Comprehensive mutagenesis identifies the peptide repertoire of a p53 T-cell receptor mimic antibody that displays no toxicity in mice transgenic for human HLA-A*0201. by Iva Trenevska, Amanda P Anderson, Carol Bentley, Tasneem Hassanali, Sarah Wiblin, Shaun Maguire, Francesco Pezzella, Alison H Banham, Demin Li

“…T-cell receptor mimic (TCRm) antibodies have expanded the repertoire of antigens targetable by monoclonal antibodies, to include peptides derived from intracellular proteins that are presented by major histocompatibility complex class I (MHC-I) molecules on the cell surface. We have previously used this approach to target p53, which represents a valuable target for cancer immunotherapy because of the high frequency of its deregulation by mutation or other mechanisms. …”
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Histone methyltransferase WHSC1 loss dampens MHC-I antigen presentation pathway to impair IFN-γ–stimulated antitumor immunity by Jiale Ren, Ni Li, Siyu Pei, Yannan Lian, Li Li, Yuchong Peng, Qiuli Liu, Jiacheng Guo, Xuege Wang, Ying Han, Guoying Zhang, Hanling Wang, Yaqi Li, Jun Jiang, Qintong Li, Minjia Tan, Junjie Peng, Guohong Hu, Yichuan Xiao, Xiong Li, Moubin Lin, Jun Qin

“…IFN-γ–stimulated MHC class I (MHC-I) antigen presentation underlies the core of antitumor immunity. …”
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Endoplasmic reticulum chaperones and their roles in the immunogenicity of cancer vaccines by Michael William Graner, Kevin O Lillehei, Emmanuel eKatsanis

“…It is also the transport route for peptides generated in the cytosol by the proteasome into the ER for loading onto major histocompatibility complex class I (MHC I) molecules for eventual antigen presentation at the cell surface. …”
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Isolation and characterization of novel murine epiphysis derived mesenchymal stem cells. by Chun-Chun Cheng, Wei-Shiung Lian, Felix Shih-Hsiang Hsiao, I-Hsuan Liu, Shau-Ping Lin, Yen-Hua Lee, Chia-Chun Chang, Guan-Yu Xiao, Hsin-Yi Huang, Ching-Feng Cheng, Winston Teng-Kuei Cheng, Shinn-Chih Wu

“…Notably, EMSCs did not express major histocompatibility complex class I (MHC I) or MHC II under our culture system. EMSCs also successfully suppressed the proliferation of splenocytes triggered by concanavalin A (Con A) or allogeneic splenocytes, and decreased the expression of IL-1, IL-6 and TNF-α in Con A-stimulated splenocytes suggesting their anti-inflammatory properties. …”
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IRF1 and NF-kB restore MHC class I-restricted tumor antigen processing and presentation to cytotoxic T cells in aggressive neuroblastoma. by Silvia Lorenzi, Matteo Forloni, Loredana Cifaldi, Chiara Antonucci, Arianna Citti, Renata Boldrini, Marco Pezzullo, Aurora Castellano, Vincenzo Russo, Pierre van der Bruggen, Patrizio Giacomini, Franco Locatelli, Doriana Fruci

“…Neuroblastoma (NB), the most common solid extracranial cancer of childhood, displays a remarkable low expression of Major Histocompatibility Complex class I (MHC-I) and Antigen Processing Machinery (APM) molecules, including Endoplasmic Reticulum (ER) Aminopeptidases, and poorly presents tumor antigens to Cytotoxic T Lymphocytes (CTL). …”
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The Full Model of the pMHC-TCR-CD3 Complex: A Structural and Dynamical Characterization of Bound and Unbound States by Josephine Alba, Marco D’Abramo

“…The machinery involved in cytotoxic T-cell activation requires three main characters: the major histocompatibility complex class I (MHC I) bound to the peptide (p), the T-cell receptor (TCR), and the CD3 complex, a multidimer interfaced with the intracellular side. …”
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Differential expression of major histocompatibility complex class I in developmental glioneuronal lesions by Prabowo Avanita S, Iyer Anand M, Anink Jasper J, Spliet Wim GM, van Rijen Peter C, Aronica Eleonora

