Management of Iron Overload in Beta-Thalassemia Patients: Clinical Practice Update Based on Case Series by Valeria Maria Pinto, Gian Luca Forni

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A Novel Combination Cancer Therapy with Iron Chelator Targeting Cancer Stem Cells via Suppressing Stemness by Yuki Katsura, Toshiaki Ohara, Kazuhiro Noma, Takayuki Ninomiya, Hajime Kashima, Takuya Kato, Hiroaki Sato, Satoshi Komoto, Toru Narusaka, Yasuko Tomono, Boyi Xing, Yuehua Chen, Hiroshi Tazawa, Shunsuke Kagawa, Yasuhiro Shirakawa, Tomonari Kasai, Masaharu Seno, Akihiro Matsukawa, Toshiyoshi Fujiwara

“…Iron metabolism appears important for maintenance of stemness in CSCs. An iron chelator combined with chemotherapy may be a novel approach via suppressing stemness for CSC targeted therapy.…”
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Chelation Therapy Associated with Antioxidant Supplementation Can Decrease Oxidative Stress and Inflammation in Multiple Sclerosis: Preliminary Results by Alessandra Vezzoli, Simona Mrakic-Sposta, Cinzia Dellanoce, Michela Montorsi, Daniele Vietti, Maria Elena Ferrero

“…The aim of this study was to investigate the efficacy of an antioxidant treatment (calcium disodium ethylenediaminetetracetic acid—EDTA) chelation therapy associated with a micronutrient complex in MS patients. …”
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Endocrine Complications and the Effect of Compliance with Chelation Therapy in Patients with Beta Thalassemia Major in Eastern Province of Saudi Arabia by Habbash F, Al-Bati W, Al-Hashim H, Aldossari M, Alali A, Alalyani K, Al-Ebrahim Z, Hamed N, Eraqe S, Binayfan Z, Al Marri A, Aljaber T

“…The percentage of patients who were not compliant with chelation therapy was 21.6% and 9.1% of patients were not taking them at all.Conclusion: Despite the role of chelation therapy in the management of iron overload, the risk of secondary endocrine and metabolic complications remained considerable. …”
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The Role of Iron-Chelating Therapy in Improving Neurological Outcome in Patients with Intracerebral Hemorrhage: Evidence-Based Case Report by Mochamad Iskandarsyah Agung Ramadhan, Shierly Novitawati Sitanaya, Ariadri Hafian Wulandaru Hakim, Yetty Ramli

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Long-Term Neuroradiological and Clinical Evaluation of NBIA Patients Treated with a Deferiprone Based Iron-Chelation Therapy by Nicola Romano, Giammarco Baiardi, Valeria Maria Pinto, Sabrina Quintino, Barbara Gianesin, Riccardo Sasso, Andrea Diociasi, Francesca Mattioli, Roberta Marchese, Giovanni Abbruzzese, Antonio Castaldi, Gian Luca Forni

“…Promising strategies include the use of deferiprone (DFP), an orally administered bidentate iron chelator with the ability to pass through the blood–brain barrier. …”
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Novel Bifunctional [16]aneS₄-Derived Chelators for Soft Radiometals by Natan J. W. Straathof, Charlotte B. Magnus, Fedor Zhuravlev, Andreas I. Jensen

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The Iron Chelator Desferrioxamine Increases the Efficacy of Bedaquiline in Primary Human Macrophages Infected with BCG by Christina Cahill, Fiona O’Connell, Karl M. Gogan, Donal J. Cox, Sharee A. Basdeo, Jacintha O’Sullivan, Stephen V. Gordon, Joseph Keane, James J. Phelan

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Evaluating the iron chelator function of sirtinol in non-small cell lung cancer by Michael S. Petronek, Khaliunaa Bayanbold, Koffi Amegble, Ann M. Tomanek-Chalkley, Bryan G. Allen, Douglas R. Spitz, Charvann K. Bailey

“…Thus, sirtuins 1 and 2 represent valuable targets for cancer therapy. Recent studies show that sirtinol functions as a tridentate iron chelator by binding Fe3+ with 3:1 stoichiometry. …”
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Knowledge, Attitude, and Practice of Young Paediatricians About Chelation Therapyin Transfusion-Dependent Thalassemia Major Children by Misbah Fakih, Faisal Basheer, Saad Ateeq, Farooq Ikram, Hafsa Asad, Qamar uz Zaman Khan

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Overview of current chelation practices by Y. Aydinok

