Showing 181 - 200 results of 469 for search '"Chronic myelogenous leukemia"', query time: 0.16s Refine Results
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    A Novel Methoxybenzyl 5-Nitroacridone Derivative Effectively Triggers G1 Cell Cycle Arrest in Chronic Myelogenous Leukemia K562 Cells by Inhibiting CDK4/6-Mediated Phosphorylation of Rb by Bin Zhang, Ting Zhang, Tian-Yi Zhang, Ning Wang, Shan He, Bin Wu, Hai-Xiao Jin

    Published 2020-07-01
    “…Among a new series of acridone derivatives previously synthesized, it was found that the methoxybenzyl 5-nitroacridone derivative <b>8q</b> has nanomolar cytotoxicity in vitro against human chronic myelogenous leukemia K562 cells. In order to further explore the possible anti-leukemia mechanism of action of <b>8q</b> on K562 cells, a metabolomics and molecular biology study was introduced. …”
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    Sirtuin 1 inhibits lipopolysaccharide-induced inflammation in chronic myelogenous leukemia k562 cells through interacting with the Toll-like receptor 4-nuclear factor κ B-reactive oxygen species signaling axis by Lei Wang, Mingming Wang, Hongju Dou, Wenjie Lin, Lifang Zou

    Published 2020-03-01
    “…Abstract Background Chronic myelogenous leukemia (CML) is a clonal myeloproliferative neoplasm resulting from BCR–ABL-transformed hematopoietic stem cells. …”
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