PTEN Mediates Activation of Core Clock Protein BMAL1 and Accumulation of Epidermal Stem Cells by Chiara Zagni, Luciana O. Almeida, Tarek Balan, Marco T. Martins, Luciana K. Rosselli-Murai, Petros Papagerakis, Rogerio M. Castilho, Cristiane H. Squarize

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Circulating Exosomal miRNAs Signal Circadian Misalignment to Peripheral Metabolic Tissues by Abdelnaby Khalyfa, Shobhan Gaddameedhi, Elena Crooks, Chunling Zhang, Yan Li, Zhuanhong Qiao, Wojciech Trzepizur, Steve A. Kay, Jorge Andrade, Brieann C. Satterfield, Devon A. Hansen, Leila Kheirandish-Gozal, Hans P. A. Van Dongen, David Gozal

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Response to Stimulations Inducing Circadian Rhythm in Human Induced Pluripotent Stem Cells by Hitomi Kaneko, Taku Kaitsuka, Kazuhito Tomizawa

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mRNA levels of circadian clock components Bmal1 and Per2 alter independently from dosing time-dependent efficacy of combination treatment with valsartan and amlodipine in spontaneo... by Peter Potucek, Michal Radik, Gabriel Doka, Eva Kralova, Peter Krenek, Jan Klimas

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Influence of <i>ApoE</i> Genotype and <i>Clock</i> T3111C Interaction with Cardiovascular Risk Factors on the Progression to Alzheimer’s Disease in Subjective Cognitive Decline and... by Valentina Bessi, Juri Balestrini, Silvia Bagnoli, Salvatore Mazzeo, Giulia Giacomucci, Sonia Padiglioni, Irene Piaceri, Marco Carraro, Camilla Ferrari, Laura Bracco, Sandro Sorbi, Benedetta Nacmias

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An Ultradian Feeding Schedule in Rats Affects Metabolic Gene Expression in Liver, Brown Adipose Tissue and Skeletal Muscle with Only Mild Effects on Circadian Clocks by Paul de Goede, Satish Sen, Yan Su, Ewout Foppen, Vincent-Joseph Poirel, Etienne Challet, Andries Kalsbeek

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Identification and Characterization of <i>PSEUDO-RESPONSE REGULATOR</i> (<i>PRR</i>) <i>1a</i> and <i>1b</i> Genes by CRISPR/Cas9-Targeted Mutagenesis in Chinese Cabbage (<i>Brassi... by Nan-Sun Kim, Jihyeon Yu, Sangsu Bae, Hyang Suk Kim, Soyoung Park, Kijong Lee, Soo In Lee, Jin A. Kim

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Sensitive to freezing6 integrates cellular and environmental inputs to the plant circadian clock. by Knight, H, Thomson, A, Mcwatters, H

“…This study shows that large changes in level and timing of clock gene expression may have little effect upon clock outputs. …”

Evidence for widespread dysregulation of circadian clock progression in human cancer by Jarrod Shilts, Guanhua Chen, Jacob J. Hughey

“…Subsequent analysis of data from clock gene knockouts in mice suggested that perturbed clock gene co-expression in human cancer is not caused solely by the inactivation of clock genes. …”
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Clinical and genetic associations of the CLOCK circadian rhythm gene and depressive disorders in patients with alcohol dependence syndrome during the period of alcohol abstinence by N. R. Tulbaeva, R. F. Nasyrova, D. A. Smirnova, Z. Sh. Ashurov, I. S. Efremov, V. S. Dobrodeeva, A. E. Abdrakhmanova, A. R. Asadullin

“…The CLOCK gene is associated with the development of depression in patients suffering from alcohol dependence. …”
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Ror homolog nhr-23 is essential for both developmental clock and circadian clock in C. elegans by Shingo Hiroki, Hikari Yoshitane

