Pharmacokinetic Evaluation by Modeling and Simulation Analysis of a Donepezil Patch Formulation in Healthy Male Volunteers by Yoon SK, Bae KS, Hong DH, Kim SS, Choi YK, Lim HS

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An interactive R-Shiny app for quickly visualizing a tidy, long dataset with multiple dimensions with an application in clinical trial simulations for platform trials by Elias Laurin Meyer, Constantin Kumaus, Michal Majka, Franz Koenig

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SIMPLE—A modular tool for simulating complex platform trials by Elias Laurin Meyer, Tobias Mielke, Tom Parke, Peter Jacko, Franz Koenig

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NCC: An R-package for analysis and simulation of platform trials with non-concurrent controls by Pavla Krotka, Katharina Hees, Peter Jacko, Dominic Magirr, Martin Posch, Marta Bofill Roig

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Clinical trial simulation to evaluate tenofovir disoproxil fumarate/emtricitabine HIV pre-exposure prophylaxis dosing during pregnancy by Rachel K. Scott, Yifan Yu, Mark A. Marzinke, Jenell S. Coleman, Craig W. Hendrix, Robert Bies

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Validation of a simplified-geometry model of inhaled formoterol pharmacodynamics in asthmatic patients by Simona Panunzi, Claudio Gaz, Claudio Gaz, Fabio Cibella, Andrea De Gaetano, Andrea De Gaetano, Andrea De Gaetano

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Simulating clinical trials for model-informed precision dosing: using warfarin treatment as a use case by David Augustin, Ben Lambert, Martin Robinson, Ken Wang, David Gavaghan

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Personalized statin treatment plan using counterfactual approach with multi-objective optimization over benefits and risks by Yue Liang, Pui Ying Yew, Matt Loth, Terrence J. Adam, Julian Wolfson, Peter J. Tonellato, Chin-Lin Chi

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EARLY HEALTH TECHNOLOGIES ASSESSMENT — NEW APPROACH TO IMPROVING THE EFFICIENCY OF THE MEDICAL TECHNOLOGY DEVELOPMENT PROCESS by N. Z. Musina, V. V. Omelyanovskiy, A. V. Krasheninnikova

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The inclusion of real world evidence in clinical development planning by Reynaldo Martina, David Jenkins, Sylwia Bujkiewicz, Pascale Dequen, Keith Abrams, on behalf of GetReal Workpackage 1

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A Model-Informed Drug Development (MIDD) Approach for a Low Dose of Empagliflozin in Patients with Type 1 Diabetes by Curtis K. Johnston, Rena J. Eudy-Byrne, Ahmed Elmokadem, Valerie Nock, Jan Marquard, Nima Soleymanlou, Matthew M. Riggs, Karl-Heinz Liesenfeld

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