Combination of concurrent targeted and immune-therapy with nivolumab and cetuximab: new perspectives for squamous cell carcinoma treatment by A. M. Mudunov, A. V. Ignatova, A. S. Morozova, S. O. Podvyaznikov, Yu. V. Alymov

“…In our study, all 6 patients had prior check-point inhibitor exposure with nivolumab. Cetuximab was added to a treatment protocol after evidence-based progression during check-point inhibitor therapy. …”
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PEMBUATAN MODEL TIGA DIMENSI CANDI GEBANG MENGGUNAKAN METODE FOTOGRAMETRI JARAK DEKAT by , I NYOMAN HENDY G.J, , Bambang Kun Cahyono, ST., M.Sc.

“…The Steps in this project,are the measurement coordinate Ground Control Point (GCP) as the control point and Independent Check Point (ICP) as a check point. Taking photos of Temple Gebang performed radially with the average distance is 10 meters. …”

DGA Clustering and Analysis: Mastering Modern, Evolving Threats, DGALab by Alexander Chailytko, Aliaksandr Trafimchuk

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Treatment of Patients with Malignant Peritoneal Mesothelioma by Claire Y. Li, Timothy Kennedy, Henry Richard Alexander

“…Future clinical research using a combination of check point blockade with surgical cytoreduction is a high clinical priority.…”
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Do body mass index and waist-to-height ratio over the preceding decade predict retinal microvasculature in 11-12 year olds and midlife adults? by Liu, M, Lycett, K, Wong, TY, Kerr, JA, He, M, Juonala, M, Olds, T, Dwyer, T, Burgner, D, Wake, M

“…</br> <br><strong>Methods: </strong>Participants/design: 1288 11–12 year olds (51% girls) and 1264 parents (87% mothers) in the population-based Child Health CheckPoint (CheckPoint) module within the Longitudinal Study of Australian Children (LSAC). …”

About some approaches modeling of the vehicle on simulator by V. G. Mikhailov

“…By the spent modelling of the vehicle 6х6 with ma = 21200 kg it is established that it has fuel consumption of km of 63,56 l/100, average speed of 66,1 km/h and number of switchings of a check point 7 (at t&gt; 10 c). And basically check point switching occurs on last 3 higher drives.…”
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Virus-Based Immuno-Oncology Models by Juliana Sitta, Pier Paolo Claudio, Candace M. Howard

“…The definition of hot vs. cold tumors and the role of the tumor microenvironment enlightened the once obscure understanding of low response rates of solid tumors to immune check point inhibitors. Although the major scope found in the literature focuses on the T cell modulation, the innate immune system is also a promising oncolytic tool. …”
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APC mutation correlated with poor response of immunotherapy in colon cancer by Bing Li, Guoliang Zhang, Xuejie Xu

“…APC mutation was associated with lower TMB, lower expression of immune check point molecules (PD-1/PD-L1/PD-L2), higher TP, lower MSI-High proportion and less CD8 + T cells and follicular helper T cells infiltration. …”
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Lung Cancer in the Course of COPD-Emerging Problems Today by Robert Uliński, Iwona Kwiecień, Joanna Domagała-Kulawik

“…Cytotoxic T cells, lymphocytes B and regulatory T cells with the important role of check point molecules are involved in both processes. …”
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Severe Gastritis Due to Nivolumab Treatment of a Metastatic Melanoma Patient by George Samonis, Aikaterini Bousmpoukea, Aristea Molfeta, Antonios D. Kalkinis, Kalliopi Petraki, Christos Koutserimpas, Dimitrios Bafaloukos

“…Nivolumab, an anti-PD-1 check point inhibitor, is an immunotherapeutic agent, representing a major step in the treatment of melanoma. …”
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A cross‐cohort study examining the associations of metabolomic profile and subclinical atherosclerosis in children and their parents: The child health checkpoint study and Avon lon... by Juonala, M, Ellul, S, Lawlor, D, Santos Ferreira, D, Carlin, J, Cheung, M, Dwyer, T, Wake, M, Saffery, R, Burgner, D

