In-phasic cytosolic-nuclear Ca2+ rhythms in suprachiasmatic nucleus neurons by Sota Hiro, Sota Hiro, Sota Hiro, Kenta Kobayashi, Kenta Kobayashi, Tomomi Nemoto, Tomomi Nemoto, Tomomi Nemoto, Ryosuke Enoki, Ryosuke Enoki, Ryosuke Enoki

“…Transcriptional regulation occurs in the nucleus in the TTFL model, and Ca2+-dependent kinase regulates the clock gene transcription. However, the Ca2+ regulatory mechanisms between cytosol and nucleus as well as the ionic origin of Ca2+ rhythms remain unclear. …”
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Functional polymorphisms in circadian positive feedback loop genes predict postsurgical prognosis of gastric cancer by Yibing Chen, Dandan Wang, Yucen Song, Xiaofei Zhang, Zhihui Jiao, Juqin Dong, Lin Lü, Zhengzhi Zou, Wei Du, Falin Qu

“…Immunohistochemical analysis further demonstrated that the genotype of rs11133399 was significantly associated with the expression level of CLOCK in GC tissues, suggesting that this SNP might affect the prognosis of GC through its influence on the expression of CLOCK gene. Conclusions Our data indicate that SNPs in CPFL genes might contribute to the clinical outcome of GC through their impact on gene expression. …”
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Acclimation of circadian rhythms in woodland strawberries (Fragaria vesca L.) to Arctic and mid-latitude photoperiods by Corine Faehn, Michael Reichelt, Axel Mithöfer, Timo Hytönen, Jørgen Mølmann, Laura Jaakola

“…Results The Arctic photoperiod induced lower expression in IT4 and NOR13 for six clock genes (FvLHY, FvRVE8, FvPRR9, FvPRR7, FvPRR5, and FvLUX), in IT1 for three genes (FvLHY, FvPRR9, and FvPRR5) and in NOR2 for one gene (FvPRR9). …”
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Daily Rhythmicity of Muscle-Related and Rhythm Genes Expression in Mackerel Tuna (<i>Euthynnus affinis</i>) by Wenwen Wang, Shiming Dai, Longlong Liu, Zhengyi Fu, Rui Yang, Gang Yu, Zhenhua Ma, Humin Zong

“…The present study showed that mackerel tuna muscle rhythm genes and functional genes varied significantly in expression levels depending on weather, time of day, and light intensity and that the expression levels of myogenic genes were closely related to clock gene expression. The fish were also able to adapt to changes in light intensity in different weather conditions through positive physiological regulation.…”
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Comparative transcriptome analysis and CRISPR/Cas9 gene editing reveal that E4BP4 mediates lithium upregulation of Per2 expression by Qin Zhou, Kankan Wang, Jiameng Qiu, Di Zhu, Tian Tian, Yunfei Zhang, Ximing Qin

“…Animal and cellular studies have found that lithium salt can upregulate the expression of the clock gene Per2, but the mechanism is unknown. We aim to understand the mechanism underlying the Per2 upregulation by lithium treatment. …”
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Circadian Gene <i>PER2</i> Silencing Downregulates <i>PPARG</i> and <i>SREBF1</i> and Suppresses Lipid Synthesis in Bovine Mammary Epithelial Cells by Yujia Jing, Yifei Chen, Shan Wang, Jialiang Ouyang, Liangyu Hu, Qingyong Yang, Mengzhi Wang, Bin Zhang, Juan J. Loor

“…<i>PER2,</i> a circadian clock gene, is associated with mammary gland development and lipid synthesis in rodents, partly via regulating peroxisome proliferator-activated receptor gamma (<i>PPARG</i>). …”
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gcProfileMakeR: An R Package for Automatic Classification of Constitutive and Non-Constitutive Metabolites by Fernando Perez-Sanz, Victoria Ruiz-Hernández, Marta I. Terry, Sara Arce-Gallego, Julia Weiss, Pedro J. Navarro, Marcos Egea-Cortines

“…These included a wild type, <i>Deficiens nicotianoides</i> and <i>compacta</i> affecting floral identity and <i>RNAi:AmLHY</i> targeting a circadian clock gene. We identified differences in scent constitutive and non-constitutive profiles as well as in timing of emission. gcProfileMakeR is a very useful tool to define constitutive and non-constitutive scent profiles. …”
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Copper-induced diurnal hepatic toxicity is associated with Cry2 and Per1 in mice by Sarah Tominaga, Hiroki Yoshioka, Satoshi Yokota, Yosuke Tsukiboshi, Masumi Suzui, Makoto Nagai, Hirokazu Hara, Tohru Maeda, Nobuhiko Miura

“…We observed increased expression of three clock genes (Ciart, Cry2, and Per1) after CuCl2 treatment. …”
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Shank3 modulates sleep and expression of circadian transcription factors by Ashley M Ingiosi, Hannah Schoch, Taylor Wintler, Kristan G Singletary, Dario Righelli, Leandro G Roser, Elizabeth Medina, Davide Risso, Marcos G Frank, Lucia Peixoto

“…Overall, our study shows that Shank3 is an important modulator of sleep and clock gene expression.…”
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Circadian pathway genetic variation and cancer risk: evidence from genome-wide association studies by Simone Mocellin, Saveria Tropea, Clara Benna, Carlo Riccardo Rossi

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Bmal1 Regulates Prostate Growth via Cell-Cycle Modulation by Masakatsu Ueda, Jin Kono, Atsushi Sengiku, Yoshiyuki Nagumo, Bryan J. Mathis, Shigeki Shimba, Makoto Mark Taketo, Takashi Kobayashi, Osamu Ogawa, Hiromitsu Negoro

