Electrocatalysis by Hydrogenases: Lessons for Building Bio-Inspired Devices by McPherson, I, Vincent, K

“…We review recent developments in composite enzyme-inorganic catalysts, some of the biological and materials challenges in building devices based on enzymes, and the future opportunities for devices based on biological catalysts, including fuel cells, light-driven fuel production and coupled catalysis for chemical synthesis. © 2014 Sociedade Brasileira de Quimica.…”

5-epi-deoxyrhamnojirimycin is a potent inhibitor of an alpha-L-rhamnosidase: 5-epi-deoxymannojirimycin is not a potent inhibitor of an alpha-D-mannosidase by Davis, B, Hull, A, Smith, C, Nash, R, Watson, A, Winkler, D, Griffiths, R, Fleet, G

“…Whereas deoxyrhamnojirimycin (LRJ) 1 shows no significant inhibition of naringinase (an α-L-rhamnosidase), its C-5 epimer 2 is a potent and specific inhibitor of the enzyme and demonstrates the value of unambiguous chemical synthesis of such materials in the evaluation of their biological properties. …”

Assembly of a biocompatible triazole-linked gene by one-pot click-DNA ligation by Kukwikila, M, Gale, N, El-Sagheer, A, Brown, T, Tavassoli, A

“…The chemical synthesis of oligonucleotides and their enzyme-mediated assembly into genes and genomes has significantly advanced multiple scientific disciplines. …”

Strategies for constructing and operating DNA origami linear actuators by Benson, E, Carrascosa Marzo, R, Bath, J, Turberfield, AJ

“…These machine components provide a basis for applications in molecular machinery and nanoscale manufacture including programmed chemical synthesis.…”

Nanoscale active matter matters: challenges and opportunities for self-propelled nanomotors by Santiago Gonzalez, I

“…Solutions to current challenges are proposed, which include a chemical synthesis approach, new characterisation of motor activity and potential uses of nanomotors in nanomedicine.…”

In‐situ electrochemical X‐ray diffraction: a rigorous method to navigate within phase diagrams reveals β‐Fe1+xSe as superconductor for all x by Rasche, B, Yang, M, Nikonow, L, Cooper, JFK, Murray, CA, Day, SJ, Kleiner, K, Clarke, SJ, Compton, RG

“…These observations exploit the exquisite control afforded by electrochemistry in contrast with classical approaches of chemical synthesis.…”

The root growth-regulating brevicompanine natural products modulate the plant circadian clock by De Montaigu, A, Oeljeklaus, J, Krahn, J, Suliman, M, Halder, V, De Ansorena, E, Nickel, S, Schlicht, M, Plíhal, O, Kubiasová, K, Radová, L, Kracher, B, Tóth, R, Kaschani, F, Coupland, G, Kombrink, E, Kaiser, M

“…Plant growth regulating properties of brevicompanines (Brvs), natural products of the fungus Penicillium brevicompactum, have been known for several years, but further investigations into the molecular mechanism of their bioactivity have not been performed. Following chemical synthesis of brevicompanine derivatives, we studied their activity in the model plant Arabidopsis by a combination of plant growth assays, transcriptional profiling, and numerous additional bioassays. …”

Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes. by Roach, P, Clifton, I, Fülöp, V, Harlos, K, Barton, G, Hajdu, J, Andersson, I, Schofield, C, Baldwin, J

“…Penicillin antibiotics are all produced from fermentation-derived penicillins because their chemical synthesis is not commercially viable. The key step in penicillin biosynthesis, in which both the beta-lactam and thiazolidine rings of the nucleus are created, is mediated by isopenicillin N synthase (IPNS), which binds ferrous iron and uses dioxygen as a cosubstrate. …”

Metabolic engineering of functional phytochemicals by Umar, Kabir Mustapha, Mohammed, Abdulkarim Sabo, Radu, Son, Abdul Hamid, Azizah, Saari, Nazamid

