Association of rotating night shift work, CLOCK, MTNR1A, MTNR1B genes polymorphisms and their interactions with type 2 diabetes among steelworkers: a case–control study by Qinglin Li, Shengkui Zhang, Han Wang, Zhende Wang, Xiaohong Zhang, Yongbin Wang, Juxiang Yuan

“…The interaction between MTNR1A gene rs2119882 locus and CLOCK gene rs1801260 locus was associated with the risk of type 2 diabetes (RERI = 1.07, (95% CI, 0.23–1.91); AP = 0.77, (95% CI, 0.36–1.17)). …”
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Melatonin: a ferroptosis inhibitor with potential therapeutic efficacy for the post-COVID-19 trajectory of accelerated brain aging and neurodegeneration by Asmaa Yehia, Osama A. Abulseoud

“…COVID-19 incites neuroinflammation, iron dysregulation, reactive oxygen species (ROS) accumulation, antioxidant system repression, renin-angiotensin system (RAS) disruption, and clock gene alteration. These events pave the way for ferroptosis, which shows its signature in COVID-19, premature aging, and neurodegenerative disorders. …”
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It's not all in the brain by Lauren J Francey, John B Hogenesch

“…A clock gene expressed in skeletal muscle plays a bigger role in regulating sleep than it does in the brain.…”
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Loss of thyroid gland circadian PER2 rhythmicity in aged mice and its potential association with thyroid cancer development by Junguee Lee, Hae Joung Sul, Hyunsu Choi, Dong Hyun Oh, Minho Shong

“…However, potential age-related changes in the expression rhythmicity of clock genes and the effects of these changes on the thyroid gland remain unknown. …”
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Early Time-Restricted Feeding Amends Circadian Clock Function and Improves Metabolic Health in Male and Female Nile Grass Rats by Chidambaram Ramanathan, Hayden Johnson, Suman Sharma, Wangkuk Son, Melissa Puppa, Saba Neyson Rohani, Aaryani Tipirneni-Sajja, Richard J. Bloomer, Marie van der Merwe

“…This study explored the effect of early and late time-restricted feeding (TRF) on weight and adiposity, food consumption, glycemic control, clock gene expression, and liver metabolite composition in diurnal Nile grass rats (NGRs). …”
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Disruption of the Expression of the Placental Clock and Melatonin Genes in Preeclampsia by Aïssatou Bailo Diallo, Benjamin Coiffard, Raoul Desbriere, Maria Katsogiannou, Xavier Donato, Florence Bretelle, Soraya Mezouar, Jean-Louis Mege

“…Placental macrophages exhibited significant circadian expression of clock genes but one third of placental macrophages lost clock gene rhythmicity; the clock gene oscillations were restored by co-culture with trophoblasts. …”
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2.4 GHz Electromagnetic Field Influences the Response of the Circadian Oscillator in the Colorectal Cancer Cell Line DLD1 to miR-34a-Mediated Regulation by Soňa Olejárová, Roman Moravčík, Iveta Herichová

“…Therefore, the present study was designed to reveal if 24 h exposure to 2.4 GHz RF-EMF influences miR-34a-induced changes in clock gene expression, migration and proliferation in colorectal cancer cell line DLD1. …”
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The circadian clock in the piriform cortex intrinsically tunes daily changes of odor-evoked neural activity by Shunsuke Takeuchi, Kimiko Shimizu, Yoshitaka Fukada, Kazuo Emoto

“…Loss of the clock gene, Bmal1, in the piriform cortex largely abolishes the circadian rhythm of odor-evoked activity in mice, suggesting a broader regulatory role for Bmal1 in olfactory neural activity and transmission.…”
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REVIEW OF RESEARCH ON THE RELATIONSHIP BETWEEN CIRCADIAN RHYTHMS AND CARCINOGENESIS USING ANIMAL MODELS by G. S. Kireeva, E. A. Gubareva, M. A. Maydin, A. V. Panchenko, M. L. Tyndyk, E. I. Fedoros, S. S. Kruglov, V. K. Osetnik, V. N. Anisimov

“…Purpose of the study: to review in vivo studies on the relationship and role of various molecular genetic components of the circadian rhythm system in the initiation and development of malignant neoplasms. in contrast to clinical and epidemiological studies, animal models, including transgenic animal models, can model various changes and disturbances in the activity of clock genes and track the results of these changes.Material and Methods. the review includes data from studies carried out over the past 10 years in animal models, studying the mechanisms and effects of disturbances in the system of circadian rhythms related to the formation and development of tumors. the data sources for the review were the Medline, embase and scopus databases.Results. analysis of the literature has shown that interference with the work of the «biological clock» by changing the light cycle, disrupting the expression of clock genes and other manipulations is a factor predisposing to the development of tumors. in tumors of various types, the expression of clock genes is often mismatched, and it is unclear at what stage of their formation this occurs. in addition, the development of tumors disrupts the circadian homeostasis of the body. there are three key areas of research aimed at studying the role of circadian rhythms in tumor development: disturbance of circadian rhythms as a carcinogenic factor, disturbances in the clock gene system in a tumor, disturbances in the clock gene system of the whole organism, provoked by tumor development.Conclusion. the results of studies on animal models demonstrate that the relationship between the disturbance of circadian rhythms and the tumor process is complex since the causal relationship has not yet been studied. in this regard, the prospect of targeted pharmacological correction of circadian rhythms in clinical practice in cancer patients does not seem to be the nearest one.…”
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Effect of miR-34a on the expression of clock and clock-controlled genes in DLD1 and Lovo human cancer cells with different backgrounds with respect to p53 functionality and 17β-est... by Roman Moravčík, Soňa Olejárová, Jana Zlacká, Iveta Herichová

