Precision caffeine therapy for apnea of prematurity and circadian rhythms: New possibilities open up by Hao-Ran Dai, Hao-Ran Dai, Hong-Li Guo, Ya-Hui Hu, Jing Xu, Xuan-Sheng Ding, Rui Cheng, Feng Chen

“…Interestingly, the significant association between Clock gene polymorphisms and the response to caffeine therapy offers an opportunity to advance our understanding of potential mechanistic pathways. …”
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The PRMT6/PARP1/CRL4B Complex Regulates the Circadian Clock and Promotes Breast Tumorigenesis by Tianshu Yang, Wei Huang, Tianyu Ma, Xin Yin, Jingyao Zhang, Miaomiao Huo, Ting Hu, Tianyang Gao, Wei Liu, Die Zhang, Hefen Yu, Xu Teng, Min Zhang, Hao Qin, Yunkai Yang, Baowen Yuan, Yan Wang

“…Abstract Circadian rhythms, as physiological systems with self‐regulatory functions in living organisms, are controlled by core clock genes and are involved in tumor development. The protein arginine methyltransferase 6 (PRMT6) serves as an oncogene in a myriad of solid tumors, including breast cancer. …”
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Cold-induced suspension and resetting of Ca2+ and transcriptional rhythms in the suprachiasmatic nucleus neurons by Ryosuke Enoki, Naohiro Kon, Kimiko Shimizu, Kenta Kobayashi, Sota Hiro, Ching-Pu Chang, Tatsuto Nakane, Hirokazu Ishii, Joe Sakamoto, Yoshifumi Yamaguchi, Tomomi Nemoto

“…These data also indicate that stable Ca2+ oscillation precedes clock gene transcriptional rhythms in SCN neurons.…”
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Does a Red House Affect Rhythms in Mice with a Corrupted Circadian System? by Menekse Öztürk, Marc Ingenwerth, Martin Sager, Charlotte von Gall, Amira A. H. Ali

“…At the cellular level, molecular clockwork composed of interlocked transcriptional/translational feedback loops of clock genes drives rhythmic gene expression. Mice with targeted deletion of the essential clock gene <i>Bmal1</i> (Bmal1−/−) have an impaired light input pathway into the circadian system and show a loss of circadian rhythms. …”
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Antiproliferative Effects of Cynara Cardunculus in Colorectal Cancer Cells Are Modulated by the Circadian Clock by Luise Fuhr, Alireza Basti, Teresa Silva Brás, Maria F. Duarte, Angela Relógio

“…Here, we used the human colorectal cancer (CRC) cell line HCT116 and its knockout variants for different core-clock genes (<i>BMAL1</i>, <i>PER2</i>, <i>NR1D1</i>), to investigate the treatment effect of <i>C. cardunculus</i> lipophilic leaf extract under different clock scenarios. …”
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Bmal1 function in skeletal muscle regulates sleep by J Christopher Ehlen, Allison J Brager, Julie Baggs, Lennisha Pinckney, Cloe L Gray, Jason P DeBruyne, Karyn A Esser, Joseph S Takahashi, Ketema N Paul

“…Whole-body knockout of the circadian clock gene Bmal1 in mice affects several aspects of sleep, however, the cells/tissues responsible are unknown. …”
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Contribution of membrane-associated oscillators to biological timing at different timescales by Monika Stengl, Anna C. Schneider

“…They comprise nuclear clockworks of transcriptional/translational feedback loops (TTFL) that generate ∼24 h rhythms in clock gene expression entrained to the environmental day-night cycle. …”
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The circadian clock modulates Anopheles gambiae infection with Plasmodium falciparum by Tibebu Habtewold, Sofia Tapanelli, Ellen K. G. Masters, Nikolai Windbichler, George K. Christophides

“…The effect of the circadian clock on the infection outcome is also investigated through silencing of the CLOCK gene that is central in the regulation of animal circadian rhythms. …”
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Biological Significance of Photoreceptor Photocycle Length: VIVID Photocycle Governs the Dynamic VIVID-White Collar Complex Pool Mediating Photo-adaptation and Response to Changes... by Arko Dasgupta, Chen-Hui Chen, ChangHwan Lee, Amy S Gladfelter, Jay C Dunlap, Jennifer J Loros

“…Additionally, transcription of the clock gene frequency (frq) is sensitive to changing light intensity in a wild-type strain but not in the fast photo-reversion mutant indicating that the establishment of this dynamic VVD-WCC pool is essential in general photobiology and circadian biology. …”
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Genetic and environmental perturbations alter the rhythmic expression pattern of a circadian long non-coding RNA, Per2AS, in mouse liver [version 2; peer review: 2 approved] by Shihoko Kojima, Heather A. Pieno, Maisy W. Rhoades, Kyle R. Batty, Ayana N. Jackson, Lin Miao