“…These findings indicate that core clock gene Bmal1 is involved in prostate growth via the modulation of the cell cycle and provide a rationale for further research to link the pathogenesis of benign prostatic hyperplasia or cancer with the circadian clock.…”
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Uncovering the Novel Role of NR1D1 in Regulating BNIP3-Mediated Mitophagy in Ulcerative Colitis by Yidong Chen, Junrong Li, Shuang Li, Yiyu Cheng, Xiaoyu Fu, Jiamin Li, Liangru Zhu

“…Background: Ulcerative colitis (UC) is a chronic, incurable condition characterized by mucosal inflammation and intestinal epithelial cell (IEC) damage. The circadian clock gene NR1D1, implicated in UC and the critical mitophagy process for epithelial repair, needs further exploration regarding its role in mitophagy regulation in UC. …”
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Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals by Montagner, Alexandra, Korecka, Agata, Polizzi, Arnaud, Lippi, Yannick, Blum, Yuna, Canlet, Cécile, Tremblay-Franco, Marie, Gautier-Stein, Amandine, Burcelin, Rémy, Yen, Yi-Chun, Je, Hyunsoo Shawn, Maha, Al-Asmakh, Mithieux, Gilles, Arulampalam, Velmurugesan, Lagarrigue, Sandrine, Guillou, Hervé, Pettersson, Sven, Wahli, Walter

“…Here, we report that germ-free (GF) mice display altered daily oscillation of clock gene expression with a concomitant change in the expression of clock output regulators. …”
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The severity of endothelial dysfunction, oxidative stress, lipid metabolism disorders, decreased elastic properties and tone of peripheral vessels in patients with different POAG c... by Yu. E. Filippova, T. N. Malishevskaya, S. N. Kolomeichuk, D. G. Gubin, A. S. Vlasova

“…The hospitalized patients were examined for daily melatonin profile and key biological clock genes typed by real-time polymerase chain reaction. …”
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PER2 binding to HSP90 enhances immune response against oral squamous cell carcinoma by inhibiting IKK/NF-κB pathway and PD-L1 expression by Hong Tang, Shilin Yin, Zhiwei Zhang, Jie Ren, Kai Yang, Deping Sun

“…Here we investigate the role and molecular mechanism of the core clock gene Period2 (PER2) in regulating PD-L1 expression and its role in the combination therapy of oral squamous cell carcinoma (OSCC).Methods Quantitative real-time PCR, western blotting or immunohistochemistry to detect expression of PER2 and PD-L1 in OSCC tissues and cells. …”
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PER2 Circadian Oscillation Sensitizes Esophageal Cancer Cells to Chemotherapy by Juan Alfonso Redondo, Romain Bibes, Alizée Vercauteren Drubbel, Benjamin Dassy, Xavier Bisteau, Eleonore Maury, Benjamin Beck

“…In the present study, we confirm that PER2 oscillations still occur in human cancer cells in vitro in spite of a deregulated circadian clock gene expression. Profiling of eSCC cells by RNAseq reveals that when PER2 expression is low, several transcripts related to apoptosis are upregulated. …”
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Effects of eyestalk ablation on growth, feeding behavior, movement and circadian gene expression in Haliotis discus hannai by Shuang Liang, Chuigen Zeng, Jian Liang, Xuan Luo, Xiaolong Gao, Caihuan Ke, Yongren Li, Limei Chen, Huiru Liu, Yongjun Guo

“…The expression of five core clock genes (clock, cry, rho, tipin, per) exhibited significant circadian rhythms in H. discus hannai, while their rhythmic oscillation significance was weaker in the EA group, except for the tipin transcript. …”
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Targeting clock-controlled gene Nrf2 ameliorates inflammation-induced intervertebral disc degeneration by Pandi Peng, Dong Wang, Xiaolong Xu, Di Wang, Bo Gao, Han Wang, Haoruo Jia, Qiliang Shang, Chao Zheng, Chu Gao, Jianxin Mao, Zhuojing Luo, Liu Yang, Xueyu Hu

“…In this study, we found that the circadian clock of NP cells was totally disrupted by knockdown of the core clock gene brain and muscle arnt-like protein-1 (Bmal1), which thus induced the dysfunction of NP cells. …”
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Gut microbiota and hepatic PPARS in the regulation of liver circadian rhythm by Oh, Penny Hui Yun

“…In our antibiotic-induced selective depletion of gut microbiota, elimination of gram- positive bacteria by antibiotic treatment perturbed liver circadian rhythm as shown by the altered hepatic core clock gene expression and changes in proteins and metabolites under circadian regulation. …”
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Defining diurnal fluctuations in mouse choroid plexus and CSF at high molecular, spatial, and temporal resolution by Ryann M. Fame, Peter N. Kalugin, Boryana Petrova, Huixin Xu, Paul A. Soden, Frederick B. Shipley, Neil Dani, Bradford Grant, Aja Pragana, Joshua P. Head, Suhasini Gupta, Morgan L. Shannon, Fortunate F. Chifamba, Hannah Hawks-Mayer, Amanda Vernon, Fan Gao, Yong Zhang, Michael J. Holtzman, Myriam Heiman, Mark L. Andermann, Naama Kanarek, Jonathan O. Lipton, Maria K. Lehtinen

“…Diurnal variation in ChP TTR depended on Bmal1 clock gene expression. We achieved real-time tracking of CSF-TTR in awake Ttr mNeonGreen mice via multi-day intracerebroventricular fiber photometry. …”
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