Molecular characterization and expression of DERL1 in bovine ovarian follicles and corpora lutea by Lussier Jacques G, Ndiaye Kalidou, Pate Joy L

“…Co-immunoprecipitation using luteal tissues showed that DERL1 interacts with class I MHC but not with VIMP or p97 ATPase. The interaction between DERL1 and MHC I suggests that, in the CL, DERL1 may regulate the integrity of MHC I molecules that are transported to the ER membrane. …”
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A loop structure allows TAPBPR to exert its dual function as MHC I chaperone and peptide editor by Lina Sagert, Felix Hennig, Christoph Thomas, Robert Tampé

“…Adaptive immunity vitally depends on major histocompatibility complex class I (MHC I) molecules loaded with peptides. Selective loading of peptides onto MHC I, referred to as peptide editing, is catalyzed by tapasin and the tapasin-related TAPBPR. …”
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Targeting MHC-I molecules for cancer: function, mechanism, and therapeutic prospects by Xiangyu Wu, Tianhang Li, Rui Jiang, Xin Yang, Hongqian Guo, Rong Yang

“…Abstract The molecules of Major histocompatibility class I (MHC-I) load peptides and present them on the cell surface, which provided the immune system with the signal to detect and eliminate the infected or cancerous cells. …”
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Reassessing human MHC-I genetic diversity in T cell studies by Roderick C. Slieker, Daniël O. Warmerdam, Maarten H. Vermeer, Remco van Doorn, Mirjam H. M. Heemskerk, Ferenc A. Scheeren

“…Abstract The Major Histocompatibility Complex class I (MHC-I) system plays a vital role in immune responses by presenting antigens to T cells. …”
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Activation by SLAM Family Receptors Contributes to NK Cell Mediated "Missing-Self" Recognition. by Elisenda Alari-Pahissa, Camille Grandclément, Beena Jeevan-Raj, Georges Leclercq, André Veillette, Werner Held

“…Natural Killer (NK) cells attack normal hematopoietic cells that do not express inhibitory MHC class I (MHC-I) molecules, but the ligands that activate NK cells remain incompletely defined. …”
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MHC Class I Downregulation in Cancer: Underlying Mechanisms and Potential Targets for Cancer Immunotherapy by Annelisa M. Cornel, Iris L. Mimpen, Stefan Nierkens

“…One major mechanism through which solid tumors can avoid anti-tumor immunity is the downregulation of major histocompatibility complex class I (MHC-I), which causes reduced recognition by- and cytotoxicity of CD8⁺ T-cells. …”
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Isolation and characterisation of exosomes from human cancer cell lines and patient material. by Wang, Xiaohui.

“…Exosomes isolated from plasma of cancer patients also contained more exosomal proteins and showed elevated amounts of MHC class I, MHC class II, CD86, CD9 and CD81 when compared to healthy donors. …”
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High-throughput characterization of HLA-E-presented CD94/NKG2x ligands reveals peptides which modulate NK cell activation by Huisman, BD, Guan, N, Rückert, T, Garner, L, Singh, NK, McMichael, AJ, Gillespie, GM, Romagnani, C, Birnbaum, ME

“…HLA-E is a non-classical class I MHC protein involved in innate and adaptive immune recognition. …”

Kupffer cell staining by an HFE-specific monoclonal antibody: implications for hereditary haemochromatosis. by Bastin, J, Jones, M, O'Callaghan, C, Schimanski, L, Mason, D, Townsend, A

“…It binds HFE but does not recognize other recombinant non-classic MHC class I proteins (HLA-E, F and G), nor does it react with a variety of recombinant classic class I MHC molecules. COS cells transfected with HFE in culture are stained specifically. …”

MICAL-L1-related and unrelated mechanisms underlying elongated tubular endosomal network (ETEN) in human dendritic cells by Compeer, E, Boes, M

“…Additional clustering of class I MHC and ICAM-1 by a cognate interaction between antigen-laden DC and antigen-specific CD8+ T-cells induces formation of transferrin-positive tubules emanating from the endosomal recycling compartment (ERC). …”

Therapeutic antibodies against intracellular tumor antigens by Trenevska, I, Li, D, Banham, A

