Recent progress in chemical approaches for the development of novel neuraminidase inhibitors by Mahal, A, Duan, M, Zinad, DS, Mohapatra, RK, Obaidullah, AJ, Wei, X, Pradhan, MK, Das, D, Kandi, V, Zinad, HS, Zhu, Q

“…This review focuses on the recent advances in chemical synthesis pathways used for the development of new neuraminidase agents along with the medicinal aspects of chemically modified molecules, including the structure–activity relationship, which provides further rational designs of more active small molecules.…”

Design of artificial metalloenzymes for C-C cross-coupling reactions by Sharma, M

“…New strategies to combine the complementary features of enzyme and transition metal catalysis are crucial for exploiting the pre-evolved selectivities of enzymes in chemical synthesis. In order to exploit the inherent selectivity of a serine protease Subtilisin (SBL) for C-C crosscoupling reactions, the interplay of natural substrate binding pockets and the nucleophilic machinery of the enzyme with the metal catalyst was central to our approach. …”

Biomolecular engineering of microorganisms for natural products production by O'Neill, EC

“…In the future it may be possible, rather than relying on chemical synthesis, to design and build artificial pathways to synthesize completely new compounds as desired.…”

Microbial transformation of steroid / Balqis Haya Ismail by Ismail, Balqis Haya

“…This phenomenon allows a compound to be modified into another compound by using green synthesis instead of chemical synthesis. In this study, Mesterolone as the substrate undergoes fermentation with identified Aspergillus SSW and 11L2. …”
Get full text

Synthesis and characterization of copper selenide and tin selenide powders by mechanical alloying method by Loh, Yen Nee, Talib, Zainal Abidin, Zainal, Zulkarnain, Liew, Josephine Ying Chyi

“…The low-temperature phase selection of the binary compound in this system is seen as a direct consequence of the thermodynamic facilitation, coupled with the capability of mechano-chemical synthesis to aid in overcoming kinetic constraints.…”

Organic synthesis of 1,2-O-Isopropylidene-3-acyl glycerol by Amberlite XAD-7 adsorbed lipase of Pseudomonas sp. AK by Lo, Ya Sien, Omar, Ibrahim Che

“…MG can be chemically synthesized via glycerolysis or hydrolysis of fats and oils at high temperature using inorganic catalysts. Chemical synthesis through esterification of 1,2-0-isopropylidene glycerol with acid chloride, followed by subsequent hydrolysis of the ketal has also been reported (Quinn et al., 1967).…”
Get full text

Modeling And Optimization Of Solvent-Free Isoamyl Acetate Production Via Enzymatic Esterification by Yusoff Azudin, Nurhazwani

“…Studies on esterification processes begin with traditional extraction of ester from plants,followed by chemical synthesis route. Nowadays, the esterification process has shifted to biocatalytic flavor due to consumer's inclination towards natural compared to chemical resources. …”
Get full text

5.33 Advanced Chemical Experimentation and Instrumentation, Fall 2005 by Gheorghiu, Mircea D., Tokmakoff, Andrei

“…Advanced experimentation, with particular emphasis on chemical synthesis and the fundamentals of quantum chemistry illustrated through molecular spectroscopy. …”
Get full text

Controlled reduction of nitriles by sodium hydride and zinc chloride by Ong, Derek Yiren, Chiba, Shunsuke

“…As the method allows the reduction of various aliphatic and aromatic nitriles with a concise procedure under milder reaction conditions and exhibits wide functional group compatibility, it is well suited for use in various opportunities in chemical synthesis.…”
Get full text

Furan-based molecules for organic electronics by Ng, Shane Gene Rong

“…The purpose of this project is to aid in the chemical synthesis and characterization of conjugated polymers for organic electronics. …”
Get full text

In silico genome-scale modeling and constraint-based analysis of microorganisms for bioelectricity generation and electrosynthesis. by Mao, Ning.