“…The goal of this review is to summarize current concepts in iron chelation therapies based on the considerable amount of prospective data obtained by clinical studies.…”
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Unscrambling the Role of Redox-Active Biometals in Dopaminergic Neuronal Death and Promising Metal Chelation-Based Therapy for Parkinson’s Disease by Alfredo Gonzalez-Alcocer, Ana Patricia Duarte-Jurado, Adolfo Soto-Dominguez, Maria de Jesus Loera-Arias, Eliud Enrique Villarreal-Silva, Odila Saucedo-Cardenas, Roberto Montes de Oca-Luna, Aracely Garcia-Garcia, Humberto Rodriguez-Rocha

“…Herein, we addressed the involvement of redox-active biometals, iron, and copper, as oxidative stress and neuronal death inducers, as well as the current metal chelation-based therapy in PD.…”
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Efficiency and Safety of Desferioxamine Chelation Therapy in Paediatric Patients with Transfusion-Dependent Anaemia: Experience of two Centres from Sudan by Atif Ahmed Saad, Samah Ahmed Masaod, Osman Bashir Elhassan, Azza Ahmed Zulfu

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Combination therapy using microwave ablation and d-mannose-chelated iron oxide nanoparticles inhibits hepatocellular carcinoma progression by Rui Cui, Luo Wang, Dongyun Zhang, Kun Zhang, Jianping Dou, Linan Dong, Yixuan Zhang, Jiapeng Wu, Longfei Tan, Jie Yu, Ping Liang

“…Despite being a common therapy for hepatocellular carcinoma (HCC), insufficient thermal ablation can leave behind tumor residues that can cause recurrence. …”
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Markers of Renal Complications in Beta Thalassemia Patients with Iron Overload Receiving Chelation Agent Therapy: A Systematic Review by Romadhon PZ, Ashariati A, Bintoro SUY, Thaha M, Suryantoro SD, Windradi C, Mahdi BA, Novendrianto D, Widiyastuti KN, Martani OS, Widiasi ED, Agustin ED, Prabowo E, Putra YR, Thahadian HF, Adhikara IM, Adyarini DD, Prahasanti K, Putri AE, Yusoff NM

“…Despite better survival due to blood transfusion and iron chelation therapy, the previously unrecognized renal complication remain a burden of disease affecting this population —the primary concern on how iron overload and chelation therapy correlated with renal impairment is still controversial. …”
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Markers of Renal Complications in Beta Thalassemia Patients with Iron Overload Receiving Chelation Agent Therapy: A Systematic Review by Romadhon, Pradana Zaky, Ashariati, Ami, Bintoro, Siprianus Ugroseno Yudho, Thaha, Mochammad, Suryantoro, Satriyo Dwi, Windradi, Choirina, Mahdi, Bagus Aulia, Novendrianto, Dwiki, Widiyastuti, Krisnina Nurul, Martani, Okla Sekar, Widiasi, Etha Dini, Agustin, Esthiningrum Dewi, Prabowo, Emil, Putra, Yasjudan Rastrama, Thahadian, Harik Firman, Adhikara, Imam Manggalya, Adyarini, Dwita Dyah, Prahasanti, Kartika, Putri, Aditea Etnawati, Yusoff, Narazah Mohd

“…Despite better survival due to blood transfusion and iron chelation therapy, the previously unrecognized renal complication remain a burden of disease affecting this population —the primary concern on how iron overload and chelation therapy correlated with renal impairment is still controversial. …”
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The Disturbed Iron Phenotype of Tumor Cells and Macrophages in Renal Cell Carcinoma Influences Tumor Growth by Matthias Schnetz, Julia K. Meier, Claudia Rehwald, Christina Mertens, Anja Urbschat, Elisa Tomat, Eman A. Akam, Patrick Baer, Frederik C. Roos, Bernhard Brüne, Michaela Jung

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Comparison of the Mean Serum Ferritin Levels in Thalassaemia Major Patients after Giving Deferasirox and Deferoxamine by Seema Aftab, Amber Kamran, Shahina Hanif

Subjects: “…Ferritin, thalassemia major, chelation therapy, deferasirox, deferoxamine.…”
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N-Based Polydentate Ligands and Corresponding Zn(II) Complexes: A Structural and Spectroscopic Study by Giorgio Volpi, Stefano Zago, Roberto Rabezzana, Eliano Diana, Emanuele Priola, Claudio Garino, Roberto Gobetto

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Clinical Profile and Cardiac Complications of Haemoglobinopathies in Children at Tertiary Care Centre in Hyderabad, India: A Cross-sectional Study by Paramesh Pandala, Siddhartha Gangadhari, Raghava Polanki, Rakesh Kotha, B venkateshwarlu

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