“…<p>Abstract</p> <p>Purpose</p> <p>The expression of the major histocompatibility complex class I (MHC-I) in the brain has received considerable interest not only because of its fundamental role in the immune system, but also for its non-immune functions in the context of activity-dependent brain development and plasticity.…”
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Optimization of HSP-70 and Gp96 Production by Prostate and Erythroleukemia Cell Lines: Implication for Cancer Vaccine Preparation by Nowruz Delirezh, Pouria Malekkhatabi, Ghasem Akbari

“…These proteins such as Hsp70 and gp96 have a critical role in presentation of major histocompatibility complex class I (MHC-I)-restricted antigens and induction of CD8+ T cells (TCD8+) responses. …”
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Us3 kinase encoded by herpes simplex virus 1 mediates downregulation of cell surface major histocompatibility complex class I and evasion of CD8+ T cells. by Takahiko Imai, Naoto Koyanagi, Ryo Ogawa, Keiko Shindo, Tadahiro Suenaga, Ayuko Sato, Jun Arii, Akihisa Kato, Hiroshi Kiyono, Hisashi Arase, Yasushi Kawaguchi

“…Detection and elimination of virus-infected cells by CD8(+) cytotoxic T lymphocytes (CTLs) depends on recognition of virus-derived peptides presented by major histocompatibility complex class I (MHC-I) molecules on the surface of infected cells. …”
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Chikungunya virus infection disrupts MHC-I antigen presentation via nonstructural protein 2. by Brian C Ware, M Guston Parks, Mariana O L da Silva, Thomas E Morrison

“…Here, using a recombinant CHIKV strain encoding the fluorescent protein VENUS with an embedded CD8+ T cell epitope, SIINFEKL, we observed a marked loss of both MHC class I (MHC-I) surface expression and antigen presentation by CHIKV-infected joint tissue fibroblasts. …”
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Tumor mouse model confirms MAGE-A3 cancer immunotherapeutic as an efficient inducer of long-lasting anti-tumoral responses. by Catherine Gérard, Nathalie Baudson, Thierry Ory, Jamila Louahed

“…In the present study, different aspects of the murine anti-tumor immune responses induced by a recombinant MAGE-A3 protein (recMAGE-A3) in combination with different immunostimulants (AS01, AS02, CpG7909 or AS15) were investigated.Based on cytokine profile analyses and protection against challenge with MAGE-A3-expressing tumor, the combination recMAGE-A3+AS15 was selected for further experimental work, in particular to study the mechanisms of anti-tumor responses. By using MHC class I-, MHC class II-, perforin-, B-cell- and IFN-γ- knock-out mice and CD4+ T cell-, CD8+ T cell- and NK cell- depleted mice, we demonstrated that CD4+ T cells and NK cells are the main anti-tumor effectors, and that IFN-γ is a major effector molecule. …”
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Natural Killer T Cell Diversity and Immunotherapy by Eduardo I. Tognarelli, Cristián Gutiérrez-Vera, Pablo A. Palacios, Ignacio A. Pasten-Ferrada, Fernanda Aguirre-Muñoz, Daniel A. Cornejo, Pablo A. González, Leandro J. Carreño

“…Invariant natural killer T cells (iNKTs), a type of unconventional T cells, share features with NK cells and have an invariant T cell receptor (TCR), which recognizes lipid antigens loaded on CD1d molecules, a major histocompatibility complex class I (MHC-I)-like protein. This interaction produces the secretion of a wide array of cytokines by these cells, including interferon gamma (IFN-γ) and interleukin 4 (IL-4), allowing iNKTs to link innate with adaptive responses. …”
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Therapeutic Antibodies against Intracellular Tumor Antigens by Iva Trenevska, Demin Li, Alison H. Banham

