Enhanced Immunological Tolerance by HLA-G1 from Neural Progenitor Cells (NPCs) Derived from Human Embryonic Stem Cells (hESCs) by Hong-Xi Zhao, Feng Jiang, Ya-Jing Zhu, Li Wang, Ke Li, Yang Li, Xiao-Hong Wang, Ling-Song Li, Yuan-Qing Yao

“…Conclusions: Ectopic expression of HLA-G1, a non-classical major histocompatibility complex class I (MHC I) antigen that was originally discovered involving in engraftment tolerance during pregnancy, can enhance the immunological tolerance in differentiated neural progenitor cells (NPCs). …”
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NK cell education: Physiological and pathological influences by Philippe Rascle, Philippe Rascle, Griffin Woolley, Griffin Woolley, Stephanie Jost, Stephanie Jost, Cordelia Manickam, Cordelia Manickam, R. Keith Reeves, R. Keith Reeves, R. Keith Reeves

“…The sensitivity of the response is largely defined by interactions between self-major histocompatibility complex class I (MHC-I) molecules and specific inhibitory NK cell receptors, so-called NK cell education. …”
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Stimulation of dendritic cells enhances immune response after photodynamic therapy by Mroz, Pawel, Castano, Ana P., Hamblin, Michael R.

“…The induction of specific CD8+ Tlymphocyte cells that recognize major histocompatibility complex class I (MHC-I) restricted epitopes of TAAs is a highly desirable goal in cancer therapy. …”
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Molecular characterization of MHC class I alpha 1 and 2 domains in Asian seabass (lates calcarifer) by Loh, Zhixuan, Huan, Xuelu, Awate, Sunita, Schrittwieser, Markus, Renia, Laurent, Ren, Ee Chee

“…In humans, the highly polymorphic MHC class I (MHC-I) molecules play an important role in antigen presentation for the adaptive immune system. …”
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Developing anti-p53/HLA-A*0201 T-cell receptor mimic antibodies for cancer immunotherapy by Trenevska, I

“…<p>T-cell receptor mimic (TCRm) antibodies target a dual antigen epitope consisting of a peptide derived from an intracellular protein, and the major histocompatibility complex class I (MHC-I) molecule that presents the peptide at the cell surface. …”

Generation and Characterisation of Human Mesenchymal Stem Cells from Human Umbilical Cord by Tong, Chih Kong

“…The data show that UC-MSC express common MSC surface markers (CD105+, CD73+, CD29+, CD90+, CD34-, CD45-, MHC class I+, MHC class II-, CD80-,CD86-) and are capable of differentiating into osteoblasts and adipocytes. …”
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Dynamics of Viral Infection and Evolution of SARS-CoV-2 Variants in the Calabria Area of Southern Italy by Carmela De Marco, Carmela De Marco, Claudia Veneziano, Claudia Veneziano, Alice Massacci, Matteo Pallocca, Nadia Marascio, Angela Quirino, Angela Quirino, Giorgio Settimo Barreca, Aida Giancotti, Luigia Gallo, Angelo Giuseppe Lamberti, Barbara Quaresima, Barbara Quaresima, Gianluca Santamaria, Flavia Biamonte, Flavia Biamonte, Stefania Scicchitano, Enrico Maria Trecarichi, Enrico Maria Trecarichi, Alessandro Russo, Alessandro Russo, Daniele Torella, Daniele Torella, Aldo Quattrone, Carlo Torti, Carlo Torti, Giovanni Matera, Giovanni Matera, Caterina De Filippo, Francesco Saverio Costanzo, Francesco Saverio Costanzo, Francesco Saverio Costanzo, Giuseppe Viglietto, Giuseppe Viglietto

“…Prediction analysis of the effects of mutations on the immune response (i.e., binding to class I MHC and/or recognition of T cells) indicated that T29I in B.1 variant; A701S in Alpha variant; and T19R in Delta variant were predicted to impair binding to class I MHC whereas the mutations A67S identified in Alpha; E484K identified in Gamma; and E156G and ΔF157/R158 identified in Delta were predicted to impair recognition by T cells. …”
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Proteomic Analysis Identifies FNDC1, A1BG, and Antigen Processing Proteins Associated with Tumor Heterogeneity and Malignancy in a Canine Model of Breast Cancer by Yonara G. Cordeiro, Leandra M. Mulder, René J. M. van Zeijl, Lindsay B. Paskoski, Peter van Veelen, Arnoud de Ru, Ricardo F. Strefezzi, Bram Heijs, Heidge Fukumasu

“…In contrast, we observed a lower intensity of peptides matching calnexin, PDIA3, and HSPA5 in poorly differentiated cells, which enriched for protein folding in the endoplasmic reticulum and antigen processing, assembly, and loading of class I MHC. Over-representation of collagen metabolism, coagulation cascade, extracellular matrix components, cadherin-binding and cell adhesion pathways also distinguished cell populations. …”
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The Time Course of MHC-I Expression in C57BL/6J and A/J Mice Correlates with the Degree of Retrograde Gliosis in the Spinal Cord following Sciatic Nerve Crush by Bruno Henrique de Melo Lima, André Luis Bombeiro, Luciana Politti Cartarozzi, Alexandre Leite Rodrigues de Oliveira

“…The pleiotropic role of the major histocompatibility complex class I (MHC-I) reflects the close association between the nervous and immune systems. …”
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The temporal expression pattern of classical MHC class I in sleep-restricted mice: Generalizations and broader implications by Colette S. Kabrita, Samar Al Bitar, Esther Ghanem