“…Furthermore, intracellular proteins can be degraded by the proteasome into short, commonly 8-10 amino acid long, peptides that are presented on the cell surface in the context of major histocompatibility complex class I (MHC-I) molecules. These tumor-associated peptide-MHC-I complexes can then be targeted by antibodies known as T-cell receptor mimic (TCRm) or T-cell receptor (TCR)-like antibodies, which recognize epitopes comprising both the peptide and the MHC-I molecule, similarly to the recognition of such complexes by the TCR on T cells. …”

Expression and function of HLA-B27 in lipid-linked form: implications for cytotoxic T lymphocyte-induced apoptosis signal transduction. by Gao, X, Quinn, C, Bell, J, Mcmichael, A

“…Furthermore, PI-B27 transfectant CHO cells undergo rapid DNA fragmentation when pulsed with the appropriate peptide and treated with specific CTL, suggesting that the cytoplasmic and transmembrane domains of the heavy chain of class I MHC molecules are not required in CTL-induced apoptosis signal transduction in target cells.…”

Unveiling the Immunogenicity of Ovarian Tumors as the Crucial Catalyst for Therapeutic Success by Galaxia M. Rodriguez, Edward Yakubovich, Barbara C. Vanderhyden

“…One of the main barriers behind the poor therapeutic outcome is the reduced expression of Major Histocompatibility Complexes class I (MHC I) which occurs in approximately 60% of EOC cases. …”
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Regulation of transgene expression in genetic immunization by Harms J.S., Oliveira S.C., Splitter G.A.

“…Our objective was to determine the effect of IFN-<FONT FACE="Symbol">g</FONT> on transgene expression driven by viral SV40 or CMV promoter/enhancer and the mammalian promoter/enhancer for the major histocompatibility complex class I (MHC I) gene. We transfected the luciferase gene driven by these three promoters into 14 cell lines of many tissues and several species. …”
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Thimet Oligopeptidase Biochemical and Biological Significances: Past, Present, and Future Directions by Emer S. Ferro, Mayara C. F. Gewehr, Ami Navon

“…Beyond its previously well characterized role in major histocompatibility class I (MHC-I) antigen presentation, the recent characterization of the THOP1 C57BL6/N null mice (THOP1^−/−) phenotype suggests new key functions for THOP1 in hyperlipidic diet-induced obesity, insulin resistance and non-alcoholic liver steatosis. …”
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A Kmer-based paired-end read de novo assembler and genotyper for canine MHC class I genotyping by Yuan Feng, Paul R. Hess, Stephen M. Tompkins, William H. Hildebrand, Shaying Zhao

“…Summary: The major histocompatibility complex class I (MHC-I) genes are highly polymorphic. MHC-I genotyping is required for determining the peptide epitopes available to an individual’s T-cell repertoire. …”
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Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses by Ting Wu, Jing Guan, Andreas Handel, David C. Tscharke, John Sidney, Alessandro Sette, Linda M. Wakim, Xavier Y. X. Sng, Paul G. Thomas, Nathan P. Croft, Anthony W. Purcell, Nicole L. La Gruta

“…Here, using mass spectrometry and flow cytometry, the authors characterize the kinetics of influenza A virus class I MHC epitopes cross-presented in professional antigen presenting cells and identify new epitopes that elicit T cell responses in infected mice.…”
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Human papillomavirus type 16 (HPV-16) E5 protein and HLA class I by MR Haghshenas, B Marchetti, M Saveria Campo, GH Ashrafi

“…We have shown that E5 prevents transport of the major histocompatibility class I (MHC I) to the cell surface and retains the complex in the GA. …”
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CD8+ T cell-mediated neuronal dysfunction and degeneration in limbic encephalitis by Petra eEhling, Petra eEhling, Nico eMelzer, Thomas eBudde, Sven G Meuth, Sven G Meuth

“…While effects of plasma cell-derived antibodies on neuronal function and integrity are increasingly becoming characterized, potentially contributing effects of T cell-mediated immune mechanisms remain poorly understood.CD8+ T cells are known to directly interact with major histocompatibility complex class I (MHC I) expressing neurons in an antigen-specific manner. …”
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Variations in MHC class I antigen presentation and immunopeptidome selection pathways [version 1; peer review: 3 approved] by Anita J. Zaitouna, Amanpreet Kaur, Malini Raghavan

“…Major histocompatibility class I (MHC-I) proteins mediate immunosurveillance against pathogens and cancers by presenting antigenic or mutated peptides to antigen receptors of CD8+ T cells and by engaging receptors of natural killer (NK) cells. …”
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