“…Abstract Animals have internal clocks that generate biological rhythms. In mammals, clock genes such as Period form the circadian clock to generate approximately 24-h biological rhythms. …”
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Time-Restricted Feeding in Mice Prevents the Disruption of the Peripheral Circadian Clocks and Its Metabolic Impact during Chronic Jetlag by Louis Desmet, Theo Thijs, Rosalie Mas, Kristin Verbeke, Inge Depoortere

“…Fecal short-chain fatty acid (SCFA) concentrations, plasma ghrelin and corticosterone levels, and colonic clock gene mRNA expression were measured. Preventing the disruption of the food intake pattern during chronic jetlag using TRF restored the rhythmicity in hypothalamic clock gene mRNA expression of <i>Reverbα</i> but not of <i>Arntl</i>. …”
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The Important Tumor Suppressor Role of PER1 in Regulating the Cyclin&ndash;CDK&ndash;CKI Network in SCC15 Human Oral Squamous Cell Carcinoma Cells [Retraction] by Fu X, Li H, Yang K, Chen D, Tang H

“…Oncotarget. 2016;7:20574&#x2013;20583. https://doi.org/10.18632/oncotarget.7827; Figure 4A from Zhao Q, Zheng G, Yang K, et al. The clock gene PER1 plays an important role in regulating the clock gene network in human oral squamous cell carcinoma cells. …”
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Machine learning and expression analyses reveal circadian clock features predictive of anxiety by Aziz Zafar, Rebeccah Overton, Ziad Attia, Ahmet Ay, Krista Ingram

“…Abstract Mood disorders, including generalized anxiety disorder, are associated with disruptions in circadian rhythms and are linked to polymorphisms in circadian clock genes. Molecular mechanisms underlying these connections may be direct—via transcriptional activity of clock genes on downstream mood pathways in the brain, or indirect—via clock gene influences on the phase and amplitude of circadian rhythms which, in turn, modulate physiological processes influencing mood. …”
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The circadian clock protein Cryptochrome 1 is a direct target and feedback regulator of the Hippo pathway by Abdelhalim Azzi, Zhipeng Tao, Yang Sun, Hannah Erb, Carla Guarino, Xu Wu

“…The activity of various signaling pathways affects clock gene expression. Here, we show that the core circadian clock gene CRY1 is a direct target of the Hippo pathway effector YAP. …”
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A real-time measurement system for gene expression rhythms from deep tissues of freely moving mice under light-dark conditions by Mizuki Nakaya, Miho Wakamatsu, Hinaki Motegi, Ami Tanaka, Kenneth Sutherland, Masayori Ishikawa, Michitaka Ozaki, Hiroki Shirato, Kazuko Hamada, Toshiyuki Hamada

“…Disturbances in clock gene expression due to desynchronization of clock gene expression of the external LD cycle are risk factors for developing various diseases. …”
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Neuroendocrine effects of the duper mutation in Syrian hamsters: a role for Cryptochrome 1 by Emily N. C. Manoogian, Michael Seifu Bahiru, Emily Jue Wang, Mary Holder, Eric L. Bittman

“…In light of the finding that the duper allele is a stop codon in Cryptochrome 1, our results suggest important neuroendocrine functions of this core circadian clock gene.…”
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Machine Learning Analyses Reveal Circadian Features Predictive of Risk for Sleep Disturbance by Overton R, Zafar A, Attia Z, Ay A, Ingram KK

“…In addition, the mediation of clock gene effects on sleep disturbance indicates circadian influences on the quality of sleep. …”
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The role of medullary dorsal horn circuits in the diurnal regulation of nociception by Zirpel, F

“…To study circadian control, mice carrying a global knockout for the clock genes <em>Cry1</em> and <em>Cry2</em>, and mice with knockout of the clock gene Bmal1 in Advillin-positive neurons, a model for clock gene knockout in peripheral neurons, were used. …”

Glutamate and clock help bean bugs track seasonal reproductive changes. by Sergio Hidalgo, Joanna C Chiu

“…A new study in PLOS Biology uncovers changes in glutamate dynamics in the bean bug that are dependent on photoperiod and a clock gene.…”
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