Nef Obtained from Individuals with HIV-1 Vary in Their Ability to Antagonize SERINC3- and SERINC5-Mediated HIV-1 Restriction by Zita Kruize, Ad C. van Nuenen, Stan W. van Wijk, Arginell F. Girigorie, Karel A. van Dort, Thijs Booiman, Neeltje A. Kootstra

“…Nef is a multifunctional viral protein that has the ability to downregulate cell surface molecules, including CD4 and major histocompatibility complex class I (MHC-I) and, as recently shown, also members of the serine incorporator family (SERINC). …”
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Improved prediction of MHC-peptide binding using protein language models by Nasser Hashemi, Boran Hao, Mikhail Ignatov, Mikhail Ignatov, Ioannis Ch. Paschalidis, Ioannis Ch. Paschalidis, Ioannis Ch. Paschalidis, Pirooz Vakili, Sandor Vajda, Sandor Vajda, Sandor Vajda, Dima Kozakov, Dima Kozakov, Dima Kozakov

“…Major histocompatibility complex Class I (MHC-I) molecules bind to peptides derived from intracellular antigens and present them on the surface of cells, allowing the immune system (T cells) to detect them. …”
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A broadened HLA ligandome uncovers new immunotherapy targets for pancreatic cancer + A prime editor mouse to model a broad spectrum of somatic mutations by Ely, Zackery A.

“…A subset of tumors is computationally predicted to harbor potentially immunogenic peptides for MHC class I (MHC-I) presentation, but the nature, expression, and immunogenicity of these peptides has yet to be determined. …”
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IFN-τ Mediated Control of Bovine Major Histocompatibility Complex Class I Expression and Function via the Regulation of bta-miR-148b/152 in Bovine Endometrial Epithelial Cells by Haichong Wu, Kangfeng Jiang, Shuai Guo, Jing Yang, Gan Zhao, Changwei Qiu, Ganzhen Deng

“…IFN-τ, a type I interferon produced by the trophoblasts of ruminants, has various important immune functions, including effects on the expression of major histocompatibility complex (MHC) class I (MHC-I). A previous study has reported that IFN-τ promotes the expression of MHC-I molecules on endometrial cells. …”
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Pathologic characterization of white striping myopathy in broiler chickens by Francesco Prisco, Davide De Biase, Giuseppe Piegari, Ilaria d'Aquino, Adriano Lama, Federica Comella, Raffaelina Mercogliano, Ludovico Dipineto, Serenella Papparella, Orlando Paciello

“…There was diffuse sarcoplasmic and sarcolemmal overexpression of the major histocompatibility complex class I (MHC I). The severity of the histologic lesions was positively correlated with the macroscopic degree of white striations. …”
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Peptidomes and Structures Illustrate Two Distinguishing Mechanisms of Alternating the Peptide Plasticity Caused by Swine MHC Class I Micropolymorphism by Xiaohui Wei, Song Wang, Zhuolin Li, Zibin Li, Zehui Qu, Suqiu Wang, Baohua Zou, Ruiying Liang, Chun Xia, Chun Xia, Nianzhi Zhang

“…The micropolymorphism of major histocompatibility complex class I (MHC-I) can greatly alter the plasticity of peptide presentation, but elucidating the underlying mechanism remains a challenge. …”
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Improved haplotype resolution of highly duplicated MHC genes in a long-read genome assembly using MiSeq amplicons by Samantha Mellinger, Martin Stervander, Max Lundberg, Anna Drews, Helena Westerdahl

“…Single exons, representing MHC class I (MHC-I) and class IIB (MHC-IIB) alleles, were sequenced in the focal individual and mapped to the annotated MHC alleles in the original long-read genome assembly. …”
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Characterization of the peripheral blood transcriptome and adaptive evolution of the MHC I and TLR gene families in the wolf (Canis lupus) by Guangshuai Liu, Honghai Zhang, Guolei Sun, Chao Zhao, Shuai Shang, Xiaodong Gao, Tian Xia, Xiufeng Yang