“…Initially only a few of these important phytochemicals are produced commercially by chemical synthesis. However, recent developments in the field of biotechnology have provided metabolic engineering strategies that use microorganisms as cell factories for high production of these products. …”
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Phase engineering of multimetallic nanostructures for electrocatalytic applications by Cui Xiaoya

“…In this thesis, I will present my research works on structure engineering (i.e., phase engineering and defects engineering) of multimetallic nanostructures via wet chemical synthesis and electron beam irradiation under high-resolution TEM for electrocatalytic applications. …”
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New methods to synthesize nanosized oxides for energy storage applications by Ng, Vincent Ming Hong

“…However, most are prepared by complex chemical synthesis which are not feasible for scaling up to industrial production. …”
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Let’s Make White Phosphorus Obsolete by Geeson, Michael Baily, Cummins, Christopher C

“…Methods used by nature, or in the chemistry of other elements such as silicon, are discussed as model processes for the future of phosphorus in chemical synthesis.…”
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Protein Synthesis and Bioconjugation for Design of Antimicrobial Conjugates by Saebi, Azin

“…The first strategy, chemical synthesis of proteins, enables access to proteins equipped with modifications and conjugation handles that are valuable for unlocking their therapeutic potential. …”
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A Roadmap to the Assembly of Synthetic DNA from Raw Materials by Sanghvi, Yogesh

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Development, processing and characterization of advanced polymer thin and ultra thin film systems for semiconductor manufacturing and optoelectronic devices by Hu, Xiao.

“…For the chemistry viewpoint, the synthetic methods studied include conventional organic chemical synthesis, electrochemical synthesis, sol gel synthesis and plasma synthesis.…”
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Exploration of advanced nanostructured materials for onboard hydrogen storage by Ngene, Peter.

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Isolation, structural identification, synthesis, and pharmacological profiling of 1,2-trans-dihydro-1,2-diol metabolites of the utrophin modulator ezutromid by Chatzopoulou, M, Claridge, T, Davies, K, Davies, S, Elsey, D, Emer, E, Fletcher, A, Harriman, S, Robinson, N, Rowley, J, Russell, A, Tinsley, J, Weaver, R, Wilkinson, I, Willis, N, Wilson, F, Wynne, G

“…Herein, we describe the structural elucidation of the main metabolites of ezutromid, the regio- and relative stereochemical assignments of DHD1 and DHD3, their de novo chemical synthesis, and their production in systems in vitro. …”

Structure of a cephalosporin synthase. by Valegård, K, van Scheltinga, A, Lloyd, MD, Hara, T, Ramaswamy, S, Perrakis, A, Thompson, A, Lee, H, Baldwin, J, Schofield, C, Hajdu, J, Andersson, I

“…These antibiotics are produced from fermentation-derived materials as their chemical synthesis is not commercially viable. Unconventional steps in their biosynthesis are catalysed by Fe(II)-dependent oxidases/oxygenases; isopenicillin N synthase (IPNS) creates in one step the bicyclic nucleus of penicillins, and deacetoxycephalosporin C synthase (DAOCS) catalyses the expansion of the penicillin nucleus into the nucleus of cephalosporins. …”

Recent advances in lipopolysaccharide-based glycoconjugate vaccines by Zhu, H, Rollier, CS, Pollard, AJ

“…<br> <strong>Expert opinion</strong> Advances in LPS harvesting, LPS chemical synthesis, and newer carrier proteins in the past decade have propelled LPS-based glycoconjugate vaccines toward further development, through to clinical evaluation. …”

Inhibition of mammalian glycan biosynthesis produces non-self antigens for a broadly neutralising, HIV-1 specific antibody. by Scanlan, C, Ritchie, G, Baruah, K, Crispin, M, Harvey, D, Singer, B, Lucka, L, Wormald, M, Wentworth, P, Zitzmann, N, Rudd, P, Burton, D, Dwek, R

“…Moreover, this study provides an alternative protein engineering approach to the design of a carbohydrate vaccine for HIV-1 by chemical synthesis.…”