“…Considering the scarcity of information regarding circadian rhythms in major histocompatibility class I (MHC-I) expression in SR, we designed a study that assessed the temporal expression of MHC-I in murine lymph nodes and spleen and the subsequent effects of sleep recovery. …”
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Antigen Export during Liver Infection of the Malaria Parasite Augments Protective Immunity by Georgina N. Montagna, Macarena Beigier-Bompadre, Martina Becker, Richard A. Kroczek, Stefan H. E. Kaufmann, Kai Matuschewski

“…Intracellular Plasmodium parasites likely minimize antigen presentation by surface-expressed major histocompatibility complex class I (MHC-I) molecules on infected cells, yet they actively remodel their host cells by export of parasite factors. …”
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Dopaminergic neurons show increased low-molecular-mass protein 7 activity induced by 6-hydroxydopamine in vitro and in vivo by Ming-Shu Mo, Gui-Hua Li, Cong-Cong Sun, Shu-Xuan Huang, Lei Wei, Li-Min Zhang, Miao-Miao Zhou, Zhuo-Hua Wu, Wen-Yuan Guo, Xin-Ling Yang, Chao-Jun Chen, Shao-Gang Qu, Jian-Xing He, Ping-Yi Xu

“…Abstract Background Abnormal expression of major histocompatibility complex class I (MHC-I) is increased in dopaminergic (DA) neurons in the substantia nigra (SN) in Parkinson’s disease (PD). …”
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Immunoinformatic-Based Prediction of Candidate Epitopes for the Diagnosis and Control of Paratuberculosis (Johne’s Disease) by Bruno Tilocca, Alessio Soggiu, Viviana Greco, Cristian Piras, Norma Arrigoni, Matteo Ricchi, Domenico Britti, Andrea Urbani, Paola Roncada

“…For each previously-described immunoreactive protein, we predicted the epitopes capable of eliciting an immune response by binding both B-cells and/or class I MHC antigens. The retrieved peptide sequences were analyzed for their specificity and cross-reactivity. …”
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Epitope vaccine design for Toxoplasma gondii based on a genome-wide database of membrane proteins by Xuan-Wu Li, Ni Zhang, Zhuo-Lin Li, Nouhoum Dibo, Zhen-Rong Ma, Bin Lu, Ye-Hong Huang, Yun-Feng Chang, Hong-Zhi Chen, Xiang Wu

“…Eight epitopes for major histocompatibility complex (MHC) class I (MHC-I) molecules and 18 epitopes for MHC-II molecules were ultimately selected, for which world population coverage percentiles were 71.94% and 99.76%, respectively. …”
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Long-lasting postoperative analgesia with local anesthetic-loaded hydrogels prevent tumor recurrence via enhancing CD8+T cell infiltration by Mingxu Zhao, Shasha Zhu, Ding Zhang, Chang Zhou, Zhilai Yang, Chunhui Wang, Xuesheng Liu, Jiqian Zhang

“…More interestingly, ropivacaine-loaded hydrogel was found to upregulate major histocompatibility complex class I (MHC-I) in tumor cells by impairing autophagy. …”
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NLRP3 inflammasome up-regulates major histocompatibility complex class I expression and promotes inflammatory infiltration in polymyositis by Ping Xia, Yu-Quan Shao, Cong-Cong Yu, Yu Xie, Zhi-Jie Zhou

“…Meanwhile, LPS/ATP challenged activation of NLRP3 inflammasome induced overexpression of major histocompatibility complex class I (MHC-I), a key molecular of PM in the co-cultured C2C12 cells. …”
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Immunoinformatics approach of epitope prediction for SARS-CoV-2 by Nourelislam Awad, Rania Hassan Mohamed, Nehal I. Ghoneim, Ahmed O. Elmehrath, Nagwa El-Badri

“…Several immunoinformatic approaches were employed to identify the SARS-CoV-2 epitopes that bind specifically with the major histocompatibility molecules class I (MHC-I). We utilized immunoinformatic tools to analyze the whole viral protein sequences, to identify the SARS-CoV-2 epitopes responsible for binding to the most frequent human leukocyte antigen (HLA) alleles in the Egyptian population. …”
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Prediction of an immunogenic peptide ensemble and multi-subunit vaccine for Visceral leishmaniasis using bioinformatics approaches by Manu Kupani, Rajeev Kumar Pandey, Sharad Vashisht, Satyendra Singh, Vijay Kumar Prajapati, Sanjana Mehrotra

“…The ensemble was evaluated for Class I MHC immunogenicity and toxicity. Further, immunogenic peptides were randomly selected and used to design vaccine constructs. …”
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Mass Spectrometry Reveals Changes in MHC I Antigen Presentation After Lentivector Expression of a Gene Regulation System by Roland Vogel, Reem Al-Daccak, Oliver Drews, Jessy Alonzeau, Gabor Mester, Dominique Charron, Stefan Stevanovic, Jacques Mallet

“…Stable cell lines were established, and the peptides presented by major histocompatibility complex class I (MHC I) molecules on transduced and wild-type (wt) cells were compared by differential mass spectrometry. …”
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Immunogenetic variation shapes the gut microbiome in a natural vertebrate population by Charli S. Davies, Sarah F. Worsley, Kathryn H. Maher, Jan Komdeur, Terry Burke, Hannah L. Dugdale, David S. Richardson

“…Results We characterised MHC class I (MHC-I), MHC class II (MHC-II) and GM variation in individuals within a natural population of the Seychelles warbler (Acrocephalus sechellensis). …”
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