Showing 181 - 200 results of 664 for search '"Clock (gene)"', query time: 0.11s Refine Results
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    Improving circadian rhythm disturbance reduces myocardial ischemia-reperfusion injury in diabetic rats by QIN Xiaoying, LIU Hui, HAN Chongfang, HE Jiandong

    Published 2024-02-01
    Subjects: “…biological clock gene|circadian rhythm disorder|diabetes|myocardial ischemia-reperfusion…”
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    Proinflammatory Cytokines Perturb Mouse and Human Pancreatic Islet Circadian Rhythmicity and Induce Uncoordinated β-Cell Clock Gene Expression via Nitric Oxide, Lysine Deacetylases, and Immunoproteasomal Activity by Phillip Alexander Keller Andersen, Volodymyr Petrenko, Peter Horskjær Rose, Melissa Koomen, Nico Fischer, Seyed Mojtaba Ghiasi, Tina Dahlby, Charna Dibner, Thomas Mandrup-Poulsen

    Published 2020-12-01
    “…Real-time recording of Per2:luciferase reporter activity in murine and human pancreatic islets demonstrated that the proinflammatory cytokine interleukin-1β (IL-1β) lengthened the circadian period. qPCR-profiling of core clock gene expression in insulin-producing cells suggested that the combination of the proinflammatory cytokines IL-1β and interferon-γ (IFN-γ) caused pronounced but uncoordinated increases in mRNA levels of multiple core clock genes, in particular of reverse-erythroblastosis virus α <i>(Rev-erbα)</i>, in a dose- and time-dependent manner. …”
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