Showing 101 - 120 results of 790 for search '"Chelation therapy', query time: 0.12s Refine Results
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    Iron chelating agents for iron overload diseases by Guido Crisponi, Valeria Marina Nurchi, Maria Antonietta Zoroddu

    Published 2014-09-01
    “…Although iron is an essential element for life, an excessive amount may become extremely toxic both for its ability to generate reactive oxygen species, and for the lack in humans of regulatory mechanisms for iron excretion. Chelation therapy has been introduced in clinical practice in the seventies of last century to defend thalassemic patients from the effects of iron overload and, in spite of all its limitations, it has dramatically changed both life expectancy and quality of life of patients. …”
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    Deferasirox, an oral chelator in the treatment of iron overload by I. Portioli

    Published 2013-05-01
    “…BACKGROUND Deferasirox is a once-daily oral iron chelator developed for treating iron overload complicating long-term transfusion therapy in patients with diseases such as beta-thalassemia and myelodysplastic syndromes. …”
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    Site-Specific Dual-Labeling of a VHH with a Chelator and a Photosensitizer for Nuclear Imaging and Targeted Photodynamic Therapy of EGFR-Positive Tumors by Emma Renard, Estel Collado Camps, Coline Canovas, Annemarie Kip, Martin Gotthardt, Mark Rijpkema, Franck Denat, Victor Goncalves, Sanne A. M. van Lith

    Published 2021-01-01
    “…Here, we optimized site-specific conjugation of the chelator DTPA and the photosensitizer IRDye700DX to anti-epidermal growth factor receptor (EGFR) VHH 7D12, for applications in nuclear imaging and photodynamic therapy. 7D12 was site-specifically equipped with bimodal probe DTPA-tetrazine-IRDye700DX using the dichlorotetrazine conjugation platform. …”
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    Metabolic Analysis of DFO-Resistant Huh7 Cells and Identification of Targets for Combination Therapy by Koichi Fujisawa, Toshihiko Matsumoto, Naoki Yamamoto, Takahiro Yamasaki, Taro Takami

    Published 2023-10-01
    “…Since intracellular metabolism is significantly altered by inhibiting various proteins by iron chelation, we investigated combination anticancer therapy targeting metabolic changes that are forcibly modified by iron chelator administration. …”
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