“…Given that Per2AS expression is antiphasic to Period2 (Per2), a core circadian clock gene, and transcribed from the antisense strand of Per2, we hypothesized that the rhythmic Per2AS expression is driven either by its own promoter or by the rhythmic Per2 transcription via transcriptional interference. …”
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New insights into the mechanisms of diabetic kidney disease: Role of circadian rhythm and Bmal1 by Zhimei Peng, Yanting Liang, Xueying Liu, Jie Shao, Nan Hu, Xinzhou Zhang

“…This brief review discusses the clinical relevance of circadian rhythms in DKD and how the core clock gene encoding brain and muscle arnt-like protein 1 (BMAL1) functions owing to the importance of circadian rhythm disruption processes, including the excretion of urinary protein and irregular blood pressure, which occur in DKD. …”
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The Antihypertensive Guanabenz Exacerbates Integrated Stress Response and Disrupts the Brain Circadian Clock by Hao Lin, Muhammad Naveed, Aidan Hansen, Tracy G. Anthony, Ruifeng Cao

“…These results uncover a significant yet previously unidentified role of guanabenz in regulating circadian rhythms and indicate that exacerbated ISR activation can impair the functions of the brain’s circadian clock by disrupting clock gene expression.…”
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Postnatal Deletion of Bmal1 in Cardiomyocyte Promotes Pressure Overload Induced Cardiac Remodeling in Mice by Qing Liang, Hu Xu, Min Liu, Lei Qian, Jin Yan, Guangrui Yang, Lihong Chen

“…Background Mice with cardiomyocyte‐specific deletion of Bmal1, a core clock gene, had spontaneous abnormal cardiac metabolism, dilated cardiomyopathy, and shortened lifespan. …”
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Exacerbated Age-Related Hippocampal Alterations of Microglia Morphology, β-Amyloid and Lipofuscin Deposition and Presenilin Overexpression in <i>Per1</i>^−/−-Mice by Jan Hendrik Börner, Oliver Rawashdeh, Abdelhaq Rami

“…Therefore, we chose to study the link between aging and loss of clock gene <i>Per1</i>^−/−-mice. Young and aged C3H- and <i>Per1</i>^−/−-mice were used as models to analyze the hippocampal distribution of Aβ42, lipofuscin, presenilin, microglia, synaptophysin and doublecortin. …”
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β-Receptor blocker enhances the anabolic effect of PTH after osteoporotic fracture by Jie Huang, Tong Wu, Yi-Rong Jiang, Xuan-Qi Zheng, Huan Wang, Hao Liu, Hong Wang, Hui-Jie Leng, Dong-Wei Fan, Wan-Qiong Yuan, Chun-Li Song

“…Furthermore, PTH increased the expression of the circadian clock gene Bmal1, which was inhibited by NE-βAR signaling. …”
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Chronic Inflammation Disrupts Circadian Rhythms in Splenic CD4+ and CD8+ T Cells in Mice by Misa Hirose, Alexei Leliavski, Leonardo Vinícius Monteiro de Assis, Olga Matveeva, Ludmila Skrum, Werner Solbach, Henrik Oster, Isabel Heyde

“…In both treatment groups, clock gene expression rhythms were altered with differential effects for baseline expression and peak phase compared with control mice. …”
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The circadian clock modulates Anopheles gambiae infection with Plasmodium falciparum. by Tibebu Habtewold, Sofia Tapanelli, Ellen K G Masters, Nikolai Windbichler, George K Christophides

“…The effect of the circadian clock on the infection outcome is also investigated through silencing of the CLOCK gene that is central in the regulation of animal circadian rhythms. …”
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Low circadian amplitude and delayed phase are linked to seasonal affective disorder (SAD) by Luvna Dhawka, Yejin Cha, Ahmet Ay, Krista K Ingram

“…Limitations: Our study examined clock gene expression from peripheral tissues which represent circadian rhythms influenced by both intrinsic, physiological and external, environmental factors. …”
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Black ginger (Kaempferia parviflora) extract enhances circadian rhythm and promotes lipolysis in mice fed a high-fat diet by Izumi Yoshida, Takashi Mishima, Momochika Kumagai, Yushi Takahashi, Kazuhiro Fujita, Tomoji Igarashi

“…Moreover, following RNAi knockdown of clock genes in 3T3-L1 adipocytes, KPE was found to enhance clock gene expression and induce lipolysis-related gene expression in adipocytes. …”
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Birds of a feather flock together: a dataset for Clock and Adcyap1 genes from migration genetics studies by Louis-Stéphane Le Clercq, Gaia Bazzi, Joan Ferrer Obiol, Jacopo G. Cecere, Luca Gianfranceschi, J. Paul Grobler, Antoinette Kotzé, Marta Riutort León, Jacob González-Solís, Diego Rubolini, Miriam Liedvogel, Desiré Lee Dalton

“…Genetic factors affecting intrinsic timekeeping mechanisms, such as circadian clock genes, have been explored, yielding inconsistent findings with potential lineage-dependency. …”
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