“…In linear regression analyses adjusted for age, sex, body mass index, and blood pressure, there was no evidence of metabolite associations in either children or adults for cIMT at a 10% false discovery threshold. In CheckPoint adults, glucose was positively, and some high‐density lipoprotein‐cholesterol derived measures and amino acids (glutamine, histidine, tyrosine) inversely associated with PWV.…”

PD-1 and PD-L1 Checkpoint Signaling Inhibition for Cancer Immunotherapy: Mechanism, Combinations, and Clinical Outcome by Hashem O. Alsaab, Hashem O. Alsaab, Samaresh Sau, Rami Alzhrani, Rami Alzhrani, Katyayani Tatiparti, Ketki Bhise, Sushil K. Kashaw, Sushil K. Kashaw, Arun K. Iyer, Arun K. Iyer

“…In recent times, more than four check point antibody inhibitors have been commercialized for targeting PD-1, PDL-1, and CTLA-4. …”
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Identification and Clinical Application of Immunological Receptors Targeting Mutated Antigens Expressed by Solid Tumors by Anna Pasetto

“…In the recent years, immunotherapy has achieved impressive results utilizing different approaches, from (chimeric antigen receptor) CAR-T cells directed against CD19 for the treatment of leukemia and lymphomas to the Nobel prize-winning strategy of check-point inhibition for the treatment of several solid tumors [...]…”
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Development of a Self-Emulsifying Drug Delivery System for Optimized Topical Delivery of Clofazimine by Daniélle van Staden, Jeanetta du Plessis, Joe Viljoen

“…Check-point formulations, able to withstand phase separation after 24 h at an ambient temperature, were subjected to characterization studies. …”
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Bone health, activity and sedentariness at age 11-12 years: Cross-sectional Australian population-derived study by Osborn, W, Simm, P, Olds, T, Lycett, K, Mensah, F, Muller, J, Fraysse, F, Ismail, N, Vlok, J, Burgner, D, Carlin, J, Edwards, B, Dwyer, T, Azzopardi, P, Ranganathan, S, Wake, M

“…<br/><br/> <strong>Results</strong> Of 1357 children attending the CheckPoint, 864 (64%) provided both bone and accelerometry data (mean age 11.4 years (standard deviation (SD) 0.5); 49% male). …”

Telomere length and vascular phenotypes in a population‐based cohort of children and midlife adults by Nguyen, M, Vryer, R, Ranganathan, S, Lycett, K, Grobler, A, Dwyer, T, Juonala, M, Saffery, R, Burgner, D, Wake, M

“…</p> <p><strong>Methods and Results</strong> Population‐based cross‐sectional CheckPoint (Child Health CheckPoint) study of 11‐ to 12‐year‐old children and their parents, nested within the LSAC (Longitudinal Study of Australian Children). …”

Singgah sahur UMP by UMP, PNC

“…Nizar Najib (sepuluh dari kanan), barisan pengurusan UMP serta sukarelawan bertugas bergambar sempena Program Singgah Sahur UMP@Kuala Lumpur di Check Point 1, Masjid Negara, Kuala Lumpur, semalam.…”
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Sequential therapy with supercharged NK cells with either chemotherapy drug cisplatin or anti-PD-1 antibody decreases the tumor size and significantly enhances the NK function in H... by Kawaljit Kaur, Po-Chun Chen, Meng-Wei Ko, Ao Mei, Emanuela Senjor, Emanuela Senjor, Emanuela Senjor, Subramaniam Malarkannan, Subramaniam Malarkannan, Janko Kos, Janko Kos, Anahid Jewett, Anahid Jewett

“…Furthermore, the success of check point inhibitor PD-L1 may relate to the levels of expression on tumor cells.…”
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Ground Control Point Distribution for Accurate Kilometre-Scale Topographic Mapping Using an RTK-GNSS Unmanned Aerial Vehicle and SfM Photogrammetry by Eilidh Stott, Richard D. Williams, Trevor B. Hoey

“…However, acquiring spatially distributed independent check points to check for systematic errors is recommended. …”
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PREVALENCE OF PHARYNGEAL AND RECTAL CHLAMYDIA TRACHOMATIS AND NEISSERIA GONORRHOEAE INFECTIONS AMONG MSM IN SOFIA, BULGARIA by Ivva Philipova, Elena Birindjieva, Alexander Milanov, Savina Stoitsova

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