W. Toumbourou

“…Five themes emerged from the data: 1) a shift to below-the-line marketing and digital technologies to target youth; 2) industry develops new tactics to undermine tobacco control; 3) cigarette packet branding – the last remaining marketing channel; 4) political factors hindering tobacco control; and 5) broader involvement and collaboration in tobacco control. …”
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Mitigation of Significant Data Noise in F17 SSMIS Observations since October 2017 by Huijie Dong, Xiaolei Zou

“…The data noise is as large as 15 K for channels 1–3, 2.5 K for channel 4, 0.5 K for channels 5–7, and 0.75 K for channel 24. …”
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Large scale expression changes of genes related to neuronal signaling and developmental processes found in lateral septum of postpartum outbred mice. by Brian E Eisinger, Changjiu Zhao, Terri M Driessen, Michael C Saul, Stephen C Gammie

“…Fifteen K+ channel related genes showed altered expression, as did dopamine receptors Drd1a and Drd2 (both downregulated), hypocretin receptor 1 (Hcrtr1), kappa opioid receptor 1 (Oprk1), and transient receptor potential channel 4 (Trpc4). Expression of a large number of genes linked to developmental processes or cell differentiation were also altered in postpartum LS, including chemokine (C-X-C) motif ligand 12 (Cxcl12), fatty acid binding protein 7 (Fabp7), plasma membrane proteolipid (Pllp), and suppressor of cytokine signaling 2 (Socs2). …”
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