“…In this study, the peripheral blood transcriptome of wolves was generated via RNA-seq to advance understanding of the wolf immunome, with a special focus on the major histocompatibility complex class I (MHC I) and toll-like receptor (TLR) gene families, which are involved in pathogen recognition and defense. …”
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Transcriptome Analysis Shows That IFN-I Treatment and Concurrent SAV3 Infection Enriches MHC-I Antigen Processing and Presentation Pathways in Atlantic Salmon-Derived Macrophage/De... by Cheng Xu, Øystein Evensen, Hetron Mweemba Munang’andu

“…We found that concurrent treatment of TO-cells with IFN-I and SAV3 infection (SAV3/IFN⁺) significantly enriched the major histocompatibility complex class I (MHC-I) pathway unlike the non-IFN-I treated TO-cells (SAV3/IFN^−) that had lower expression levels of MHC-I pathway-related genes. …”
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NLRC5-CIITA Fusion Protein as an Effective Inducer of MHC-I Expression and Antitumor Immunity by Madanraj Appiya Santharam, Akhil Shukla, Dominique Levesque, Thomas A. Kufer, François-Michel Boisvert, Sheela Ramanathan, Subburaj Ilangumaran

“…Aggressive tumors evade cytotoxic T lymphocytes by suppressing MHC class-I (MHC-I) expression that also compromises tumor responsiveness to immunotherapy. …”
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Identification of prognostic and bone metastasis​‐related alternative splicing signatures in mesothelioma by Runzhi Huang, Zixuan Zheng, Sijia Liu, Penghui Yan, Dianwen Song, Huabin Yin, Peng Hu, Xiaolong Zhu, Zhengyan Chang, Yihan Liu, Juanwei Zhuang, Tong Meng, Zongqiang Huang, Jie Zhang

“…Finally, we proposed that splicing factor (SF) HSPA1A could regulate SNX5‐58744‐AT (R = −0.414) and SNX5‐58745‐AT (R = 0.414) through the pathway “Class I MHC mediated antigen processing and presentation” (R = 0.400). …”
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Soluble and Exosome-Bound α-Galactosylceramide Mediate Preferential Proliferation of Educated NK Cells with Increased Anti-Tumor Capacity by Arnika K. Wagner, Ulf Gehrmann, Stefanie Hiltbrunner, Valentina Carannante, Thuy T. Luu, Tanja I. Näslund, Hanna Brauner, Nadir Kadri, Klas Kärre, Susanne Gabrielsson

“…Natural killer (NK) cells can kill target cells via the recognition of stress molecules and down-regulation of major histocompatibility complex class I (MHC-I). Some NK cells are educated to recognize and kill cells that have lost their MHC-I expression, e.g., tumor or virus-infected cells. …”
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ANGPTL2‐mediated epigenetic repression of MHC‐I in tumor cells accelerates tumor immune evasion by Tsuyoshi Kadomatsu, Chiaki Hara, Ryoma Kurahashi, Haruki Horiguchi, Jun Morinaga, Keishi Miyata, Sohtaro Kurano, Hisashi Kanemaru, Satoshi Fukushima, Kimi Araki, Masaya Baba, W. Marston Linehan, Tomomi Kamba, Yuichi Oike

“…Loss or downregulation of major histocompatibility complex class I (MHC‐I) contributes to tumor immune evasion. …”
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Current advances in cancer vaccines targeting NY-ESO-1 for solid cancer treatment by Hong Zhou, Hong Zhou, Hong Zhou, Yipeng Ma, Yipeng Ma, Fenglan Liu, Fenglan Liu, Bin Li, Bin Li, Dongjuan Qiao, Dongjuan Qiao, Peigen Ren, Mingjun Wang, Mingjun Wang

