Characterizing the tumor microenvironment at the single-cell level reveals a novel immune evasion mechanism in osteosarcoma by Weijian Liu, Hongzhi Hu, Zengwu Shao, Xiao Lv, Zhicai Zhang, Xiangtian Deng, Qingcheng Song, Yong Han, Tao Guo, Liming Xiong, Baichuan Wang, Yingze Zhang

“…We also found that major histocompatibility complex class I (MHC-I) molecules were downregulated in cancer cells. …”
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Control of Viral Infection by Natural Killer Cell Inhibitory Receptors by Bijal A. Parikh, Michael D. Bern, Sytse J. Piersma, Liping Yang, Diana L. Beckman, Jennifer Poursine-Laurent, Béatrice Plougastel-Douglas, Wayne M. Yokoyama

“…Summary: Major histocompatibility complex class I (MHC-I)-restricted immune responses are largely attributed to cytotoxic T lymphocytes (CTLs). …”
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Outside-in signaling through the major histocompatibility complex class-I cytoplasmic tail modulates glutamate receptor expression in neurons by Brett A. Eyford, Maciej J. Lazarczyk, Kyung Bok Choi, Merina Varghese, Hitesh Arora, Suresh Kari, Lonna Munro, Cheryl G. Pfeifer, Allison Sowa, Daniel R. Dickstein, Dara L. Dickstein, Wilfred A. Jefferies

“…Abstract The interplay between AMPA-type glutamate receptors (AMPARs) and major histocompatibility complex class I (MHC-I) proteins in regulating synaptic signaling is a crucial aspect of central nervous system (CNS) function. …”
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Exosomes derived from rAAV/AFP-transfected dendritic cells elicit specific T cell-mediated immune responses against hepatocellular carcinoma by Li J, Huang SL, Zhou Z, Lin W, Chen S, Chen M, Ye Y

“…In addition, Dex-sensitized DC precursors seemed more effective to trigger major histocompatibility complex class I (MHC I)-restricted CTL response and allow DCs to make full use of the minor antigen peptides, thereby maximally activating specific immune responses against HCC.Conclusion: It is concluded that Dexs, which combine the advantages of DCs and cell-free vectors, are promising to completely, or at least in part, replace mature DCs (mDCs) to function as cancer vaccines or natural antitumor adjuvant. …”
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Clustered Regularly Interspaced Short Palindromic Repeats/Cas9 Gene Editing Technique in Xenotransplantation by Meisam Naeimi Kararoudi, Seyyed S. Hejazi, Ezgi Elmas, Mats Hellström, Maryam Naeimi Kararoudi, Arvind M. Padma, Dean Lee, Hamid Dolatshad

“…Here, we provide an overview of the CRISPR approaches that have been used to modify genes which are vital in improving xenograft survival rate, including cytidine monophosphate-N-acetylneuraminic acid hydroxylase, B1,4N-acetylgalactosaminyltransferase, isoglobotrihexosylceramide synthase, class I MHC, von Willebrand factor, C3, and porcine endogenous retroviruses. …”
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Quantitative Analysis of Interaction Between CADM1 and Its Binding Cell-Surface Proteins Using Surface Plasmon Resonance Imaging by Takeshi Ito, Yutaka Kasai, Yuki Kumagai, Daisuke Suzuki, Misaki Ochiai-Noguchi, Daisuke Irikura, Shiro Miyake, Yoshinori Murakami

“…SPRi analysis identified a new interaction between CADM1 and CADM4, where this heterophilic interaction was shown to be involved in morphological spreading of adult T-cell leukemia (ATL) cells expressing CADM1 when incubated on CADM4-coated glass. Moreover, class-I MHC-restricted T-cell-associated molecule (CRTAM) was identified to show the highest affinity to CADM1 among its binding partners by comparing the dissociation constants calculated from the SPR sensorgrams. …”
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Structural basis for self-discrimination by neoantigen-specific TCRs by John P. Finnigan, Jenna H. Newman, Yury Patskovsky, Larysa Patskovska, Andrew S. Ishizuka, Geoffrey M. Lynn, Robert A. Seder, Michelle Krogsgaard, Nina Bhardwaj

“…Abstract T cell receptors (TCR) are pivotal in mediating tumour cell cytolysis via recognition of mutation-derived tumour neoantigens (neoAgs) presented by major histocompatibility class-I (MHC-I). Understanding the factors governing the emergence of neoAg from somatic mutations is a major focus of current research. …”
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TAPBPR mediates peptide dissociation from MHC class I using a leucine lever by F Tudor Ilca, Andreas Neerincx, Clemens Hermann, Ana Marcu, Stefan Stevanović, Janet E Deane, Louise H Boyle

“…Tapasin and TAPBPR are known to perform peptide editing on major histocompatibility complex class I (MHC I) molecules; however, the precise molecular mechanism(s) involved in this process remain largely enigmatic. …”
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The p36 Isoform of Murine Cytomegalovirus m152 Protein Suffices for Mediating Innate and Adaptive Immune Evasion by Annette Fink, Angeliqué Renzaho, Matthias J. Reddehase, Niels A. W. Lemmermann