“…Furthermore, intracellular proteins can be degraded by the proteasome into short, commonly 8–10 amino acid long, peptides that are presented on the cell surface in the context of major histocompatibility complex class I (MHC-I) molecules. These tumor-associated peptide–MHC-I complexes can then be targeted by antibodies known as T-cell receptor mimic (TCRm) or T-cell receptor (TCR)-like antibodies, which recognize epitopes comprising both the peptide and the MHC-I molecule, similar to the recognition of such complexes by the TCR on T cells. …”
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Swine Enteric Coronaviruses (PEDV, TGEV, and PDCoV) Induce Divergent Interferon-Stimulated Gene Responses and Antigen Presentation in Porcine Intestinal Enteroids by Lingdan Yin, Xiang Liu, Dongmei Hu, Yi Luo, Guozhong Zhang, Pinghuang Liu

“…Mechanistically, we demonstrated that IFNs treatment markedly elevated the expression of NOD-like receptor (NLR) family NLRC5 and major histocompatibility complex class I (MHC-I) molecules. Together, our results indicate unique and common viral strategies for manipulating the global IFN responses and antigen presentation utilized by SECoVs, which help us a better understanding of host-SECoVs interactions.…”
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The relationship between Listeria infections and host immune responses: Listeriolysin O as a potential target by Zixuan Cong, Yan Xiong, Lyu Lyu, Beibei Fu, Dong Guo, Zhou Sha, Bo Yang, Haibo Wu

“…We describe the invasion of host cells by Lm and the subsequent removal of Lm by CD8 T cells and CD4 T cells upon receipt of the LLO epitopes from major histocompatibility complex class I (MHC-I) and major histocompatibility complex class II (MHC-II). …”
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The intracellular domain of major histocompatibility class-I proteins is essential for maintaining excitatory spine density and synaptic ultrastructure in the brain by Maciej J. Lazarczyk, Brett A. Eyford, Merina Varghese, Hitesh Arora, Lonna Munro, Tahia Warda, Cheryl G. Pfeifer, Allison Sowa, Daniel R. Dickstein, Timothy Rumbell, Wilfred A. Jefferies, Dara L. Dickstein

“…Abstract Major histocompatibility complex class I (MHC-I) proteins are expressed in neurons, where they regulate synaptic plasticity. …”
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Molecular Characterization of MHC Class I Alpha 1 and 2 Domains in Asian Seabass (<i>Lates calcarifer</i>) by Zhixuan Loh, Xuelu Huan, Sunita Awate, Markus Schrittwieser, Laurent Renia, Ee Chee Ren

“…In humans, the highly polymorphic MHC class I (MHC-I) molecules play an important role in antigen presentation for the adaptive immune system. …”
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Lymphocyte receptor cis interactions in immune cell signaling by Mørch, A

“…Finally, in Chapter 6, we turn to the study of cis interactions between an inhibitory NK-cell receptor and class I MHC molecules. Guided by structural biology, we determine how novel malarial surface antigens have evolved to bind inhibitory molecules even when ‘masked’ by MHC-I binding in cis. …”

Consistent patterns of expression of HLA class I free heavy chains in healthy individuals and raised expression in spondyloarthropathy patients point to physiological and pathologi... by Raine, T, Brown, D, Bowness, P, Hill Gaston, J, Moffett, A, Trowsdale, J, Allen, R

“…OBJECTIVES: Major histocompatibility complex class I (MHC-I) proteins exist at the cell surface in antigen presenting forms and as beta2m-independent free heavy chains (FHCs). …”

The Role of HLA-G in Tumor Escape: Manipulating the Phenotype and Function of Immune Cells by Lu Liu, Lu Liu, Lijun Wang, Lihong Zhao, Chen He, Ganlu Wang

“…Human leukocyte antigen-G (HLA-G) is a non-classical major histocompatibility complex class I (MHC I) molecule, and under physiological conditions, its expression is strictly restricted to the maternal–fetal interface and immune-privileged organs where HLA-G is expected to contribute to establishment and maintenance of immune tolerance. …”
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