Update of sleep alterations in depression by Andrés Barrera Medina, DeboraYoaly Arana Lechuga, Oscar Sánchez Escandón, Javier Velázquez Moctezuma

“…Among the mechanisms of sleep disturbances in depression are hyperactivation of the hypothalamic-pituitary-adrenal axis, CLOCK gene polymorphism and primary sleep disorders. …”
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Fibroblast-like synoviocytes orchestrate daily rhythmic inflammation in arthritis by Downton, P, Dickson, SH, Ray, DW, Bechtold, DA, Gibbs, JE

“…The deletion of essential clock gene Bmal1 in FLS reduced susceptibility to collagen-induced arthritis but did not impact symptomatic severity in affected mice. …”

Circadian expression of Fabp7 mRNA is disrupted in Bmal1 KO mice by Jason R. Gerstner, Georgios K. Paschos

“…Here we examined the circadian expression of Fabp7 mRNA in the hypothalamus of core clock gene Bmal1 knock-out (KO) mice. We observed that the circadian rhythm of Fabp7 mRNA expression is blunted, while overall Fabp7 mRNA levels are significantly higher in Bmal1 KO compared to control (C57BL/6 J) mice. …”
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Transcription factor CBF-1 is critical for circadian gene expression by modulating WHITE COLLAR complex recruitment to the frq locus. by Xuemei Cao, Xiao Liu, Hongda Li, Yumeng Fan, Jiabin Duan, Yi Liu, Qun He

“…Transcription of the Neurospora crassa circadian clock gene frequency (frq) is an essential process in the negative feedback loop that controls circadian rhythms. …”
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The TIME FOR COFFEE gene maintains the amplitude and timing of Arabidopsis circadian clocks. by Hall, A, Bastow, R, Davis, S, Hanano, S, Mcwatters, H, Hibberd, V, Doyle, MR, Sung, S, Halliday, K, Amasino, R, Millar, A

“…Thus, we identify TIC as a regulator of the clock gene circuit. In contrast to tic and elf3 single mutants, tic elf3 double mutants are completely arrhythmic. …”

Mutual Effects of Orexin and Bone Morphogenetic Proteins on Gonadotropin Expression by Mouse Gonadotrope Cells by Yoshiaki Soejima, Nahoko Iwata, Nanako Nakayama, Shinichi Hirata, Yasuhiro Nakano, Koichiro Yamamoto, Atsuhito Suyama, Kohei Oguni, Takahiro Nada, Satoshi Fujisawa, Fumio Otsuka

“…Collectively, the results indicate that orexin regulates gonadotropin expression via clock gene expression by mutually interacting with GnRH action and the pituitary BMP system in gonadotrope cells.…”
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Chromatin Dynamics and Transcriptional Control of Circadian Rhythms in <i>Arabidopsis</i> by Aida Maric, Paloma Mas

“…From the initial discovery more than 13 years ago of a parallelism between the oscillations in chromatin status and the transcriptional rhythms of an <i>Arabidopsis</i> clock gene, a number of studies have later expanded considerably our view on the circadian epigenome and transcriptome landscapes. …”
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Gut microbes and the liver circadian clock partition glucose and lipid metabolism by Katya Frazier, Sumeed Manzoor, Katherine Carroll, Orlando DeLeon, Sawako Miyoshi, Jun Miyoshi, Marissa St. George, Alan Tan, Evan A. Chrisler, Mariko Izumo, Joseph S. Takahashi, Mrinalini C. Rao, Vanessa A. Leone, Eugene B. Chang

“…To assess this relationship, we utilized mice with liver-specific deletion of the core circadian clock gene Bmal1 via Albumin-cre maintained in either conventional or germ-free housing conditions. …”
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Reconsidering the Role of Melatonin in Rheumatoid Arthritis by Iona J. MacDonald, Chien-Chung Huang, Shan-Chi Liu, Chih-Hsin Tang

“…In addition, disturbance of the circadian rhythm is associated with RA development and melatonin has been found to affect clock gene expression in joints of RA. This review summarizes current understanding about the immunopathogenic characteristics of melatonin in RA disease. …”
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Circadian desynchrony promotes metabolic disruption in a mouse model of shiftwork. by Johanna L Barclay, Jana Husse, Brid Bode, Nadine Naujokat, Judit Meyer-Kovac, Sebastian M Schmid, Hendrik Lehnert, Henrik Oster