“…Gene knockout studies were carried out targeting at NADH drain maximization in the metabolic system, so that the reducing power of the microorganism would be boosted towards better bioelectricity generation and/or electrically enhanced chemical synthesis. Two gene knockout algorithms were used. …”
Get full text

Reduced graphene oxide-templated photochemical synthesis and in situ assembly of Au nanodots to orderly patterned Au nanodot chains by Wei, Yanyan, Qi, Xiaoying, Huang, Xiao, Zhou, Xiaozhu, Wu, Shixin, Zhang, Juan, Boey, Freddy Yin Chiang, Zhang, Hua

“…The results clearly demonstrate that reduced graphene oxide sheets modified with functional organic molecules can be used as templates for the synthesis and in situ assembly of metal nanostructures, thus opening up new possibilities for future graphene-based chemical synthesis.…”
Get full text
Get full text

Transcription of click-linked DNA in human cells. by Birts, C, Sanzone, A, El-Sagheer, A, Blaydes, J, Brown, T, Tavassoli, A

“…Click DNA ligation promises an alternative to the current enzymatic approaches for DNA assembly, with the ultimate goal of using efficient chemical reactions for the total chemical synthesis and assembly of genes and genomes. Such an approach would enable the incorporation of various chemically modified bases throughout long stretches of DNA, a feat not possible with current polymerase-based methods. …”

Electrocatalysis by Hydrogenases: Lessons for Building Bio-Inspired Devices by McPherson, I, Vincent, K

“…We review recent developments in composite enzyme-inorganic catalysts, some of the biological and materials challenges in building devices based on enzymes, and the future opportunities for devices based on biological catalysts, including fuel cells, light-driven fuel production and coupled catalysis for chemical synthesis. © 2014 Sociedade Brasileira de Quimica.…”

5-epi-deoxyrhamnojirimycin is a potent inhibitor of an alpha-L-rhamnosidase: 5-epi-deoxymannojirimycin is not a potent inhibitor of an alpha-D-mannosidase by Davis, B, Hull, A, Smith, C, Nash, R, Watson, A, Winkler, D, Griffiths, R, Fleet, G

“…Whereas deoxyrhamnojirimycin (LRJ) 1 shows no significant inhibition of naringinase (an α-L-rhamnosidase), its C-5 epimer 2 is a potent and specific inhibitor of the enzyme and demonstrates the value of unambiguous chemical synthesis of such materials in the evaluation of their biological properties. …”

Assembly of a biocompatible triazole-linked gene by one-pot click-DNA ligation by Kukwikila, M, Gale, N, El-Sagheer, A, Brown, T, Tavassoli, A

“…The chemical synthesis of oligonucleotides and their enzyme-mediated assembly into genes and genomes has significantly advanced multiple scientific disciplines. …”

Strategies for constructing and operating DNA origami linear actuators by Benson, E, Carrascosa Marzo, R, Bath, J, Turberfield, AJ

“…These machine components provide a basis for applications in molecular machinery and nanoscale manufacture including programmed chemical synthesis.…”

Nanoscale active matter matters: challenges and opportunities for self-propelled nanomotors by Santiago Gonzalez, I

“…Solutions to current challenges are proposed, which include a chemical synthesis approach, new characterisation of motor activity and potential uses of nanomotors in nanomedicine.…”

In‐situ electrochemical X‐ray diffraction: a rigorous method to navigate within phase diagrams reveals β‐Fe1+xSe as superconductor for all x by Rasche, B, Yang, M, Nikonow, L, Cooper, JFK, Murray, CA, Day, SJ, Kleiner, K, Clarke, SJ, Compton, RG

“…These observations exploit the exquisite control afforded by electrochemistry in contrast with classical approaches of chemical synthesis.…”

The root growth-regulating brevicompanine natural products modulate the plant circadian clock by De Montaigu, A, Oeljeklaus, J, Krahn, J, Suliman, M, Halder, V, De Ansorena, E, Nickel, S, Schlicht, M, Plíhal, O, Kubiasová, K, Radová, L, Kracher, B, Tóth, R, Kaschani, F, Coupland, G, Kombrink, E, Kaiser, M

“…Plant growth regulating properties of brevicompanines (Brvs), natural products of the fungus Penicillium brevicompactum, have been known for several years, but further investigations into the molecular mechanism of their bioactivity have not been performed. Following chemical synthesis of brevicompanine derivatives, we studied their activity in the model plant Arabidopsis by a combination of plant growth assays, transcriptional profiling, and numerous additional bioassays. …”