“…With respect to the possible use of miR-34a in cancer treatment, clock genes can be considered as off-target genes, as changes in their expression induced by miR-34a treatment do not contribute to the oncostatic functions of miR-34a. …”
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Cell–Fibronectin Interactions and Actomyosin Contractility Regulate the Segmentation Clock and Spatio-Temporal Somite Cleft Formation during Chick Embryo Somitogenesis by Patrícia Gomes de Almeida, Pedro Rifes, Ana P. Martins-Jesus, Gonçalo G. Pinheiro, Raquel P. Andrade, Sólveig Thorsteinsdóttir

“…PSM cells undergo cyclic waves of segmentation clock gene expression, followed by Notch-dependent upregulation of <i>meso1</i> in the rostral PSM which induces somite cleft formation. …”
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Molecular genetics of timing in intrinsic circadian rhythm sleep disorders. by Wijnen, H, Boothroyd, C, Young, M, Claridge-Chang, A

“…A striking example was last year's discovery of a point mutation in a human clock gene that produces a sleep phase syndrome. This finding suggested that other intrinsic sleep disorders may have genetic underpinnings, and that less debilitating variations in sleep/wake behavior may be revealed by molecular screening of known clock genes in broader human populations.…”

The Opioid Receptor Influences Circadian Rhythms in Human Keratinocytes through the β-Arrestin Pathway by Paul Bigliardi, Seetanshu Junnarkar, Chinmay Markale, Sydney Lo, Elena Bigliardi, Alex Kalyuzhny, Sheena Ong, Ray Dunn, Walter Wahli, Mei Bigliardi-Qi

“…The recent emphasis on circadian rhythmicity in critical skin cell functions related to homeostasis, regeneration and aging has shed light on the importance of the <i>PER2</i> circadian clock gene as a vital antitumor gene. Furthermore, delta-opioid receptors (DOPrs) have been identified as playing a crucial role in skin differentiation, proliferation and migration, which are not only essential for wound healing but also contribute to cancer development. …”
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Sleep and Microbiome in Psychiatric Diseases by Jolana Wagner-Skacel, Nina Dalkner, Sabrina Moerkl, Kathrin Kreuzer, Aitak Farzi, Sonja Lackner, Annamaria Painold, Eva Z. Reininghaus, Mary I. Butler, Susanne Bengesser

“…Methods: A PubMed search (studies published between April 2015–April 2020) was conducted with the keywords: “sleep, microbiome and psychiatry”; “sleep, microbiome and depression”; “sleep, microbiome and bipolar disorder”, “sleep, microbiome and schizophrenia”, “sleep, microbiome and anorexia nervosa”, “sleep, microbiome and substance use disorder”, “sleep, microbiome and anxiety”; “clock gene expression and microbiome”, “clock gene expression and nutrition”. …”
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The chondrocyte-intrinsic circadian clock is disrupted in human osteoarthritis by Snelling, S, Forster, A, Mukherjee, S, Price, A, Poulsen, R

“…We investigated whether clock gene expression differed in osteoarthritic compared to "healthy" chondrocytes and used RNAi to determine whether the differences observed could affect chondrocyte phenotype. …”

E4BP4 Coordinates Circadian Control of Cognition in Delirium by Min Chen, Li Zhang, Mingting Shao, Jianhao Du, Yifei Xiao, Fugui Zhang, Tianpeng Zhang, Yifang Li, Qianqian Zhou, Kaisheng Liu, Zhigang Wang, Baojian Wu

“…Likewise, global deletion of E4bp4 (E4 promoter‐binding protein), a clock gene markedly altered in delirium conditions, results in exacerbated delirium‐associated cognitive decline. …”
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The hepatocyte insulin receptor is required to program the liver clock and rhythmic gene expression by Fougeray, Tiffany, Polizzi, Arnaud, Régnier, Marion, Fougerat, Anne, Ellero-Simatos, Sandrine, Lippi, Yannick, Smati, Sarra, Lasserre, Frédéric, Tramunt, Blandine, Huillet, Marine, Dopavogui, Léonie, Salvi, Juliette, Nédélec, Emmanuelle, Gigot, Vincent, Smith, Lorraine, Naylies, Claire, Sommer, Caroline, Haas, Joel T., Wahli, Walter, Duez, Hélène, Gourdy, Pierre, Gamet-Payrastre, Laurence, Benani, Alexandre, Burnol, Anne-Françoise, Loiseau, Nicolas, Postic, Catherine, Montagner, Alexandra, Guillou, Hervé

“…This change in core-clock gene expression is associated with defective reprogramming of liver gene expression. …”
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Interdependence of nutrient metabolism and the circadian clock system: Importance for metabolic health by Aleix Ribas-Latre, Kristin Eckel-Mahan

“…In addition, we review several studies looking at clock gene SNPs in humans and the metabolic phenotypes or tendencies associated with particular clock gene mutations. …”
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Circadian Misalignment and Metabolic Disorders: A Story of Twisted Clocks by Aurore Woller, Didier Gonze

“…In this review, we summarize several experimental works pertaining to the effect of adverse conditions on clock gene expression and on physiology, and we show how computational models can bring interesting insights into the links between circadian misalignment and metabolic diseases.…”
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Bioluminescence Imaging of Gene Expression in Utero by Meera T. Saxena, Sara J. Aton, Charles Hildebolt, Julie L. Prior, Ute Abraham, David Piwnica-Worms, Erik D. Herzog

“…These results demonstrate the feasibility of in utero imaging of mammalian gene expression, tracking of fetal gene expression from the same litter, and early detection of mammalian clock gene expression. We conclude that luciferase-based reporters can provide a sensitive, noninvasive measure of in utero gene expression.…”
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