“…Two weeks of timed sleep restriction has moderate effects on diurnal activity patterns, feeding behavior, and clock gene regulation in the circadian pacemaker of the suprachiasmatic nucleus. …”
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Epidemiological research progress on effects of night shift work on female reproductive health by Hualong ZHEN, Binbin HUANG, Minmin JIANG, Fangbiao TAO

“…The potential biological mechanisms connecting night shift work to female reproductive health were also introduced, e.g. melatonin regulation, clock gene regulation, and sex hormone regulation. Through this review, we propose to provide a reference for determining occupational risk factors, conducting subsequent relevant studies, and formulating rational health promotion strategies.…”
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Light sets the brain’s daily clock by regional quickening and slowing of the molecular clockworks at dawn and dusk by Suil Kim, Douglas G McMahon

“…Thus, circadian entrainment is encoded by SCN clock gene waveform changes that arise from spatiotemporally distinct intrinsic responses within the SCN neural network.…”
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Ripply suppresses Tbx6 to induce dynamic-to-static conversion in somite segmentation by Taijiro Yabe, Koichiro Uriu, Shinji Takada

“…Abstract The metameric pattern of somites is created based on oscillatory expression of clock genes in presomitic mesoderm. However, the mechanism for converting the dynamic oscillation to a static pattern of somites is still unclear. …”
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The circadian clock, aging and its implications in cancer by Abdol-Hossein Rezaeian, Fabin Dang, Wenyi Wei

“…There is also increasing evidence showing that tumor microenvironment can disrupt specific clock gene functions to facilitate tumorigenesis. Although there is great progress in understanding the molecular mechanisms of the circadian clock, aging and cancer, elucidating their complex relationships among these processes remains challenging. …”
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Clocking Epilepsies: A Chronomodulated Strategy-Based Therapy for Rhythmic Seizures by Sha Sun, Han Wang

“…Conversely, circadian misalignment and circadian clock gene variants contribute to epileptic pathogenesis. …”
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Accurate timekeeping is controlled by a cycling activator in Arabidopsis by Polly Yingshan Hsu, Upendra K Devisetty, Stacey L Harmer

“…Indeed, a central regulatory mechanism is the repression of evening-phased clock genes via the binding of morning-phased Myb-like repressors to evening element (EE) promoter motifs. …”
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A spatial model of the plant circadian clock reveals design principles for coordinated timing by Mark Greenwood, Isao T Tokuda, James C W Locke

“…We found that both varied light sensitivity and long‐distance coupling could generate period differences between organs, while local coupling was required to generate the spatial waves of clock gene expression observed experimentally. We then examined our model under noisy light‐dark cycles and found that local coupling minimized timing errors caused by the noise while allowing each plant region to maintain a different clock phase. …”
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Circadian profiling in two mouse models of lysosomal storage disorders; Niemann Pick type-C and Sandhoff disease. by Richardson, K, Livieratos, A, Dumbill, R, Hughes, S, Ang, G, Smith, D, Morris, L, Brown, L, Peirson, S, Platt, F, Davies, K, Oliver, P

“…To investigate whether the pathological features of lysosomal storage disorders (LSDs) influence the core molecular clock or the circadian behavioural abnormalities reported in some patients, we examined mouse models of Niemann-Pick Type-C (Npc1 mutant, Npc1(nih)) and Sandhoff (Hexb knockout, Hexb(-/-)) disease using wheel-running activity measurement, neuropathology and clock gene expression analysis. Both mutants exhibited regular, entrained rest/activity patterns under light:dark (LD) conditions despite the onset of their respective neurodegenerative phenotypes. …”

Disrupted circadian rhythms in a mouse model of schizophrenia. by Oliver, P, Sobczyk, M, Maywood, E, Edwards, B, Lee, S, Livieratos, A, Oster, H, Butler, R, Godinho, S, Wulff, K, Peirson, SN, Fisher, S, Chesham, J, Smith, J, Hastings, M, Davies, K, Foster, R

“…Retinal inputs appear normal in mutants, and clock gene rhythms within the suprachiasmatic nucleus (SCN) are normally phased both in vitro and in vivo. …”

When clocks go bad: neurobehavioural consequences of disrupted circadian timing by Barnard, A, Nolan, P

“…Furthermore, the response of these mutants to psychoactive drugs suggests that clock genes can modify a number of the brain's critical neurotransmitter systems. …”