“…Cancer vaccines, an important element of cancer immunotherapy, function by presenting an exogenous source of TAA proteins, peptides, and antigenic epitopes to CD4+ T cells via major histocompatibility complex class II (MHC-II) and to CD8+ T cells via major histocompatibility complex class I (MHC-I). These mechanisms further enhance the immune response against TAAs mediated by cytotoxic T lymphocytes (CTLs) and helper T cells. …”
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Tumor MHC Expression Guides First-Line Immunotherapy Selection in Melanoma by Elena Shklovskaya, Jenny H Lee, Su Yin Lim, Ashleigh Stewart, Bernadette Pedersen, Peter Ferguson, Robyn PM Saw, John F Thompson, Brindha Shivalingam, Matteo S Carlino, Richard A Scolyer, Alexander M Menzies, Georgina V Long, Richard F Kefford, Helen Rizos

“…A novel quantitative score was developed to determine the tumor cell expression of antigen-presenting MHC class I (MHC-I) molecules, and to correlate expression data with treatment response. …”
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ProGeo-neo: a customized proteogenomic workflow for neoantigen prediction and selection by Yuyu Li, Guangzhi Wang, Xiaoxiu Tan, Jian Ouyang, Menghuan Zhang, Xiaofeng Song, Qi Liu, Qibin Leng, Lanming Chen, Lu Xie

“…Results Here we report the construction of proteogenomics prediction of neoantigen (ProGeo-neo) pipeline, which incorporates the following modules: mining tumor specific antigens from next-generation sequencing genomic and mRNA expression data, predicting the binding mutant peptides to class I MHC molecules by latest netMHCpan (v.4.0), verifying MHC-peptides by MaxQuant with mass spectrometry proteomics data searched against customized protein database, and checking potential immunogenicity of T-cell-recognization by additional screening methods. …”
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Rhoptry and Dense Granule Secreted Effectors Regulate CD8+ T Cell Recognition of Toxoplasma gondii Infected Host Cells by Leah M. Rommereim, Barbara A. Fox, Kiah L. Butler, Viviana Cantillana, Gregory A. Taylor, Gregory A. Taylor, David J. Bzik

“…Here, we investigated the role of parasite-secreted effectors in regulating host access to parasitophorous vacuole (PV) localized parasite antigens and their presentation to CD8+ T cells by the major histocompatibility class I (MHC-I) pathway. Antigen presentation of PV localized parasite antigens by MHC-I was significantly increased in macrophages and/or dendritic cells infected with mutant parasites that lacked expression of secreted GRA (GRA2, GRA3, GRA4, GRA5, GRA7, GRA12) or ROP (ROP5, ROP18) effectors. …”
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Microglia cause structural remodeling of noradrenergic axon in the trigeminal spinal subnucleus caudalis after infraorbital nerve injury in rats by Yoshinori Hayashi, Jo Otsuji, Eri Oshima, Suzuro Hitomi, Junjun Ni, Kentaro Urata, Ikuko Shibuta, Koichi Iwata, Masamichi Shinoda

“…Major histocompatibility complex class I (MHC-I) was upregulated in Vc microglia after IONI. …”
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BND-22, a first-in-class humanized ILT2-blocking antibody, promotes antitumor immunity and tumor regression by Frank Nestle, Ilana Mandel, Dana Haves Ziv, Ilana Goldshtein, Tsuri Peretz, Dror Alishekevitz, Anna Fridman Dror, Motti Hakim, Sharon Hashmueli, Itay Friedman, Yair Sapir, Rita Greco, Hongjing Qu, Dmitri Wiederschain, Lily Pao, Sharad Sharma, Tehila Ben Moshe

“…In the tumor microenvironment, binding of class I MHC (in particular HLA-G) to ILT2 on immune cells mediates a strong inhibitory effect, which manifests in inhibition of antitumor cytotoxicity of T and NK cells, and prevention of phagocytosis of the tumor cells by macrophages.Methods We describe here the development and characteristics of BND-22, a novel, humanized monoclonal antibody that selectively binds to ILT2 and blocks its interaction with classical MHC I and HLA-G. …”
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Studies on the molecular mechanism of T cell triggering and detection and characterization of antigen-specific T cells by Stone, Jennifer Drignat, 1976-

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