“…The MHC-class I (MHC-I)-like viral (MHC-Iv) m152 gene product of murine cytomegalovirus (mCMV) was the first immune evasion molecule described for a member of the β-subfamily of herpesviruses as a paradigm for analogous functions of human cytomegalovirus proteins. …”
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Dendritic cells and natural killer cells: The road to a successful oncolytic virotherapy by Matin Ghasemi, Laleh Abbasi, Leila Ghanbari Naeini, Pajman Kokabian, Najmeh Nameh Goshay Fard, Nozar Givtaj

“…Numerous OVs are potent causal agents of class I MHC pathway-related chemicals, enabling early tumor/viral immune recognition and cytokine-mediated response. …”
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Distinct Polymorphisms in HLA Class I Molecules Govern Their Susceptibility to Peptide Editing by TAPBPR by F. Tudor Ilca, Linnea Z. Drexhage, Gemma Brewin, Sarah Peacock, Louise H. Boyle

“…Summary: Understanding how peptide selection is controlled on different major histocompatibility complex class I (MHC I) molecules is pivotal for determining how variations in these proteins influence our predisposition to infectious diseases, cancer, and autoinflammatory conditions. …”
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Relationship between genome‐wide and MHC class I and II genetic diversity and complementarity in a nonhuman primate by Rachel M. Petersen, Christina M. Bergey, Christian Roos, James P. Higham

“…We found that genome‐wide diversity was not associated with MHC diversity, and that diversity at class I MHC loci was not correlated with diversity at class II loci. …”
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Identification of disease-related genes in Plasmodium berghei by network module analysis by Junhao Lin, Shan Zeng, Qiong Chen, Guanghui Liu, Suyue Pan, Xuewu Liu

“…P. berghei lacks some proteins belonging to P. chabaudi and possesses some specific T-cell epitopes binding by class-I MHC, which might together contribute to the occurrence of experimental cerebral malaria (ECM). …”
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Endocytic Recycling of MHC Class I Molecules in Non-professional Antigen Presenting and Dendritic Cells by Sebastian Montealegre, Sebastian Montealegre, Sebastian Montealegre, Peter M. van Endert, Peter M. van Endert, Peter M. van Endert

“…Major histocompatibility complex class I (MHC I) molecules are glycoproteins that display peptide epitopes at the cell surface of nucleated cells for recognition by CD8+ T cells. …”
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A T cell receptor transgenic approach to the study of thymocyte development and autoimmune disease by Delaney, Joseph R. C. (Joseph Robert Clarke), 1969-

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Neutralizing interleukin-4 prevents transplant arteriosclerosis mediated by indirect pathway T cells under CD40-CD154 costimulation blockade. by Spriewald, B, Ensminger, S, Bushell, A, Wood, K

“…METHODS: MHC class I-mismatched CBK (H2k+Kb) donor aortas were transplanted into CBA (H2k) recipients who can only recognize the graft through CD8+ T cells and CD4+ T cells responding to the class I MHC mismatch through the indirect pathway of allorecognition. …”

The structural basis of immune receptor signalling by Hamer, R, Rebecca Hamer

“…This work investigates the mechanisms of binding of T cell receptors (TCRs) to Class I MHC-peptide complexes (pMHC). The structure of a TCR specific for the Melan-A tumour antigen bound to its cognate pMHC was solved to a resolution of 2.5 Å which gives insight into how this TCR could be mutated to optimize binding and subsequently used as a cancer vaccine. …”

Positive and negative selection in transgenic mice expressing a T-cell receptor specific for influenza nucleoprotein and endogenous superantigen. by Mamalaki, C, Elliott, J, Norton, T, Yannoutsos, N, Townsend, A, Chandler, P, Simpson, E, Kioussis, D

“…This clone is CD8+ and recognizes alpha alpha 366-374 of the nucleoprotein (NP 366-374) of influenza virus (A/NT/60/68), in the context of Class I MHC Db (Townsend et al., 1986). The receptor utilizes the V beta 11 and V alpha 4 gene segments for the beta chain and alpha chain, respectively (Palmer et al., 1989). …”

The MHC Class-I Transactivator NLRC5: Implications to Cancer Immunology and Potential Applications to Cancer Immunotherapy by Akhil Shukla, Maryse Cloutier, Madanraj Appiya Santharam, Sheela Ramanathan, Subburaj Ilangumaran

“…CD8⁺ cytotoxic T lymphocytes (CTLs), which kill tumor cells and provide antitumor immunity, select their targets by recognizing tumor antigenic peptides presented by MHC class-I (MHC-I) molecules. Cancer cells circumvent immune surveillance using diverse strategies. …”
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Spinal motoneuron synaptic plasticity after axotomy in the absence of inducible nitric oxide synthase by Zanon Renata G, Simões Gustavo F, Emirandetti Amanda, Oliveira Alexandre LR

“…The present work investigated the importance of inducible nitric oxide synthase (iNOS) activity in acute and late glial responses after injury and in major histocompatibility complex class I (MHC I) expression and synaptic plasticity of inputs to lesioned alpha motoneurons.…”
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